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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il7tm1Dnax
targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
MGI:1857652
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il7tm1Dnax/Il7tm1Dnax involves: 129P2/OlaHsd MGI:3769349
hm2
Il7tm1Dnax/Il7tm1Dnax involves: 129P2/OlaHsd * C57BL/6 MGI:2180085
cx3
Il7tm1Dnax/Il7tm1Dnax
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129P2/OlaHsd * 129S/SvEv MGI:3776482


Genotype
MGI:3769349
hm1
Allelic
Composition
Il7tm1Dnax/Il7tm1Dnax
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7tm1Dnax mutation (0 available); any Il7 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at E14, thymocytes are about 100-fold lower than in heterozygous littermates
• however, differentiation of thymic progenitors into pro-T cells appears to be normal

hematopoietic system
• at E14, thymocytes are about 100-fold lower than in heterozygous littermates
• however, differentiation of thymic progenitors into pro-T cells appears to be normal

endocrine/exocrine glands
• at E14, thymocytes are about 100-fold lower than in heterozygous littermates
• however, differentiation of thymic progenitors into pro-T cells appears to be normal




Genotype
MGI:2180085
hm2
Allelic
Composition
Il7tm1Dnax/Il7tm1Dnax
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7tm1Dnax mutation (0 available); any Il7 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymus reduced in size and weight, but normal structure
• reduced cellularity
• lymphopoiesis blocked at pro-B to pre-B cell stage
• lymphopenia
• retention of normal CD4 to CD8 ratio
• CD8 expression on T cells is reduced by 60%
• spleen reduced in size and weight, but retains the normal structure
• reduced absolute numbers of both mature B and T cells in spleen

immune system
• thymus reduced in size and weight, but normal structure
• reduced cellularity
• lymphopoiesis blocked at pro-B to pre-B cell stage
• lymphopenia
• retention of normal CD4 to CD8 ratio
• CD8 expression on T cells is reduced by 60%
• spleen reduced in size and weight, but retains the normal structure
• reduced absolute numbers of both mature B and T cells in spleen
• Peyer's patches undetected
• lymph nodes undetected

endocrine/exocrine glands
• thymus reduced in size and weight, but normal structure
• reduced cellularity




Genotype
MGI:3776482
cx3
Allelic
Composition
Il7tm1Dnax/Il7tm1Dnax
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7tm1Dnax mutation (0 available); any Il7 mutation (22 available)
Rag2tm1Fwa mutation (41 available); any Rag2 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 2-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice

hematopoietic system
• 2-fold less NK cells are found in the spleen 5 days after transfer into these recipient mice compared to control mice





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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory