Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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immune system
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• during the chronic phase of antigen exposure
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• chronic inflammation in response to oxazolone exposure is inhibited compared to in similarly treated wild-type mice
• however, acute inflammation in response to oxazolone exposure is normal
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hematopoietic system
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• during the chronic phase of antigen exposure
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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immune system
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• T lymphocyte migration and accumulation into cutaneous inflammatory regions induced by a combination of IFN-gamma and TNF-alpha is inhibited by about 25%, however IFN-gamma, TNF-alpha, and ConA, has no effect on T cell infiltration
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hematopoietic system
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• T lymphocyte migration and accumulation into cutaneous inflammatory regions induced by a combination of IFN-gamma and TNF-alpha is inhibited by about 25%, however IFN-gamma, TNF-alpha, and ConA, has no effect on T cell infiltration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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skeleton
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• accelerated incidence of induced arthritis, 23% compared to 2% of DBA/1 mice by 28 days
• increase in number of affected paws
• consistently higher arthritis severity scores as determined by inflammation, paw/digit distortion and ankylosis
• onset of arthritis occurs as early as day 14 with a median onset of 34 days
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immune system
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• increased levels of serum IgG anti-type II collagen antibody measured in collagen immunized mice as compared to immunized DBA/1 mice
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• increased levels of IL10 and IL5 measured in stimulated splenocytes
• decreased levels of IL2 and IL4 measured in stimulated splenocytes
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• accelerated incidence of induced arthritis, 23% compared to 2% of DBA/1 mice by 28 days
• increase in number of affected paws
• consistently higher arthritis severity scores as determined by inflammation, paw/digit distortion and ankylosis
• onset of arthritis occurs as early as day 14 with a median onset of 34 days
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hematopoietic system
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• increased levels of serum IgG anti-type II collagen antibody measured in collagen immunized mice as compared to immunized DBA/1 mice
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Allelic
Composition |
Selptm1Bay/Selptm1Bay
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Genetic
Background |
either: B6.129S7-Selptm1Bay or (involves: 129S7/SvEvBrd * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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hematopoietic system
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• after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)
• leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)
• treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second
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• systemic leukocyte counts are ~9800/ul (~61% neutrophils, ~37% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)
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immune system
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• after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)
• leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)
• treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second
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• systemic leukocyte counts are ~9800/ul (~61% neutrophils, ~37% lymphocytes) compared to wild-type counts of ~5660/ul (53% neutrophils, 46% lymphocytes)
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cellular
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• after surgery to exteriorize cremaster muscle, mice do not display leukocyte rolling for the first hour, but a significant amount of rolling is detected after 2 hours (~8% rolling leukocyte flux)
• leukocytes show intermittent interactions with endothelium causing an increase in rolling velocity to ~129 um/second (~35 um/second in wild-type)
• treatment with Tnfa (tumor necrosis factor alpha) reduces rolling velocity to ~5 um/second
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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hematopoietic system
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• circulating neutrophils are increased in mutants and this increases with age of mice
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immune system
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• circulating neutrophils are increased in mutants and this increases with age of mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
|
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immune system
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• Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours
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• elevated peripheral leukocyte count in contrast to controls following infection with S. pneumoniae
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• 2-3 fold increase in numbers of circulating neutrophils
(J:24239)
• mild neutrophilia in contrast to controls following infection with S. pneumoniae
(J:101979)
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• increase in splenic thrombosis and necrosis in contrast to controls following infection with S. pneumoniae
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• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
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• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae
• survival rate was 19% in contrast to a 57% rate for wild-type mice
• decreased ability to clear bacteremia among survivors
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behavior/neurological
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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liver/biliary system
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• higher incidence in contrast to controls following infection with S. pneumoniae
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growth/size/body
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• observed 48 hours post-infection with S. pneumoniae
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vision/eye
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• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
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hematopoietic system
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• Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours
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• elevated peripheral leukocyte count in contrast to controls following infection with S. pneumoniae
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• 2-3 fold increase in numbers of circulating neutrophils
(J:24239)
• mild neutrophilia in contrast to controls following infection with S. pneumoniae
(J:101979)
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• increase in splenic thrombosis and necrosis in contrast to controls following infection with S. pneumoniae
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cellular
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• higher incidence in contrast to controls following infection with S. pneumoniae
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• Streptococcus pneumoniae induced peritonitis reduced neutrophil emigration into peritoneum by 61-69% after 2-4 hours
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nervous system
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N |
• no significant differences are detected in motor function (assessed at 1-5 days after CCI) or cognitive function (assessed at 14-20 days after injury) between mutants and wild-type mice
• no significant differences are seen in contusion volume of the injured hemisphere or in volume of uninjured or injured hemisphere between wild-type and mutants 21 days after CCI
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immune system
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N |
• no difference in neutrophil accumulation at injury site at 24 hours after CCI is detected between mutant and wild-type mice
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homeostasis/metabolism
immune system
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• double mutants show no spontaneous rolling leukocyte activity
• treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants
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cellular
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• double mutants show no spontaneous rolling leukocyte activity
• treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants
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hematopoietic system
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• double mutants show no spontaneous rolling leukocyte activity
• treatment with Tnfa induces leukocyte rolling although leukocytes show no spontaneous rolling activity; rolling flux fraction is ~22%, compared to ~36% in Icam1-deficient single mutants
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immune system
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• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation
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• circulating neutrophils are increased in mice with acute croton oil dermatitis
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• in response to croton oil application to the ear in young mice (7-14 weeks), inflammation is significantly reduced relative to controls
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hematopoietic system
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• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation
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• circulating neutrophils are increased in mice with acute croton oil dermatitis
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homeostasis/metabolism
integument
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N |
• triply deficient mice do not develop spontaneous skin lesions up to 55 weeks of age
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• dermal edema is decreased by 41% within 6 hours of croton oil irritation in young mice (7-14 weeks), and partial suppression of edema in older (23-35 weeks) mice
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cellular
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• migration is completely defective in acute croton oil dermatitis model in young mice (7-14 weeks); older mice show complete abrogation of neutrophil migration in response to irritation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm2Alb mutation
(0 available);
any
Sele mutation
(51 available)
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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immune system
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• rolling is severely compromised
• rolling flux and rolling fraction are reduced relative to wild-type
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• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type
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• circulating neutrophils are increased in mutants and this increases with age of mice
(J:112286)
• circulating neutrophils are increased to a greater extent in older mutants showing spontaneous lesions than in those without spontaneous lesions
(J:112286)
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• lymphoid follicles forming the white pulp are effaced and infrequently observed due to expansion of the red pulp by extramedullary hematopoiesis
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• migration is defective in young mice (7-14 weeks) in acute croton oil dermatitis model
• in older mutants (23-35 weeks), neutrophil emigration during irritant dermatitis shows no compromise compared to wild-type
• in young mice (8 weeks) with croton oil-induced lesions on their backs 15 days before acute croton oil-induced dermatitis on the ear, a 5-fold greater emigration of neutrophils to the ear irritation is observed compared to mutants without experimental lesions on their backs, while circulating neutrophil numbers are similar for both groups
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• structures aren't recognized in mutant cervical lymph nodes
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• structures aren't recognized in mutant cervical lymph nodes
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• both old and young mice show severe cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is more severe than in Sele/Selp/Sell-triple null mice
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• GM-CSF levels are elevated 6-7-fold above levels in wild-type or Sell-null mice
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• standardized volume fraction of emigrated neutrophils in dermis of irritated ears is 0.017 +/- 0.006, compared to 0.317 in irritated ears of wild-type mice
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hematopoietic system
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• rolling is severely compromised
• rolling flux and rolling fraction are reduced relative to wild-type
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• mice show massive extramedullary hematopoiesis with identifiable myeloid and megakaryocytic lineages, and lesser erythroid component
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• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type
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• circulating neutrophils are increased in mutants and this increases with age of mice
(J:112286)
• circulating neutrophils are increased to a greater extent in older mutants showing spontaneous lesions than in those without spontaneous lesions
(J:112286)
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• lymphoid follicles forming the white pulp are effaced and infrequently observed due to expansion of the red pulp by extramedullary hematopoiesis
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• migration is defective in young mice (7-14 weeks) in acute croton oil dermatitis model
• in older mutants (23-35 weeks), neutrophil emigration during irritant dermatitis shows no compromise compared to wild-type
• in young mice (8 weeks) with croton oil-induced lesions on their backs 15 days before acute croton oil-induced dermatitis on the ear, a 5-fold greater emigration of neutrophils to the ear irritation is observed compared to mutants without experimental lesions on their backs, while circulating neutrophil numbers are similar for both groups
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cardiovascular system
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• in mutants, alveolocapillary walls are engorged with leukocytes; these leukocytes are confined to small vascular spaces and do not infiltrate the interstitial supporting tissue or alveolar and airway spaces
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respiratory system
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• lung tissue displays decreasing cellularity within alveolocapillary walls with severely affected interstitial areas
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• in mutants, alveolocapillary walls are engorged with leukocytes; these leukocytes are confined to small vascular spaces and do not infiltrate the interstitial supporting tissue or alveolar and airway spaces
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integument
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• mice develop mucocutaneous infections or ulcerative dermatitis
(J:70682)
• at 15 months, mice show large areas of ulceration on the neck
(J:70682)
• mice develop spontaneous skin lesions characterized by polymorphonuclear leukocytes
(J:112286)
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cellular
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• rolling is severely compromised
• rolling flux and rolling fraction are reduced relative to wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm2Alb mutation
(0 available);
any
Sele mutation
(51 available)
Selltm2Alb mutation
(0 available);
any
Sell mutation
(41 available)
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
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immune system
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N |
• GM-CSF levels are comparable to levels in wild-type or Sell-null mutants; elevation observed in Sele/Selp double null mice is absent
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• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
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• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
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• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type, but are ~half the value found in Sele/Selp double mutants
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• in liver parenchyma and sinusoids, neutrophil numbers are ~2-fold higher in mutants after Gal/ET treatment; numbers of neutrophils in liver tissue are significantly elevated 4 hours prior to Gal/ET treatment, compared to controls
(J:106550)
• more neutrophils accumulate in the hepatic vascular beds (sinusoids and venules) after Gal/ET treatment in mutants than in wild-type controls
(J:106550)
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• moderate disruption of splenic architecture is observed
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• lymphoid follicles of the white pulp are identified occasionally and have irregular shapes and sizes
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• both old and young mice show severe cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is more severe than in Sele/Selp/Sell-triple null mice
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• both old and young mice show marked cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is less severe than in Sele/Sell-double null mice
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• both old and younger mice show bronchial lymphoid aggregates
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hematopoietic system
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• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
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• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
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• mice show moderate extramedullary hematopoiesis in sinusoid of red pulp
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• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type, but are ~half the value found in Sele/Selp double mutants
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• in liver parenchyma and sinusoids, neutrophil numbers are ~2-fold higher in mutants after Gal/ET treatment; numbers of neutrophils in liver tissue are significantly elevated 4 hours prior to Gal/ET treatment, compared to controls
(J:106550)
• more neutrophils accumulate in the hepatic vascular beds (sinusoids and venules) after Gal/ET treatment in mutants than in wild-type controls
(J:106550)
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• moderate disruption of splenic architecture is observed
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• lymphoid follicles of the white pulp are identified occasionally and have irregular shapes and sizes
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respiratory system
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• both old and younger mice show bronchial lymphoid aggregates
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• lung tissue displays decreasing cellularity within alveolocapillary walls, but this is less severe than in Sele/Selp double-nulls
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• only a small increase in leukocytes in alveolocapillary walls are observed and occasional small bronchial lymphoid aggregates are found
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cardiovascular system
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• only a small increase in leukocytes in alveolocapillary walls are observed and occasional small bronchial lymphoid aggregates are found
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liver/biliary system
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• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, area on necrosis is attenuated 68% compared to treated controls
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• mutants show decreased liver injury relative to treated controls at 7 hours after treatment with Gal/ET
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homeostasis/metabolism
integument
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N |
• mice do not show skin ulcerations as seen in double Sele/Selp mutants
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cellular
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• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, area on necrosis is attenuated 68% compared to treated controls
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• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
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• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm2Alb mutation
(0 available);
any
Sele mutation
(51 available)
Selptm1Bay mutation
(3 available);
any
Selp mutation
(56 available)
|
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immune system
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• elevated peripheral leukocyte count (3 fold) relative to controls prior to and following infection
• decreased peritoneal WBC count relative to peripheral WBC count following infection
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• neutrophilia in contrast to controls following infection with S. pneumoniae
• decreased number of neutrophils in peritoneal fluid relative to peripheral absolute neutrophil counts following infection
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• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
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• severity and duration of morbidity higher than wild-type after infection with Streptococcus pneumoniae
• decreased survival rate after post-infection day 5
• decreased ability to clear bacteremia among survivors
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behavior/neurological
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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• observed following infection with S. pneumoniae
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growth/size/body
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• 48 hours post-infection with S. pneumoniae
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vision/eye
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• panophthalmitis observed in 8% of mice following infection with S. pneumoniae
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hematopoietic system
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• elevated peripheral leukocyte count (3 fold) relative to controls prior to and following infection
• decreased peritoneal WBC count relative to peripheral WBC count following infection
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• neutrophilia in contrast to controls following infection with S. pneumoniae
• decreased number of neutrophils in peritoneal fluid relative to peripheral absolute neutrophil counts following infection
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immune system
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• Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
• Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space
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• 4-5 fold increase in numbers of circulating neutrophils
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hematopoietic system
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• Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
• Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space
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• 4-5 fold increase in numbers of circulating neutrophils
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cellular
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• Streptococcus pneumoniae induced peritonitis eliminated neutrophil emigration into peritoneum
• Streptococcus pneumoniae induced pneumonia did not reduce neutrophil recruitment or edema formation in the alveolar space
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mortality/aging
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• overall survival is reduced compared to Faslpr homozygotes (median survival is 20 weeks vs 26 weeks for Fas mutants); renal lesions are severe at time of death
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immune system
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• severe neutrophil accumulation at 20 weeks is observed in kidneys
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• in kidney and cultured primary renal endothelial cells, levels of CCL2 are elevated compared to Faslpr controls at 20 weeks; expression levels are increased further upon LPS treatment of cells
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• at 20 weeks of age, kidneys display higher lesion scores than controls
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• double mutants show more rapid onset of cutaneous inflammation than Faslpr homozygotes
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hematopoietic system
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• severe neutrophil accumulation at 20 weeks is observed in kidneys
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renal/urinary system
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• at 20 weeks of age, severely affected glomeruli display necrosis of large areas of the tuft
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• at 20 weeks of age, severely affected glomeruli display capsular fibrosis and proliferation of the lining of Bowman's capsule
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• at 20 weeks of age, foot processes are fused
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• at 20 weeks of age, foot processes are diffusely effaced
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• lesions at 20 weeks are characterized by neutrophil infiltration of the glomerular tuft, proliferation of mesangial and endothelial cells, mild multifocal tubular atrophy, and interstitial mixed inflammatory cell accumulation
• more severely affected glomeruli have necrosis of large areas of the tuft, fibrin deposition, proliferation of lining of Bowman's capsule with fusion of the tuft (synechia), capsular fibrosis, and pericapsular lymphocyte accumulation
• subepithelial and subendothelial electron-dense deposits are detected
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• at 20 weeks of age, proliferation of endothelial cells is observed
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• at 20 weeks of age, cellularity of mesangium is moderately increased
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• at 20 weeks of age, kidneys display higher lesion scores than controls
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• at 20 weeks of age, markedly expanded mesangium due to mesangial matrix increase is observed
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• at 20 weeks of age, proliferation of lining of Bowman's capsule is observed
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• at 20 weeks of age, proliferation of lining of Bowman's capsule with fusion of the tuft (synechia) is observed
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• at 20 weeks of age, severely affected glomeruli exhibit fibrin deposition
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• at 20 weeks of age, mild multifocal tubular atrophy is observed
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• progressive decline in renal function is observed, during progression to end-stage renal disease
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cardiovascular system
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• at 20 weeks of age, proliferation of endothelial cells is observed
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integument
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• double mutants show more rapid onset of cutaneous inflammation than Faslpr homozygotes
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cellular
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• at 20 weeks of age, cellularity of mesangium is moderately increased
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• at 20 weeks of age, severely affected glomeruli display necrosis of large areas of the tuft
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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Analysis Tools