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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Krastm1Mok
targeted mutation 1, Motoya Katsuki
MGI:1857551
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Krastm1Mok/Krastm1Mok involves: 129S/SvEv * C57BL/6J MGI:3589198
ht2
Krastm1Mok/Kras+ involves: 129S/SvEv * C57BL/6J MGI:3589197
cx3
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
B6.129S-Nrastm1Mok Krastm1Mok MGI:4821324
cx4
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361201
cx5
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361202
cx6
Krastm1Mok/Krastm1Mok
Tg(HRAS)7Mok/0
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361206
cx7
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)7Mok/0
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361207
cx8
Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821326
cx9
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821330
cx10
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821336
cx11
Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
involves: 129S/SvEv * C57BL/6 MGI:4821325
cx12
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821323
cx13
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821327
cx14
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821329
cx15
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821335


Genotype
MGI:3589198
hm1
Allelic
Composition
Krastm1Mok/Krastm1Mok
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die between E12.5 and term

cardiovascular system
• at E15.5, 2 out of 6 homozygotes display extremely thin ventricular walls along with a swollen heart and a rounded apex, while 3 out of 6 mutants show thin ventricular walls in the absence of swelling; the remaining one homozygote displays a morphologically normal heart
• at E15.5, homozygotes display a thin ventricular myocardium relative to wild-type mice
• at E10.5-E13.5, mutant hearts appear to be smaller than wild-type hearts
• at E15.5, 5 out of 6 homozygotes exhibit thin ventricular walls, in the absence of ventricular septal defects
• no significant differences in ventricular wall thickness are observed at E11.5 and E13.5
• at E15.5, mutant hearts display insufficient cardiomyocyte proliferation, in the absence of abnormal cell differentiation or cell death

embryo
• at E10.5-E13.5, homozygous embryos appear to be shorter than wild-type embryos

growth/size/body
• at E10.5-E13.5, homozygous embryos appear to be shorter than wild-type embryos

nervous system
• at E11.5 and E12.5, homozygotes exhibit a significantly increased apoptosis of motoneurons in the ventral horn of lower medulla and the upper cervical spinal cord

muscle
• at E15.5, mutant hearts display insufficient cardiomyocyte proliferation, in the absence of abnormal cell differentiation or cell death

hematopoietic system
N
• at E12.5, homozygotes exhibit neither anemia nor abnormal red blood cells in peripheral blood vessels

liver/biliary system
N
• at E12.5, homozygotes display a histologically normal liver relative to wild-type mice

cellular
• at E15.5, mutant hearts display insufficient cardiomyocyte proliferation, in the absence of abnormal cell differentiation or cell death
• at E11.5 and E12.5, homozygotes exhibit a significantly increased apoptosis of motoneurons in the ventral horn of lower medulla and the upper cervical spinal cord




Genotype
MGI:3589197
ht2
Allelic
Composition
Krastm1Mok/Kras+
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• heterozygotes are viable, fertile and display no behavioral deficits or spontaneous tumor formation up to 20 months of age




Genotype
MGI:4821324
cx3
Allelic
Composition
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Genetic
Background
B6.129S-Nrastm1Mok Krastm1Mok
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 19 of 26 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4361201
cx4
Allelic
Composition
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most deaths occur between E18.5 and birth
• do not survive to weaning




Genotype
MGI:4361202
cx5
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (20 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• development is normal to E9.5
• most are dead by E11.5
• none are found at E13.5




Genotype
MGI:4361206
cx6
Allelic
Composition
Krastm1Mok/Krastm1Mok
Tg(HRAS)7Mok/0
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Tg(HRAS)7Mok mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice survive and reproduce
• hearts are normal




Genotype
MGI:4361207
cx7
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)7Mok/0
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (20 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
Tg(HRAS)7Mok mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• born in expected numbers




Genotype
MGI:4821326
cx8
Allelic
Composition
Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (38 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Tg(HRAS)2Jic mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 1 of 13 mice develop chylous ascites unlike wild-type mice

immune system
• few mice exhibit lymphatic vessel hypoplasia




Genotype
MGI:4821330
cx9
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (20 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
Tg(HRAS)2Jic mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no mice exhibit chylous ascites




Genotype
MGI:4821336
cx10
Allelic
Composition
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
Tg(HRAS)2Jic mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• no mice exhibit chylous ascites




Genotype
MGI:4821325
cx11
Allelic
Composition
Flt4tm1.1Ichi/Flt4+
Krastm1Mok/Kras+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1.1Ichi mutation (0 available); any Flt4 mutation (38 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• all mice develop chylous ascites unlike wild-type mice
• intestinal

immune system
• mice develop lymphatic vessel hypoplasia unlike wild-type mice




Genotype
MGI:4821323
cx12
Allelic
Composition
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 5 of 76 mice develop chylous ascites unlike wild-type mice

immune system
• in the small intestine




Genotype
MGI:4821327
cx13
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (20 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 20 of 135 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821329
cx14
Allelic
Composition
Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (20 available)
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 35 of 37 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821335
cx15
Allelic
Composition
Krastm1Mok/Kras+
Nrastm1Mok/Nrastm1Mok
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Mok mutation (6 available); any Kras mutation (32 available)
Nrastm1Mok mutation (7 available); any Nras mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 6 of 6 mice develop chylous ascites unlike wild-type mice





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory