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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
plt
paucity of lymph node T-cells
MGI:1857881
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
plt/plt B6.DDD-plt MGI:4430603
hm2
plt/plt C.DDD-plt MGI:3762343
hm3
plt/plt either: B6.DDD-plt or C.DDD-plt MGI:4437582
hm4
plt/plt involves: DDD/1 MGI:2660691


Genotype
MGI:4430603
hm1
Allelic
Composition
plt/plt
Genetic
Background
B6.DDD-plt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• no single positive T cell abnormalities other than the migration defect from cortex to medulla of the thymus
• single positive T cells fail to localize to the medulla of the thymus in newborns
• single positive T cells are retained in the cortex of the thymus
• single positive thymocytes are retained by the cortex rather than migrating to the medulla
• reduced in size in the adult thymus
• medullary volume is about 50% that found in controls

hematopoietic system
• single positive T cells fail to localize to the medulla of the thymus in newborns
• single positive T cells are retained in the cortex of the thymus
• single positive thymocytes are retained by the cortex rather than migrating to the medulla
• reduced in size in the adult thymus
• medullary volume is about 50% that found in controls

cellular
• single positive T cells fail to localize to the medulla of the thymus in newborns
• single positive T cells are retained in the cortex of the thymus

endocrine/exocrine glands
• single positive thymocytes are retained by the cortex rather than migrating to the medulla
• reduced in size in the adult thymus
• medullary volume is about 50% that found in controls




Genotype
MGI:3762343
hm2
Allelic
Composition
plt/plt
Genetic
Background
C.DDD-plt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the amount of CD4+ or CD8+ T cells are decreased in lymph nodes compared to in wild-type mice
• however, remaining single positive cells undergo normal activation and proliferation alloresponses
• mice exhibit impaired T cell activation following receipt of islet allografts compared to wild-type mice
• however, T cell alloresponses are normal
• islet allografts function for over 120 days compared to in wild-type mice in which rejection occurs at 14 days
• unlike in wild-type mice, cardiac allograft survival time is doubled after the spleen is removed
• however, cardiac allografts are rejected at the same tempo as in wild-type mice

hematopoietic system
• the amount of CD4+ or CD8+ T cells are decreased in lymph nodes compared to in wild-type mice
• however, remaining single positive cells undergo normal activation and proliferation alloresponses
• mice exhibit impaired T cell activation following receipt of islet allografts compared to wild-type mice
• however, T cell alloresponses are normal




Genotype
MGI:4437582
hm3
Allelic
Composition
plt/plt
Genetic
Background
either: B6.DDD-plt or C.DDD-plt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• as early as 5 weeks of age, mice exhibit lesions in exocrine glands unlike wild-type mice
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

immune system
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice
• mice exhibit autoimmune exocrinopathy unlike wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

homeostasis/metabolism
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

digestive/alimentary system
• mice exhibit parotid gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit submandibular gland tissue damage associated with inflammation unlike wild-type mice
• mice exhibit sialadenitis unlike wild-type mice
• parotid glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• submandibular glands exhibit periductal lymphocyte infiltration unlike in wild-type mice

vision/eye
• lacrimal glands exhibit periductal lymphocyte infiltration causing destruction of acinar cells unlike in wild-type mice
• lacrimal glands exhibit periductal lymphocyte infiltration unlike in wild-type mice
• mice exhibit dacryoadenitis unlike wild-type mice

cellular
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

hematopoietic system
• FTY720-treated mice exhibit an accumulation of mature thymocytes in the cortex rather than medulla of the thymus as in similarly treated wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Sjogren's syndrome DOID:12894 OMIM:270150
J:110910




Genotype
MGI:2660691
hm4
Allelic
Composition
plt/plt
Genetic
Background
involves: DDD/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
plt mutation (4 available); any plt mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the total number of T cells in lymph nodes is smaller than in BALB/c mice
• the number of either CD4+ or CD8+ T cells is decreased compared to in CBA, B6, C3H and BALB/c mice
• the number of T cells in the blood and spleen is increased compared to in wild-type mice
• the number of T cells in the peripheral lymph nodes and Peyer's patches with memory phenotype is increased compared to in wild-type mice
• unlike in wild-type spleens, T cells are found within the red pulp
• unlike in wild-type spleens, few T cells are found within the white pulp
• most Peyer's patches are smaller than in wild-type mice
• T cells are hardly observed in T cell zones but are observed in B cell zones (J:47460)
• low density of T cells in subcortical area (J:47819)
• the number of lymph node cells is reduced by 10 and 6 times in males and females, respectively, than in CBA and B6 mice (J:15290)
• T cell cellularity within the peripheral lymph nodes is decreased (J:47460)
• the amount of T cells in the subcortical area is extremely low
• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)
• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)
• T cell migration into lymph nodes is defective (J:47819)

hematopoietic system
• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)
• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)
• T cell migration into lymph nodes is defective (J:47819)
• the total number of T cells in lymph nodes is smaller than in BALB/c mice
• the number of either CD4+ or CD8+ T cells is decreased compared to in CBA, B6, C3H and BALB/c mice
• the number of T cells in the blood and spleen is increased compared to in wild-type mice
• the number of T cells in the peripheral lymph nodes and Peyer's patches with memory phenotype is increased compared to in wild-type mice
• unlike in wild-type spleens, T cells are found within the red pulp
• unlike in wild-type spleens, few T cells are found within the white pulp

cellular
• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)
• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)
• T cell migration into lymph nodes is defective (J:47819)





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory