All Phenotypes Gria2<tm1Rod> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gria2^tm1Rod
targeted mutation 1, John Roder
MGI:1857436

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria2^tm1Rod/Gria2^tm1Rod	B6.129-Gria2^tm1Rod/J	MGI:4834610
hm2	Gria2^tm1Rod/Gria2^tm1Rod	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2176810
ht3	Gria2^tm1Rod/Gria2⁺	B6.129-Gria2^tm1Rod/J	MGI:4834611
cx4	Gria2^tm1Rod/Gria2^tm1Rod Tg(SOD1*G93A)1Gur/0	B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur	MGI:4834606
cx5	Gria2^tm1Rod/Gria2⁺ Tg(SOD1*G93A)1Gur/0	B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur	MGI:4834607
cx6	Gria2^tm1Rod/Gria2^tm1Rod Gria3^tm1Zpj/Y	involves: 129/Sv * C57BL/6	MGI:2674947

Allelic Composition	Gria2^tm1Rod/Gria2^tm1Rod
Genetic Background	B6.129-Gria2^tm1Rod/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Rod mutation (2 available); any Gria2 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

• abolished AMPA receptor-mediated cell death in cultured motor neurons by the external polyamine 1-naphtyl acetyl spermine (NAS)

abnormal AMPA-mediated synaptic currents ( J:104951 )

• high degree of inhibition by the external NAS, a strong inward rectification and a high relative Ca2+ permeability

• higher elevations of the intracellular Ca2+ concentration upon AMPA receptor stimulation

• normal number of AMPA receptors in the cell membrane

behavior/neurological

abnormal response to novel object ( J:104951 )

• reduced object exploration

impaired coordination ( J:104951 )

• unable to walk on a rotarod

decreased grip strength ( J:104951 )

• slightly lower grip strength in fore limbs

abnormal limb posture ( J:104951 )

• abnormal posturing of both forelimbs and hind limbs during manipulations

decreased locomotor activity ( J:104951 )

• reduced spontaneous activity during the night

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

• abolished AMPA receptor-mediated cell death in cultured motor neurons by the external polyamine 1-naphtyl acetyl spermine (NAS)

cellular

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

• abolished AMPA receptor-mediated cell death in cultured motor neurons by the external polyamine 1-naphtyl acetyl spermine (NAS)

Allelic Composition	Gria2^tm1Rod/Gria2^tm1Rod
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Rod mutation (2 available); any Gria2 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:64275 )

• by 2 - 3 weeks of age about 20% of homozygotes die

behavior/neurological

decreased exploration in new environment ( J:64275 )

abnormal response to novel object ( J:64275 )

• object exploration is reduced

decreased grooming behavior ( J:64275 )

abnormal reflex ( J:64275 )

• impaired eye closure reflex to approaching objects

impaired coordination ( J:64275 )

• impaired coordination on rotorod test; however no signs of seizure activity were detected by observation, EEG, or post-mortem pyramidal cell dropout in the hippocampus

nervous system

enhanced long-term potentiation ( J:64275 )

• LTP in CA1 region of the hippocampus is enhanced 2-fold and non-saturating

growth/size/body

decreased body size ( J:64275 )

• body size is reduced at 2 - 3 weeks of age; however by 6 - 7 weeks, surviving homozygotes were the same size as littermates

decreased body weight ( J:64275 )

• body weight is reduced at 2 - 3 weeks of age; however by 6 - 7 weeks, surviving homozygotes were the same weight as littermates

Allelic Composition	Gria2^tm1Rod/Gria2⁺
Genetic Background	B6.129-Gria2^tm1Rod/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Rod mutation (2 available); any Gria2 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

abnormal AMPA-mediated synaptic currents ( J:104951 )

• high degree of inhibition by the external polyamine 1-naphtyl acetyl spermine (NAS), a strong inward rectification and a high relative Ca2+ permeability

• higher elevations of the intracellular Ca2+ concentration upon AMPA receptor stimulation

• normal number of AMPA receptors in the cell membrane

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

cellular

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

Allelic Composition	Gria2^tm1Rod/Gria2^tm1Rod Tg(SOD1*G93A)1Gur/0
Genetic Background	B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Rod mutation (2 available); any Gria2 mutation (75 available)
Tg(SOD1*G93A)1Gur mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:104951 )

• shortened lifespan (116.50.6 vs. 137.12.6 days), compare with Tg(SOD1*G93A)1Gur mice

behavior/neurological

impaired coordination ( J:104951 )

• unable to walk on a rotarod

decreased grip strength ( J:104951 )

• decreased grip strength in forelimbs

hindlimb paralysis ( J:104951 )

• earlier onset (99.32.1 days vs. 117.31.8 days), compare with Tg(SOD1*G93A)1Gur mice

nervous system

decreased motor neuron number ( J:104951 )

• decreased number of the large neurons in the ventral horn of the lumbar spinal cord

abnormal AMPA-mediated synaptic currents ( J:104951 )

• higher elevations of the intracellular Ca2+ concentration upon AMPA receptor stimulation

Allelic Composition	Gria2^tm1Rod/Gria2⁺ Tg(SOD1*G93A)1Gur/0
Genetic Background	B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Rod mutation (2 available); any Gria2 mutation (75 available)
Tg(SOD1*G93A)1Gur mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:104951 )

• decreased number of the large neurons in the ventral horn of the lumbar spinal cord

Allelic Composition	Gria2^tm1Rod/Gria2^tm1Rod Gria3^tm1Zpj/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2^tm1Rod mutation (2 available); any Gria2 mutation (75 available)
Gria3^tm1Zpj mutation (0 available); any Gria3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:84336 )

• normal at birth

• increased mortality at 2 to 4 weeks of age

• to about 20-30%

• gradual increase of global abnormalities

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:84336 )

tremors ( J:84336 )

• severe tremors associated with movements

decreased locomotor activity ( J:84336 )

nervous system

nervous system phenotype ( J:84336 )

N	• no gross anatomic abnormalities seen in the CNS • synaptic structures in the CA1 region appear normal

abnormal synaptic plasticity ( J:84336 )

• synaptic plasticity was greater

abnormal excitatory postsynaptic potential ( J:84336 )

• field excitatory postsynaptic potential was reduced to 10-20% of wild-type and was significantly lower than in Gria2 mutant homozygotes

enhanced long-term potentiation ( J:84336 )

• in the CA1 region

abnormal long-term depression ( J:84336 )

• in the CA1 region LTD is enhanced

• limited effect of D15 peptide in blocking LTD

growth/size/body

decreased body size ( J:84336 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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