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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Crybb2Phil
Philly cataract
MGI:1857342
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Crybb2Phil/Crybb2Phil Swiss Webster MGI:2183031


Genotype
MGI:2183031
hm1
Allelic
Composition
Crybb2Phil/Crybb2Phil
Genetic
Background
Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crybb2Phil mutation (0 available); any Crybb2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dry weight is markedly reduced
• while normal lenses maintain a high potassium--low sodium content, in mutant lenses this ratio is reversed, beginning at about 15 days; appears to be due to a change in membrane permeability rather than to a defect in the cation pump mechanism
• visible to the naked eye at 5 to 6 weeks after birth, faint anterior opacity is visible at 15 days of age by slit lamp observation
• at 45 days, there is total dense nuclear opacity along with striking anterior and posterior subcapsular opacity

Mouse Models of Human Disease
OMIM ID Ref(s)
Cataract 3, Multiple Types; CTRCT3 601547 J:11126





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory