Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation
(1 available);
any
Rela mutation
(24 available)
|
|
|
mortality/aging
|
|
• despite normal appearance up to E13, all mice are dead by E15
|
liver/biliary system
|
|
• most mice exhibit fetal liver cell apoptosis by E14.5
|
cardiovascular system
|
|
• most mice exhibit abdominal hemorrhage by E14.5
|
cellular
|
|
• most mice exhibit fetal liver cell apoptosis by E14.5
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation
(1 available);
any
Rela mutation
(24 available)
|
|
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation
(1 available);
any
Rela mutation
(24 available)
|
|
|
nervous system
|
|
• at E14, the number of neurons in the trigeminal ganglia is decrease compared to in wild-type mice
|
|
|
• survival following treatment of sensory neurons with NGF is lower than for similarly treated wild-type neurons due to increased apoptosis
• however, sensory neurons exhibit normal survival response to BDNF
|
|
|
• apoptosis in the trigeminal ganglia of E14 mice is increased compared to in wild-type mice
|
cellular
|
|
• embryonic fibroblasts treated with mTNF-alpha exhibit decreased survival compared to similarly treated cells
|
|
|
• apoptosis in the trigeminal ganglia of E14 mice is increased compared to in wild-type mice
|
immune system
|
N |
• mice exhibit normal dendritic cell development and maturation
|
|
|
• when cells are used to reconstitute a Rag2 null mouse, the number of marginal zone B cells is reduced to one third of normal
|
hematopoietic system
|
|
• when cells are used to reconstitute a Rag2 null mouse, the number of marginal zone B cells is reduced to one third of normal
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation
(1 available);
any
Rela mutation
(24 available)
|
|
|
mortality/aging
|
|
• after E14 mice begin to die and none survive to birth
|
liver/biliary system
|
|
• liver degeneration is associated with increased apoptosis of liver cells
|
|
|
• E15 to E16, mice exhibit liver degeneration that specifically targets hepatocytes leaving hematopoietic precursors and red blood cells intact
• liver degeneration is associated with increased apoptosis of liver cells
|
cardiovascular system
|
|
• at E16, surviving mice exhibit massive abdominal hemorrhage
|
cellular
|
|
• liver degeneration is associated with increased apoptosis of liver cells
|
mortality/aging
|
|
• despite normal appearance up to E12, all mice are dead by E14
|
hematopoietic system
|
N |
• despite impaired erythropoeisis, hematopoietic development potential is normal
|
|
|
• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
|
|
|
• 2.5-fold compared to in wild-type mice
|
|
|
• mice and irradiated wild-type mice transplanted with mutant mice bone marrow exhibit impaired erythropoiesis
|
|
|
• irradiated mice reconstituted with mutant bone marrow exhibit granulocytosis of fetal liver cells
|
liver/biliary system
|
|
• most mice exhibit fetal liver cell apoptosis by E13.5
|
cardiovascular system
|
|
• most mice exhibit abdominal hemorrhage by E13.5
|
immune system
|
|
• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
|
|
|
• irradiated mice reconstituted with mutant bone marrow exhibit granulocytosis of fetal liver cells
|
cellular
|
|
• most mice exhibit fetal liver cell apoptosis by E13.5
|
|
|
• increased apoptosis during monocyte differentiation in culture results in a reduced frequency of granulocyte and macrophage colonies compared to cultures from wild-type mice
|
mortality/aging
|
|
• triple homozygous pups die within 12 hours of birth
|
|
|
• fewer than expected triple homozygous mutants are found at birth
|
integument
|
|
• the epidermis is marginally thinner
|
mortality/aging
|
|
• triple homozygous pups die within 12 hours of birth
|
cellular
|
|
• transit-amplifying epidermal cells display a delay in G1/S phase progression
|
|
|
• transit-amplifying epidermal cells display reduced proliferation
|
embryo
|
|
• triple homozygous embryos are about 30% smaller compared to littermate controls
|
growth/size/body
|
|
• triple homozygous embryos are about 30% smaller compared to littermate controls
|
integument
|
|
• about a 24 hour delay in hair placode formation is seen compared to control littermates
|
|
|
• at E18 the hair follicles that are present are only rudimentary buds lacking hair shafts
|
|
|
• at E18, 70% fewer hair follicles are present compared to control littermates
|
|
|
• the cells in the basal cell layer are organized differently and the basal cell profile area is reduced by about 33%
|
|
|
• the number of differentiating keratinocytes is reduced
|
|
|
• the epidermis is significantly thinner
|
hematopoietic system
|
|
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
|
|
|
• in culture, very few dendritic cells differentiate from bone marrow cells
|
immune system
|
|
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
|
|
|
• in culture, very few dendritic cells differentiate from bone marrow cells
|
cellular
|
|
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
|
digestive/alimentary system
|
|
• mice exhibit colonic perforations and typhlocolitis
|
|
|
• mice exhibit typhlocolitis
|
immune system
|
|
• mice exhibit typhlocolitis
|
|
|
• mice are more sensitive to typhlocolitis induced by H. hepaticus than wild-type mice with a more rapid onset of diarrhea, enlargement and thickening of the colon, thickening of the mucosa characterized by extensive ulcerations, elongated irregularly shaped glands and crypt abscesses, lamina propria fibrosis and infiltration granulation tissue, dilated lymphatics, and multifocal necrotizing vasculitis with thrombosis, and expanded submucosa and serosa with infiltration
|
nervous system
|
|
• Schwann cell apoptosis is increased compared to in wild-type mice 24 hours post-axotomy
|
mortality/aging
|
|
• mice die around the same time as Relatm1Bal homozygotes: Bid deletion does not rescue the lethality
|
liver/biliary system
|
|
• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos
|
|
|
• at E14.5 and 15.5, embryos show similar level of liver destruction as control Rela-null embryos
|
cardiovascular system
|
|
• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos
|
cellular
|
|
• mouse embryonic fibroblasts are partially protected from TNF-alpha-induced apoptosis compared to exposed Relatm1Bal homozygous mouse embryonic fibroblasts
|
mortality/aging
|
|
• mice die between 6 and 17 days after birth
• however, prenatal lethality observed in Relatm1Bal homozygotes is reversed
|
hematopoietic system
|
|
• at the time of death mice exhibit foci of degeneration in the thymus
|
|
|
• in the liver of 2 to 7 day old mice
|
|
|
• at the time of death, mice exhibit less compact germinal centers compared to in wild-type mice
|
liver/biliary system
|
|
• at the time of death mice, exhibit acute hepatitis with massive neutrophilic infiltration and necrotic foci
|
cardiovascular system
|
|
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs
|
growth/size/body
|
|
• within the first week after birth, mice become runted despite continued nursing
|
respiratory system
|
|
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs
|
immune system
|
|
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs
|
|
|
• at the time of death mice exhibit foci of degeneration in the thymus
|
|
|
• at the time of death, mice exhibit less compact germinal centers compared to in wild-type mice
|
|
|
• at the time of death mice, exhibit acute hepatitis with massive neutrophilic infiltration and necrotic foci
|
|
|
• at the time of death, some mice exhibit neutrophilic infiltration of the heart and lungs
|
endocrine/exocrine glands
|
|
• at the time of death mice exhibit foci of degeneration in the thymus
|
cellular
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1Bal mutation
(1 available);
any
Rela mutation
(24 available)
Tg(SERPINA1-BCL2)1Pva mutation
(0 available)
|
|
|
liver/biliary system
|
|
• over-expression of Bcl-2 transgene fails to prevent hepatocyte apoptosis induced by endogenous TNF-alpha
|
cellular
|
|
• over-expression of Bcl-2 transgene fails to prevent hepatocyte apoptosis induced by endogenous TNF-alpha
|
Analysis Tools