Phenotypes associated with this allele
Allelic Composition |
Gata1tm1Sho/Gata1+
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
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hematopoietic system
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• anemia is present at birth and during the neonatal period, then decreases as the mice age
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• in vitro culture of bone marrow cells demonstrates that cells lacking Gata1 expression can not make eosinophils
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immune system
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• in vitro culture of bone marrow cells demonstrates that cells lacking Gata1 expression can not make eosinophils
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
Tg(Gata1*)#Mym mutation
(0 available)
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hematopoietic system
immune system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
Tg(Gata1*)#Mym mutation
(0 available)
|
|
|
hematopoietic system
immune system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
Tg(Gata1)#Mym mutation
(0 available)
|
|
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hematopoietic system
N |
• mice exhibit normal numbers of megakaryocytes at P5
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
Tg(Gata1)#Mym mutation
(0 available)
|
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hematopoietic system
N |
• mice exhibit normal numbers of megakaryocytes at P5
|
Allelic Composition |
Gata1tm1Sho/Y
|
|
Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
|
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mortality/aging
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• male mice die between E10.5 and E11.5 due to severe anemia
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hematopoietic system
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• embryonic red blood cells are arrested at the proerythroblast stage and display occasional nuclear fragmentation
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• no red blood is evident in the vasculature of otherwise normal appearing males at E9.5 and E10.5
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