Mouse Genome Informatics
hm1
    Slc12a2sy-ns/Slc12a2sy-ns
involves: C57BL/6 * MK/ReJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological

hearing/vestibular/ear
• both Reissner's membrane in the cochlea and the walls of the vestibular compartments exhibited extensive collapse
• Reissner's membrane appeared to be fused with underlying structures
• thin semicircular canals
• collapse of endolymphatic space
• fail to develop a normal cytoarchitecture
• inner and outer sulcus epithelia fail to develop a normal cytoarchitecture
• no discernible auditory brainstem responses (ABR) to maximum output stimuli at 99 dB
• profoundly deaf at 2-3 month of age

nervous system


Mouse Genome Informatics
cx2
    Slc12a2sy-ns/sy
involves: C57BL/6 * MK/ReJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological

hearing/vestibular/ear
• no discernible auditory brainstem responses (ABR) to maximum output stimuli at 99 dB
• profoundly deaf at 2-3 month of age