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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpi1b-m1Neu
mutant 1, Neuherberg
MGI:1857497
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpi1b-m1Neu/Gpi1b-m1Neu C3.Cg-Gpi1b-m1Neu MGI:2177287


Genotype
MGI:2177287
hm1
Allelic
Composition
Gpi1b-m1Neu/Gpi1b-m1Neu
Genetic
Background
C3.Cg-Gpi1b-m1Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpi1b-m1Neu mutation (1 available); any Gpi1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 4-6 weeks of age, there is a 20-30% reduction in the number of expected homozygous animals
• some homozygous animals die in the period between birth and weaning age (J:35956)

growth/size/body
• mice weigh about 20% of the weight exhibited by controls
• approximately a five-fold increase

hematopoietic system
• approximately a five-fold increase
• reticulocyte counts are 60-70% compared to 2% in controls
• concentrations of ATP and ADP are elevated in erythrocytes
• a twofold increase of lactate formation and glucose consumption in erythorcytes is also observed
• mutant erythrocytes are more resistant to osmotic stress than controls

immune system
• approximately a five-fold increase

liver/biliary system

homeostasis/metabolism
• in blood, GPI activity is reduced to 21% of the mean normal ativities

cardiovascular system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory