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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fsttm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:1857467
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fsttm1Zuk/Fsttm1Zuk B6.129S7-Fsttm1Zuk MGI:3589667
hm2
Fsttm1Zuk/Fsttm1Zuk involves: 129S7/SvEvBrd MGI:3042284
hm3
Fsttm1Zuk/Fsttm1Zuk involves: 129S7/SvEvBrd * C57BL/6 MGI:3042286
ht4
Fsttm1Zuk/Fst+ B6.129S7-Fsttm1Zuk MGI:5319775
ht5
Fsttm1Zuk/Fst+ involves: 129S7/SvEvBrd MGI:3814734
ht6
Fsttm1Zuk/Fst+ involves: 129S7/SvEvBrd * C57BL/6 MGI:3814735
cn7
Amhr2tm3(cre)Bhr/Amhr2+
Fsttm1Zuk/Fsttm2Zuk
involves: 129S/SvEv * C57BL/6J MGI:3042275
cx8
Fsttm1Zuk/Fst+
Fstl3tm1.1Sjl/Fstl3tm1.1Sjl
B6.129-Fsttm1Zuk Fstl3tm1.1Sjl MGI:5319774
cx9
Fsttm1Zuk/Fst+
Mstntm1Sjl/Mstn+
B6.129-Mstntm1Sjl Fsttm1Zuk MGI:5319777
cx10
Fsttm1Zuk/Fst+
Mstntm1Sjl/Mstntm1Sjl
B6.129-Mstntm1Sjl Fsttm1Zuk MGI:5319776
cx11
Fsttm1Zuk/Fsttm1Zuk
Wfikkn1tm1.1Sjl/Wfikkn1+
involves: 129S7/SvEvBrd * C57BL/6 MGI:5546338
cx12
Fsttm1Zuk/Fsttm1Zuk
Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
involves: 129S7/SvEvBrd * C57BL/6 MGI:5546336
cx13
Fsttm1Zuk/Fst+
Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
involves: 129S7/SvEvBrd * C57BL/6 MGI:5546337
cx14
Fsttm1Zuk/Fsttm1Zuk
Gdf11tm1Clf/Gdf11tm1Clf
involves: 129X1/SvJ * C57BL/6J * CD-1 MGI:3589668


Genotype
MGI:3589667
hm1
Allelic
Composition
Fsttm1Zuk/Fsttm1Zuk
Genetic
Background
B6.129S7-Fsttm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons (J:81451)
• homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)

taste/olfaction
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)

vision/eye
• mutant retinas exhibit a 26% reduction in the number of cells in the ganglion cell layer and a marked decrease in thickness of the differentiated ganglion cell layer (J:99244)
• unlike the situation in olfactory epithelium, mutant retinas display normal overall thickness as well as normal progenitor cell proliferation (J:99244)
• in addition, mutant retinas show no obvious differences in amacrine cell or photoreceptor production relative to wild-type (J:99244)
• mutant retinas exhibit a 26% reduction in the number of cells in the ganglion cell layer and a marked decrease in thickness of the differentiated ganglion cell layer (J:99244)
• unlike the situation in olfactory epithelium, mutant retinas display normal overall thickness as well as normal progenitor cell proliferation (J:99244)
• in addition, mutant retinas show no obvious differences in amacrine cell or photoreceptor production relative to wild-type (J:99244)

respiratory system
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)

craniofacial
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)

cellular
• homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons (J:81451)
• homozygotes display decreased olfactory epithelium neurogenesis, as shown by significantly reduced neurogenin-1-expressing immediate neuronal precursors and Ncam1-expressing olfactory receptor neurons (J:81451)

growth/size/body
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• homozygotes display a 38% decrease in thickness of the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)
• at E17.5, homozygotes display a 37% decrease in proliferating, neurogenin-1-expressing immediate neuronal precursors within the olfactory epithelium (J:81451)




Genotype
MGI:3042284
hm2
Allelic
Composition
Fsttm1Zuk/Fsttm1Zuk
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes survive to birth but die within a few hours of birth due to respiratory failure (J:23925)
• homozygotes survive to birth but die within a few hours of birth due to respiratory failure (J:23925)

craniofacial
• all newborn homozygotes (11 of 11) show delayed development of lower incisors (J:23925)
• all newborn homozygotes (11 of 11) show delayed development of lower incisors (J:23925)
• 55% (6 of 11) newborn homozygotes lack a hard palate (J:23925)
• 55% (6 of 11) newborn homozygotes lack a hard palate (J:23925)

growth/size/body
• all newborn homozygotes (11 of 11) show delayed development of lower incisors (J:23925)
• all newborn homozygotes (11 of 11) show delayed development of lower incisors (J:23925)
• 55% (6 of 11) newborn homozygotes lack a hard palate (J:23925)
• 55% (6 of 11) newborn homozygotes lack a hard palate (J:23925)
• at E18.5, homozygotes are smaller than wild-type counterparts (J:23925)
• at E18.5, homozygotes are smaller than wild-type counterparts (J:23925)
• at E18.5, homozygotes weigh ~12% less than wild-type counterparts (J:23925)
• at E18.5, homozygotes weigh ~12% less than wild-type counterparts (J:23925)
• newborn homozygotes are growth retarded (J:23925)
• newborn homozygotes are growth retarded (J:23925)

muscle
• newborn homozygotes show decreased muscle mass in the diaphragmatic, pectoralis major and intercostal muscles (J:23925)
• however, no primary defects are observed as determined by analysis of ATPase activity, glycogen content and mitochondria (J:23925)
• newborn homozygotes show decreased muscle mass in the diaphragmatic, pectoralis major and intercostal muscles (J:23925)
• however, no primary defects are observed as determined by analysis of ATPase activity, glycogen content and mitochondria (J:23925)

skeleton
• in 81.8% (9 of 11) homozygotes, development of the thirteenth pair of ribs is limited (J:23925)
• Background Sensitivity: a higher percentage of homozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (81.8% vs 61%, respectively) (J:23925)
• in 81.8% (9 of 11) homozygotes, development of the thirteenth pair of ribs is limited (J:23925)
• Background Sensitivity: a higher percentage of homozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (81.8% vs 61%, respectively) (J:23925)
• in 2 of 11 homozygotes, the thirteenth pair of ribs is absent (J:23925)
• in 2 of 11 homozygotes, the thirteenth pair of ribs is absent (J:23925)
• all (11 of 11) newborn homozygotes have five lumbar vertebrae instead of six found in wild-type mice (J:23925)
• all (11 of 11) newborn homozygotes have five lumbar vertebrae instead of six found in wild-type mice (J:23925)

digestive/alimentary system
• 55% (6 of 11) newborn homozygotes lack a hard palate (J:23925)
• 55% (6 of 11) newborn homozygotes lack a hard palate (J:23925)

homeostasis/metabolism
• newborn homozygotes appear cyanotic (J:23925)
• newborn homozygotes appear cyanotic (J:23925)

respiratory system
• newborn homozygotes fail to breathe (J:23925)
• mutant lungs are sank in liquid, and alveolar spaces appear poorly expanded, although no primary pulmonary defects are detected (J:23925)
• newborn homozygotes fail to breathe (J:23925)
• mutant lungs are sank in liquid, and alveolar spaces appear poorly expanded, although no primary pulmonary defects are detected (J:23925)

integument
• mutant whiskers are very thin and incorrectly oriented with shafts projecting parallel before turning perpendicularly (J:23925)
• mutant whiskers are very thin and incorrectly oriented with shafts projecting parallel before turning perpendicularly (J:23925)
• newborns display a 25% increase in the stratum corneum cells relative to wild-type controls (J:23925)
• newborns display a 25% increase in the stratum corneum cells relative to wild-type controls (J:23925)
• newborn homozygotes show a thickened granular and stratum corneum (J:23925)
• newborn homozygotes show a thickened granular and stratum corneum (J:23925)
• newborn homozygotes appear hypoxic (pale) (J:23925)
• newborn homozygotes appear hypoxic (pale) (J:23925)
• newborn homozygotes display a shiny skin (J:23925)
• newborn homozygotes display a shiny skin (J:23925)
• newborn homozygotes display a taut skin (J:23925)
• newborn homozygotes display a taut skin (J:23925)

Mouse Models of Human Disease
OMIM ID Ref(s)
Restrictive Dermopathy, Lethal 275210 J:23925




Genotype
MGI:3042286
hm3
Allelic
Composition
Fsttm1Zuk/Fsttm1Zuk
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes survive to birth but die within a few hours of birth due to respiratory failure (J:23925)
• homozygotes survive to birth but die within a few hours of birth due to respiratory failure (J:23925)

craniofacial
• 92% (23 of 34) newborn homozygotes show delayed development of lower incisors (J:23925)
• 92% (23 of 34) newborn homozygotes show delayed development of lower incisors (J:23925)
• 21.4% (6 of 28) newborn homozygotes lack a hard palate (J:23925)
• 21.4% (6 of 28) newborn homozygotes lack a hard palate (J:23925)
• 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate (J:23925)
• 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate (J:23925)
• 6 of 34 newborn homozygotes lack lower incisors (J:23925)
• 6 of 34 newborn homozygotes lack lower incisors (J:23925)

growth/size/body
• 92% (23 of 34) newborn homozygotes show delayed development of lower incisors (J:23925)
• 92% (23 of 34) newborn homozygotes show delayed development of lower incisors (J:23925)
• 21.4% (6 of 28) newborn homozygotes lack a hard palate (J:23925)
• 21.4% (6 of 28) newborn homozygotes lack a hard palate (J:23925)
• 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate (J:23925)
• 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate (J:23925)
• 6 of 34 newborn homozygotes lack lower incisors (J:23925)
• 6 of 34 newborn homozygotes lack lower incisors (J:23925)
• at E18.5, homozygotes are smaller than wild-type counterparts (J:23925)
• at E18.5, homozygotes are smaller than wild-type counterparts (J:23925)
• at E18.5, homozygotes weigh ~12% less than wild-type counterparts (J:23925)
• at E18.5, homozygotes weigh ~12% less than wild-type counterparts (J:23925)
• newborn homozygotes are growth retarded (J:23925)
• newborn homozygotes are growth retarded (J:23925)

muscle
• newborn homozygotes show decreased muscle mass in the diaphragmatic, pectoralis major and intercostal muscles (J:23925)
• however, no primary defects are observed as determined by analysis of ATPase activity, glycogen content and mitochondria (J:23925)
• newborn homozygotes show decreased muscle mass in the diaphragmatic, pectoralis major and intercostal muscles (J:23925)
• however, no primary defects are observed as determined by analysis of ATPase activity, glycogen content and mitochondria (J:23925)

skeleton
• in 4 of 28 homozygotes, one or both of the seventh ribs fail to fuse to the sternum (J:23925)
• in 4 of 28 homozygotes, one or both of the seventh ribs fail to fuse to the sternum (J:23925)
• in 61% (17 of 28) homozygotes, development of the thirteenth pair of ribs is limited (J:23925)
• Background Sensitivity: a higher percentage of homozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (81.8% vs 61%, respectively) (J:23925)
• in 61% (17 of 28) homozygotes, development of the thirteenth pair of ribs is limited (J:23925)
• Background Sensitivity: a higher percentage of homozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (81.8% vs 61%, respectively) (J:23925)
• in 28.6% (8 of 28) homozygotes, the thirteenth pair of ribs is absent (J:23925)
• in 28.6% (8 of 28) homozygotes, the thirteenth pair of ribs is absent (J:23925)
• all (28 of 28) newborn homozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect (J:23925)
• all (28 of 28) newborn homozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect (J:23925)

digestive/alimentary system
• 21.4% (6 of 28) newborn homozygotes lack a hard palate (J:23925)
• 21.4% (6 of 28) newborn homozygotes lack a hard palate (J:23925)
• 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate (J:23925)
• 15.8% (3 of 19) newborn homozygotes display a cleft secondary palate (J:23925)

homeostasis/metabolism
• newborn homozygotes appear cyanotic (J:23925)
• newborn homozygotes appear cyanotic (J:23925)

respiratory system
• newborn homozygotes fail to breathe (J:23925)
• mutant lungs are sank in liquid, and alveolar spaces appear poorly expanded, although no primary pulmonary defects are detected (J:23925)
• newborn homozygotes fail to breathe (J:23925)
• mutant lungs are sank in liquid, and alveolar spaces appear poorly expanded, although no primary pulmonary defects are detected (J:23925)

integument
• mutant whiskers are very thin and incorrectly oriented with shafts projecting parallel before turning perpendicularly (J:23925)
• mutant whiskers are very thin and incorrectly oriented with shafts projecting parallel before turning perpendicularly (J:23925)
• newborns display a 25% increase in the stratum corneum cells relative to wild-type controls (J:23925)
• newborns display a 25% increase in the stratum corneum cells relative to wild-type controls (J:23925)
• newborn homozygotes show a thickened granular and stratum corneum (J:23925)
• newborn homozygotes show a thickened granular and stratum corneum (J:23925)
• newborn homozygotes appear hypoxic (pale) (J:23925)
• newborn homozygotes appear hypoxic (pale) (J:23925)
• newborn homozygotes display a shiny skin (J:23925)
• newborn homozygotes display a shiny skin (J:23925)
• newborn homozygotes display a taut skin (J:23925)
• newborn homozygotes display a taut skin (J:23925)

Mouse Models of Human Disease
OMIM ID Ref(s)
Restrictive Dermopathy, Lethal 275210 J:23925




Genotype
MGI:5319775
ht4
Allelic
Composition
Fsttm1Zuk/Fst+
Genetic
Background
B6.129S7-Fsttm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• increase in the proportion of smaller fibers that stain more darkly in hematoxylin and eosin stained sections corresponding to mixed glycolytic/oxidative type IIa fibers (J:182827)
• shift towards more oxidative fibers (J:182827)
• decrease in mean fiber diameter for each fiber type (J:182827)
• increase in the proportion of smaller fibers that stain more darkly in hematoxylin and eosin stained sections corresponding to mixed glycolytic/oxidative type IIa fibers (J:182827)
• shift towards more oxidative fibers (J:182827)
• decrease in mean fiber diameter for each fiber type (J:182827)
• about 15-20% lower than wild-type (J:182827)
• decreased triceps weight (J:182827)
• about 15-20% lower than wild-type (J:182827)
• decreased triceps weight (J:182827)
• increase in the percentage of oxidative type I fibers (J:182827)
• increase in the percentage of oxidative type I fibers (J:182827)
• increase in the number of oxidative type I fibers (J:182827)
• increase in the number of oxidative type I fibers (J:182827)
• decreased weight (J:182827)
• decreased weight (J:182827)
• lower twitch and tetanic force production (J:182827)
• but no change in specific force (J:182827)
• lower twitch and tetanic force production (J:182827)
• but no change in specific force (J:182827)

homeostasis/metabolism
• impaired muscle regeneration and enhanced fibrosis in the gastrocnemius muscle following cardiotoxin-induced injury (J:182827)
• impaired muscle regeneration and enhanced fibrosis in the gastrocnemius muscle following cardiotoxin-induced injury (J:182827)




Genotype
MGI:3814734
ht5
Allelic
Composition
Fsttm1Zuk/Fst+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• in 26.6% (4 of 15) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively) (J:23925)
• in 26.6% (4 of 15) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively) (J:23925)
• 86.6% (13 of 15) heterozygotes have five lumbar vertebrae instead of six found in wild-type controls (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively) (J:23925)
• 86.6% (13 of 15) heterozygotes have five lumbar vertebrae instead of six found in wild-type controls (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively) (J:23925)




Genotype
MGI:3814735
ht6
Allelic
Composition
Fsttm1Zuk/Fst+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• in 17% (6 of 35) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively) (J:23925)
• in 17% (6 of 35) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively) (J:23925)
• 60% (21 of 35) heterozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively) (J:23925)
• 60% (21 of 35) heterozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect (J:23925)
• Background Sensitivity: a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively) (J:23925)




Genotype
MGI:3042275
cn7
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Fsttm1Zuk/Fsttm2Zuk
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (9 available)
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Fsttm2Zuk mutation (0 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the majority of ovaries in 8 month old mice appeared hemorrhagic (J:89081)
• the majority of ovaries in 8 month old mice appeared hemorrhagic (J:89081)
• ovaries were histologically normal through 21 days of age (J:89081)
• defects became apparent after 3 months of age (J:89081)
• ovaries were histologically normal through 21 days of age (J:89081)
• defects became apparent after 3 months of age (J:89081)
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone (J:89081)
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone (J:89081)
• decreased numbers of antral follicles (J:89081)
• decreased numbers of antral follicles (J:89081)
• observed in 2 mice (J:89081)
• observed in 2 mice (J:89081)

homeostasis/metabolism
N
• circulating estradiol levels did not differ from those of controls (J:89081)
• circulating estradiol levels did not differ from those of controls (J:89081)

reproductive system
N
• male mice were fertile (J:89081)
• male mice were fertile (J:89081)
• the majority of ovaries in 8 month old mice appeared hemorrhagic (J:89081)
• the majority of ovaries in 8 month old mice appeared hemorrhagic (J:89081)
• ovaries were histologically normal through 21 days of age (J:89081)
• defects became apparent after 3 months of age (J:89081)
• ovaries were histologically normal through 21 days of age (J:89081)
• defects became apparent after 3 months of age (J:89081)
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone (J:89081)
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone (J:89081)
• decreased numbers of antral follicles (J:89081)
• decreased numbers of antral follicles (J:89081)
• observed in 2 mice (J:89081)
• observed in 2 mice (J:89081)
• impaired ovulation in response to human chorionic gonadotropin (hCG) (J:89081)
• impaired only in mature adult mice (6 months of age), ovulation was normal in 3 week old mice (J:89081)
• impaired ovulation in response to human chorionic gonadotropin (hCG) (J:89081)
• impaired only in mature adult mice (6 months of age), ovulation was normal in 3 week old mice (J:89081)
• of 11 female experimental mice, 1 was completely infertile (J:89081)
• of 11 female experimental mice, 1 was completely infertile (J:89081)
• of 11 female experimental mice, 10 showed reduced fertility, yielding reduced litter number and size (J:89081)
• of 11 female experimental mice, 10 showed reduced fertility, yielding reduced litter number and size (J:89081)
• impaired only in mature adult mice (6 months of age), fertilization was normal in 3 week old mice (J:89081)
• impaired only in mature adult mice (6 months of age), fertilization was normal in 3 week old mice (J:89081)

cardiovascular system
• the majority of ovaries in 8 month old mice appeared hemorrhagic (J:89081)
• the majority of ovaries in 8 month old mice appeared hemorrhagic (J:89081)




Genotype
MGI:5319774
cx8
Allelic
Composition
Fsttm1Zuk/Fst+
Fstl3tm1.1Sjl/Fstl3tm1.1Sjl
Genetic
Background
B6.129-Fsttm1Zuk Fstl3tm1.1Sjl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fstl3tm1.1Sjl mutation (0 available); any Fstl3 mutation (3 available)
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• similar to mice heterozygous for Fsttm1Zuk alone (J:182827)
• similar to mice heterozygous for Fsttm1Zuk alone (J:182827)




Genotype
MGI:5319777
cx9
Allelic
Composition
Fsttm1Zuk/Fst+
Mstntm1Sjl/Mstn+
Genetic
Background
B6.129-Mstntm1Sjl Fsttm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Mstntm1Sjl mutation (0 available); any Mstn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• relative to mice heterozygous for Mstntm1Sjl alone (J:182827)
• relative to mice heterozygous for Mstntm1Sjl alone (J:182827)

growth/size/body
• relative to mice heterozygous for Mstntm1Sjl alone (J:182827)
• relative to mice heterozygous for Mstntm1Sjl alone (J:182827)




Genotype
MGI:5319776
cx10
Allelic
Composition
Fsttm1Zuk/Fst+
Mstntm1Sjl/Mstntm1Sjl
Genetic
Background
B6.129-Mstntm1Sjl Fsttm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Mstntm1Sjl mutation (0 available); any Mstn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• relative to mice homoozygous for Mstntm1Sjl alone (J:182827)
• relative to mice homoozygous for Mstntm1Sjl alone (J:182827)




Genotype
MGI:5546338
cx11
Allelic
Composition
Fsttm1Zuk/Fsttm1Zuk
Wfikkn1tm1.1Sjl/Wfikkn1+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Wfikkn1tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• 50% of mice have only 12 thoracic vertebrae (J:201148)
• 50% of mice have only 12 thoracic vertebrae (J:201148)
• in 50% of mice the 13th pair of ribs consist of one anlage and the other is absent and in the other 50% of mice both 13th ribs are missing (J:201148)
• in 50% of mice the 13th pair of ribs consist of one anlage and the other is absent and in the other 50% of mice both 13th ribs are missing (J:201148)




Genotype
MGI:5546336
cx12
Allelic
Composition
Fsttm1Zuk/Fsttm1Zuk
Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Wfikkn1tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Axial skeleton patterning defects in Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl, Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl Fsttm1Zuk/Fsttm1Zuk, Gdf11tm1Sjl/Gdf11+ and Gdf11tm1Sjl/Gdf11tm1Sjl mice.

skeleton
• mice have cervical ribs on one side or both sides (J:201148)
• mice have cervical ribs on one side or both sides (J:201148)
• both 13th ribs are missing (J:201148)
• most mice have 6 or 6.5 attached ribs (J:201148)
• both 13th ribs are missing (J:201148)
• most mice have 6 or 6.5 attached ribs (J:201148)
• mice have cervical ribs on one side or both sides (J:201148)
• mice have cervical ribs on one side or both sides (J:201148)
• all mice have only 12 thoracic vertebrae (J:201148)
• all mice have only 12 thoracic vertebrae (J:201148)
• one mouse had only 4 lumbar vertebrae (J:201148)
• one mouse had only 4 lumbar vertebrae (J:201148)




Genotype
MGI:5546337
cx13
Allelic
Composition
Fsttm1Zuk/Fst+
Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Wfikkn1tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Axial skeleton patterning defects in Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl, Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl Fsttm1Zuk/Fsttm1Zuk, Gdf11tm1Sjl/Gdf11+ and Gdf11tm1Sjl/Gdf11tm1Sjl mice.

skeleton
• cervical ribs are seen on one or both sides in most mice (J:201148)
• cervical ribs are seen on one or both sides in most mice (J:201148)
• over 90% of mice are missing both 13th ribs (J:201148)
• over 90% of mice are missing both 13th ribs (J:201148)
• cervical ribs are seen on one or both sides in most mice (J:201148)
• cervical ribs are seen on one or both sides in most mice (J:201148)
• most mice have 12 thoracic vertebrae (J:201148)
• most mice have 12 thoracic vertebrae (J:201148)
• 25% of mice have 6/7 lumbar vertebrae (J:201148)
• 25% of mice have 6/7 lumbar vertebrae (J:201148)




Genotype
MGI:3589668
cx14
Allelic
Composition
Fsttm1Zuk/Fsttm1Zuk
Gdf11tm1Clf/Gdf11tm1Clf
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (1 available); any Fst mutation (3 available)
Gdf11tm1Clf mutation (0 available); any Gdf11 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double mutant retinas display an expanded differentiated ganglion cell layer, similar to that observed in Gdf11tm1Clf mutant retinas (J:99244)
• at E17.5, the neuroblastic layer of double mutant retinas shows a 3-fold increase in migrating ganglion cells relative to wild-type retinas (J:99244)
• double mutant retinas display an expanded differentiated ganglion cell layer, similar to that observed in Gdf11tm1Clf mutant retinas (J:99244)
• at E17.5, the neuroblastic layer of double mutant retinas shows a 3-fold increase in migrating ganglion cells relative to wild-type retinas (J:99244)

vision/eye
• double mutant retinas display an expanded differentiated ganglion cell layer, similar to that observed in Gdf11tm1Clf mutant retinas (J:99244)
• at E17.5, the neuroblastic layer of double mutant retinas shows a 3-fold increase in migrating ganglion cells relative to wild-type retinas (J:99244)
• double mutant retinas display an expanded differentiated ganglion cell layer, similar to that observed in Gdf11tm1Clf mutant retinas (J:99244)
• at E17.5, the neuroblastic layer of double mutant retinas shows a 3-fold increase in migrating ganglion cells relative to wild-type retinas (J:99244)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory