Mouse Genome Informatics
hm1
    Apobtm2Sgy/Apobtm2Sgy
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism


Mouse Genome Informatics
ht2
    Apobtm2Sgy/Apobtm4Sgy
involves: 129/Sv * 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein B; APOB 107730 J:46549


Mouse Genome Informatics
cx3
    Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her

involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• age related accumulation of esterified cholesterol in the basement of the retinal pigment epithelial layer
• losses in rod and cone sensitivity only after 14 months of age

pigmentation
• age related accumulation of esterified cholesterol in the basement of the retinal pigment epithelial layer


Mouse Genome Informatics
cx4
    Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
Tg(Ins-Igf2)1Fbos/?

involves: 129S7/SvEvBrd * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• elevated relative to mice lacking the transgene at 6 months regardless of diet
• difference from controls lacking the transgene persists on a high fat diet but not on a normal diet at 15 months
• plasma insulin levels are 2X control levels at 6 months in fed mice and fasted mice on a high fat diet
• fasted mice on a normal diet do not show elevated insulin
• reduced insulin sensitivity over the course of an insulin tolerance test
• sustained elevation of blood glucose during a glucose tolerance test regardless of diet
• blood insulin is unchanged over the course of a glucose tolerance test

cardiovascular system
• lesion thickness increases more on a high fat diet than does lesion area
• increased calcification of lesions after 15 months on a high fat diet, particularly for females