Mouse Genome Informatics
hm1
    Cftrtm3Bay/Cftrtm3Bay
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• at least 60% die within one month after birth due to intestinal obstruction

digestive/alimentary system
• exhibit dilatation of the crypts of Lieberkuhn and the presence of eosinophilic concretions in the crypts of the small and large intestine
• cAMP stimulated chloride secretion is defective in the colon
• many exhibit intestinal disease as indicated by intestinal obstruction

growth/size/body
• those that survive the newborn period are smaller and grow more slowly

reproductive system
• adult females are almost always sterile, although males are fertile (J:29656)

endocrine/exocrine glands
• exhibit dilatation of the crypts of Lieberkuhn and the presence of eosinophilic concretions in the crypts of the small and large intestine
• exhibit a variable degree of pancreatic atrophy

liver/biliary system
N
• no abnormal liver/biliary system phenotypes detected (J:29656)

respiratory system
N
• no abnormal respiratory system phenotypes detected (J:29656)

Mouse Models of Human Disease
OMIM IDRef(s)
Cystic Fibrosis; CF 219700 J:29656