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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il2rgtm1Wjl
targeted mutation 1, Warren J Leonard
MGI:1857455
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il2rgtm1Wjl/Il2rgtm1Wjl B6.129S4-Il2rgtm1Wjl/J MGI:3769353
cn2
B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5469014
cn3
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0
involves: 129S4/SvJae * C57BL/6 MGI:5469013
cn4
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
involves: 129S4/SvJae * C57BL/6 MGI:5469012
cn5
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5469011
cx6
Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/?
B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj MGI:4356292
cx7
Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl
involves: 129S4/SvJae * C57BL/6 MGI:3624431
cx8
Il2rgtm1Wjl/Il2rgtm1Wjl
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129S/SvEv * 129S4/SvJae MGI:3817878
cx9
Il2rgtm1Wjl/Y
Prkdcscid/Prkdcscid
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz MGI:3770662
cx10
Il2rgtm1Wjl/Il2rgtm1Wjl
Prkdcscid/Prkdcscid
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz MGI:3770657
cx11
Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ MGI:3813939
ot12
Il2rgtm1Wjl/Y involves: 129S4/SvJae * C57BL/6 MGI:3624447


Genotype
MGI:3769353
hm1
Allelic
Composition
Il2rgtm1Wjl/Il2rgtm1Wjl
Genetic
Background
B6.129S4-Il2rgtm1Wjl/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen
• reduced numbers of splenocytes
• decrease in the proportion and absolute number of CD11c+ dendritic cells in the spleen
• in culture, dendritic cells are resistant to cytokine withdrawal-induced apoptosis
• bone marrow-derived dendritic cells overproduce IL12 and IL10

hematopoietic system
• the proportion and absolute number of CD11c+ dendritic cells is decreased in the spleen
• reduced numbers of splenocytes
• decrease in the proportion and absolute number of CD11c+ dendritic cells in the spleen




Genotype
MGI:5469014
cn2
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (67 available)
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (85 available)
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469013
cn3
Allelic
Composition
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (85 available)
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice

hematopoietic system
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469012
cn4
Allelic
Composition
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (85 available)
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
• of invariant NK T cells in the thymus, spleen and liver
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice

hematopoietic system
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
• of invariant NK T cells in the thymus, spleen and liver
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice




Genotype
MGI:5469011
cn5
Allelic
Composition
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (85 available)
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Tg(Cd4-cre)1Cwi mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:4356292
cx6
Allelic
Composition
Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background
B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the presence of the transgene prevents the splenomegaly associated with Il2rgtm1Wjl homozygotes due to decreased lymphocyte numbers and size
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes

hematopoietic system
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes




Genotype
MGI:3624431
cx7
Allelic
Composition
Il2rgtm1Wjl/Y
Crlf2tm1Wjl/Crlf2tm1Wjl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crlf2tm1Wjl mutation (1 available); any Crlf2 mutation (13 available)
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

hematopoietic system
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls

endocrine/exocrine glands
• double knockout mice have very reduced thymic cellularity; cellularity is reduced from that observed in Ilr2g single knockouts which is significantly less than that of controls




Genotype
MGI:3817878
cx8
Allelic
Composition
Il2rgtm1Wjl/Il2rgtm1Wjl
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Rag2tm1Fwa mutation (43 available); any Rag2 mutation (83 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals succumb to M. tuberculosis within 30 days, showing same median survival time as Ifng-null mice while wild-type survive infection for entire period of observation

immune system
• cells do not produce any interferon gamma after incubation of splenocytes with mycobacteria
• at 28 days post-infection (p.i.), lungs display massive lesions occupying about 60% of lung space compared to lungs in Rag2-null mice
• mice are more susceptible to infection than Rag2-null single mutants and show similar survival time to Ifng-null mice
• in lungs and spleens of M. tuberculosis-infected mice at 28 days post-infection (p.i.), bacterial loads are >2 log higher than in infected wild-type mice

respiratory system
• at 28 days post-infection (p.i.), lungs display massive lesions occupying about 60% of lung space compared to lungs in Rag2-null mice

hematopoietic system




Genotype
MGI:3770662
cx9
Allelic
Composition
Il2rgtm1Wjl/Y
Prkdcscid/Prkdcscid
Genetic
Background
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Prkdcscid mutation (101 available); any Prkdc mutation (124 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the majority of autopsies indicate no evidence of lymphomas
• median survival time is lengthened to between 59-95 weeks (median 89 weeks) in contrast to the shorter lifespan observed homozygous Prkdcscid controls

cellular
• mice do not survive doses above or equal to 400cGy

hematopoietic system
• thymus consists mostly of stromal cells with sporadic cyst structures
• slight decrease in packed cell volume at 10 weeks as compared to to Prkdcscid controls
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
• spleens are deficient in B220+ IgK+ B cells
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
• spleens are deficient in mature T cells
• spleens are deficient in mature T cells
• spleens do not have detectable follicles
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
• no detectable immunoglobulin in mice at 394-426 days of age

immune system
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
• spleens are deficient in B220+ IgK+ B cells
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
• spleens are deficient in mature T cells
• spleens are deficient in mature T cells
• no detectable immunoglobulin in mice at 394-426 days of age
• lymph tissues are severely depleted of lymphoid cells
• thymus consists mostly of stromal cells with sporadic cyst structures
• spleens do not have detectable follicles
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
• lymph nodes in the double mutant are markedly smaller than those of homozygous Prkdcscid mice
• lymph nodes are hypocellular
• mice support CD34+ human stem cell engraftment at much higher levels than Prkdcscid controls (J:109833)
• human CD45+ cells comprise almost 50% of cells in the spleen, approximately 35% in bone marrow and thymus, and 6% in blood at 10 weeks post-engraftment (J:109833)
• irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1tm1Mom homozygotes (J:140388)
• percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.CB17-Prkdcscid mice (J:140388)
• levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.CB17-Prkdcscid mice (J:140388)
• CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.CB17-Prkdcscid mice (J:140388)
• engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.CB17-Prkdcscid (J:140388)

endocrine/exocrine glands
• thymus consists mostly of stromal cells with sporadic cyst structures




Genotype
MGI:3770657
cx10
Allelic
Composition
Il2rgtm1Wjl/Il2rgtm1Wjl
Prkdcscid/Prkdcscid
Genetic
Background
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Prkdcscid mutation (101 available); any Prkdc mutation (124 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival time is lengthened to between 59-95 weeks (median 89 weeks) in contrast to the shorter lifespan observed homozygous Prkdcscid controls
• the majority of autopsies indicate no evidence of lymphomas

immune system
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
• spleens are deficient in B220+ IgK+ B cells
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
• spleens are deficient in mature T cells
• spleens are deficient in mature T cells
• no detectable immunoglobulin in mice at 394-426 days of age
• lymph tissues are severely depleted of lymphoid cells
• thymus consists mostly of stromal cells with sporadic cyst structures
• sporadic cyst structures
• spleens do not have detectable follicles
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
• lymph nodes in the double mutant are markedly smaller than those of homozygous Prkdcscid mice
• lymph nodes are hypocellular
• mice support CD34+ human stem cell engraftment at much higher levels than Prkdcscid controls
• human CD45+ cells comprise almost 50% of cells in the spleen, approximately 35% in bone marrow and thymus, and 6% in blood at 10 weeks post-engraftment

hematopoietic system
• thymus consists mostly of stromal cells with sporadic cyst structures
• sporadic cyst structures
• slight decrease in packed cell volume at 10 weeks as compared to to Prkdcscid controls
• decrease in peripheral leukocytes at 10 weeks as compared to to Prkdcscid controls
• flow cytometric analysis indicates that spleen cells exhibit a reduction in B220+ IgK- immature B cells in comparison to Prkdcscid controls
• spleens are deficient in B220+ IgK+ B cells
• mice are deficient in cells expressing NK cell markers in comparison to Prkdcscid controls
• spleen cells from poly(I:C) stimulated 6-8 week old mice exhibit very low levels of NK cell cytotoxic activity
• spleens are deficient in mature T cells
• spleens are deficient in mature T cells
• spleens do not have detectable follicles
• two fold reduction in nucleated spleen cell numbers in comparison to Prkdcscid controls
• no detectable immunoglobulin in mice at 394-426 days of age

cellular
• mice do not survive doses above or equal to 400cGy

neoplasm
• mice irradiated with doses below 400cGy do not exhibit thymic lymphomas in contrast to homozygous Prkdcscid controls

homeostasis/metabolism
• streptozotocin-diabetic mice are not restored to euglycemia after receiving transplants of 1000 to 3000 IEQ, while 4000 IEQ transplant was successful in two long-term survivors
• streptozotocin effectively induced hyperglycemia essentially equally in male and female mice at doses of 120to 160 mg/kg; some mice do not become hyperglycemic at all doses of streptozotocin administered

endocrine/exocrine glands
• thymus consists mostly of stromal cells with sporadic cyst structures
• sporadic cyst structures




Genotype
MGI:3813939
cx11
Allelic
Composition
Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no lymphoid cells are present
• no defined cortical region is observed
• no defined medullary region is observed
• thymus contains large cysts
• natural killer cell (NK; DX5+LGL+ cells) are absent
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
• spleen contains mainly myeloid-like cells and few lymphoid cells
• spleen contains no follicles (or germinal centers)
• mature T and B cell populations are absent
• there are diminished CD3+CD4+ and CD3+CD8+ T cells and Igk+ light chain+ B cells in the spleen
• cells functioning in innate immunity are severely decreased in number
• irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1tm1Mom homozygotes
• percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.129S7(B6)-Rag1tm1Mom homozygotes
• levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.129S7(B6)-Rag1tm1Mom mice
• CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.129S7(B6)-Rag1tm1Mom mice
• engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.129S7(B6)-Rag1tm1Mom mice

hematopoietic system
• no lymphoid cells are present
• no defined cortical region is observed
• no defined medullary region is observed
• thymus contains large cysts
• natural killer cell (NK; DX5+LGL+ cells) are absent
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
• spleen contains mainly myeloid-like cells and few lymphoid cells
• spleen contains no follicles (or germinal centers)

endocrine/exocrine glands
• no lymphoid cells are present
• no defined cortical region is observed
• no defined medullary region is observed
• thymus contains large cysts




Genotype
MGI:3624447
ot12
Allelic
Composition
Il2rgtm1Wjl/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• less potent proliferation of splenic T cells to mitogen stimulation

immune system
• cecum inflammation is visible in the lamina propia
• there is a reduced number of double-positive T cells in the thymus
• there is a reduced number of double-negative T cells in the thymus
• after treatment with anti-Tpte, null mice show increased numbers of B cells in the spleen which contribute to the increased splenic cellularity
• absolute numbers are reduced in the spleen
• NK1.1 positive cells are not detected
• 10- to 20- fold drop in percentage of CD8 positive T cells found in three week old spleen
• percentages of CD8 positive T cells in spleen return to normal by 9 weeks of age
• no gamma-delta T cells are found in the thymus or the skin
• no gamma-delta IEL are found in the intestine
• there is a reduced number of single-postive T cells in the thymus
• when Tpte-deficient CD4+ T cells are injected into irradiated knockouts, transferred cells exhibit less expansion compared to wild-type CD4+ T cells
• cortex is reduced in size
• after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts
• thymus is very small
• about a 2 fold increase in cellularity at nine weeks of age
• about a 10 fold reduction in cellularity at three weeks of age
• gut associated lymphoid tissue was absent in the small and large intestine
• small, with few follicles and no germinal centers
• peripheral lymph nodes are not identifiable
• less potent proliferation of splenic T cells to mitogen stimulation
• marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
• no NK cytolytic acitivity detected
• concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice
• IFN-gamma production by stimulated T cells is reduced by a 1000 fold
• production of IL-2 by stimulated T cells is reduced by about 40%
• production of IL-4 by stimulated T cells is reduced by about 40%

digestive/alimentary system
• crypt height is increased and inflammation is visible in the lamina propia
• cecum inflammation is visible in the lamina propia

hematopoietic system
• less potent proliferation of splenic T cells to mitogen stimulation
• cortex is reduced in size
• after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts
• thymus is very small
• marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation
• there is a reduced number of double-positive T cells in the thymus
• there is a reduced number of double-negative T cells in the thymus
• after treatment with anti-Tpte, null mice show increased numbers of B cells in the spleen which contribute to the increased splenic cellularity
• absolute numbers are reduced in the spleen
• NK1.1 positive cells are not detected
• 10- to 20- fold drop in percentage of CD8 positive T cells found in three week old spleen
• percentages of CD8 positive T cells in spleen return to normal by 9 weeks of age
• no gamma-delta T cells are found in the thymus or the skin
• no gamma-delta IEL are found in the intestine
• there is a reduced number of single-postive T cells in the thymus
• when Tpte-deficient CD4+ T cells are injected into irradiated knockouts, transferred cells exhibit less expansion compared to wild-type CD4+ T cells
• about a 2 fold increase in cellularity at nine weeks of age
• about a 10 fold reduction in cellularity at three weeks of age
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
• IL-4 production by basophil/mast cell incubation is increased 10- to 45- fold
• concentrations of all immunoglobulins but IgM are diminished in sera of 5-week old mice
• no NK cytolytic acitivity detected

endocrine/exocrine glands
• cortex is reduced in size
• after 1 week of daily injections of anti-Tpte, thymic cellularity is increased 5-10 fold in null mice; injections had no effect on cellularity in double knockouts
• thymus is very small
• marked reduction in proliferation of thymocytes in response to PMA and IL-4 stimulation





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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory