Mouse Genome Informatics
hm1
    Cd40tm1Kik/Cd40tm1Kik
B6.129P2-Cd40tm1Kik/J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

immune system
• impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7
• impaired priming of IFN-gamma producing T cells
• increased susceptibility to aerosol Mycobacterium tuberculosis infection
• increased bacterial loads in lung and spleen
• 40% of infected mice moribund 3 - 4 weeks postinfection

homeostasis/metabolism
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion
• significantly reduced infarct volumes

nervous system
• significantly reduced infarct volumes

skeleton
• significantly reduced
• significantly reduced
• significantly reduced


Mouse Genome Informatics
hm2
    Cd40tm1Kik/Cd40tm1Kik
involves: 129P2/OlaHsd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit well-developed thymic medullas
• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7
• NP-CG immunized mice fail to generate NP-specific germinal center B cells

hematopoietic system
• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7
• NP-CG immunized mice fail to generate NP-specific germinal center B cells


Mouse Genome Informatics
hm3
    Cd40tm1Kik/Cd40tm1Kik
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in non-SPF facilities compared to wild-type controls
• failed to form
• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• response to thymus-independent (TI) antigens was in tact
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations in unimmunized mice
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations in unimmunized mice
• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations of IgG1 in unimmunized mice
• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations of IgG2a in unimmunized mice
• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations of IgG2b in unimmunized mice
• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• IgG3 serum concentrations in unimmunized mice are not decreased

immune system
N
• normal numbers and ratios of T and B cells
• in non-SPF facilities compared to wild-type controls
• failed to form
• in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis
• deposition of IgG and complement in glomeruli not observed
• glomeruli almost normal
• fibrin deposition in glomeruli not observed
• failure to induce proteinuria
• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• response to thymus-independent (TI) antigens was in tact
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations in unimmunized mice
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations in unimmunized mice
• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations of IgG1 in unimmunized mice
• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations of IgG2a in unimmunized mice
• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• decreased serum concentrations of IgG2b in unimmunized mice
• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin
• IgG3 serum concentrations in unimmunized mice are not decreased


Mouse Genome Informatics
cx4