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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc12a2sy-ns
no syndactylism
MGI:1857838
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc12a2sy-ns/Slc12a2sy-ns involves: C57BL/6 * MK/ReJ MGI:2174736
cx2
Slc12a2sy-ns/sy involves: C57BL/6 * MK/ReJ MGI:3698318


Genotype
MGI:2174736
hm1
Allelic
Composition
Slc12a2sy-ns/Slc12a2sy-ns
Genetic
Background
involves: C57BL/6 * MK/ReJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2sy-ns mutation (1 available); any Slc12a2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
• both Reissner's membrane in the cochlea and the walls of the vestibular compartments exhibited extensive collapse
• Reissner's membrane appeared to be fused with underlying structures
• thin semicircular canals
• collapse of endolymphatic space
• fail to develop a normal cytoarchitecture
• inner and outer sulcus epithelia fail to develop a normal cytoarchitecture
• no discernible auditory brainstem responses (ABR) to maximum output stimuli at 99 dB
• profoundly deaf at 2-3 month of age

nervous system




Genotype
MGI:3698318
cx2
Allelic
Composition
Slc12a2sy-ns/sy
Genetic
Background
involves: C57BL/6 * MK/ReJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2sy-ns mutation (1 available); any Slc12a2 mutation (23 available)
sy mutation (1 available); any sy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
• no discernible auditory brainstem responses (ABR) to maximum output stimuli at 99 dB
• profoundly deaf at 2-3 month of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory