Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-1Acrg mutation
(0 available);
any
Ednrb mutation
(103 available)
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mortality/aging
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• described as embryonic lethal
(J:100221)
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Allelic Composition |
Ednrbs-1Acrg/Ednrb+
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Genetic Background |
involves: 101/Rl * C3H/Rl |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-1Acrg mutation
(0 available);
any
Ednrb mutation
(103 available)
|
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growth/size/body
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• described as small and runted
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs mutation
(19 available);
any
Ednrb mutation
(103 available)
Ednrbs-1Acrg mutation
(0 available);
any
Ednrb mutation
(103 available)
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growth/size/body
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• described as small and runted
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pigmentation
integument
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-1Acrg mutation
(0 available);
any
Ednrb mutation
(103 available)
Ednrbs-9ThW mutation
(1 available);
any
Ednrb mutation
(103 available)
|
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muscle
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• motor neuron innervation of the diaphragm is incomplete
• sensory neurons in the diaphragm are smaller and exhibit either increased branching or defasiculation
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nervous system
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• at E14.5, neuromuscular junctions (NMJ) are only modestly malformed
• at E18.5, NMJs contain nerve endings that overshoot the postsynaptic receptor plaque results in a lack of muscle stimulation and possess sprouts with varicose endings
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• motor neuron innervation of the diaphragm is incomplete
• sensory neurons in the diaphragm are smaller and exhibit either increased branching or defasiculation
• the phrenic nerve is decreased in diameter and consists of fewer axons compared to wild-type mice
• at E14.5, ingrowing nerves have abnormal endings with large varicosities at the end of the axons
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respiratory system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbs-1Acrg mutation
(0 available);
any
Ednrb mutation
(103 available)
Ednrbs-48UThc mutation
(1 available);
any
Ednrb mutation
(103 available)
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nervous system
N |
• innervation of the diaphragm and respiration are normal
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respiratory system
N |
• innervation of the diaphragm and respiration are normal
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muscle
N |
• innervation of the diaphragm and respiration are normal
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