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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gata1tm1Sho
targeted mutation 1, Stuart Orkin
MGI:1857600
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gata1tm1Sho/Gata1+ involves: 129S4/SvJae * C57BL/6 MGI:2177552
cx2
Gata1tm1Sho/Y
Tg(Gata1*)#Mym/0
involves: 129S4/SvJae * C57BL/6 * DBA/2J MGI:4450924
cx3
Gata1tm1Sho/Gata1tm1Sho
Tg(Gata1*)#Mym/0
involves: 129S4/SvJae * C57BL/6 * DBA/2J MGI:4450925
cx4
Gata1tm1Sho/Y
Tg(Gata1)#Mym/0
involves: 129S4/SvJae * C57BL/6 * DBA/2J MGI:4450926
cx5
Gata1tm1Sho/Gata1tm1Sho
Tg(Gata1)#Mym/0
involves: 129S4/SvJae * C57BL/6 * DBA/2J MGI:4450927
ot6
Gata1tm1Sho/Y involves: 129S4/SvJae * C57BL/6 MGI:2177553


Genotype
MGI:2177552
ht1
Allelic
Composition
Gata1tm1Sho/Gata1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• anemia is present at birth and during the neonatal period, then decreases as the mice age
• in vitro culture of bone marrow cells demonstrates that cells lacking Gata1 expression can not make eosinophils

immune system
• in vitro culture of bone marrow cells demonstrates that cells lacking Gata1 expression can not make eosinophils




Genotype
MGI:4450924
cx2
Allelic
Composition
Gata1tm1Sho/Y
Tg(Gata1*)#Mym/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
Tg(Gata1*)#Mym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:4450925
cx3
Allelic
Composition
Gata1tm1Sho/Gata1tm1Sho
Tg(Gata1*)#Mym/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
Tg(Gata1*)#Mym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:4450926
cx4
Allelic
Composition
Gata1tm1Sho/Y
Tg(Gata1)#Mym/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
Tg(Gata1)#Mym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal numbers of megakaryocytes at P5




Genotype
MGI:4450927
cx5
Allelic
Composition
Gata1tm1Sho/Gata1tm1Sho
Tg(Gata1)#Mym/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
Tg(Gata1)#Mym mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal numbers of megakaryocytes at P5




Genotype
MGI:2177553
ot6
Allelic
Composition
Gata1tm1Sho/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Sho mutation (0 available); any Gata1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• male mice die between E10.5 and E11.5 due to severe anemia

hematopoietic system
• embryonic red blood cells are arrested at the proerythroblast stage and display occasional nuclear fragmentation
• no red blood is evident in the vasculature of otherwise normal appearing males at E9.5 and E10.5





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory