All Phenotypes Adcy1<tm1Drs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adcy1^tm1Drs
targeted mutation 1, Daniel R Storm
MGI:1857775

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy1^tm1Drs/Adcy1^tm1Drs	involves: 129 * Black Swiss	MGI:3622146
hm2	Adcy1^tm1Drs/Adcy1^tm1Drs	involves: 129S7/SvEvBrd	MGI:3809555
hm3	Adcy1^tm1Drs/Adcy1^tm1Drs	involves: 129S7/SvEvBrd * C57BL/6	MGI:3622140
cx4	Adcy1^tm1Drs/Adcy1^tm1Drs Adcy8^tm1Ljm/Adcy8^tm1Ljm	involves: 129 * Black Swiss	MGI:3622151
cx5	Adcy1^tm1Drs/Adcy1^tm1Drs Adcy8^tm1Ljm/Adcy8^tm1Ljm	involves: 129/Sv * C57BL/6	MGI:3622142

Allelic Composition	Adcy1^tm1Drs/Adcy1^tm1Drs
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1^tm1Drs mutation (0 available); any Adcy1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:107678 )

• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in mutants this allodynia is significantly reduced in Adcy1^tm1Drs

increased chemical nociceptive threshold ( J:107678 )

• phase 2 responses to formalin injection are decreased in mutants

Allelic Composition	Adcy1^tm1Drs/Adcy1^tm1Drs
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1^tm1Drs mutation (0 available); any Adcy1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:164682 )

N	• locus coeruleus neurons exhibit normal firing in response to chronic morphine treatment and withdrawal

Allelic Composition	Adcy1^tm1Drs/Adcy1^tm1Drs
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1^tm1Drs mutation (0 available); any Adcy1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:22287 )

• in a transfer test in the Morris water task, mutants show no preference for the quadrant where the platform had been located while wild-type mice spent increase time in that quadrant and crossed the target area more frequently

nervous system

abnormal excitatory postsynaptic potential ( J:22287 )

• the rate of increase of the EPSP slope for mutants is half that of controls after tetanic stimulation; maximal EPSP slope above baseline is reduced by 40% in mutants

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:22287 )

• adenylyl cyclase 1 activity is reduced 63% in the cerebellum, 38% in the neocortex and 46% in the hippocampus of mutant mice

Allelic Composition	Adcy1^tm1Drs/Adcy1^tm1Drs Adcy8^tm1Ljm/Adcy8^tm1Ljm
Genetic Background	involves: 129 * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1^tm1Drs mutation (0 available); any Adcy1 mutation (70 available)
Adcy8^tm1Ljm mutation (0 available); any Adcy8 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:107678 )

• at 1 and 3 days after injection of complete Freunds' adjuvant into the hindpaw, wild-type mice withdraw their hindpaw in response to stimulation of the ipsilateral or contralateral hind paw, but in double knockouts this allodynia is completely abolished

• after nerve injury, reduction in mechanical sensitivity in double knockouts was reduced of abolished compared with wild-type

increased chemical nociceptive threshold ( J:107678 )

• phase 2 responses to formalin injection (10-55 minutes after injection) are decreased in mutants, to a greater extent than in Adcy8 knockouts

• phase 3 responses to formalin injection (55-120 minutes following) are decreased in mutants relative to wild-type

Allelic Composition	Adcy1^tm1Drs/Adcy1^tm1Drs Adcy8^tm1Ljm/Adcy8^tm1Ljm
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired passive avoidance behavior ( J:57343 )

• double knockout animals exhibit passive avoidance learning but display a memory deficit as early as 30 minutes after training; lower latencies are also apparent 24 hours and 8 days after training compared with single knockouts or wild-type; latencies are comparable to controls after forskolin treatment of CA1 of the hippocampus15 minutes before training

abnormal contextual conditioning behavior ( J:57343 )

• double knockouts exhibit a decrease in freezing behavior compared to wild-type after 8 days in a contextual learning paradigm

nervous system

reduced long-term potentiation ( J:57343 )

• sustained L-LTP could not be generated in hippocampal slices from double knockout mice; the fEPSP slope exhibited a significant decrement at all times after tetanus; LTP dropped off after 80 minutes compared to 3 hours in each of the single knockouts

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