Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Hyn mutation
(12 available);
any
Selp mutation
(56 available)
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immune system
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• macrophage recruitment in a peritonitis model is reduced even 48 hours after challenge
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• rolling of leukocytes in subcutaneous vessels is significantly lower under both basal conditions and post-ischemia-reperfusion, but not completely eliminated
• leukocyte rolling is reduced even four hours after challenge; exhibit significantly fewer rolling cells and their velocity is reduced
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• increased numbers of circulating neutrophils
• clearing of neutrophils from the circulation is delayed in the first 2 to 3 hours after neutrophil injection, but is normal by 5 hours
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hematopoietic system
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• macrophage recruitment in a peritonitis model is reduced even 48 hours after challenge
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• rolling of leukocytes in subcutaneous vessels is significantly lower under both basal conditions and post-ischemia-reperfusion, but not completely eliminated
• leukocyte rolling is reduced even four hours after challenge; exhibit significantly fewer rolling cells and their velocity is reduced
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• increased numbers of circulating neutrophils
• clearing of neutrophils from the circulation is delayed in the first 2 to 3 hours after neutrophil injection, but is normal by 5 hours
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cellular
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• macrophage recruitment in a peritonitis model is reduced even 48 hours after challenge
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• rolling of leukocytes in subcutaneous vessels is significantly lower under both basal conditions and post-ischemia-reperfusion, but not completely eliminated
• leukocyte rolling is reduced even four hours after challenge; exhibit significantly fewer rolling cells and their velocity is reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Hyn mutation
(12 available);
any
Selp mutation
(56 available)
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immune system
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• there is a third decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF
• there is also a third decrease in the number of adhering leukocytes within these mesenteric venules
• mean velocity of leukocytes is decreased
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• eosinophil numbers are about two-thirds higher in the blood
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• neutrophils numbers are slightly increased
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection
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hematopoietic system
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• there is a third decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF
• there is also a third decrease in the number of adhering leukocytes within these mesenteric venules
• mean velocity of leukocytes is decreased
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• eosinophil numbers are about two-thirds higher in the blood
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• neutrophils numbers are slightly increased
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection
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cellular
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• there is a third decrease in the number of rolling leukocytes within the mesenteric venules of mice treated with TNF
• there is also a third decrease in the number of adhering leukocytes within these mesenteric venules
• mean velocity of leukocytes is decreased
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Hyn mutation
(12 available);
any
Selp mutation
(56 available)
|
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immune system
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• exhibit virtually total absence of leukocyte rolling in mesenteric venules
• two secretagogues (the calcium ionophore A23187 and hydrogen peroxide) that result in increased rolling in wild-type fail to stimulate any significant rolling in homozygotes
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• exhibit a 2.4-fold increase in circulating neutrophil counts
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• exhibit delayed recruitment of neutrophils to the peritoneal cavity upon experimentally induced inflammation
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hematopoietic system
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• exhibit virtually total absence of leukocyte rolling in mesenteric venules
• two secretagogues (the calcium ionophore A23187 and hydrogen peroxide) that result in increased rolling in wild-type fail to stimulate any significant rolling in homozygotes
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• exhibit a 2.4-fold increase in circulating neutrophil counts
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• exhibit delayed recruitment of neutrophils to the peritoneal cavity upon experimentally induced inflammation
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homeostasis/metabolism
cardiovascular system
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• hemorrhagic skin lesions induced by injection of lipopolysaccharide followed by tumor necrosis factor are larger by a factor of two compared to controls
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cellular
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• exhibit virtually total absence of leukocyte rolling in mesenteric venules
• two secretagogues (the calcium ionophore A23187 and hydrogen peroxide) that result in increased rolling in wild-type fail to stimulate any significant rolling in homozygotes
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integument
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• hemorrhagic skin lesions induced by injection of lipopolysaccharide followed by tumor necrosis factor are larger by a factor of two compared to controls
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mortality/aging
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• fatalities are seen in mutants older than 3 months of age that develop bacterial dermatitis
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hematopoietic system
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• leukocyte rolling along mesenteric venules is virtually absent in these mice
• TNF pre-treatment leads to a slight increase in rolling though the rolling flux is 46-fold less than in controls
• the velocity of the rare leukocyte that does bind is much greater than those in wld-type
• the number of adhering leukocytes is 6-fold less than controls
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• splenic weights are increased about 2-fold
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• spleens contain 2-fold more cells
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• differentiating myeloid precursors are significantly more numerous, however blast forms are not increased, and precursor cells from the erythroid lineage are less numerous in the bone marrow, resulting in a myeloid to erythroid ratio that is increased more than 5-fold
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• spleens contain increased numbers of CFU-GM
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• erythropoiesis is partially translocated to the spleen
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• myeloid precursor are more numerous in the bone marrow
• the myeloid to erythroid ratio is increased more than 5-fold in these mice
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• neutrophilic granulocytes compromise most of the cells of the bone marrow with an average of 60% of cells containing the segmented bands and rings morphology as compared to 42% in wild-type mice
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• increased extramedullary hematopoietic activity in the spleen
• 3 of 10 show evidence of extramedullary hematopoietic activity in the liver
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• precursor cells of the erythroid lineage are under represented in the bone marrow
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• the number of BFU-E in the spleen are significantly increased
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• there is a 3.9-fold elevation in the mean number of leukocytes in the blood
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• eosinophil numbers are increased 6.3-fold
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• more than 16-fold increase in mature polymorphonuclear neutrophils
• neonates exhibit a 3.3-fold increase in neutrophil numbers
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• lymphocyte numbers are increased 1.5-fold
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• monocyte numbers are increased 9.8-fold in the blood
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• neutrophil recruitment in an induced peritonitis model is reduced
• there is a five-fold impairment in the number of neutrophils recruited by thioglycollate injection
• fewer than expected neutrophils are found at the site of skin lesions
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immune system
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• leukocyte rolling along mesenteric venules is virtually absent in these mice
• TNF pre-treatment leads to a slight increase in rolling though the rolling flux is 46-fold less than in controls
• the velocity of the rare leukocyte that does bind is much greater than those in wld-type
• the number of adhering leukocytes is 6-fold less than controls
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• splenic weights are increased about 2-fold
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• spleens contain 2-fold more cells
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• myeloid precursor are more numerous in the bone marrow
• the myeloid to erythroid ratio is increased more than 5-fold in these mice
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• neutrophilic granulocytes compromise most of the cells of the bone marrow with an average of 60% of cells containing the segmented bands and rings morphology as compared to 42% in wild-type mice
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• there is a 3.9-fold elevation in the mean number of leukocytes in the blood
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• eosinophil numbers are increased 6.3-fold
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• more than 16-fold increase in mature polymorphonuclear neutrophils
• neonates exhibit a 3.3-fold increase in neutrophil numbers
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• lymphocyte numbers are increased 1.5-fold
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• monocyte numbers are increased 9.8-fold in the blood
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• neutrophil recruitment in an induced peritonitis model is reduced
• there is a five-fold impairment in the number of neutrophils recruited by thioglycollate injection
• fewer than expected neutrophils are found at the site of skin lesions
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• exhibit a 5-fold elevation in GM-CSF levels
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• mice have 40-fold higher levels of circulating IL-3 than controls
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• show a high prevalence of spontaneous bacterial dermatitis with or without ulceration, with the majority of mutants 4 months or older developing dermatitis
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homeostasis/metabolism
cellular
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• neutrophilic granulocytes compromise most of the cells of the bone marrow with an average of 60% of cells containing the segmented bands and rings morphology as compared to 42% in wild-type mice
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• leukocyte rolling along mesenteric venules is virtually absent in these mice
• TNF pre-treatment leads to a slight increase in rolling though the rolling flux is 46-fold less than in controls
• the velocity of the rare leukocyte that does bind is much greater than those in wld-type
• the number of adhering leukocytes is 6-fold less than controls
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growth/size/body
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• splenic weights are increased about 2-fold
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• spleens contain 2-fold more cells
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immune system
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• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
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• leukocyte numbers are slightly increased
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• eosinophil numbers are about 4-fold higher in the blood
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• neutrophils numbers are slightly increased
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene
• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease
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hematopoietic system
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
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• leukocyte numbers are slightly increased
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• eosinophil numbers are about 4-fold higher in the blood
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• neutrophils numbers are slightly increased
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
|
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene
• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease
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cellular
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
|
immune system
|
|
• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
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• eosinophil numbers are about two-thirds higher in the blood
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observedat 2 hours than those elicited from mice that are null homozygotes for just one gene
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hematopoietic system
|
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• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
|
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• eosinophil numbers are about two-thirds higher in the blood
|
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observedat 2 hours than those elicited from mice that are null homozygotes for just one gene
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cellular
|
|
• there is also slight decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
|
immune system
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
• there is a decrease of about half in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
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• leukocyte numbers are increased about 50%
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• eosinophil numbers are about 7-fold higher in the blood
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• neutrophils numbers are increased around 5-fold
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• monocyte number are increased about 4-fold
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene
• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease
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hematopoietic system
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
• there is a decrease of about half in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
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• leukocyte numbers are increased about 50%
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• eosinophil numbers are about 7-fold higher in the blood
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• neutrophils numbers are increased around 5-fold
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• monocyte number are increased about 4-fold
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene
• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease
|
cellular
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
• there is a decrease of about half in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
|
immune system
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
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• there is a 2.5 fold increase in leukocyte numbers
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• eosinophil numbers are about 6-fold higher in the blood
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• neutrophils numbers are increased almost 10-fold
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• monocyte number are increased about 5-fold
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene
|
hematopoietic system
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
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• there is a 2.5 fold increase in leukocyte numbers
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• eosinophil numbers are about 6-fold higher in the blood
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• neutrophils numbers are increased almost 10-fold
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• monocyte number are increased about 5-fold
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• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge
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• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice
• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene
|
cellular
|
|
• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF
• there is a three-quarter decrease in the number of adhering leukocytes within these mesenteric venules
• a population of leukocytes that are "fast rollers" is evident in these mice that are not observed in wild-type mice
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Analysis Tools