About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il1r1tm1Roml
targeted mutation 1, Mark A Labow
MGI:1857441
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il1r1tm1Roml/Il1r1tm1Roml C.Cg-Il1r1tm1Roml MGI:3622351
hm2
Il1r1tm1Roml/Il1r1tm1Roml involves: 129S1/Sv MGI:3762043
hm3
Il1r1tm1Roml/Il1r1tm1Roml involves: 129S1/Sv * BALB/c MGI:3721963
hm4
Il1r1tm1Roml/Il1r1tm1Roml involves: 129S1/Sv * C57BL/6 MGI:2179490
hm5
Il1r1tm1Roml/Il1r1tm1Roml NOD.Cg-Il1r1tm1Roml MGI:3622312
cn6
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * C57BL/6 MGI:3850053
cx7
Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 MGI:5007930
cx8
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129S1/Sv * C57BL/6 MGI:5474283
cx9
Il1r1tm1Roml/Il1r1tm1Roml
Tg(KRT14-Il1f6)1Hblu/?
involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3762044


Genotype
MGI:3622351
hm1
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
C.Cg-Il1r1tm1Roml
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals
• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented
• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures

hematopoietic system
• cell infiltration, particularly eosinophils as well as lymphocytes, in response to OVA challenge in sensitized mice is reduced by 70% in knockout animals
• in knockouts after 1 day after four OVA challenges, the numbers of CD4+ and CD8+ cells are reduced 20-fold and 6-fold respectively compared to wild-type; after 8 challenges, only CD4+ T cells are reduced while CD8+ cells are augmented
• after OVA-challenge, levels of IgM, IgG and IgE are considerably reduced in the lung and the serum
• proliferation of CD4+ T cells from lung draining lymph nodes after restimulation with OVA and irradiated splenocytes is reduced after the last of 4 nasal allergen exposures




Genotype
MGI:3762043
hm2
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the skin of IMQ-treated mice
• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

skeleton
• do not respond to collagen type II injections as do controls by developing arthritis for at least 14 days

integument
N
• mice have normal skin

hematopoietic system
• in the skin of IMQ-treated mice

homeostasis/metabolism
N
• IMQ-treated mice develop psoriasis as in wild-type mice




Genotype
MGI:3721963
hm3
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

homeostasis/metabolism
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

neoplasm
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit reduced tumor number and delayed incidence compared with type mice

hematopoietic system
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired




Genotype
MGI:2179490
hm4
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice have reduced circulating levels of IL-6 after turpentine injection
• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection
• 50% reduction in paw swelling one day after injection in paw with methylated BSA
• fibroblasts fail to produce IL-6 in response to IL-1alpha or IL-1beta
• 5 days after infection with Listeria monocytogenes, mice have 100- and 1000-fold greater listerial CFU in their spleens and livers, respectively, as compared with their WT littermates

homeostasis/metabolism
• mice have reduced circulating levels of IL-6 after turpentine injection
• reduced levels of serum amyloid protein and serum amyloid A after turpentine injection
• IL-1beta injection fails to increase body temperature




Genotype
MGI:3622312
hm5
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Genetic
Background
NOD.Cg-Il1r1tm1Roml
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system
• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age
• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:87251




Genotype
MGI:3850053
cn6
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (11 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• postnatal lethality does not occur to mice on a IL-1 receptor null background

immune system
• variable skin inflammation is observed

integument
• variable skin inflammation is observed




Genotype
MGI:5007930
cx7
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
Mefvtm5.1(MEFV)Chae mutation (0 available); any Mefv mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes
• bone marrow CD11b+ cells and bone marrow-derived dendritic cells secrete IL1beta when stimulated with LPS alone, unlike wild-type cells




Genotype
MGI:5474283
cx8
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Nlrp1aNeut1/Nlrp1aNeut1
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
Nlrp1aNeut1 mutation (0 available); any Nlrp1a mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• inflammatory disease does not develop
• increased sensitivity to lymphocytic choriomeningitis virus although virus titers remain like controls

hematopoietic system

homeostasis/metabolism
• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment

mortality/aging
• death with hypoplastic bone marrow in approximately 12 days after 5-fluorouracil treatment




Genotype
MGI:3762044
cx9
Allelic
Composition
Il1r1tm1Roml/Il1r1tm1Roml
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background
involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (18 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory