Mouse Genome Informatics
Swiss Webster
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• dry weight is markedly reduced
• while normal lenses maintain a high potassium--low sodium content, in mutant lenses this ratio is reversed, beginning at about 15 days; appears to be due to a change in membrane permeability rather than to a defect in the cation pump mechanism
• visible to the naked eye at 5 to 6 weeks after birth, faint anterior opacity is visible at 15 days of age by slit lamp observation
• at 45 days, there is total dense nuclear opacity along with striking anterior and posterior subcapsular opacity

Mouse Models of Human Disease
Cataract 3, Multiple Types; CTRCT3 601547 J:11126