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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Acox1tm1Jkr
targeted mutation 1, Janardan K Reddy
MGI:1857811
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Acox1tm1Jkr/Acox1tm1Jkr involves: 129P2/OlaHsd * C57BL/6J MGI:2652088
ht2
Acox1tm1Jkr/Acox1+ involves: 129P2/OlaHsd * C57BL/6J MGI:2652090


Genotype
MGI:2652088
hm1
Allelic
Composition
Acox1tm1Jkr/Acox1tm1Jkr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acox1tm1Jkr mutation (0 available); any Acox1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hepatocellular alterations in liver of Acox1tm1Jkr/Acox1tm1Jkr mice

neoplasm
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara

liver/biliary system
• liver weight accounted for ~11% of total body weight compared to 4% in wild-type mice
• severe microvesicular fatty metamorphosis
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara
• hepatic adenomas and carcinomas developed by 15 months of age, putatively due to sustained activation of Ppara
• impaired peroxisome assembly, hepatocyte cell death followed by hepatocellular regeneration
• regenerated hepatocytes exhibited massive spontaneous peroxisome proliferation and led to a complete reversal of fatty metamorphosis by 6 to 8 months of age

homeostasis/metabolism
• accumulation of very long chain fatty acids in blood

reproductive system
• reduced numbers of spermatozoa
• reduced numbers of round spermatids

growth/size/body
• mutant mice weighed 40 to 50% less than wild-type littermates during first 5 months of age

endocrine/exocrine glands

Mouse Models of Human Disease
OMIM ID Ref(s)
Peroxisomal Acyl-Coa Oxidase Deficiency 264470 J:35794




Genotype
MGI:2652090
ht2
Allelic
Composition
Acox1tm1Jkr/Acox1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acox1tm1Jkr mutation (0 available); any Acox1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mild microvesicular fatty metamorphosis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory