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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cftrtm3Bay
targeted mutation 3, Baylor College of Medicine
MGI:1857898
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cftrtm3Bay/Cftrtm3Bay involves: 129S7/SvEvBrd MGI:2177541


Genotype
MGI:2177541
hm1
Allelic
Composition
Cftrtm3Bay/Cftrtm3Bay
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm3Bay mutation (0 available); any Cftr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at least 60% die within one month after birth due to intestinal obstruction

digestive/alimentary system
• exhibit dilatation of the crypts of Lieberkuhn and the presence of eosinophilic concretions in the crypts of the small and large intestine
• cAMP stimulated chloride secretion is defective in the colon
• many exhibit intestinal disease as indicated by intestinal obstruction

growth/size/body
• those that survive the newborn period are smaller and grow more slowly

reproductive system
• adult females are almost always sterile, although males are fertile

endocrine/exocrine glands
• exhibit dilatation of the crypts of Lieberkuhn and the presence of eosinophilic concretions in the crypts of the small and large intestine
• exhibit a variable degree of pancreatic atrophy

liver/biliary system
N
• no abnormal liver/biliary system phenotypes detected

respiratory system
N
• no abnormal respiratory system phenotypes detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Cystic Fibrosis; CF 219700 J:29656





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory