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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfrsf1atm1Mak
targeted mutation 1, Tak Mak
MGI:1857261
Summary 27 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak involves: 129S2/SvPas MGI:3706991
hm2
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:3053442
hm3
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak involves: 129S2/SvPas * C57BL/6J * NOD MGI:3622767
ht4
Tnfrsf1atm1Mak/Tnfrsf1a+ involves: 129S2/SvPas MGI:5573130
cn5
Map3k7tm1Aki/Map3k7tm1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 MGI:5464102
cn6
Tab2tm2.1Aki/Tab2tm2.1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:5464104
cn7
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5582487
cn8
Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3817624
cn9
Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 MGI:3794992
cn10
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 MGI:3690542
cn11
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2 MGI:7256612
cn12
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5582492
cn13
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0
involves: 129S2/SvPas * C57BL/6 * SJL MGI:4829677
cx14
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5305973
cx15
Tbk1tm1Yeh/Tbk1tm1Yeh
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129P2/OlaHsd * C57BL/6J MGI:3050533
cx16
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J MGI:3609627
cx17
Relatm2.1Gho/Relatm2.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac MGI:5574110
cx18
Relatm1.1Gho/Relatm1.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 MGI:3794990
cx19
Fastm1Cgn/Fastm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 MGI:3690543
cx20
TnfBpsm1/TnfBpsm1
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 MGI:6272039
cx21
TnfBpsm1/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 MGI:6272040
cx22
Tnfem5Boui/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1a+
involves: 129S2/SvPas * C57BL/6 MGI:6730103
cx23
Tg(KRT5-Nfkbia*)3Rto/0
Tg(Krt5-Tnfr1)#Rsab/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * CBA MGI:5582489
cx24
Tg(CAG-Lyn*)#Paau/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5512885
cx25
Tg(INS-Il10)#Sar/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * NOD MGI:3622768
cx26
Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:3609629
cx27
Chuktm1Ver/Chuktm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:3609632


Genotype
MGI:3706991
hm1
Allelic
Composition
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes succumb to infection following challenge with L. monocytogenes (J:4753)
• in contrast to wildtype, homozygotes exhibit very high titers of Listeria in spleen and liver by day 6 post-infection (J:4753)
• increased susceptibility to L. monocytogenes-induced lethality with 100% lethality even when infected with a low titer of bacteria (J:139030)
• all mice infected with Listeria monocytogenes die unlike wild-type mice (J:210950)
• no mice treated with TNF die unlike wild-type mice

immune system
• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells
• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls
• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection
• in response to LPS stimulation, compared to controls
• mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice
• homozygotes are resistant to high dose (100 ug) bacterial LPS challenge and lethal doses of staphylococcal enterotoxin B (J:4753)
• homozygotes succumb to infection following challenge with L. monocytogenes (J:4753)
• in contrast to wildtype, homozygotes exhibit very high titers of Listeria in spleen and liver by day 6 post-infection (J:4753)
• increased susceptibility to L. monocytogenes-induced lethality with 100% lethality even when infected with a low titer of bacteria (J:139030)
• all mice infected with Listeria monocytogenes die unlike wild-type mice (J:210950)

hematopoietic system
• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells
• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls

homeostasis/metabolism
• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection
• in response to LPS stimulation, compared to controls
• slower recovery after superficial injury causes increased trans-epidermal water loss
• TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice

skeleton
• significantly increased

integument
• slower recovery after superficial injury causes increased trans-epidermal water loss

cellular
• in mouse embryonic fibroblasts exposed to hypoxia




Genotype
MGI:3053442
hm2
Allelic
Composition
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to infection with Mycobacterium avium, mice developed extensive tissue necrosis in all infected tissues and persistent granulomatous lesions which went through acute disintegration before death
• mice depleted of either CD4+ or CD8+ cells after granuloma initiation stayed healthy to day 38 postinfection, with no signs of granuloma destruction




Genotype
MGI:3622767
hm3
Allelic
Composition
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• deficient mice do not develop diabetes over a 24-week period




Genotype
MGI:5573130
ht4
Allelic
Composition
Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice treated with TNF die unlike all wild-type mice

immune system
• decreased induction in TNF-treated mice

homeostasis/metabolism
• decreased induction in TNF-treated mice
• TNF-treated mice fail to exhibit lethality, as great IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice




Genotype
MGI:5464102
cn5
Allelic
Composition
Map3k7tm1Aki/Map3k7tm1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7tm1Aki mutation (0 available); any Map3k7 mutation (48 available)
Tg(Tek-cre)12Flv mutation (1 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
N
• blood vessels do not exhibit regression and exhibit normal vessel length and branching

cellular
N
• embryonic endothelial cell apoptosis is rescued




Genotype
MGI:5464104
cn6
Allelic
Composition
Tab2tm2.1Aki/Tab2tm2.1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tab2tm2.1Aki mutation (0 available); any Tab2 mutation (22 available)
Tg(Tek-cre)12Flv mutation (1 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• as in Tab2tm2.1Aki/Tab2tm2.1Aki Tg(Tek-cre)12Flv mice




Genotype
MGI:5582487
cn7
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (36 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice reach adulthood without showing inflammatory skin lesions




Genotype
MGI:3817624
cn8
Allelic
Composition
Chuktm1Yhu/Chuktm1Yhu
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (31 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die slightly earlier than Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice

integument
• as in Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice
• as in Chuktm1Yhu/Chuktm1Yhu Tg(KRT5-cre)1Jlj mice




Genotype
MGI:3794992
cn9
Allelic
Composition
Relatm1.2Gho/Relatm1.2Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1.2Gho mutation (0 available); any Rela mutation (23 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygous mice die before 40 days
• the embryonic lethality seen among Relatm1.2Gho is completely rescued




Genotype
MGI:3690542
cn10
Allelic
Composition
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (76 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (55 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• B and T cell distribution in the lymph nodes is normal
• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type
• mice are almost completely resistant to induction of experimental autoimmune encephalomyelitis (EAE) by injection of MOG p35-55
• almost no oligodendrocyte apoptosis after EAE induction unlike in wild-type mice
• reduction in demyelination and inflammation after induction of EAE is greater than in mutant mice wild-type for Tnfrsf1a
• 24 days after induction of EAE, minimal axonal injury is seen in spinal cords




Genotype
MGI:7256612
cn11
Allelic
Composition
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (14 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal circulating inflammatory cytokine and chemokine levels

integument
N
• no dermatitis and normal epidermal thickness up to age older than 40 weeks




Genotype
MGI:5582492
cn12
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (36 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice reach adulthood without showing inflammatory skin lesions




Genotype
MGI:4829677
cn13
Allelic
Composition
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfaip3tm1.1Gvl mutation (0 available); any Tnfaip3 mutation (30 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice exhibit decreased susceptibility compared to Tnfrsf1atm1Mak/Tnfrf1+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice
• mice exhibit increased susceptibility compared to in Tnfrsf1atm1Mak homozygotes

immune system
• mice exhibit decreased susceptibility compared to Tnfrsf1atm1Mak/Tnfrf1+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice
• mice exhibit increased susceptibility compared to in Tnfrsf1atm1Mak homozygotes




Genotype
MGI:5305973
cx14
Allelic
Composition
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
Tnip1Gt(E059E05)Wrst mutation (0 available); any Tnip1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 6 months of birth
• slightly fewer than expected mice are born alive

immune system
• mice develop similar inflammatory disease (body weight loss, anemia, neutrophilia, leukocyte organ infiltrations, and glomerulonephritis) as observed in Tnip1Gt(E059E05)Wrst homozygotes

hematopoietic system

growth/size/body

renal/urinary system




Genotype
MGI:3050533
cx15
Allelic
Composition
Tbk1tm1Yeh/Tbk1tm1Yeh
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1tm1Yeh mutation (1 available); any Tbk1 mutation (42 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• double homozygotes develop to term unlike Tbk1tm1Yeh homozygotes that die at around E14.5




Genotype
MGI:3609627
cx16
Allelic
Composition
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Ver mutation (0 available); any Ikbkb mutation (36 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygotes develop to term but die within the first postnatal month, unlike Ikbkbtm1Ver mutant embryos that die at ~E12.5-E13.5




Genotype
MGI:5574110
cx17
Allelic
Composition
Relatm2.1Gho/Relatm2.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm2.1Gho mutation (0 available); any Rela mutation (23 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50%-60% die sometime between 1 and 6 months of age

vision/eye
• vascularized and proliferative corneal lesion developed in the central region of the cornea
• neutrophils and macrophages
• at 25 days, the corneal epithelium is slightly thinner and keratinocytes are less orderly
• occasional dying keratinocytes are present
• severe corneal epithelial thickening is observed, occurring abruptly at the junction of the central and peripheral

liver/biliary system
• slowly progressive hepatic inflammation
• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils
• capsular fibrosis and inflammation is also seen

cardiovascular system
• vascularized and proliferative corneal lesion developed in the central region of the cornea

immune system
• neutrophils and macrophages
• slowly progressive hepatic inflammation
• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils




Genotype
MGI:3794990
cx18
Allelic
Composition
Relatm1.1Gho/Relatm1.1Gho
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relatm1.1Gho mutation (0 available); any Rela mutation (23 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a few mice survived to birth died about 1 month after birth
• most homozygous mice died in utero before birth
• very small number of mutant mice survived to birth

vision/eye
• a few mice survived to birth show eye developmental defect and were blind
• a few mice survived to birth show eye developmental defect and were blind




Genotype
MGI:3690543
cx19
Allelic
Composition
Fastm1Cgn/Fastm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (76 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduction in the onset and severity, but not incidence of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55
• about a 75% reduction in oligodendrocyte apoptosis after EAE induction compared to wild-type mice
• inflammation after EAE induction is also reduced




Genotype
MGI:6272039
cx20
Allelic
Composition
TnfBpsm1/TnfBpsm1
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TnfBpsm1 mutation (0 available); any Tnf mutation (38 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system

skeleton
N
• mice do not develop rheumatoid arthritis




Genotype
MGI:6272040
cx21
Allelic
Composition
TnfBpsm1/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TnfBpsm1 mutation (0 available); any Tnf mutation (38 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system

skeleton
N
• mice do not develop rheumatoid arthritis




Genotype
MGI:6730103
cx22
Allelic
Composition
Tnfem5Boui/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfem5Boui mutation (0 available); any Tnf mutation (38 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system

digestive/alimentary system
• inflammatory bowel disease (IBD) in gut in surviving mice at age P20

immune system
• inflammatory bowel disease (IBD) in gut in surviving mice at age P20
• deformed ankles and wrists in surviving mice from age P7
• large pannus tissue invasion in synovial joints in surviving mice at age P20

mortality/aging
• surviving mice die by age 33 days
• 80% of embryos die within hours of birth

respiratory system
• failure to initiate respiration: underinflated lungs in pups that died within hours of birth

skeleton
• deformed ankles and wrists in surviving mice from age P7
• large pannus tissue invasion in synovial joints in surviving mice at age P20




Genotype
MGI:5582489
cx23
Allelic
Composition
Tg(KRT5-Nfkbia*)3Rto/0
Tg(Krt5-Tnfr1)#Rsab/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-Nfkbia*)3Rto mutation (0 available)
Tg(Krt5-Tnfr1)#Rsab mutation (0 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in most mice within 10 days

integument
• within the first 3 to 4 days after birth
• within the first 3 to 4 days after birth

immune system
• within the first 3 to 4 days after birth




Genotype
MGI:5512885
cx24
Allelic
Composition
Tg(CAG-Lyn*)#Paau/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Lyn*)#Paau mutation (0 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice exhibit normal skin architecture and all mice reach adulthood




Genotype
MGI:3622768
cx25
Allelic
Composition
Tg(INS-Il10)#Sar/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 60% of deficient transgenic mice develop diabetes by 5 weeks (blood glucose measuring >300 mg/dl), while 100% develop diabetes by 10 weeks compared to 0% of nontransgenic littermates

homeostasis/metabolism
• mice are considered diabetic after a blood glucose measure of >300 mg/dl




Genotype
MGI:3609629
cx26
Allelic
Composition
Chuktm1Ver/Chuktm1Ver
Ikbkbtm1Ver/Ikbkbtm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Ver mutation (0 available); any Chuk mutation (31 available)
Ikbkbtm1Ver mutation (0 available); any Ikbkb mutation (36 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• triple homozygotes survive to ~E16.5, exhibiting a morphology similar to that observed in Chuktm1Ver mutant embryos

limbs/digits/tail
• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuktm1Ver mutant embryos
• at E14.5, triple homozygotes exhibit curled tails, similar to those observed in Chuktm1Ver mutant embryos

nervous system
• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuktm1Ver and Ikbkbtm1Ver

embryo
• at E14.5, triple homozygotes exhibit dumpy limb buds, similar to those observed in Chuktm1Ver mutant embryos
• at E14.5, triple homozygotes exhibit a neural tube defect, similar to that observed in mice doubly homozygous for Chuktm1Ver and Ikbkbtm1Ver




Genotype
MGI:3609632
cx27
Allelic
Composition
Chuktm1Ver/Chuktm1Ver
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Ver mutation (0 available); any Chuk mutation (31 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at E14.5, double homozygotes exhibit dumpy limb buds, similar to those observed in Chuktm1Ver mutant embryos
• at E14.5, double homozygotes exhibit curled tails, similar to those observed in Chuktm1Ver mutant embryos

embryo
• at E14.5, double homozygotes exhibit dumpy limb buds, similar to those observed in Chuktm1Ver mutant embryos





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory