All Phenotypes Il1r1<tm1Roml> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il1r1^tm1Roml
targeted mutation 1, Mark A Labow
MGI:1857441

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1r1^tm1Roml/Il1r1^tm1Roml	C.Cg-Il1r1^tm1Roml	MGI:3622351
hm2	Il1r1^tm1Roml/Il1r1^tm1Roml	involves: 129S1/Sv	MGI:3762043
hm3	Il1r1^tm1Roml/Il1r1^tm1Roml	involves: 129S1/Sv * BALB/c	MGI:3721963
hm4	Il1r1^tm1Roml/Il1r1^tm1Roml	involves: 129S1/Sv * C57BL/6	MGI:2179490
hm5	Il1r1^tm1Roml/Il1r1^tm1Roml	NOD.Cg-Il1r1^tm1Roml	MGI:3622312
cn6	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp3^tm1Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129 * C57BL/6	MGI:3850053
cx7	Il1r1^tm1Roml/Il1r1^tm1Roml Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae}	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5007930
cx8	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp1a^Neut1/Nlrp1a^Neut1	involves: 129S1/Sv * C57BL/6	MGI:5474283
cx9	Il1r1^tm1Roml/Il1r1^tm1Roml Tg(KRT14-Il1f6)1Hblu/?	involves: 129S1/Sv * C57BL/6 * DBA/2	MGI:3762044

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	C.Cg-Il1r1^tm1Roml

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:82863 )

• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

decreased eosinophil cell number ( J:82863 )

• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals

decreased T cell number ( J:82863 )

• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented

decreased immunoglobulin level ( J:82863 )

• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

hematopoietic system

decreased T cell proliferation ( J:82863 )

• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

decreased eosinophil cell number ( J:82863 )

• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals

decreased T cell number ( J:82863 )

decreased immunoglobulin level ( J:82863 )

• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum

cellular

decreased T cell proliferation ( J:82863 )

• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

decreased susceptibility to induced arthritis ( J:120707 )

• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

skeleton

decreased susceptibility to induced arthritis ( J:120707 )

• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

integument

integument phenotype ( J:126327 )

N	• mice have normal skin

hematopoietic system

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:193548 )

N	• IMQ-treated mice develop psoriasis as in wild-type mice

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	involves: 129S1/Sv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

hematopoietic system

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-6 level ( J:42373 )

• mice have reduced circulating levels of IL-6 after turpentine injection

decreased circulating serum amyloid protein level ( J:42373 )

• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection

decreased susceptibility to type IV hypersensitivity reaction ( J:42373 )

• 50% reduction in paw swelling one day after injection in paw with methylated BSA

decreased interleukin-6 secretion ( J:42373 )

• fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta

increased susceptibility to bacterial infection ( J:42373 )

• 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:42373 )

• mice have reduced circulating levels of IL-6 after turpentine injection

decreased circulating serum amyloid protein level ( J:42373 )

• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection

impaired febrile response ( J:42373 )

• IL-1beta injection fails to increase body temperature

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml
Genetic Background	NOD.Cg-Il1r1^tm1Roml

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell death ( J:87251 )

• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system

decreased susceptibility to autoimmune diabetes ( J:87251 )

• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age

• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:87251

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp3^tm1Hhf/Nlrp3⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nlrp3^tm1Hhf mutation (1 available); any Nlrp3 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:150054 )

N	• postnatal lethality does not occur to mice on a IL-1 receptor null background

immune system

skin inflammation ( J:150054 )

• variable skin inflammation is observed

integument

skin inflammation ( J:150054 )

• variable skin inflammation is observed

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Mefv^{tm5.1(MEFV)Chae}/Mefv^{tm5.1(MEFV)Chae}
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Mefv^{tm5.1(MEFV)Chae} mutation (0 available); any Mefv mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172117 )

N	• mice do not exhibit inflammatory phenotypes observed in Mefv^{tm5.1(MEFV)Chae} homozygotes

increased interleukin-1 beta secretion ( J:172117 )

• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Nlrp1a^Neut1/Nlrp1a^Neut1
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:191055 )

N	• inflammatory disease does not develop

abnormal leukopoiesis ( J:191055 )

abnormal leukocyte cell number ( J:191055 )

decreased eosinophil cell number ( J:191055 )

decreased lymphocyte cell number ( J:191055 )

decreased monocyte cell number ( J:191055 )

increased susceptibility to Riboviria infection ( J:191055 )

• increased sensitivity to lymphocytic choriomeningitis virus although virus titers remain like controls

hematopoietic system

abnormal leukopoiesis ( J:191055 )

thrombocytopenia ( J:191055 )

abnormal leukocyte cell number ( J:191055 )

decreased eosinophil cell number ( J:191055 )

decreased lymphocyte cell number ( J:191055 )

decreased monocyte cell number ( J:191055 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191055 )

• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:191055 )

• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

Allelic Composition	Il1r1^tm1Roml/Il1r1^tm1Roml Tg(KRT14-Il1f6)1Hblu/?
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Roml mutation (2 available); any Il1r1 mutation (39 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:126327 )

• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice

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