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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tap1tm1Arp
targeted mutation 1, Philip Ashton-Rickardt
MGI:1857253
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tap1tm1Arp/Tap1tm1Arp B6.129S2-Tap1tm1Arp/J MGI:3722073
hm2
Tap1tm1Arp/Tap1tm1Arp involves: 129S2/SvPas MGI:3694695
hm3
Tap1tm1Arp/Tap1tm1Arp involves: 129S2/SvPas * C57BL/6 MGI:3621930
cx4
Erap1tm1Nsha/Erap1tm1Nsha
Tap1tm1Arp/Tap1tm1Arp
B6.129-Erap1tm1Nsha Tap1tm1Arp MGI:3706235
cx5
Tap1tm1Arp/Tap1tm1Arp
X/Yaa
BXSB.129S2(B6)-Tap1tm1Arp/Dcr MGI:6094248
cx6
Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Tap1tm1Arp/Tap1tm1Arp
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:5478623
cx7
Erap1tm1Nsha/Erap1tm1Nsha
Tap1tm1Arp/Tap1tm1Arp
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2 MGI:3706311
cx8
Cd74tm1Doi/Cd74tm1Doi
Tap1tm1Arp/Tap1tm1Arp
involves: 129S2/SvPas * C57BL/6 MGI:3814823


Genotype
MGI:3722073
hm1
Allelic
Composition
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
B6.129S2-Tap1tm1Arp/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), 70% of mice survive a low dose but all mice succumb to a high dose

immune system
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice
• following infection with a low dose of IEO, CD8+ T cells in the spleen are reduced (1.2%+/-0.2% of splenocytes compared to 8.0%+/-0.4% of splenocytes in wild-type mice)
• mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice
• at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), 70% of mice survive a low dose but all mice succumb to a high dose

hematopoietic system
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice
• following infection with a low dose of IEO, CD8+ T cells in the spleen are reduced (1.2%+/-0.2% of splenocytes compared to 8.0%+/-0.4% of splenocytes in wild-type mice)




Genotype
MGI:3694695
hm2
Allelic
Composition
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice have very few mature CD8+ T cells (J:64177)
• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)
• mutants show a strong CTL response to syngeneic antigens from wild-type
• CD8+ T cell responses to virus and protein antigen are reduced due to inability of dendritic cells to efficiently present antigen
• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma
• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma
• expression is only ~5% of wild-type (J:64177)
• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)
• most MHC class I molecules lack high-affinity peptides
• MHC class I heterodimers lacking high-affinity peptides are retained in the endoplasmic reticulum and targeted for degradation in the cytosol

hematopoietic system
• mice have very few mature CD8+ T cells (J:64177)
• CD8+ T cell number in periphery, and in thymus, is reduced (J:64349)
• mutants show a strong CTL response to syngeneic antigens from wild-type




Genotype
MGI:3621930
hm3
Allelic
Composition
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• exhibit a 30-40 fold reduction in CD4-CD8- T cells in spleen, blood and lymph nodes, but not thymus
• class I heavy chains in spleen lymphoblasts are defective in acquisition of EndoH resistance suggesting a defect in class I maturation
• when ovalbumin is introduced by osmotic shock, mutant cells show impairment in presentation of OVA-derived epitopes
• mutant bone marrow-derived dendritic cells (BM-DC) treated with ovalbumin-immune complexes (OVA-IC) do not present the MHC class I-restricted epitope after OVA-IC internalization
• splenocytes exhibit little or no H2-Kb or -Db surface expression, however, at lower temperatures (26C) surface expression is increased
• class I Kb and Db molecules have little heavy chain sialylation indicating an impaired delivery to trans Golgi

hematopoietic system
• exhibit a 30-40 fold reduction in CD4-CD8- T cells in spleen, blood and lymph nodes, but not thymus
• class I heavy chains in spleen lymphoblasts are defective in acquisition of EndoH resistance suggesting a defect in class I maturation




Genotype
MGI:3706235
cx4
Allelic
Composition
Erap1tm1Nsha/Erap1tm1Nsha
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
B6.129-Erap1tm1Nsha Tap1tm1Arp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erap1tm1Nsha mutation (0 available); any Erap1 mutation (39 available)
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• processing of certain antigenic precursors in the ER is defective in mutant splenocytes, because Arts functions as a unique protease




Genotype
MGI:6094248
cx5
Allelic
Composition
Tap1tm1Arp/Tap1tm1Arp
X/Yaa
Genetic
Background
BXSB.129S2(B6)-Tap1tm1Arp/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
Yaa mutation (10 available); any Yaa mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of Tap1 intensifies the severity to a mean survival of only 23 weeks of ag




Genotype
MGI:5478623
cx6
Allelic
Composition
Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Yod1*)Hpl mutation (0 available); any Col1a1 mutation (104 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (15 available); any Gt(ROSA)26Sor mutation (392 available)
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• APCs from doxycycline-treated mice exhibit enhanced antigen cross-presentation compared with control cells




Genotype
MGI:3706311
cx7
Allelic
Composition
Erap1tm1Nsha/Erap1tm1Nsha
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erap1tm1Nsha mutation (0 available); any Erap1 mutation (39 available)
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• BEko cells in wild-type mice are not activated by APCs (antigen expressing cells) from double mutants, compared to activation elicited by Arts1-single null APCs; response is similar to response of wild-type BEkos to Tap1-deficient APCs




Genotype
MGI:3814823
cx8
Allelic
Composition
Cd74tm1Doi/Cd74tm1Doi
Tap1tm1Arp/Tap1tm1Arp
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Doi mutation (1 available); any Cd74 mutation (21 available)
Tap1tm1Arp mutation (3 available); any Tap1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• numbers of typical (i.e. CD4+- or CD8+- T cells) are reduced
• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

immune system
• numbers of typical (i.e. CD4+- or CD8+- T cells) are reduced
• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls





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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory