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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apobtm2Sgy
targeted mutation 2, Stephen G Young
MGI:1857304
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apobtm2Sgy/Apobtm2Sgy involves: 129/Sv * C57BL/6 MGI:2661996
ht2
Apobtm2Sgy/Apobtm4Sgy involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:2672089
cx3
Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd * C57BL/6 MGI:4367110
cx4
Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
Tg(Ins-Igf2)1Fbos/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:4367111


Genotype
MGI:2661996
hm1
Allelic
Composition
Apobtm2Sgy/Apobtm2Sgy
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobtm2Sgy mutation (4 available); any Apob mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:2672089
ht2
Allelic
Composition
Apobtm2Sgy/Apobtm4Sgy
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobtm2Sgy mutation (4 available); any Apob mutation (86 available)
Apobtm4Sgy mutation (0 available); any Apob mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein B; APOB 107730 J:46549




Genotype
MGI:4367110
cx3
Allelic
Composition
Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobtm2Sgy mutation (4 available); any Apob mutation (86 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• age related accumulation of esterified cholesterol in the basement of the retinal pigment epithelial layer
• losses in rod and cone sensitivity only after 14 months of age

pigmentation
• age related accumulation of esterified cholesterol in the basement of the retinal pigment epithelial layer




Genotype
MGI:4367111
cx4
Allelic
Composition
Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
Tg(Ins-Igf2)1Fbos/?
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobtm2Sgy mutation (4 available); any Apob mutation (86 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
Tg(Ins-Igf2)1Fbos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• elevated relative to mice lacking the transgene at 6 months regardless of diet
• difference from controls lacking the transgene persists on a high fat diet but not on a normal diet at 15 months
• plasma insulin levels are 2X control levels at 6 months in fed mice and fasted mice on a high fat diet
• fasted mice on a normal diet do not show elevated insulin
• reduced insulin sensitivity over the course of an insulin tolerance test
• sustained elevation of blood glucose during a glucose tolerance test regardless of diet
• blood insulin is unchanged over the course of a glucose tolerance test

cardiovascular system
• lesion thickness increases more on a high fat diet than does lesion area
• increased calcification of lesions after 15 months on a high fat diet, particularly for females





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory