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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nf2tm1Tyj
targeted mutation 1, Tyler Jacks
MGI:1857941
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nf2tm1Tyj/Nf2tm1Tyj involves: 129S2/SvPas * C57BL/6J MGI:2447457
ht2
Nf2tm1Tyj/Nf2+ either: (involves: 129S2/SvPas * 129S4/SvJae * C57BL/6) or (involves: 129S2/SvPas * C57BL/6J) MGI:2447459


Genotype
MGI:2447457
hm1
Allelic
Composition
Nf2tm1Tyj/Nf2tm1Tyj
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm1Tyj mutation (1 available); any Nf2 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die between E7.5 and E8.5; underdeveloped structures observed at E6.5

embryo
• abnormal morphology of the visceral endoderm is suggestive of a defect in the establishment of the primary dorsal-ventral axis
• gastrulation is not initiated
• mesoderm does not form due to failure of gastrulation
• abnormal visceral endoderm; more than one region of squamous morphology is often seen suggesting a defect in the establishment of the primary embryonic axis




Genotype
MGI:2447459
ht2
Allelic
Composition
Nf2tm1Tyj/Nf2+
Genetic
Background
either: (involves: 129S2/SvPas * 129S4/SvJae * C57BL/6) or (involves: 129S2/SvPas * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm1Tyj mutation (1 available); any Nf2 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• schwannomas, meningiomas, or ependymomas were not detected
• increased incidence of highly metastatic tumors, including osteosarcoma, lymphoma, lung adenocarcinomas, hepatocellular carcinoma and fibrosarcoma
• osteosarcoma frequency was higher in females and the frequency of fibrosarcomas was higher in males

respiratory system

skeleton

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT familial meningioma DOID:4586 J:47282





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory