About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam2tm1Dgm
targeted mutation 1, Diana G Myles
MGI:1857764
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam2tm1Dgm/Adam2tm1Dgm involves: 129P2/OlaHsd * C57BL/6N MGI:2654752
cx2
 		Adam2tm1Dgm/Adam2tm1Dgm
Adam3tm1Pmkf/Adam3tm1Pmkf 		involves: C57BL/6N MGI:3039874


Genotype
MGI:2654752
hm1
Allelic
Composition		 Adam2tm1Dgm/Adam2tm1Dgm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam2tm1Dgm mutation (1 available); any Adam2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired sperm migration in female genital tract ( J:50040 )
• migration of sperm from the uterus into the oviduct is impaired
• sperm count and motility are otherwise normal
reduced male fertility ( J:50040 )
• fertility rate is 2% compared to wild-type
impaired fertilization ( J:50040 )
• the ability of sperm from mutant mice to bind to and fuse with the egg plasma membrane is reduced
• once fused, egg activation proceeds normally
impaired binding of sperm to zona pellucida ( J:50040 )
• sperm are unable to adhere to the zona pellucida

cellular
impaired sperm migration in female genital tract ( J:50040 )
• migration of sperm from the uterus into the oviduct is impaired
• sperm count and motility are otherwise normal




Genotype
MGI:3039874
cx2
Allelic
Composition		 Adam2tm1Dgm/Adam2tm1Dgm
Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam2tm1Dgm mutation (1 available); any Adam2 mutation (42 available)
Adam3tm1Pmkf mutation (1 available); any Adam3 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:69282 )
• the ability of sperm from mutant mice to bind to and fuse with eggs is reduced to the same extent as in either single knock out mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory