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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd1tm1Gru
targeted mutation 1, Michael Grusby
MGI:1857482
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd1tm1Gru/Cd1tm1Gru B6.129S2-Cd1tm1Gru MGI:4430268
hm2
Cd1tm1Gru/Cd1tm1Gru involves: 129S2/SvPas * BALB/c MGI:2653847


Genotype
MGI:4430268
hm1
Allelic
Composition
Cd1tm1Gru/Cd1tm1Gru
Genetic
Background
B6.129S2-Cd1tm1Gru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1tm1Gru mutation (7 available); any Cd1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• area of choroidal neovascularization induced by photocoagulation is significantly reduced

vision/eye
• area of choroidal neovascularization induced by photocoagulation is significantly reduced




Genotype
MGI:2653847
hm2
Allelic
Composition
Cd1tm1Gru/Cd1tm1Gru
Genetic
Background
involves: 129S2/SvPas * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1tm1Gru mutation (7 available); any Cd1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls

immune system
N
• despite near absence of IL-4-secreting NK-like T cells in the thymus, homozygotes are able to mount a normal TH2 response producing IgE levels comparable to those detected in control littermates after immunization with anti-IgD
• reduced incidence of myocarditis caused by Coxsackie virus infection
• substantial reduction in airway eosinophilia in response to OVA challenge
• decreased Interferon gamma positive CD4+ cells
• homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)-/low, Vbeta8int CD44high (the NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)
• in vivo, homozygotes fail to promptly produce IL-4 after intravenous injection with anti-CD3
• in contrast, the induction of IFN-gamma mRNA after T cell receptor ligation remains unaffected
• cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls

hematopoietic system
• substantial reduction in airway eosinophilia in response to OVA challenge
• decreased Interferon gamma positive CD4+ cells
• homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)-/low, Vbeta8int CD44high (the NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)

neoplasm
• metastasis to the lung is reduced as measured by iv injection of colon carcinoma cell line CT26

cardiovascular system
• reduced incidence of myocarditis caused by Coxsackie virus infection

respiratory system
• hyper-reactivity does not develop in response to OVA challenge





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory