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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ednrbs-36Pub
Pu239 citrate alpha ray induced 36
MGI:1857333
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ednrbs-36Pub/Ednrbs-36Pub B6.Cg-Ednrbs-36Pub MGI:3759580
hm2
Ednrbs-36Pub/Ednrbs-36Pub involves: 101/Rl * C3H/Rl MGI:3850247
ht3
Ednrbs-36Pub/Ednrb+ involves: 101/Rl * C3H/Rl MGI:3850248
ht4
Ednrbs/Ednrbs-36Pub involves: 101/Rl * C3H/Rl MGI:3850249
cx5
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo MGI:3759582
cx6
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)69Tpo/0
B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo MGI:3759584
cx7
Ednrbs-36Pub/Ednrb+
Spry2tm1.1Mrt/Spry2+
involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J MGI:3759579


Genotype
MGI:3759580
hm1
Allelic
Composition
Ednrbs-36Pub/Ednrbs-36Pub
Genetic
Background
B6.Cg-Ednrbs-36Pub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology
• at E18.5, palatal processes of palatine bones are absent
• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth
• incidence is 27%
• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae
• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth
• homozygotes show high incidence (83%) of cleft secondary palate
• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate
• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

skeleton
• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology
• at E18.5, palatal processes of palatine bones are absent
• extent of ossification in palate at E15.5 is significantly reduced compared to wild-type

digestive/alimentary system
• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology
• at E18.5, palatal processes of palatine bones are absent
• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth
• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae
• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth
• homozygotes show high incidence (83%) of cleft secondary palate
• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate
• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type

cellular
• at E14.5, mitotic index in palates is increased relative to wild-type; indices are also elevated regionally compared to wild-type at E13.5 and E15.5
• proliferation is elevated in epithelium and mesenchyme, most significantly in the mid to posterior palate

growth/size/body
• at E18.5, palatal processes of the maxilla are reduced or vestigal in morphology
• at E18.5, palatal processes of palatine bones are absent
• at E14.5, the posterior palate has not acquired shape changes necessary for medially-directed outgrowth
• incidence is 27%
• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae
• at E14.5, region of soft palate has not acquired shape changes necessary for medially-directed outgrowth
• homozygotes show high incidence (83%) of cleft secondary palate
• at E14.5, palatal shelves have not elevated in the anterior half compared to wild-type palate
• by E15.5, palate has not elevated dorsal to tongue, compared to wild-type




Genotype
MGI:3850247
hm2
Allelic
Composition
Ednrbs-36Pub/Ednrbs-36Pub
Genetic
Background
involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3850248
ht3
Allelic
Composition
Ednrbs-36Pub/Ednrb+
Genetic
Background
involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• described as small and runted




Genotype
MGI:3850249
ht4
Allelic
Composition
Ednrbs/Ednrbs-36Pub
Genetic
Background
involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs mutation (26 available); any Ednrb mutation (73 available)
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• described as small and runted

pigmentation

integument




Genotype
MGI:3759582
cx5
Allelic
Composition
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
Genetic
Background
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
Tg(Spry2)2Tpo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• transgenic mice show complete rescue of cleft lip phenotype
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

skeleton
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

growth/size/body
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes




Genotype
MGI:3759584
cx6
Allelic
Composition
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)69Tpo/0
Genetic
Background
B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
Tg(Spry2)69Tpo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• transgenic mice show complete rescue of cleft lip phenotype
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

skeleton
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes

growth/size/body
• at E18.5, bones of hard palate are reduced in size and show altered morphology
• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology
• incidence of cleft secondary palate is reduced to 8% in non-transgenic homozygotes




Genotype
MGI:3759579
cx7
Allelic
Composition
Ednrbs-36Pub/Ednrb+
Spry2tm1.1Mrt/Spry2+
Genetic
Background
involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-36Pub mutation (0 available); any Ednrb mutation (73 available)
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae
• compound mutants display 35% incidence of cleft secondary palate

digestive/alimentary system
• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae
• compound mutants display 35% incidence of cleft secondary palate

growth/size/body
• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae
• compound mutants display 35% incidence of cleft secondary palate





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory