Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
nervous system
|
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• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice
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• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice
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• at E12.5, dorsal forebrain lengthening is observed unlike in wild-type mice
• at E14.5, the dorsal forebrain is longer and thinner than in wild-type mice
• however, treatment with all-trans retinoic acid restores forebrain morphology
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• at E18.5, cortical layers are disorganized compared to in wild-type mice
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• at E14.5, meningeal cells end before the ventral forebrain with absent dorsal meninges unlike in wild-type mice
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embryo
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N |
• somites develop normally
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cellular
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• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice
|
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|
• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice
|
|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
mortality/aging
|
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• mutants die soon after birth due to an inability to breathe
(J:57677)
• mice die at birth
(J:105944)
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reproductive system
 |
• large follicle cysts, several of which are hemorrhagic, develop when ovaries are engrafted into a wild-type host
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• ovaries contain fewer germ cells that are found in clusters scattered throughout the ovary unlike in wild-type mice
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• after 8 weeks of engraftment into a wild-type host, ovaries display oocyte degeneration or loss
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• between E10.5 and E11.5, fewer than normal primordial germ cells migrate out of the hindgut resulting in fewer germ cells entering the developing gonads
• however, germ cell attractants are normally expressed
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• ovaries lack distinct cortex and medulla regions as in wild-type ovaries
• granulosa and thecal cell layers as well as the basement membrane separating the two are less well defined than in wild-type mice
• after 8 weeks, ovaries engrafted into a wild-type host often contain polyovular follicles and contain regions of cells not organized into follicles-like structures unlike in wild-type mice
• by week 8 after engraftment into a wild-type host, 1 of 4 ovaries contain Seroli cells tubule-like structures
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• at E18.5, mutant ovaries lack a distinct cortex region
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• by 8 weeks of engraftment into a wild-type host, remaining healthy follicles are larger than in wild-type mice
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• when ovaries are transplanted into a wild-type host, follicles fail to progress beyond the pre-antral/early antral stages
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• after 8 weeks, ovaries engrafted into a wild-type host often contain polyovular follicles and contain regions of cells not organized into follicles-like structures unlike in wild-type mice
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• at E18.5, mutant ovaries lack a distinct medulla region
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• at E18.5, mutant ovaries are smaller than wild-type
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• large follicle cysts, several of which are hemorrhagic, develop when ovaries are engrafted into a wild-type host
|
 |
• seminiferous cords are present but interspersed with regions of disorganized cells where no cords are apparent
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• at E18.5, testes exhibit a reduced tunica albuginea
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• the oviduct is shorter than normal and uncoiled
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• by E14.5, gonads are reduced compared to in wild-type mice
• mice exhibit smaller and misshapen gonads, especially in the posterior regions, compared to in wild-type mice
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embryo
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• major malformations in the branchial arch arteries and heart are found in all double heterozygotes
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• in 2 of 3 embryos examined on E10.5 and 11.5 a blister like defect is seen on the wall of left arch artery 4
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• mice exhibit a reduction in the posterior mesonephros with abnormal indentation
• at E14.5, the mesonephric tissues remain enlarged compared to in wild-type mice
• ectopic mesonephric tubules persist up to E18.5
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skeleton
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• newborns have extinsive abnormalities in the skull, vertebrae, thorax, hyoid, larynx, and appendicular skeleton
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• in newborns the basisphenoid bone is reduced and malformed
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• in newborns the calvarial bones are absent
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• the zygomatic process is enlarged and fused to the mandible
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• in newborns the digits are thinner than normal with smaller ossification centers
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• in newborns the deltoid process of the humerus is misshapen
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• in newborns the xiphoid process is misshapen
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• the absence of the sternum presumably contributes to the inability of these mutants to breath
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• in newborns the ribs are thinner than normal
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• in newborns the dorsal neural arches fail to fuse along the whole vetebral column
• in newborns the lateral arches are reduced
• at E16.5 and birth the neural arches are misshapen and have reduced ossification
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• in newborns the vetebral bodies are reduced
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• ossification of some of bones is impaired
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• in newborns all of the ossification centers of the sternum except the manubrium are absent
• at E13.5 the mesenchyme cells condense much less than in wild-type
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vision/eye
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• at E18.5, lactimal ducts are distended; the overall length of the gland duct is significantly reduced
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• at E18.5, the exorbital lobe is severely reduced compared to in wild-type mice
• significantly fewer branches and terminal buds are observed within the exorbital lobe
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• at E18.5, the intra-orbital lacrimal gland is absent
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• at E16.5, branches of the lacrimal gland are shorter and wider with fewer terminal buds than in wild-type mice
• lacrimal gland explants have fewer branches with terminal buds that are longer and wider than in wild-type lacrimal explants
• however, lacrimal gland epithelium differentiation is normal
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• lacrimal gland mesenchyme is insensitive to Bmp7 treatment unlike wild-type mesenchyme
• however, lacrimal gland epithelium proliferation in response to FGF is normal
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• reduced number of mesenchymal cells in the future stromal region
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• the arrangement of cells within the cornea is disorganized
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• fails to differentiate normally
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• cells become enlarged and separated from one another by microvilli lined spaces
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• comes to be composed of more cell layers than normal
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• significantly reduced in size
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• the eyelids are not fused at birth
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• at E18.5, the lacrimal ducts are distended with individual buds shorter and wider than in wild-type mice
• the length of the ducts and number of terminal buds are reduced compared to in wild-type mice
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cardiovascular system
|
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• major malformations in the branchial arch arteries and heart are found in all double heterozygotes
|
|
|
• in 2 of 3 embryos examined on E10.5 and 11.5 a blister like defect is seen on the wall of left arch artery 4
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• coarctation of the arch of the aorta is found at E11.5 and in newborns (3 out of 5 and 6 out of 11, respectively)
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• at E13.5 and 16.5 interruption of the arch of the aorta is found (2 out of 3 and 2 out of 6 respectively)
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• the ductus arteriosus connecting the aorta to the pulmonary artery fails to close in all newborns
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• ventricular septal defects are found at E13.5, E16.5 and in newborns (2 out of 6; 2 out of 3; 8 out of 11, respectively)
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• in newborns the normal number of leaflets is found but these are thickened and partially fused (8 out of 11)
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• in newborns the normal number of leaflets is found but these are thickened and partially fused (8 out of 11)
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• large follicle cysts, several of which are hemorrhagic, develop when ovaries are engrafted into a wild-type host
|
|
|
• at E14.5 the integrity of some blood vessels in the brain is disrupted and the surrounding area is acellular
|
craniofacial
|
|
• major malformations in the branchial arch arteries and heart are found in all double heterozygotes
|
|
|
• in 2 of 3 embryos examined on E10.5 and 11.5 a blister like defect is seen on the wall of left arch artery 4
|
|
|
• in newborns the basisphenoid bone is reduced and malformed
|
|
|
• in newborns the calvarial bones are absent
|
|
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• the zygomatic process is enlarged and fused to the mandible
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homeostasis/metabolism
limbs/digits/tail
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• in newborns the digits are thinner than normal with smaller ossification centers
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• in newborns the deltoid process of the humerus is misshapen
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nervous system
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• at E14.5 the integrity of some blood vessels in the brain is disrupted and the surrounding area is acellular
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• by E11.5 the brain size is clearly increased in mutants
• at E14.5 the integrity of some blood vessels in the brain is disrupted and the surrounding area is acellular
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endocrine/exocrine glands
|
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• large follicle cysts, several of which are hemorrhagic, develop when ovaries are engrafted into a wild-type host
|
|
|
• at E18.5, lactimal ducts are distended; the overall length of the gland duct is significantly reduced
|
|
|
• at E18.5, the exorbital lobe is severely reduced compared to in wild-type mice
• significantly fewer branches and terminal buds are observed within the exorbital lobe
|
|
|
• at E18.5, the intra-orbital lacrimal gland is absent
|
|
|
• at E16.5, branches of the lacrimal gland are shorter and wider with fewer terminal buds than in wild-type mice
• lacrimal gland explants have fewer branches with terminal buds that are longer and wider than in wild-type lacrimal explants
• however, lacrimal gland epithelium differentiation is normal
|
|
|
• ovaries lack distinct cortex and medulla regions as in wild-type ovaries
• granulosa and thecal cell layers as well as the basement membrane separating the two are less well defined than in wild-type mice
• after 8 weeks, ovaries engrafted into a wild-type host often contain polyovular follicles and contain regions of cells not organized into follicles-like structures unlike in wild-type mice
• by week 8 after engraftment into a wild-type host, 1 of 4 ovaries contain Seroli cells tubule-like structures
|
|
|
• at E18.5, mutant ovaries lack a distinct cortex region
|
|
|
• by 8 weeks of engraftment into a wild-type host, remaining healthy follicles are larger than in wild-type mice
|
|
|
• when ovaries are transplanted into a wild-type host, follicles fail to progress beyond the pre-antral/early antral stages
|
|
|
• after 8 weeks, ovaries engrafted into a wild-type host often contain polyovular follicles and contain regions of cells not organized into follicles-like structures unlike in wild-type mice
|
|
|
• at E18.5, mutant ovaries lack a distinct medulla region
|
|
|
• at E18.5, mutant ovaries are smaller than wild-type
|
|
|
• large follicle cysts, several of which are hemorrhagic, develop when ovaries are engrafted into a wild-type host
|
|
|
• seminiferous cords are present but interspersed with regions of disorganized cells where no cords are apparent
|
|
|
• at E18.5, testes exhibit a reduced tunica albuginea
|
|
|
• lacrimal gland mesenchyme is insensitive to Bmp7 treatment unlike wild-type mesenchyme
• however, lacrimal gland epithelium proliferation in response to FGF is normal
|
renal/urinary system
cellular
|
|
• the ductus arteriosus connecting the aorta to the pulmonary artery fails to close in all newborns
|
|
|
• ovaries contain fewer germ cells that are found in clusters scattered throughout the ovary unlike in wild-type mice
|
|
|
• after 8 weeks of engraftment into a wild-type host, ovaries display oocyte degeneration or loss
|
|
|
• between E10.5 and E11.5, fewer than normal primordial germ cells migrate out of the hindgut resulting in fewer germ cells entering the developing gonads
• however, germ cell attractants are normally expressed
|
growth/size/body
|
|
• large follicle cysts, several of which are hemorrhagic, develop when ovaries are engrafted into a wild-type host
|
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• at E18.5, no bursa membrane can be detected, unlike in wild-type ovaries
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
vision/eye
|
|
• Background Sensitivity: incidence and severity of anterior segment abnormalities varies with strain background
• 2 of 8 mice had obvious anterior segment abnormalities at 11 months of age
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• most eyes contain morphologically normal and abnormal regions of the iridocorneal angle
• abnormalities include large blood vessels and iris strands
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• small or absent
• in some areas the canal of Schlemm is absent, in others it is relatively normal but contains fewer giant vacuoles, and in still others it has a normal appearance
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• areas may be hypoplastic or absent
• in some places the trabecular meshwork appears compressed
• some areas where the trabecular meshwork is absent contain cells that resemble mesenchymal precursor cells
• some abnormal areas show a decrease in the amount of extracellular matrix components present
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• at 11 months of age in 2 of 8 mice, the left pupil in was eccentric
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• seen in the left eyes of 2 of 8 mice at 11 months of age
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• at 11 months of age in 1 of 8 mice in the right eye, the focal region of the peripheral cornea was opaque and resemble sclera
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
vision/eye
|
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• pigmented mice had mild developmental defects than compared to albino Tyrc-2J/Tyrc-2J, Foxc1tm1Blh /Foxc1+ mice
|
Allelic
Composition |
Foxc1tm1Blh/Foxc1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * Black Swiss |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
vision/eye
|
|
• Background Sensitivity: incidence and severity of anterior segment abnormalities varies with strain background
|
|
|
• most eyes contain morphologically normal and abnormal regions of the iridocorneal angle
• abnormalities include large blood vessels and iris strands
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• areas may be hypoplastic or absent
• in some places the trabecular meshwork appears compressed
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• 1 of 20 mice had abnormal processes extending from the iris
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• eccentric pupil present in 1 of 20 mice
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• hypoplastic development
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pigmentation
Allelic
Composition |
Foxc1tm1Blh/Foxc1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
vision/eye
|
N |
• despite abnormalities intraocular pressure is not increased
|
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• Background Sensitivity: incidence and severity of anterior segment abnormalities varies with strain background
• at N2 4 of 12 mice had anterior segment abnormalities
• at N3 and higher generations, 20 of 21 mice had anterior segment abnormalities
• 17 of 24 affected mice had abnormalities in both eyes
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• most eyes contain morphologically normal and abnormal regions of the iridocorneal angle
• abnormalities include large blood vessels and iris strands
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• areas may be hypoplastic or absent
• in some places the trabecular meshwork appears compressed
• some areas where the trabecular meshwork is absent contain cells that resemble mesenchymal precursor cells
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• displaced and/or enlarged
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• severely misplaced in some mice
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• some mice had irregular pupils with normal locations others have irregular pupils with iris tears
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• scleralization of the peripheral cornea
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• iris strands are frequently attached to the cornea
|
Allelic
Composition |
Foxc1tm1Blh/Foxc1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * CAST/Ei |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
vision/eye
|
N |
• Background Sensitivity: unlike mice on other backgrounds no clinical anterior segment abnormalities are seen in mice crossed onto the CAST/Ei background
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|
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• most eyes contain morphologically normal and abnormal regions of the iridocorneal angle
• abnormalities include large blood vessels and iris strands
|
|
|
• areas may be hypoplastic or absent
• in some places the trabecular meshwork appears compressed
• some areas where the trabecular meshwork is absent contain cells that resemble mesenchymal precursor cells
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1hith mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
|
|
|
nervous system
|
|
• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice
|
|
|
• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice
|
|
|
• at E12.5, dorsal forebrain lengthening is observed unlike in wild-type mice
• at E14.5, the dorsal forebrain is longer and thinner than in wild-type mice
• however, treatment with all-trans retinoic acid restores forebrain morphology
|
|
|
• at E18.5, cortical layers are disorganized compared to in wild-type mice
|
|
|
• at E14.5, the lateral meninges are reduced and the dorsal meninges are absent unlike in wild-type mice
|
cellular
|
|
• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice
|
|
|
• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc1tm1Tsku mutation
(0 available);
any
Foxc1 mutation
(29 available)
Tg(Tek-cre)1Rwng mutation
(0 available)
|
|
|
cellular
|
|
• isolated pulmonary microvascular endothelial cells exhibit a significant reduction in chemotactic migration towards Cxcl12
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Tyrc-2J mutation
(25 available);
any
Tyr mutation
(375 available)
|
|
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vision/eye
|
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• albino mice had severe and more extensive angle developmental defects than pigmented Foxc1tm1Blh /Foxc1+ mice
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• a small or absent Schlemm's canal
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• basal lamina extending from the cornea over the trabecular meshwork
|
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• broad synechiae occupies the region where the trabecular meshwork is normally located
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
embryo
|
N |
• despite the lack of somites, proliferation and apoptosis rates of paraxial mesoderm are normal
|
|
|
• at E9.5, mesonephric tissue is expanded and disorganized compared to in wild-type mice
|
|
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• mice exhibit ectopic expression of intermediate mesoderm markers leading to increased lateralization of somites
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
embryo
|
|
• at E9.5, mesonephric tissue is expanded and disorganized compared to in wild-type mice
|
|
|
• somites are very narrow and irregular
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
embryo
|
N |
• somites develop normally
|
Allelic
Composition |
Foxc1tm1Blh/Foxc1+
Foxc2tm1Blh/Foxc2+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * Black Swiss |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
mortality/aging
|
|
• most embryos die between E14.5 and birth
• double heterozygotes shown signs of cardiac failure between E13.5 and E15.5
|
cardiovascular system
|
|
• major malformations in the branchial arch arteries and heart are found in all double heterozygotes
|
|
|
• in 2 of 3 embryos examined on E10.5 and 11.5 a blister like defect is seen on the wall of left arch artery 4
|
|
|
• coarctation of the arch of the aorta is found in 8 of 17 embryos at E13.5
|
|
|
• at E12.5 and 13.5 type B interruption of the arch of the aorta is seen
|
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• the number of coronary vessels is decreased in embryos examined between E15.5 and E17.5
|
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• in embryos collected between E13.5 and E15.5 the superior caval veins are overexpanded
|
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• the thickness of the myocardium of the ventricles is decreased in all double heterozygotes between E13.5 and E17.5
|
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• the extent of trabeculations of the ventricles is decreased in all double heterozygotes between E13.5 and E17.5
|
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• the membraneous portion of the ventricular septum fails to fuse at E13.5 (15 out of 17)
|
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• at E13.5 dysplasia of the semilunar valves is found (8 out of 17)
|
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• the leaflets are thickened and partially fused
|
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• at E13.5 dysplasia of the semilunar valves is found (8 out of 17)
|
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• the leaflets are thickened and partially fused
|
homeostasis/metabolism
liver/biliary system
|
|
• the fetal liver is enlarged and engorged with blood
|
renal/urinary system
|
|
• 26% of newborn double heterozygotes display hydronephrosis
|
|
|
• 7 of 19 newborn double heterozygotes have hypoplastic kidneys (less than 3/4 of wild-type length)
• hypoplastic kidneys are either unilateral (71%) or bilateral (29%)
|
|
|
• 5% of newborn double heterozygotes show renal agenesis
|
|
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• 1 of 19 newborn double heterozygotes had a duplex kidney and double ureters
|
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• 1 of 19 newborn double heterozygotes had a duplex kidney and double ureters
|
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• 13 of 19 double heterozygotes have a single hydroureter
• hydroureter is either unilateral (85%) or bilateral (15%)
|
|
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• at E10.5, 2 of 3 double heterozygotes show a much broader outgrowth of the ureteric bud
|
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• at E11.0, 3 of 4 double heterozygotes exhibit an ectopic ureteric bud
|
skeleton
|
N |
• no gross malformations of the vertebral column, ribs, or skull are found
|
embryo
|
|
• major malformations in the branchial arch arteries and heart are found in all double heterozygotes
|
|
|
• in 2 of 3 embryos examined on E10.5 and 11.5 a blister like defect is seen on the wall of left arch artery 4
|
|
|
• double heterozygotes display extra mesonephric tubules distributed caudally between somites 16 and 23
|
vision/eye
|
|
• abnormalities similar to those in Foxc1tm1Blh heterozygotes are seen
|
|
|
• areas may be hypoplastic or absent
|
|
|
• intermittent abnormalities are seen
|
|
|
• more severely affected than in either single heterozygote
|
|
|
• almost completely absent in some areas
|
|
|
• corneal ulcers and immune cell infiltrates are present in some eyes
|
muscle
|
|
• the thickness of the myocardium of the ventricles is decreased in all double heterozygotes between E13.5 and E17.5
|
|
|
• the extent of trabeculations of the ventricles is decreased in all double heterozygotes between E13.5 and E17.5
|
craniofacial
|
|
• major malformations in the branchial arch arteries and heart are found in all double heterozygotes
|
|
|
• in 2 of 3 embryos examined on E10.5 and 11.5 a blister like defect is seen on the wall of left arch artery 4
|
growth/size/body
|
|
• the fetal liver is enlarged and engorged with blood
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
mortality/aging
|
|
• double homozygotes die at ~E9.0-E9.5 with a much more severe phenotype than that of either single homozygote alone
|
cardiovascular system
|
|
• at E9.0, most blood vessels are still organized into primitive plexi; no blood vessels have sprouted from the dorsal aorta
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• at E9.0, double homozygotes exhibit a dilated dorsal aorta with blood accumulated probably as a result of a weakly beating heart
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• at E9.0, double homozygotes show a disorganized myocardium
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• at E9.0, double homozygotes display a small heart
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• at E9.5, double homozygotes occasionally display an enlarged pericardial sac
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• at E9.0, double homozygotes display a weak heartbeat
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craniofacial
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• at E9.0, double homozygotes have very small first branchial arches
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• at E9.0, double homozygotes completely lack a second branchial arch and have a very small first branchial arch
• dense accumulations of mesenchymal cells with pycnotic nuclei are detected in place of a second branchial arch
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embryo
|
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• at E9.0, double homozygotes have very small first branchial arches
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|
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• at E9.0, double homozygotes completely lack a second branchial arch and have a very small first branchial arch
• dense accumulations of mesenchymal cells with pycnotic nuclei are detected in place of a second branchial arch
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|
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• at E9.5, double homozygotes are significantly smaller than wild-type embryos
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• at E9.0, double homozygotes display absence of segmented paraxial mesoderm
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• at E9.5, double homozygotes usually display an open anterior neural tube
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• at E9.0, sections at the level of the first branchial arch reveal ectopic epithelial tubes that may represent endoderm that would have formed branchial pouches
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• at E9.5, double homozygotes fail to establish A/P domains in the anterior presomitic mesoderm
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• at E9.5, double homozygotes display absence of segmented, epithelialized somites, including dermamyotome, in the trunk region
• absence of the most anterior somites (1-8) indicates a defect in early somitogenesis
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|
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• at E9.0, double mutant yolk sacs contain only enlarged vessels in a primitive plexus that has undergone very little remodeling; no small blood vessels are present
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growth/size/body
|
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• at E9.5, double homozygotes are significantly smaller than wild-type embryos
|
|
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• at E9.0, double homozygotes show a disorganized head structure, including sparse mesenchyme and enlarged blood vessels
|
nervous system
|
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• at E9.5, double homozygotes usually display an open anterior neural tube
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muscle
|
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• at E9.0, double homozygotes show a disorganized myocardium
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
mortality/aging
|
|
• mutant embryos die at ~E11.5
|
cardiovascular system
|
N |
• at E9.5, mutant embryos display no obvious defects in remodeling of blood vessels; however, an in-depth phenotype analysis is warranted
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1tm1Blh mutation
(0 available);
any
Foxc1 mutation
(29 available)
Foxc2tm1Blh mutation
(0 available);
any
Foxc2 mutation
(15 available)
|
|
|
mortality/aging
|
|
• mutant embryos die at ~E10.5, with a more severe phenotype than that of double heterozygotes or either single homozygote alone
|
cardiovascular system
|
|
• at E10.5, mutant embryos show extensive defects in the remodeling of blood vessels in the head and body
|
|
|
• at E10.5, mutant embryos exhibit variable and multiple branchial arch artery abnormalities, including an enlarged third BA artery with an ectopic branch, thin BA arteries, and generally disorganized BA arteries
|
craniofacial
|
|
• at E10.5, mutant embryos exhibit variable and multiple branchial arch artery abnormalities, including an enlarged third BA artery with an ectopic branch, thin BA arteries, and generally disorganized BA arteries
|
|
|
• at E10.5, mutant embryos lack a second branchial arch
|
embryo
|
|
• at E10.5, mutant embryos exhibit variable and multiple branchial arch artery abnormalities, including an enlarged third BA artery with an ectopic branch, thin BA arteries, and generally disorganized BA arteries
|
|
|
• at E10.5, mutant embryos lack a second branchial arch
|
|
|
• at E10.5, mutant embryos have abnormally shaped somites
|
|
|
• at E10.5, mutant embryos have abnormally small somites
|
Analysis Tools