Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation
(2 available);
any
Plaur mutation
(18 available)
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immune system
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• chronic inflammation is secondary to fibrin deposition
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• in the liver
• in the trachea of 3 in 7 mice
• however, leukocyte accumulation in standard models of inflammation is normal
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• the number of inflammatory foci is increased compared to in wild-type mice
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• 3 of 7 mice exhibit mild to moderate inflammation of the trachea unlike wild-type mice
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respiratory system
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• 3 of 7 mice exhibit mild to moderate inflammation of the trachea unlike wild-type mice
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liver/biliary system
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• the number of inflammatory foci is increased compared to in wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation
(2 available);
any
Plaur mutation
(18 available)
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renal/urinary system
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• homozygotes exhibit a redistribution of urokinase plasminogen activator (uPA) in some tissues but show no changes in the accumulation or proteolytic activation of uPA in the urogenital tract
• as in wild-type mice, most of the uPA in the urine of mutant mice is in the two-chain form
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immune system
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• activated peritoneal macrophages from mutant mice fail to promote cell-surface plasminogen activation in vitro; however, homozygotes are viable, fertile and survive to adulthood with no apparent anatomical defects
• also, homozygotes that are unchallenged by disease, infection or injury show no pathological lesions or hepatic fibrin deposits up to 6-8 months of age
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hematopoietic system
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• activated peritoneal macrophages from mutant mice fail to promote cell-surface plasminogen activation in vitro; however, homozygotes are viable, fertile and survive to adulthood with no apparent anatomical defects
• also, homozygotes that are unchallenged by disease, infection or injury show no pathological lesions or hepatic fibrin deposits up to 6-8 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation
(2 available);
any
Plaur mutation
(18 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation
(2 available);
any
Plaur mutation
(18 available)
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cardiovascular system
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• aortic vessel explants show a reduced rate of sprouting (2/3 of controls) in collagen lattices
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaurtm1Jld mutation
(2 available);
any
Plaur mutation
(18 available)
Tg(MSR1-Plau)1Ddi mutation
(1 available)
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cardiovascular system
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• exhibit more fibrosis at 15 weeks of age than single Plaur homozygotes although show a similar degree of fibrosis as seen in single Tg(MSR1-Plau)1Ddi mutants
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• exhibit significantly more cardiac macrophages at 15 weeks of age than single Plaur homozygotes, however show a similar accumulation as seen in single Tg(MSR1-Plau)1Ddi mutants
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immune system
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• exhibit significantly more cardiac macrophages at 15 weeks of age than single Plaur homozygotes, however show a similar accumulation as seen in single Tg(MSR1-Plau)1Ddi mutants
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Analysis Tools