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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bcl2tm1Mpin
targeted mutation 1, Max-Planck-Institute for Neurobiology
MGI:1857430
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bcl2tm1Mpin/Bcl2tm1Mpin involves: 129S2/SvPas * C57BL/6 MGI:2176726
cx2
Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0
involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2 MGI:2653483
cx3
Bcl2tm1Mpin/Bcl2+
Tg(SFTPC-RAF1-BxB)1Urr/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:2653486
cx4
Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(SFTPC-RAF1-BxB)1Urr/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:3693212


Genotype
MGI:2176726
hm1
Allelic
Composition
Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• onset of mortality ranges from 2 to 24 weeks, with a clustering at 7-8 weeks; some live substantially longer

growth/size/body
• weight becomes progressively smaller than wild-type, with no differences seen at P9 but not at P3

renal/urinary system

nervous system
• exhibit a progressive decrease in the number of superior cervical ganglia neurons, amounting to 60% of wild-type at P10 and 58% at P44
• progressive degeneration of sympathetic neurons during early postnatal development
• degeneration of motoneurons occurs predominately in the lateral part of the facial nucleus
• progressive degeneration of facial motoneurons during early postnatal development, before P9
• at P9, P28, and P44, the number of facial motoneurons is only 71%, 68%, and 67%, respectively, of the number present in wild-type
• although exhibit motoneuron degeneration, motoneurons are not more vulnerable than wild-type to injury at P28
• progressive degeneration of sensory neurons during early postnatal development
• retinal ganglion cell loss after the period of naturally occurring cell death
• show decreased cross-sectional area of optic nerve, reflecting a 29% loss of retinal ganglion cell axons, at P15 but not at P10, the time after the period of naturally occurring cell death
• exhibit a progressive decrease in the number of neurons present in the third lumbar dorsal root ganglion, amounting to 90% of wild-type at P9 and 56% at P44
• subpopulation of large sensory neurons is more severely affected than the small sensory neurons

homeostasis/metabolism
• exhibit a 1.7-fold increase at 10 weeks of age, but not at P13
• exhibit a 2-fold increase at 10 weeks of age, but not at P13

vision/eye
• retinal ganglion cell loss after the period of naturally occurring cell death
• show decreased cross-sectional area of optic nerve, reflecting a 29% loss of retinal ganglion cell axons, at P15 but not at P10, the time after the period of naturally occurring cell death




Genotype
MGI:2653483
cx2
Allelic
Composition
Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(H2-K-BCL2)1Josd/0
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background
involves: 129S2/SvPas * C3H * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (37 available)
Tg(H2-K-BCL2)1Josd mutation (0 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• exhibit rapid adenoma development

neoplasm
• exhibit rapid adenoma development




Genotype
MGI:2653486
cx3
Allelic
Composition
Bcl2tm1Mpin/Bcl2+
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (37 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 100% develop tumors by 1 month of age

neoplasm
• 100% develop tumors by 1 month of age




Genotype
MGI:3693212
cx4
Allelic
Composition
Bcl2tm1Mpin/Bcl2tm1Mpin
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation (1 available); any Bcl2 mutation (37 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 40% develop lung tumors at 2.5 months of age

neoplasm
• 40% develop lung tumors at 2.5 months of age
• although mutants develop lung adenomas, they show a 6-8 fold delay in tumor incidence compared to single transgenic Tg(SFTPC-RAF1-BxB)1Urr mice
• exhibit an increase in the number of apoptotic cells and a decrease in the number of proliferating cells in lung ademonas





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory