All Phenotypes Lig4<tm1Icrf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lig4^tm1Icrf
targeted mutation 1, Imperial Cancer Research Fund
MGI:1857720

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lig4^tm1Icrf/Lig4^tm1Icrf	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3655290
hm2	Lig4^tm1Icrf/Lig4^tm1Icrf	involves: 129	MGI:2182058
cx3	Lig4^tm1Icrf/Lig4^tm1Icrf Trp53^tm1Tyj/Trp53⁺	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)	MGI:3655297
cx4	Lig4^tm1Icrf/Lig4^tm1Icrf Trp53^tm1Tyj/Trp53^tm1Tyj	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)	MGI:3655296
cx5	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4⁺	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3655373
cx6	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4^tm1Icrf	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3655292
cx7	Atm^tm1Pmc/Atm⁺ Lig4^tm1Icrf/Lig4^tm1Icrf	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3655374
cx8	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4^tm1Icrf	involves: 129	MGI:3831183
cx9	Lig4^tm1Icrf/Lig4^tm1Icrf Nbn^tm2.1Jpt/Nbn^tm2.1Jpt	involves: 129	MGI:3831186
cx10	Lig4^tm1Icrf/Lig4^tm1Icrf Mre11a^tm1Jpt/Mre11a^tm1Jpt	involves: 129 * 129S7/SvEvBrd	MGI:3831181
cx11	Lig4^tm1Icrf/Lig4^tm1Icrf Nbn^tm1Jpt/Nbn^tm1Jpt	involves: 129 * 129S7/SvEvBrd	MGI:3831184

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:51608 )

• live embryos can be detected at E13.5 but not at E16.5

nervous system

increased neuron apoptosis ( J:51608 , J:65540 , J:111068 )

• in E13.5 embyros, regions of the central nervous system show extensive apoptotic cell death (J:51608)

• apoptosis is marked in the midbrain, around the pons and medulla, and in the thalamus, hypothalamus and striatum (J:51608)

• there is extensive apoptosis in the mantle layer of the spinal cord with less in the ependymal and marginal layers (J:51608)

• deficient embryos display high levels of apoptosis early in neurogenesis from E11 on localized to cells of the postmitotic premigratory populations in the CNS mainly in the intermediate zone (J:65540)

• no increased apoptosis above control levels is seen before E12; at E13.5, abundant apoptosis is seen throughout the cortex (J:111068)

cellular

increased neuron apoptosis ( J:51608 , J:65540 , J:111068 )

• in E13.5 embyros, regions of the central nervous system show extensive apoptotic cell death (J:51608)

• apoptosis is marked in the midbrain, around the pons and medulla, and in the thalamus, hypothalamus and striatum (J:51608)

• there is extensive apoptosis in the mantle layer of the spinal cord with less in the ependymal and marginal layers (J:51608)

• no increased apoptosis above control levels is seen before E12; at E13.5, abundant apoptosis is seen throughout the cortex (J:111068)

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:144172 )

N	• mice exhibit normal ionizing radiation-induced apoptosis in the developing nervous system

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Trp53^tm1Tyj/Trp53⁺
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:111068 )

• mice that survive the perinatal period die at ~6 months of age

perinatal lethality, incomplete penetrance ( J:111068 )

• mice are less robust and often die perinatally of indeterminate causes

neoplasm

decreased tumor incidence ( J:111068 )

• mice do not develop tumors before death at 6 months of age

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell derived lymphoma incidence ( J:111068 )

• pro-B cell lymphomas develop by 12 weeks of age

increased medulloblastoma incidence ( J:111068 )

• mice develop tumors by 12 weeks of age

nervous system

increased medulloblastoma incidence ( J:111068 )

• mice develop tumors by 12 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:173443

Allelic Composition	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Pmc mutation (0 available); any Atm mutation (169 available)
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:65540 )

• extensive apoptosis occurs in the spinal cord at E11.5 and the developing cortex at E14.5

cellular

increased neuron apoptosis ( J:65540 )

• extensive apoptosis occurs in the spinal cord at E11.5 and the developing cortex at E14.5

Allelic Composition	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:65540 , J:111068 )

• mice are born alive but die within 2 hours (J:65540)

• mice do not survive past P1 (J:111068)

growth/size/body

decreased body size ( J:65540 )

• newborns are significantly smaller than wild-type littermates

nervous system

decreased neuron apoptosis ( J:65540 , J:111068 )

• double mutants show a complete attenuation of apoptosis in the nervous system at all stages between E11.5 and E15.5 (J:65540)

• almost no apoptosis is observed compared to Lig4-deficient brains (J:111068)

cellular

decreased neuron apoptosis ( J:65540 , J:111068 )

• double mutants show a complete attenuation of apoptosis in the nervous system at all stages between E11.5 and E15.5 (J:65540)

• almost no apoptosis is observed compared to Lig4-deficient brains (J:111068)

Allelic Composition	Atm^tm1Pmc/Atm⁺ Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:65540 )

• extensive apoptosis occurs in the spinal cord at E11.5 and the developing cortex at E14.5

cellular

increased neuron apoptosis ( J:65540 )

• extensive apoptosis occurs in the spinal cord at E11.5 and the developing cortex at E14.5

Allelic Composition	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	involves: 129

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:144172 )

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Nbn^tm2.1Jpt/Nbn^tm2.1Jpt
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Nbn^tm2.1Jpt mutation (0 available); any Nbn mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:144172 )

• no live births are observed

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Mre11a^tm1Jpt/Mre11a^tm1Jpt
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:144172 )

• survived to birth but died thereafter

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

• mice exhibit reduced ionizing radiation-induced apoptosis in the telencephalon, metencephalon, spinal cord, and dorsal root ganglia compared to in wild-type mice

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Nbn^tm1Jpt/Nbn^tm1Jpt
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Nbn^tm1Jpt mutation (1 available); any Nbn mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:144172 )

• mice die at around mid-gestation

cellular

cellular phenotype ( J:144172 )

N	• mice exhibit normal ionizing radiation-induced apoptosis in the developing nervous system

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