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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd40tm1Kik
targeted mutation 1, Hitoshi Kikutani
MGI:1857457
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd40tm1Kik/Cd40tm1Kik B6.129P2-Cd40tm1Kik/J MGI:3035906
hm2
Cd40tm1Kik/Cd40tm1Kik involves: 129P2/OlaHsd MGI:5013462
hm3
Cd40tm1Kik/Cd40tm1Kik involves: 129P2/OlaHsd * C57BL/6 MGI:3035907
cx4
Cd40tm1Kik/Cd40tm1Kik
Tg(Tnfsf13b)1Fma/?
B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma MGI:3841106
cx5
Cd40tm1Kik/Cd40tm1Kik
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
involves: 129 * 129P2/OlaHsd * BALB/c MGI:3511170
cx6
Bank1tm1Kuro/Bank1tm1Kuro
Cd40tm1Kik/Cd40tm1Kik
involves: 129P2/OlaHsd MGI:3687154
cx7
Cd40tm1Kik/Cd40tm1Kik
Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
involves: 129P2/OlaHsd MGI:5013467
cx8
Cd40tm1Kik/Cd40tm1Kik
Tg(Igh-V-CD40lg)#Tsub/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4461234
cx9
Cd40tm1Kik/Cd40tm1Kik
Ltbrtm1Mmat/Ltbrtm1Mmat
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5013463


Genotype
MGI:3035906
hm1
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Genetic
Background
B6.129P2-Cd40tm1Kik/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles (J:75152)
• normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles (J:75152)
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion (J:108988)
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion (J:108988)

immune system
• impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7 (J:86998)
• impaired priming of IFN-gamma producing T cells (J:86998)
• impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7 (J:86998)
• impaired priming of IFN-gamma producing T cells (J:86998)
• increased susceptibility to aerosol Mycobacterium tuberculosis infection (J:86998)
• increased bacterial loads in lung and spleen (J:86998)
• 40% of infected mice moribund 3 - 4 weeks postinfection (J:86998)
• increased susceptibility to aerosol Mycobacterium tuberculosis infection (J:86998)
• increased bacterial loads in lung and spleen (J:86998)
• 40% of infected mice moribund 3 - 4 weeks postinfection (J:86998)

homeostasis/metabolism
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion (J:108988)
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion (J:108988)
• significantly reduced infarct volumes (J:108988)
• significantly reduced infarct volumes (J:108988)

nervous system
• significantly reduced infarct volumes (J:108988)
• significantly reduced infarct volumes (J:108988)

skeleton
• significantly reduced (J:145330)
• significantly reduced (J:145330)
• significantly reduced (J:145330)
• significantly reduced (J:145330)
• significantly reduced (J:145330)
• significantly reduced (J:145330)




Genotype
MGI:5013462
hm2
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit well-developed thymic medullas (J:173115)
• mice exhibit well-developed thymic medullas (J:173115)
• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7 (J:190943)
• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7 (J:190943)
• NP-CG immunized mice fail to generate NP-specific germinal center B cells (J:190943)
• NP-CG immunized mice fail to generate NP-specific germinal center B cells (J:190943)

hematopoietic system
• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7 (J:190943)
• NP-CG immunized mice fail to generate NP-specific IgG1+B cells at day 7 (J:190943)
• NP-CG immunized mice fail to generate NP-specific germinal center B cells (J:190943)
• NP-CG immunized mice fail to generate NP-specific germinal center B cells (J:190943)




Genotype
MGI:3035907
hm3
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in non-SPF facilities compared to wild-type controls (J:25007)
• in non-SPF facilities compared to wild-type controls (J:25007)
• failed to form (J:25007)
• failed to form (J:25007)
• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• response to thymus-independent (TI) antigens was in tact (J:25007)
• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• response to thymus-independent (TI) antigens was in tact (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG1 in unimmunized mice (J:25007)
• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG1 in unimmunized mice (J:25007)
• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2a in unimmunized mice (J:25007)
• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2a in unimmunized mice (J:25007)
• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2b in unimmunized mice (J:25007)
• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2b in unimmunized mice (J:25007)
• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• IgG3 serum concentrations in unimmunized mice are not decreased (J:25007)
• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• IgG3 serum concentrations in unimmunized mice are not decreased (J:25007)

immune system
N
• normal numbers and ratios of T and B cells (J:25007)
• normal numbers and ratios of T and B cells (J:25007)
• in non-SPF facilities compared to wild-type controls (J:25007)
• in non-SPF facilities compared to wild-type controls (J:25007)
• failed to form (J:25007)
• failed to form (J:25007)
• in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis (J:61673)
• deposition of IgG and complement in glomeruli not observed (J:61673)
• glomeruli almost normal (J:61673)
• fibrin deposition in glomeruli not observed (J:61673)
• failure to induce proteinuria (J:61673)
• in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis (J:61673)
• deposition of IgG and complement in glomeruli not observed (J:61673)
• glomeruli almost normal (J:61673)
• fibrin deposition in glomeruli not observed (J:61673)
• failure to induce proteinuria (J:61673)
• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• response to thymus-independent (TI) antigens was in tact (J:25007)
• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• response to thymus-independent (TI) antigens was in tact (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations in unimmunized mice (J:25007)
• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG1 in unimmunized mice (J:25007)
• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG1 in unimmunized mice (J:25007)
• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2a in unimmunized mice (J:25007)
• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2a in unimmunized mice (J:25007)
• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2b in unimmunized mice (J:25007)
• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• decreased serum concentrations of IgG2b in unimmunized mice (J:25007)
• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• IgG3 serum concentrations in unimmunized mice are not decreased (J:25007)
• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin (J:25007)
• IgG3 serum concentrations in unimmunized mice are not decreased (J:25007)




Genotype
MGI:3841106
cx4
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Tg(Tnfsf13b)1Fma/?
Genetic
Background
B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cells exhibit reduced class switching in response to T cell-dependent antigens (J:113556)
• B cells exhibit reduced class switching in response to T cell-dependent antigens (J:113556)
• the number of splenic marginal zone B cells is increased by about 3-fold (J:113556)
• the number of splenic marginal zone B cells is increased by about 3-fold (J:113556)
• mice are defective in germinal center formation upon after immunization (J:113556)
• mice are defective in germinal center formation upon after immunization (J:113556)
• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls (J:113556)
• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls (J:113556)
• anti-dsDNA antibodies of the IgM class, IgA class, and all IgG subclasses are found in circulation (J:113556)
• titers of these auto-antibodies increase with age (J:113556)
• anti-dsDNA antibodies of the IgM class, IgA class, and all IgG subclasses are found in circulation (J:113556)
• titers of these auto-antibodies increase with age (J:113556)
• kidneys of 10-month old mice have necrotic lesions (J:113556)
• immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG (J:113556)
• kidneys of 10-month old mice have necrotic lesions (J:113556)
• immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG (J:113556)

renal/urinary system
• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration (J:113556)
• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration (J:113556)
• kidneys of 10-month old mice have necrotic lesions (J:113556)
• immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG (J:113556)
• kidneys of 10-month old mice have necrotic lesions (J:113556)
• immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG (J:113556)

homeostasis/metabolism
• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration (J:113556)
• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration (J:113556)

hematopoietic system
• B cells exhibit reduced class switching in response to T cell-dependent antigens (J:113556)
• B cells exhibit reduced class switching in response to T cell-dependent antigens (J:113556)
• the number of splenic marginal zone B cells is increased by about 3-fold (J:113556)
• the number of splenic marginal zone B cells is increased by about 3-fold (J:113556)
• mice are defective in germinal center formation upon after immunization (J:113556)
• mice are defective in germinal center formation upon after immunization (J:113556)
• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls (J:113556)
• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls (J:113556)




Genotype
MGI:3511170
cx5
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
involves: 129 * 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes (J:93923)
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes (J:93923)
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes (J:93923)
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes (J:93923)
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants (J:138560)
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants (J:138560)

immune system
N
• double mutants do not exhibit production of anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, as seen in Traf3ip2 single homozygotes (J:138560)
• double mutants do not exhibit production of anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, as seen in Traf3ip2 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes (J:138560)
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes (J:93923)
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes (J:93923)
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes (J:93923)
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes (J:93923)
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants (J:138560)
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants (J:138560)
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes (J:93923)
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes (J:93923)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:93923




Genotype
MGI:3687154
cx6
Allelic
Composition
Bank1tm1Kuro/Bank1tm1Kuro
Cd40tm1Kik/Cd40tm1Kik
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bank1tm1Kuro mutation (0 available); any Bank1 mutation (2 available)
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• increased IgM response and germinal center formation seen in Bank1 single homozygotes are absent in double homozygotes (J:113321)
• increased IgM response and germinal center formation seen in Bank1 single homozygotes are absent in double homozygotes (J:113321)




Genotype
MGI:5013467
cx7
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
Tnfsf11tm1Pngr mutation (0 available); any Tnfsf11 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice (J:173115)

hematopoietic system
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice (J:173115)

endocrine/exocrine glands
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit reduced MHC IIhigh and MHC IIlow medullary thymic epithelial cells (mTEC) compared with wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice (J:173115)




Genotype
MGI:4461234
cx8
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Tg(Igh-V-CD40lg)#Tsub/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
Tg(Igh-V-CD40lg)#Tsub mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5013463
cx9
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Ltbrtm1Mmat/Ltbrtm1Mmat
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (14 available)
Ltbrtm1Mmat mutation (1 available); any Ltbr mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike Ltbrtm1Mmat homozygotes, mice do not exhibit lymphoid cell aggregates (J:173115)
• unlike Ltbrtm1Mmat homozygotes, mice do not exhibit lymphoid cell aggregates (J:173115)
• mice exhibit fewer MHC IIlow medullary thymic epithelial cells compared to in wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice (J:173115)
• mice exhibit fewer MHC IIlow medullary thymic epithelial cells compared to in wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice (J:173115)
• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice (J:173115)
• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice (J:173115)

hematopoietic system
• mice exhibit fewer MHC IIlow medullary thymic epithelial cells compared to in wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice (J:173115)
• mice exhibit fewer MHC IIlow medullary thymic epithelial cells compared to in wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice (J:173115)
• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice (J:173115)
• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice (J:173115)

endocrine/exocrine glands
• mice exhibit fewer MHC IIlow medullary thymic epithelial cells compared to in wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice (J:173115)
• mice exhibit fewer MHC IIlow medullary thymic epithelial cells compared to in wild-type mice (J:173115)
• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice (J:173115)
• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice (J:173115)
• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice (J:173115)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory