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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfrsf1btm1Mwm
targeted mutation 1, Mark Moore
MGI:1857262
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm B6.129S2-Tnfrsf1btm1Mwm MGI:3622069
hm2
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm B6.129S2-Tnfrsf1btm1Mwm/J MGI:3580520
hm3
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm involves: 129S2/SvPas * C57BL/6 MGI:4354646
hm4
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm involves: 129S2/SvPas * C57BL/6J MGI:3620002
hm5
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm involves: 129S2/SvPas * C57BL/6J * NOD MGI:3622765
cx6
Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129/Sv * C57BL/6 MGI:3053739
cx7
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4843969
cx8
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4838237
cx9
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 MGI:3622064
cx10
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * CBA MGI:4461139
cx11
Krt8tm1Rgo/Krt8tm1Rgo
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * FVB/N MGI:3711995
cx12
Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6J * NOD MGI:3622772


Genotype
MGI:3622069
hm1
Allelic
Composition
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
B6.129S2-Tnfrsf1btm1Mwm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 7 days after traumatic spinal cord injury increased cell death is seen in the center of the lesion and the rostrocaudal spread of the lesion is increased compared to wild-type
• 4 weeks after traumatic spinal cord injury locomotor performance is significantly more impaired but lesions are not significantly longer than in wild-type mice

behavior/neurological
• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice
• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice
• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration




Genotype
MGI:3580520
hm2
Allelic
Composition
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
B6.129S2-Tnfrsf1btm1Mwm/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type
• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2
• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2
• CD8+ T cells produce less interferon gamma following anti-CD3 stimulation than control cells; the result of fewer cells expressing interferon gamma as well as a decrease in the amount produced per cell
• CD8+ T cells exhibit a reduction in IL2 secretion following anti-CD3 stimulation

hematopoietic system
• proliferation of lymph node T cells is reduced in response to anti-CD3e monoclonal antibody stimulation as compared to wild-type
• purified CD8+ T cells require a 5 fold greater anti-CD3 stimulation for tritiated thymidine incorporation equivalent to wild-type, however proliferation is increased in the presence of IL2
• purified CD4+ T cells require a greater anti-CD3 stimulation for tritiated thymidine incorporation, however proliferation is increased in the presence of IL2




Genotype
MGI:4354646
hm3
Allelic
Composition
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice
• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice
• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice




Genotype
MGI:3620002
hm4
Allelic
Composition
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decreased sensitivity to exogenous tumor necrosis factor (TNF), however, death occurs at high doses
• increased mortality as compared to wild-type following injection with Listeria monocytogenes




Genotype
MGI:3622765
hm5
Allelic
Composition
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis
• none of the animals develop diabetes until 24 weeks (no blood glucose measure of >300 mg/dl)

endocrine/exocrine glands
• at 5 weeks, mice exhibit periinsulits, while transgenic littermates show severe insulitis




Genotype
MGI:3053739
cx6
Allelic
Composition
Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Gkl mutation (1 available); any Tnfrsf1a mutation (22 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen

liver/biliary system
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen




Genotype
MGI:4843969
cx7
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (27 available)
Tnfrsf1atm1Blt mutation (5 available); any Tnfrsf1a mutation (22 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
• despite the absence of germinal centers the white pulp has distinct T and B cell areas
• grossly unidentifiable and histologically hypoplastic
• thin and lack primary and secondary cortical follicles
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii
• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection
• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice

hematopoietic system
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
• despite the absence of germinal centers the white pulp has distinct T and B cell areas

respiratory system
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii




Genotype
MGI:4838237
cx8
Allelic
Composition
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (5 available); any Tnfrsf1a mutation (22 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice are able to clear infections of Pneumocystis carinii similar to controls
• despite the absence of germinal centers the white pulp has distinct T and B cell areas
• following treatment with MOG
• grossly unidentifiable and histologically hypoplastic
• thin and lack primary and secondary cortical follicles
• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice
• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice
• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice

hematopoietic system
• despite the absence of germinal centers the white pulp has distinct T and B cell areas
• following treatment with MOG




Genotype
MGI:3622064
cx9
Allelic
Composition
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnftm2Gkl only
• arthritis is more aggressive and destructive than in mice heterozygous for Tnftm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage

digestive/alimentary system
• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnftm2Gkl only

skeleton
• arthritis is more aggressive and destructive than in mice heterozygous for Tnftm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage




Genotype
MGI:4461139
cx10
Allelic
Composition
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnf)6074Gkl mutation (0 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in 4 week old mice
• in 4 week old mice
• cerebellum myelin vacuolation in 4 week old mice

immune system
• in 4 week old mice

cellular
• in 4 week old mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592




Genotype
MGI:3711995
cx11
Allelic
Composition
Krt8tm1Rgo/Krt8tm1Rgo
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt8tm1Rgo mutation (1 available); any Krt8 mutation (12 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival improved 4 fold in the absence of maternal TNFRSF1b as compared to the condition in which TNFRSF1b was present
• survival continues to be reduced




Genotype
MGI:3622772
cx12
Allelic
Composition
Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 100% of deficient transgenic animals develop diabetes by 5 weeks (blood glucose >300 mg/dl), while only 60% of non-transgenic littermates develop diabetes by 24 weeks

homeostasis/metabolism
• mice are considered diabetic after a blood glucose measure of >300 mg/dl





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory