Analysis Tools
mortality/aging
|
• die between E13.5-E16.5
|
growth/size/body
|
• a 17% reduction in body weight resulted in a reduced fetal size at E14.5; this size difference is not apparent at E12.5
|
cardiovascular system
|
• at E14.5; incompletely penetrant
|
|
• at E14.5; incompletely penetrant
|
liver/biliary system
|
• loosened liver structure seen at E14.5
|
|
• abnormal morphology and reduction in number
• no changes in growth or survival of remaining hepatocytes
|
|
• dissociated parenchymal cells exhibit signs of apoptosis
|
small liver
(
J:23170
)
|
• 40% average reduction at E12.5 and 55% average reduction at E14.5
|
|
• severe loss of cellularity noted, with the ventral side of the liver most affected
|
hematopoietic system
|
• reduced erythrocyte counts and reduced embryonal blood frequently observed, probably due to decreased liver size
|
embryo
|
• the number of trophoblast cells is severely reduced
|
|
• the entire labyrinth layer appears disorganized
|
