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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adcy1tm1Drs
targeted mutation 1, Daniel R Storm
MGI:1857775
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adcy1tm1Drs/Adcy1tm1Drs involves: 129 * Black Swiss MGI:3622146
hm2
Adcy1tm1Drs/Adcy1tm1Drs involves: 129S7/SvEvBrd MGI:3809555
hm3
Adcy1tm1Drs/Adcy1tm1Drs involves: 129S7/SvEvBrd * C57BL/6 MGI:3622140
cx4
Adcy1tm1Drs/Adcy1tm1Drs
Adcy8tm1Ljm/Adcy8tm1Ljm
involves: 129 * Black Swiss MGI:3622151
cx5
Adcy1tm1Drs/Adcy1tm1Drs
Adcy8tm1Ljm/Adcy8tm1Ljm
involves: 129/Sv * C57BL/6 MGI:3622142


Genotype
MGI:3622146
hm1
Allelic
Composition
Adcy1tm1Drs/Adcy1tm1Drs
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation (0 available); any Adcy1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in mutants this allodynia is significantly reduced in Adcy1tm1Drs
• phase 2 responses to formalin injection are decreased in mutants

integument
• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in mutants this allodynia is significantly reduced in Adcy1tm1Drs
• phase 2 responses to formalin injection are decreased in mutants




Genotype
MGI:3809555
hm2
Allelic
Composition
Adcy1tm1Drs/Adcy1tm1Drs
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation (0 available); any Adcy1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• locus coeruleus neurons exhibit normal firing in response to chronic morphine treatment and withdrawal




Genotype
MGI:3622140
hm3
Allelic
Composition
Adcy1tm1Drs/Adcy1tm1Drs
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation (0 available); any Adcy1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a transfer test in the Morris water task, mutants show no preference for the quadrant where the platform had been located while wild-type mice spent increase time in that quadrant and crossed the target area more frequently

nervous system
• the rate of increase of the EPSP slope for mutants is half that of controls after tetanic stimulation; maximal EPSP slope above baseline is reduced by 40% in mutants

homeostasis/metabolism
• adenylyl cyclase 1 activity is reduced 63% in the cerebellum, 38% in the neocortex and 46% in the hippocampus of mutant mice




Genotype
MGI:3622151
cx4
Allelic
Composition
Adcy1tm1Drs/Adcy1tm1Drs
Adcy8tm1Ljm/Adcy8tm1Ljm
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation (0 available); any Adcy1 mutation (7 available)
Adcy8tm1Ljm mutation (0 available); any Adcy8 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in double knockouts this allodynia is completely abolished
• after nerve injury, reduction in mechanical sensitivity in double knockouts was reduced of abolished compared with wild-type
• phase 2 responses to formalin injection (10-55 minutes after injection) are decreased in mutants, to a greater extent than in Adcy8 knockouts
• phase 3 responses to formalin injection (55-120 minutes following) are decreased in mutants relative to wild-type

integument
• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in double knockouts this allodynia is completely abolished
• after nerve injury, reduction in mechanical sensitivity in double knockouts was reduced of abolished compared with wild-type
• phase 2 responses to formalin injection (10-55 minutes after injection) are decreased in mutants, to a greater extent than in Adcy8 knockouts
• phase 3 responses to formalin injection (55-120 minutes following) are decreased in mutants relative to wild-type




Genotype
MGI:3622142
cx5
Allelic
Composition
Adcy1tm1Drs/Adcy1tm1Drs
Adcy8tm1Ljm/Adcy8tm1Ljm
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1Drs mutation (0 available); any Adcy1 mutation (7 available)
Adcy8tm1Ljm mutation (0 available); any Adcy8 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• double knockout animals exhibit passive avoidance learning but display a memory deficit as early as 30 minutes after training; lower latencies are also apparent 24 hours and 8 days after training compared with single knockouts or wild-type; latencies are comparable to controls after forskolin treatment of CA1 of the hippocampus15 minutes before training
• double knockouts exhibit a decrease in freezing behavior compared to wild-type after 8 days in a contextual learning paradigm

nervous system
• sustained L-LTP could not be generated in hippocampal slices from double knockout mice; the fEPSP slope exhibited a significant decrement at all times after tetanus; LTP dropped off after 80 minutes compared to 3 hours in each of the single knockouts





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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory