Mouse Genome Informatics
hm1
    Il1r1tm1Roml/Il1r1tm1Roml
C.Cg-Il1r1tm1Roml
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented
• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures
• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

hematopoietic system
• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented
• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures
• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum


Mouse Genome Informatics
hm2
    Il1r1tm1Roml/Il1r1tm1Roml
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• in the skin of IMQ-treated mice
• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

skeleton
• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

integument
N
• mice have normal skin (J:126327)

hematopoietic system
• in the skin of IMQ-treated mice

homeostasis/metabolism
N
• IMQ-treated mice develop psoriasis as in wild-type mice (J:193548)


Mouse Genome Informatics
hm3
    Il1r1tm1Roml/Il1r1tm1Roml
involves: 129S1/Sv * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

homeostasis/metabolism
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

tumorigenesis
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

hematopoietic system
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired


Mouse Genome Informatics
hm4
    Il1r1tm1Roml/Il1r1tm1Roml
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice have reduced circulating levels of IL-6 after turpentine injection
• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection
• 50% reduction in paw swelling one day after injection in paw with methylated BSA
• fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta
• 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates

homeostasis/metabolism
• mice have reduced circulating levels of IL-6 after turpentine injection
• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection
• IL-1beta injection fails to increase body temperature


Mouse Genome Informatics
hm5
    Il1r1tm1Roml/Il1r1tm1Roml
NOD.Cg-Il1r1tm1Roml
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system
• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age
• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:87251


Mouse Genome Informatics
cn6
    Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• postnatal lethality does not occur to mice on a IL-1 receptor null background (J:150054)

immune system
• variable skin inflammation is observed

integument
• variable skin inflammation is observed


Mouse Genome Informatics
cx7
    Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae

involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• mice do not exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes (J:172117)
• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells


Mouse Genome Informatics
cx8
    Il1r1tm1Roml/Il1r1tm1Roml
Nlrp1aNeut1/Nlrp1aNeut1

involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• inflammatory disease does not develop (J:191055)
• increased sensitivity to lymphocytic choriomeningitis virus although virus titers remain like controls

hematopoietic system

homeostasis/metabolism
• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

mortality/aging
• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment


Mouse Genome Informatics
cx9
    Il1r1tm1Roml/Il1r1tm1Roml
Tg(KRT14-Il1f6)1Hblu/?

involves: 129S1/Sv * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
integument
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice