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Allele Symbol Allele Name Allele ID |
Msh2tm1Mak targeted mutation 1, Tak W Mak MGI:1857940 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired
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• impaired
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• impaired
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• impaired
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• between 2 and 5 months of age, due to tumor-related illness
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• increased incidence of metastasizing lymphoma, beginning ~2 months of age, incomplete penetrance
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| N |
• no gross abnormalities were seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired
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• impaired
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• impaired
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• impaired
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the 50% survival age is around 10 months
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• 76.9% of mice develop tumors, including ovarian tumors (57.6%), lung adenomas (35.9%), lung adenocarcinoma (61.3%), lymphoma (26.9%)
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• in 57.6% of mice, with the earliest onset at 5 months of age
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• observe in 35.9% of mice
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• observe in 26.9% of mice
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• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age
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• observe in 35.9% of mice
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• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age
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• in 57.6% of mice, with the earliest onset at 5 months of age
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• in 57.6% of mice, with the earliest onset at 5 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the 50% survival age is 4.3 months and all mutants die within 10.3 months
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• 86.7% of mice develop tumors, predominantly lymphoma (76.7%) with some incidence of lung adenoma (10%)
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• observe in 10% of mice
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• observe in 76.7% of mice
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• observe in 10% of mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit enhanced polyp number in the small intestine, but not in the colon compared to double ApcMin Msh2tm1Mak heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit similar polyp formation in the small intestine and colon as mice heterozygous for ApcMin and homozygous for Msh2tm1Mak
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice become moribound and die from anemia and intestinal obstruction at a mean age of 82 days
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• mice exhibit accelerated intestinal tumorigenesis compared to single ApcMin heterozygous mice, with a large increase in number of small and large bowel adenomas that develop
• an average of 333 adenomas are seen in 10 mutants at 47-78 days of age compared to a mean of 48 adenomas in single ApcMin heterozygotes
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• mice exhibit accelerated intestinal tumorigenesis compared to single ApcMin heterozygous mice, with a large increase in number of small and large bowel adenomas that develop
• an average of 333 adenomas are seen in 10 mutants at 47-78 days of age compared to a mean of 48 adenomas in single ApcMin heterozygotes
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• due to tumors
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• mutants exhibit enhanced polyp formation in the small intestine and colon at 6 weeks of age compared to double heterozygous mice
• treatment with the Nos2 (iNOS) inhibitor L-NIL has no effect on polyp number
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| colorectal cancer | DOID:9256 |
OMIM:114500 |
J:75393 , J:200824 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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