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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rag1tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:1857241
Summary 65 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rag1tm1Mom/Rag1tm1Mom B6.129S7-Rag1tm1Mom MGI:3582287
hm2
Rag1tm1Mom/Rag1tm1Mom involves: 129S7/SvEvBrd MGI:3850561
hm3
Rag1tm1Mom/Rag1tm1Mom involves: 129S7/SvEvBrd * C57BL/10 MGI:3818487
hm4
Rag1tm1Mom/Rag1tm1Mom involves: 129S7/SvEvBrd * C57BL/6 MGI:3767321
hm5
Rag1tm1Mom/Rag1tm1Mom involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687168
hm6
Rag1tm1Mom/Rag1tm1Mom involves: 129S7/SvEvBrd * CD-1 MGI:2429492
hm7
Rag1tm1Mom/Rag1tm1Mom NOD.129S7(B6)-Rag1tm1Mom MGI:3764009
cn8
Gt(ROSA)26Sortm1(DTA)Lky/?
Il5tm1.1(icre)Lky/Il5+
Rag1tm1Mom/Rag1tm1Mom
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5558890
cn9
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3840971
cn10
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3840970
cn11
Pdpntm2.1Mlkn/Pdpntm2.1Mlkn
Rag1tm1Mom/Rag1tm1Mom
Tg(Pdgfrb-cre)9Rha/0
involves: 129S7/SvEvBrd * C57BL/6 MGI:5552953
cn12
Nlrp3tm1Hhf/Nlrp3+
Rag1tm1Mom/Rag1tm1Mom
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3850056
cx13
Man2a1tm1Jxm/Man2a1tm1Jxm
Rag1tm1Mom/Rag1tm1Mom
B6.129-Rag1tm1Mom Man2a1tm1Jxm MGI:3850631
cx14
Mpztm1Msch/Mpz+
Rag1tm1Mom/Rag1tm1Mom
B6.129S7-Mpztm1Msch Rag1tm1Mom MGI:4947955
cx15
Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom
B6.Cg-Rag1tm1Mom Cd160tm1Yxf MGI:5702315
cx16
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra,Tcrb)HRCAll/0
B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll MGI:3845009
cx17
H2u/H2u
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J) MGI:6305814
cx18
Rag1tm1Mom/Rag1tm1Mom
Tyrp1B-w/Tyrp1B-w
X/Tg(Tcra,Tcrb)9Rest
involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6 MGI:3826833
cx19
Itktm1Ljb/Itktm1Ljb
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
involves: 129 * C57BL/10 MGI:4354514
cx20
Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
involves: 129 * C57BL/6 MGI:3812196
cx21
Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:5550271
cx22
Rag1tm1Mom/Rag1tm1Mom
Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3698843
cx23
Rag1tm1Mom/Rag1tm1Mom
Tyrobptm1.1Viv/Tyrobptm1.1Viv
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10 MGI:3818486
cx24
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4940117
cx25
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:5635503
cx26
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4360345
cx27
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:5635499
cx28
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687167
cx29
Jak3tm1Ljb/Jak3tm1Ljb
Rag1tm1Mom/Rag1tm1Mom
involves: 129S4/SvJae * 129S7/SvEvBrd MGI:3769348
cx30
Rag1tm1Mom/Rag1tm1Mom
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J MGI:3699096
cx31
Col1a1tm1(tetO-Fos)Wag/Col1a1+
Rag1tm1Mom/Rag1tm1Mom
Tg(KRT5-rtTA)T2D6Sgkd/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5555860
cx32
Nfil3tm1Pbro/Nfil3tm1Pbro
Rag1tm1Mom/Rag1tm1Mom
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:5576255
cx33
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Rag1tm1Mom/Rag1tm1Mom
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:5007931
cx34
Rag1tm1Mom/Rag1tm1Mom
Rasa3scat/Rasa3scat
involves: 129S7/SvEvBrd * BALB/cBy MGI:5433362
cx35
Plcg2Ali5/Plcg2+
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5 MGI:3578558
cx36
Pstpip2Lupo/Pstpip2Lupo
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J MGI:3760618
cx37
Rag1tm1Mom/Rag1tm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
involves: 129S7/SvEvBrd * C3H/He * C57BL/6 MGI:3803975
cx38
Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL MGI:3818750
cx39
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL MGI:3818748
cx40
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
involves: 129S7/SvEvBrd * C57BL MGI:3818749
cx41
H2b/H2b
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
involves: 129S7/SvEvBrd * C57BL/6 MGI:6305871
cx42
Rag1tm1Mom/Rag1tm1Mom
Tg(CAG-Lyn*)#Paau/0
involves: 129S7/SvEvBrd * C57BL/6 MGI:5512886
cx43
Ier3tm1Mxw/Ier3tm1Mxw
Rag1tm1Mom/Rag1tm1Mom
involves: 129S7/SvEvBrd * C57BL/6 MGI:5474627
cx44
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:2665135
cx45
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:2665134
cx46
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687163
cx47
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687164
cx48
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687165
cx49
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687166
cx50
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4940115
cx51
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
involves: 129S/Sv * BALB/c * C3H * C57BL/6 MGI:3586594
cx52
Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 MGI:3622066
cx53
Rag1tm1Mom/Rag1tm1Mom
Vtcn1tm1Lpc/Vtcn1tm1Lpc
involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:3836413
cx54
Bcl6btm2Dent/Bcl6btm2Dent
Rag1tm1Mom/Rag1tm1Mom
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3719168
cx55
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
involves: 129/Sv * C57BL/6 * DBA/2 MGI:2665126
cx56
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
involves: 129/Sv * C57BL/6 * DBA/2 MGI:2665123
cx57
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell MGI:3687126
cx58
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DQA1,HLA-DQB1)73Myl/0
NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl MGI:3687028
cx59
Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ MGI:3813939
cx60
Ins2Akita/Ins2+
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz MGI:3817777
cx61
Ins2Akita/Ins2Akita
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz MGI:3817776
cx62
Rag1tm1Mom/Rag1tm1Mom
Prf1tm1Sdz/Prf1tm1Sdz
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz MGI:3580416
cx63
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ MGI:3844697
cx64
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs MGI:3618788
cx65
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Not Specified MGI:3574972


Genotype
MGI:3582287
hm1
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
B6.129S7-Rag1tm1Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after reperfusion mice do not have detectable IgM whereas wild-type have levels of 437 ug/ml

immune system
• upeon reperfusion of ischemic intestine, permeability index (PI) of injured Rag1-deficient mice is reduced compared to control treated wild-type (PI of 1.34 vs 3.26 in controls
• Rag1-deficient mice reconstituted with IgM show PI reduction similar to controls (PI of 2.86)
• after 16 days of MC903 treatment

hearing/vestibular/ear

hematopoietic system
• upeon reperfusion of ischemic intestine, permeability index (PI) of injured Rag1-deficient mice is reduced compared to control treated wild-type (PI of 1.34 vs 3.26 in controls
• Rag1-deficient mice reconstituted with IgM show PI reduction similar to controls (PI of 2.86)

integument
• after 16 days of MC903 treatment
• MC903-treated ears showed a dermal infiltrate
• MC903-treated ears display epidermal hyperplasia
• after 16 days of MC903 treatment
• after 16 days of MC903 treatment




Genotype
MGI:3850561
hm2
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• medullary thymic epithelial cells that present self antigen are present in these mice
• the number of CD44-HSA+CD25- DN thymyoctes is 2% of controls
• less proportion of these cells are actively cycling compared to controls
• intracolonic administration of the F2r (PAR-1) activating peptide, TFLLR, fails to induce inflammation in mutant colons as in wild-type mice

nervous system
• decrease in hippocampal neurogenesis

hematopoietic system
• medullary thymic epithelial cells that present self antigen are present in these mice
• the number of CD44-HSA+CD25- DN thymyoctes is 2% of controls
• less proportion of these cells are actively cycling compared to controls

cellular
• decrease in hippocampal neurogenesis

endocrine/exocrine glands
• medullary thymic epithelial cells that present self antigen are present in these mice




Genotype
MGI:3818487
hm3
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• mice exhibit normal bone morphology
• following ovariectamy, mice exhibit an increased bone loss compared to in similarly treated wild-type mice




Genotype
MGI:3767321
hm4
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• dextran sulfate sodium induced colitis is less severe than in wild-type controls
• 2 weeks or 1 month after infection with M. pulmonis, neutrophil numbers in the trachea are elevated above uninfected controls but are significantly lower than numbers in trachea of infected wild-type mice
• upon infection with Mycoplasma pulmonis, airway lymphatic vessel remodeling is largely absent from mutants, compared to significant invasion of region by lymphatic vessels in infected wild-type mice
• antigen-specific autoimmunity developed after CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest donor mice
• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection

hematopoietic system
• 2 weeks or 1 month after infection with M. pulmonis, neutrophil numbers in the trachea are elevated above uninfected controls but are significantly lower than numbers in trachea of infected wild-type mice

respiratory system
• after 4 weeks, mice show impaired vascular remodeling of the airways in response to Mycoplasma pulmonis infection whereas wild-type show complex growth and reorganization ot the vascular beds

pigmentation
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo

vision/eye
• mice develop ocular injury with disruption of retinal architecture after transplant of CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest/Rag1--mice
• mice develop ocular injury with disruption of retinal architecture after transplant of CD4-selected splenocytes from Tg(Tcra,Tcrb)9Rest/Rag1--mice

integument
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo
• after transplant of CD4-selected splenocytes, mice develop extensive vitiligo

digestive/alimentary system
• dextran sulfate sodium induced colitis is less severe than in wild-type controls




Genotype
MGI:3687168
hm5
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• nontransgenic Rag1 homozygotes have extremely small thymi
• non-transgenic Rag1-null mice display lymphopenia more severe than transgenic Rag1-null mice

immune system
• nontransgenic Rag1 homozygotes have extremely small thymi
• non-transgenic Rag1-null mice display lymphopenia more severe than transgenic Rag1-null mice

endocrine/exocrine glands
• nontransgenic Rag1 homozygotes have extremely small thymi




Genotype
MGI:2429492
hm6
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymus contains 15 to 300 times fewer cells than wild-type or heterozygous controls
• spleen and bone marrow lack mature B cells; B cells are IgM and IgD negative, and only 1/4 to 1/3 are B220-positive
• absence of V(D)J recombination
• no mature B lymphocytes are observed in lymphoid organs
• thymocytes are larger in 4-, 5-, and 7-week old mutants than in controls
• no mature T lymphocytes are seen in lymphoid organs
• thymocyte development is arrested at an early stage; cells are larger than normal, and are CD3-, TCR alphabeta-negative, CD8- CD4-
• absence of V(D)J recombination
• spleen contains 5 to 9 times fewer nonerythroid cells than wild-type or heterozygous controls
• no detectable IgM found in serum
• stroma-like structure found in inguinal lymph nodes location, with few, if any, nonerythroid cells recoverable from this structure

hematopoietic system
• thymus contains 15 to 300 times fewer cells than wild-type or heterozygous controls
• spleen and bone marrow lack mature B cells; B cells are IgM and IgD negative, and only 1/4 to 1/3 are B220-positive
• absence of V(D)J recombination
• no mature B lymphocytes are observed in lymphoid organs
• no mature T lymphocytes are seen in lymphoid organs
• thymocytes are larger in 4-, 5-, and 7-week old mutants than in controls
• thymocyte development is arrested at an early stage; cells are larger than normal, and are CD3-, TCR alphabeta-negative, CD8- CD4-
• absence of V(D)J recombination
• spleen contains 5 to 9 times fewer nonerythroid cells than wild-type or heterozygous controls
• no detectable IgM found in serum

nervous system
N
• brain is normal in structure and size

behavior/neurological
N
• normal activity, coordination and strength; normal nociception

endocrine/exocrine glands
• thymus contains 15 to 300 times fewer cells than wild-type or heterozygous controls




Genotype
MGI:3764009
hm7
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
NOD.129S7(B6)-Rag1tm1Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• IgLkappa- B220+ immature B cell numbers are increased as compared to NOD controls
• numbers of granulocytes are increased in comparison to NOD controls
• spleens of 8-11 week old mice are deficient in Igkappa+ B220+ T cells
• numbers of NK cells are increased in comparison to NOD controls
• spleens of 8-11 week old mice are deficient in CD3+ CD4+ T cells
• spleens of 8-11 week old mice are deficient in CD3+ CD8+ T cells
• numbers of macrophages are increased in comparison to NOD controls
• nucleated spleen cells are reduced in 8-11 week old mice as compared to NOD control
• no serum immunoglobulin is detected in 218-334 day old mice
• Background Sensitivity: poly I:C stimulated spleen cells exhibit low levels of NK cell cyotoxic activity in comparison to C57BL/6 homozygotes
• four to five-fold decrease in cells expressing I-Ag7 as compared to NOD control

hematopoietic system
• IgLkappa- B220+ immature B cell numbers are increased as compared to NOD controls
• numbers of granulocytes are increased in comparison to NOD controls
• spleens of 8-11 week old mice are deficient in Igkappa+ B220+ T cells
• numbers of NK cells are increased in comparison to NOD controls
• spleens of 8-11 week old mice are deficient in CD3+ CD4+ T cells
• spleens of 8-11 week old mice are deficient in CD3+ CD8+ T cells
• numbers of macrophages are increased in comparison to NOD controls
• nucleated spleen cells are reduced in 8-11 week old mice as compared to NOD control
• no serum immunoglobulin is detected in 218-334 day old mice
• Background Sensitivity: poly I:C stimulated spleen cells exhibit low levels of NK cell cyotoxic activity in comparison to C57BL/6 homozygotes




Genotype
MGI:5558890
cn8
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Lky/?
Il5tm1.1(icre)Lky/Il5+
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (504 available)
Il5tm1.1(icre)Lky mutation (1 available); any Il5 mutation (24 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no increase in type 2 innate lymphoid cells (ILC2) or induction of eotaxin-1 (Ccl11) is detected in lungs in response to administration of Il2 and Il33 in contrast to control mice lacking DTA expression which have a higher ILC2 population and Ccl11 expression




Genotype
MGI:3840971
cn9
Allelic
Composition
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (1 available); any Foxo1 mutation (7 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(CD2-Il7r)1Asin mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (7 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells

hematopoietic system
• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells




Genotype
MGI:3840970
cn10
Allelic
Composition
Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (1 available); any Foxo1 mutation (7 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Cd4-cre)1Cwi mutation (7 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cell numbers in the spleen and lymph nodes are reduced 80-90% compared to Rag-null OT-II controls

hematopoietic system
• T cell numbers in the spleen and lymph nodes are reduced 80-90% compared to Rag-null OT-II controls




Genotype
MGI:5552953
cn11
Allelic
Composition
Pdpntm2.1Mlkn/Pdpntm2.1Mlkn
Rag1tm1Mom/Rag1tm1Mom
Tg(Pdgfrb-cre)9Rha/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpntm2.1Mlkn mutation (0 available); any Pdpn mutation (27 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Pdgfrb-cre)9Rha mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

cardiovascular system
N
• mice do not exhibit bleeding into mucosal lymph nodes unlike in Pdpntm2.1Mlkn/Pdpntm2.1Mlkn Tg(Pdgfrb-cre)9Rha mice

hematopoietic system




Genotype
MGI:3850056
cn12
Allelic
Composition
Nlrp3tm1Hhf/Nlrp3+
Rag1tm1Mom/Rag1tm1Mom
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (9 available); any Lyz2 mutation (14 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (41 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis
• 70% of mice die between 7-14 days
• absence of B and T cells demonstrates disease is not caused by the adaptive immune system

growth/size/body
• mutant pups gained weight slowly, and then lost weight before dying

immune system

hematopoietic system

integument
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4




Genotype
MGI:3850631
cx13
Allelic
Composition
Man2a1tm1Jxm/Man2a1tm1Jxm
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
B6.129-Rag1tm1Mom Man2a1tm1Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1tm1Jxm mutation (1 available); any Man2a1 mutation (44 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• severe weight loss

renal/urinary system
• increased mesangial cell apoptosis between 6 and 9 months of age
• increased proteinuria
• exacerbated kidney disease
• increased macrophage infiltration of the kidney
• nephron loss
• increased tissue sclerosis

immune system
• exacerbated kidney disease
• increased macrophage infiltration of the kidney

homeostasis/metabolism
• increased proteinuria

integument

cellular
• increased mesangial cell apoptosis between 6 and 9 months of age




Genotype
MGI:4947955
cx14
Allelic
Composition
Mpztm1Msch/Mpz+
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
B6.129S7-Mpztm1Msch Rag1tm1Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpztm1Msch mutation (0 available); any Mpz mutation (22 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in the number of Schwann cells around the quadriceps femoral nerves at 13 months of age is less than that in age matched mutant mice heterozygous for the Rag1 null allele
• pathological lesions indicative of compromised myelin maintenance in the quadriceps femoral nerves at 13 months of age are less severe than those in age matched mutant mice heterozygous for the Rag1 null allele
• myelin sheaths of quadriceps femoral nerves at 13 months of age are thicker than those in age matched mutant mice heterozygous for the Rag1 null allele
• myelin degeneration in the quadriceps femoral nerves at 13 months of age is less severe than in age matched mutant mice heterozygous for the Rag1 null allele
• impaired conduction with prolonged latencies of M-responses and of F waves after distal or proximal stimulations
• impairment is less severe than in mutant mice heterozygous for the Rag1 null allele

immune system

hematopoietic system




Genotype
MGI:5702315
cx15
Allelic
Composition
Cd160tm1Yxf/Cd160tm1Yxf
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
B6.Cg-Rag1tm1Mom Cd160tm1Yxf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd160tm1Yxf mutation (1 available); any Cd160 mutation (6 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced interferon gamma production from splenocytes stimulated by Nk1.1 cross-linking

neoplasm
• increased tumor volume/weight following inoculation with NK-dependent B16 or RMA-S (no MHC class I surface expression) tumor cells as compared to homozygous Ragtm1Mom control
• tumors generated by inoculation with RMA (normal MHC class I) cells have weights similar to Ragtm1Mom controls




Genotype
MGI:3845009
cx16
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra,Tcrb)HRCAll/0
Genetic
Background
B6.Cg-Rag1tm1Mom Tg(Tcra,Tcrb)HRCAll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Tcra,Tcrb)HRCAll mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mature peripheral T cells are selected to the CD8+ lineage
• however, mice do not exhibit clonal deletion or co-receptor downregulation in the thymus or activation in the periphery
• mature peripheral T cells are selected to the CD8+ lineage

hematopoietic system
• mature peripheral T cells are selected to the CD8+ lineage
• however, mice do not exhibit clonal deletion or co-receptor downregulation in the thymus or activation in the periphery
• mature peripheral T cells are selected to the CD8+ lineage




Genotype
MGI:6305814
cx17
Allelic
Composition
H2u/H2u
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2u mutation (6 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Tcra19,Tcrb19)#Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cerebellum and spinal cord exhibit patchy lesions with mononuclear cell infiltrates
• 100% of mice develop spontaneous autoimmune encephalomyelitis within 12 months
• onset and rate of progression of disease varies, with an average age of onset of 13 weeks
• activated myelin basic protein (MBP)-specific T cells are found in the brain but not in the peripheral lymphoid tissues

behavior/neurological
• weakness or paralysis of the hind legs is seen first and then extends to the front legs
• once hind legs are completely paralyzed, the disease progresses very rapidly

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:19795




Genotype
MGI:3826833
cx18
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tyrp1B-w/Tyrp1B-w
X/Tg(Tcra,Tcrb)9Rest
Genetic
Background
involves: 101/Rl * 129S7/SvEvBrd * C3H/Rl * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Tcra,Tcrb)9Rest mutation (1 available)
Tyrp1B-w mutation (14 available); any Tyrp1 mutation (131 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• inoculation with B16 melanoma cells results in 100% tumor take in transgenic mice; tumor growth is only minimally delayed compared to non-transgenic control mice




Genotype
MGI:4354514
cx19
Allelic
Composition
Itktm1Ljb/Itktm1Ljb
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic
Background
involves: 129 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itktm1Ljb mutation (0 available); any Itk mutation (31 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Tcra5CC7,Tcrb5CC7)IWep mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor
• T cells cultured under Th1 polarizing conditions produce less IFN-gamma than controls
• Th1 T cells produce 1.5- to 200-fold less IFN-gamma than controls
• T cells cultured under Th2 polarizing conditions produce less IL-10 than controls
• T cells cultured under Th2 polarizing conditions produce less IL-4 than controls
• Th2 T cells produce 3.5- to 300-fold less IL-4 than controls
• T cells cultured under Th2 polarizing conditions produce less IL-5 than controls

hematopoietic system
• when stimulated with low concentrations of antigen, CD4 T cells differentiate predominately into a Th1 phenotype while controls develop into a Th2 phenotype
• these T cells have increased expression of the T-bet transcription factor




Genotype
MGI:3812196
cx20
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Slc46a2tm1Moki mutation (0 available); any Slc46a2 mutation (2 available)
Tg(TcraB12,TcrbB12)1Rest mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice
• double-positive T cells are absent in the thymus
• T cells are arrested in the DN3 stage

hematopoietic system
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice
• double-positive T cells are absent in the thymus
• T cells are arrested in the DN3 stage

cellular
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice

endocrine/exocrine glands
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice




Genotype
MGI:5550271
cx21
Allelic
Composition
Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndfip1Gt(RRD002)Byg mutation (0 available); any Ndfip1 mutation (6 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike Ndfip1Gt(RRD002)Byg homozygotes, mice do not develop eosinophilic inflammation and T cells do not acquire an activated phenotype in the absence of antigen




Genotype
MGI:3698843
cx22
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tnfrsf25tm1Mjo mutation (0 available); any Tnfrsf25 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocyte development is arrested at the CD25+CD44- double negative (DN) stage

immune system
• thymocyte development is arrested at the CD25+CD44- double negative (DN) stage




Genotype
MGI:3818486
cx23
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tyrobptm1.1Viv mutation (1 available); any Tyrobp mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the number of trabeculae are increased compared to wild-type mice
• however, trabecular thickness is normal
• the space between trabeculae is reduced compared to in wild-type mice
• bone mass is increased 30% compared to in Tyrobptm1.1Viv homozygotes and 60% compared to in wild-type mice and Rag1tm1Mom homozygotes
• severe
• following ovariectamy, mice exhibit an increased bone loss compared to in similarly treated wild-type mice or Tyrobptm1.1Viv homozygotes
• collagen type I degradation products are decreased 17% compared to in wild-type mice

immune system
• collagen type I degradation products are decreased 17% compared to in wild-type mice

hematopoietic system
• collagen type I degradation products are decreased 17% compared to in wild-type mice




Genotype
MGI:4940117
cx24
Allelic
Composition
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (1 available); any Ctla4 mutation (25 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraTcrb)8Rest mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit a normal lifespan

immune system
N
• CD8+ T cells exhibit a completely naive phenotype

pigmentation
N
• mice do not develop autoimmune vitiligo




Genotype
MGI:5635503
cx25
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

nervous system
• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age




Genotype
MGI:4360345
cx26
Allelic
Composition
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1Mak mutation (1 available); any Lck mutation (89 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Lck-Fyn*Y528F)5525Cjg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• the transgene partially rescues arrest of T cell development associated with Lck deficiency
• thymocyte numbers are normal
• splenic gamma-delta T cell numbers are normal
• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls
• alpha beta T cell numbers are less than half of wild-type controls

immune system
• the transgene partially rescues arrest of T cell development associated with Lck deficiency
• thymocyte numbers are normal
• splenic gamma-delta T cell numbers are normal
• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls
• alpha beta T cell numbers are less than half of wild-type controls




Genotype
MGI:5635499
cx27
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age

nervous system
• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age




Genotype
MGI:3687167
cx28
Allelic
Composition
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (21 available); any H2 mutation (264 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (28 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3769348
cx29
Allelic
Composition
Jak3tm1Ljb/Jak3tm1Ljb
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3tm1Ljb mutation (1 available); any Jak3 mutation (29 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike Jak3 null mice that are wild-type for Rag1, no splenomegaly is seen
• FACs profile of spleens resemble those of mice homozygous null for Rag1 alone

hematopoietic system
• FACs profile of spleens resemble those of mice homozygous null for Rag1 alone




Genotype
MGI:3699096
cx30
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Sh3bp2tm1Bjro mutation (0 available); any Sh3bp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone
• decreased bone mineral density in the long bones at 10 weeks of age
• no improvement in bone loss compared to mice homozygous for the Sh3bp2 allele alone

immune system
• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone
• serum levels of TNF are elevated similar to what is seen in mice homozygous for the Sh3bp2 allele alone
• mice still develop the macrophage-rich inflammatory infiltrates in internal organs and periosteal regions that are seen in mice homozygous for the Sh3bp2 allele alone

homeostasis/metabolism
• serum levels of TNF are elevated similar to what is seen in mice homozygous for the Sh3bp2 allele alone

hematopoietic system
• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone

cellular
• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone




Genotype
MGI:5555860
cx31
Allelic
Composition
Col1a1tm1(tetO-Fos)Wag/Col1a1+
Rag1tm1Mom/Rag1tm1Mom
Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation (0 available); any Col1a1 mutation (121 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(KRT5-rtTA)T2D6Sgkd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• doxycycline-treated mice exhibit normal keratinocyte proliferation and activation
• in doxycycline-treated mice but smaller than in mice with wild-type Rag1
• in doxycycline-treated mice but less so than in mice with wild-type Rag1




Genotype
MGI:5576255
cx32
Allelic
Composition
Nfil3tm1Pbro/Nfil3tm1Pbro
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfil3tm1Pbro mutation (0 available); any Nfil3 mutation (7 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not develop colitis




Genotype
MGI:5007931
cx33
Allelic
Composition
Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mefvtm5.1(MEFV)Chae mutation (0 available); any Mefv mutation (25 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• activated T cells secrete less cytokines than in activated T cells from Mefvtm5.1(MEFV)Chae homozygotes but more cytokines than in actiavted T cells from wild-type
• activated T cells exhibit increased secretion of IL1b, IL2, IL4, IL5, IL9, IL10, IL12b, IL12, IL13, IL17, IFN-gamma, RANTES, G-CSF, MIP1alpha, KC, GM-CSF, MCP-1, and MIP1beta compared with activated T cells from wild-type mice
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• in activated T cells
• mice exhibit inflammatory phenotypes observed in Mefvtm5.1(MEFV)Chae homozygotes

growth/size/body

homeostasis/metabolism




Genotype
MGI:5433362
cx34
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Rasa3scat/Rasa3scat
Genetic
Background
involves: 129S7/SvEvBrd * BALB/cBy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Rasa3scat mutation (0 available); any Rasa3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit the same phenotype as Rasa3scat homozygotes

immune system
• mice exhibit the same phenotype as Rasa3scat homozygotes




Genotype
MGI:3578558
cx35
Allelic
Composition
Plcg2Ali5/Plcg2+
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2Ali5 mutation (0 available); any Plcg2 mutation (44 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• approximately 70% of homozygous mice developed despite absence of B and T cells
• resulting in severe arthritis of the small joints of the paws and missing phalanges
• in the superficial layers of the skin of the paws and ears

skeleton
• resulting in severe arthritis of the small joints of the paws and missing phalanges

integument
• in the superficial layers of the skin of the paws and ears




Genotype
MGI:3760618
cx36
Allelic
Composition
Pstpip2Lupo/Pstpip2Lupo
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pstpip2Lupo mutation (0 available); any Pstpip2 mutation (14 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 88% of mice develop skin inflammation with a mean age of onset of 43+/-9 days compared to 98% (42.2+/-4 days) on a C3H background and 52% (124+/-92 days) on a C3H C57BL/6 background
• paw inflammation develops and is worse than in Pstpip2Lupo homozygotes on a C3H C57BL/6 background

integument
• 88% of mice develop skin inflammation with a mean age of onset of 43+/-9 days compared to 98% (42.2+/-4 days) on a C3H background and 52% (124+/-92 days) on a C3H C57BL/6 background
• paw inflammation develops and is worse than in Pstpip2Lupo homozygotes on a C3H C57BL/6 background




Genotype
MGI:3803975
cx37
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background
involves: 129S7/SvEvBrd * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte numbers increase with age
• 96% of thymocytes are double positive
• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1tm1Mom homozygotes

hematopoietic system
• thymocyte numbers increase with age
• 96% of thymocytes are double positive
• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1tm1Mom homozygotes

endocrine/exocrine glands
• thymocyte numbers increase with age




Genotype
MGI:3818750
cx38
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit a focal increase in external granule cells compared to in wild-type mice

neoplasm
N
• despite the increase in granule cells, mice do not develop medulloblastoma




Genotype
MGI:3818748
cx39
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (150 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

nervous system
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

digestive/alimentary system
• one mouse developed a stomach neoplasm

mortality/aging
• median lifespan is 14 weeks compared to 7 weeks in Trp53tm1Brd Xrcc5tm1Dbr
• maximum lifespan is 20 weeks compared to 16 weeks in Trp53tm1Brd Xrcc5tm1Dbr

neoplasm
• one mouse developed a stomach neoplasm
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

respiratory system
• one-fifth of mice exhibit labored breathing prior to death compared to two-thirds of Rag1tm1Mom Trp53tm1Brd

behavior/neurological
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:141515




Genotype
MGI:3818749
cx40
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 53% mice develop T cell lymphomas

liver/biliary system

nervous system
• mice that exhibit vertigo develop medulloblastoma
• 8.1% of mice exhibit medulloblastoma at the time of morbidity

mortality/aging
• all mice die by 45 weeks of age

neoplasm
• 53% mice develop T cell lymphomas
• mice that exhibit vertigo develop medulloblastoma
• 8.1% of mice exhibit medulloblastoma at the time of morbidity

respiratory system
• in two-thirds of mice

behavior/neurological
• one mouse exhibited an acute onset of vertigo that led to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism
• one mouse exhibited an acute onset of vertigo that led to disabled mobility and severe dehydration as a result of inability to reach the water source




Genotype
MGI:6305871
cx41
Allelic
Composition
H2b/H2b
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (23 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(Tcra19,Tcrb19)#Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not show signs of spontaneous autoimmune encephalomyelitis within 12 months and do not develop experimental autoimmune encephalomyelitis after immunization with myelin basic protein (MBP)




Genotype
MGI:5512886
cx42
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(CAG-Lyn*)#Paau/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(CAG-Lyn*)#Paau mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• skin inflammatory disease is improved compared to single Tg(CAG-Lyn*)#Paau transgenic mice




Genotype
MGI:5474627
cx43
Allelic
Composition
Ier3tm1Mxw/Ier3tm1Mxw
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ier3tm1Mxw mutation (0 available); any Ier3 mutation (4 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• dextran sulfate sodium induced colitis is more severe than in either single homozygote but less severe than in wild-type controls

immune system
• dextran sulfate sodium induced colitis is more severe than in either single homozygote but less severe than in wild-type controls




Genotype
MGI:2665135
cx44
Allelic
Composition
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
Tg(TcrLCMV)327Sdz mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

mortality/aging
• survival time at which half of the mutants are sacrificed or die due to illness is 110 days

neoplasm
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1




Genotype
MGI:2665134
cx45
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
Tg(TcrLCMV)327Sdz mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

mortality/aging
• survival time at which half of the mutants are sacrificed or die due to illness is 101 days

neoplasm
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes




Genotype
MGI:3687163
cx46
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice are diabetic; diabetes assessed by blood glucose measures >250 mg/dl on two consectutive measurements

endocrine/exocrine glands
• diabetic mice have nearly complete destruction of insulin producing cells
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls

immune system
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes
• mice develop spontaneous diabetes aged 4-32 weeks; diabetes develops only in mice with at least 1 copy of H-2g7 (incidence is 50% with homozygosity, 15% in heterozygotes); both sexes of transgenic mice are equally affected

hematopoietic system
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3687164
cx47
Allelic
Composition
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (21 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

immune system
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells
• 15% of mice heterozygous for H2g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2g7 mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3687165
cx48
Allelic
Composition
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (21 available); any H2 mutation (264 available)
H2q mutation (4 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3687166
cx49
Allelic
Composition
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2q mutation (4 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• O% of mice homozygous for H2q develop diabetes

digestive/alimentary system
N
• mice do not develop insulitis




Genotype
MGI:4940115
cx50
Allelic
Composition
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0
Genetic
Background
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (1 available); any Ctla4 mutation (25 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcrAND)53Hed mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice

immune system
• nearly all CD4+ T cells in aged mice exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice
• however, lymph node T cells maintain a naive phenotype in young mice
• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice
• in response to primary and secondary pigeon cytochrome c stimulation, the frequency of IL4-secreting T cells is increased compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice

hematopoietic system
• nearly all CD4+ T cells in aged mice exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice
• however, lymph node T cells maintain a naive phenotype in young mice
• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1tm1Mom/Rag1tm1Mom Tg(TcrAND)53Hed mice




Genotype
MGI:3586594
cx51
Allelic
Composition
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
Genetic
Background
involves: 129S/Sv * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Mcdl mutation (0 available); any Igh-J mutation (11 available)
Igk-Jtm1Mcdl mutation (0 available); any Igk-J mutation (8 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(DO11.10)10Dlo mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold

hematopoietic system
• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice
• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice
• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal
• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hyper IgE recurrent infection syndrome 1 DOID:3261 OMIM:147060
J:100072




Genotype
MGI:3622066
cx52
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only
• arthritis is similar to mice heterozygous for Tnftm2Gkl only

digestive/alimentary system
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only

skeleton
• arthritis is similar to mice heterozygous for Tnftm2Gkl only




Genotype
MGI:3836413
cx53
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Vtcn1tm1Lpc/Vtcn1tm1Lpc
Genetic
Background
involves: 129S/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Vtcn1tm1Lpc mutation (0 available); any Vtcn1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Listeria-infected mice die by day 15 post-infection compared to Rag1tm1Mom homozygotes that die at day 4 post-infection

immune system
• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in Rag1tm1Mom homozygotes
• compared to in Rag1tm1Mom homozygotes
• mice infected with Listeria exhibit increased neutrophil numbers and increased bacterial clearance compared to similarly treated Rag1tm1Mom homozygotes
• however, depletion of Gr-1+ neutrophils increases bacterial load in Listeria-infected mice
• Listeria-infected mice die by day 15 post-infection compared to Rag1tm1Mom homozygotes that die at day 4 post-infection

hematopoietic system
• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in Rag1tm1Mom homozygotes
• compared to in Rag1tm1Mom homozygotes

cellular
• proliferation of Gr1+CD11b+ neutrophil progenitors is increased compared to in Rag1tm1Mom homozygotes




Genotype
MGI:3719168
cx54
Allelic
Composition
Bcl6btm2Dent/Bcl6btm2Dent
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6btm2Dent mutation (0 available); any Bcl6b mutation (8 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice have decreased hematopoeitic progenitor cell (HPC) number and cycling in the spleen compared to in Bcl6btm2Dent homozygotes but levels are similar to those in wild-type mice
• mice have decreased HPC number and cycling in the bone marrow similar to in Bcl6btm2Dent homozygotes
• mice lack mature lymphocytes

immune system
• mice lack mature lymphocytes




Genotype
MGI:2665126
cx55
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

mortality/aging
• survival time at which half of the mutants are sacrificed or die due to illness is 238 days

neoplasm
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

hematopoietic system
• inactive V(D)J recombination

immune system
• inactive V(D)J recombination




Genotype
MGI:2665123
cx56
Allelic
Composition
Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 100% incidence of thymoma

mortality/aging
• survival time at which half of the mutants are sacrificed or die due to illness is 165 days

neoplasm
• 100% incidence of thymoma




Genotype
MGI:3687126
cx57
Allelic
Composition
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic
Background
NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Gru mutation (9 available); any H2-Ab1 mutation (48 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• animals have normal sized hearts, normal ECG, and show no sign of autoimmune pathology
• recipient animals develop cardiomegaly by 12 weeks after transfer
• mice receiving splenic lymphocytes from animals with heart block display first-degree heart block as early as 2 weeks after transfer, with 50% progressing to complete heart block in 8 weeks
• recipient animals develop mononuclear cell infiltrates within heart wall by 12 weeks after transplant
• when young mice receive splenic lymphocytes from older NOD.DQ8/H2Ab-1 mice with heart block, myocarditis is triggered in 100% of recipients

immune system
• recipient animals develop mononuclear cell infiltrates within heart wall by 12 weeks after transplant
• when young mice receive splenic lymphocytes from older NOD.DQ8/H2Ab-1 mice with heart block, myocarditis is triggered in 100% of recipients
• anticardiac myosin autoantibodies reach a titer of 1:10000 in recipient mice at 12 weeks posttransfer
• younger mice receiving splenic lymphocytes from older DQ8 transgenic, H2-Ab1-null mice with heart block develop heart block, myocarditis, and autoantibodies
• when younger mice receive serum from the same older animals, no cardiac pathology is observed
• recipient mice receiving CD4 T cells from older donor animals with heart block develop heart block as early as 4 weeks posttransfer; all animals are diseased by 12 weeks and upon necropsy, heart are enlarged
• mononuclear cells are more numerous and infiltrates more widespread than in animals that receive total splenocytes (containing CD4 T cells) in the myocardium
• disease onset is somewhat accelerated compared to recipients receiving total lymphocytes;




Genotype
MGI:3687028
cx58
Allelic
Composition
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic
Background
NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Gru mutation (9 available); any H2-Ab1 mutation (48 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(HLA-DQA1,HLA-DQB1)73Myl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice do not develop spontaneous myocarditis like NOD.B6-H2Ab1tm1Gru-Tg(HLA-DQA1,HLA-DQB1)73 mice

immune system
• mice do not develop spontaneous myocarditis like NOD.B6-H2Ab1tm1Gru-Tg(HLA-DQA1,HLA-DQB1)73 mice
• injection of splenocytes from myocarditis-affected donors into healthy transgenic mice results in acute onset of symptoms of severe heart failure 3 weeks post-transfer, reproducing symptoms of the donor mice
• injection of serum from diseased donors with high autoantibody titer does not result in myocarditis




Genotype
MGI:3813939
cx59
Allelic
Composition
Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (51 available); any Il2rg mutation (85 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no lymphoid cells are present
• no defined cortical region is observed
• no defined medullary region is observed
• thymus contains large cysts
• natural killer cell (NK; DX5+LGL+ cells) are absent
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
• spleen contains mainly myeloid-like cells and few lymphoid cells
• spleen contains no follicles (or germinal centers)
• mature T and B cell populations are absent
• there are diminished CD3+CD4+ and CD3+CD8+ T cells and Igk+ light chain+ B cells in the spleen
• cells functioning in innate immunity are severely decreased in number
• irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1tm1Mom homozygotes
• percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.129S7(B6)-Rag1tm1Mom homozygotes
• levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.129S7(B6)-Rag1tm1Mom mice
• CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.129S7(B6)-Rag1tm1Mom mice
• engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.129S7(B6)-Rag1tm1Mom mice

hematopoietic system
• no lymphoid cells are present
• no defined cortical region is observed
• no defined medullary region is observed
• thymus contains large cysts
• natural killer cell (NK; DX5+LGL+ cells) are absent
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
• spleen contains mainly myeloid-like cells and few lymphoid cells
• spleen contains no follicles (or germinal centers)

endocrine/exocrine glands
• no lymphoid cells are present
• no defined cortical region is observed
• no defined medullary region is observed
• thymus contains large cysts




Genotype
MGI:3817777
cx60
Allelic
Composition
Ins2Akita/Ins2+
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (28 available)
Prf1tm1Sdz mutation (12 available); any Prf1 mutation (40 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• islets exhibit progressively altered morphology
• insulin level is lower compared to Ins2-wild-type mice at 50 days of age and continues to diminish with age

hematopoietic system
• erythrocyte/erythocyte lineages (Ter 119+) are increased as compared to NOD controls
• percentage of granulocytes is elevated compared to NOD/Lt
• lacking in mutant animals
• mature T cells are absent in mutant animals
• percentage of granulocytes is elevated
• percentage of granulocytes is elevated

immune system
• percentage of granulocytes is elevated compared to NOD/Lt
• lacking in mutant animals
• mature T cells are absent in mutant animals
• percentage of granulocytes is elevated
• percentage of granulocytes is elevated

homeostasis/metabolism
N
• spontaneously hyperglycemic mice are restored to euglycemia after receiving islet transplants at a dose of 4000 islet equivalents (IEQ) and remain euglycemic for the length of observation; at levels of 2000 and 3000 IEQ, mice display a drop in blood sugar, but eventually return to hyperglycemic status
• glucose regulation is impaired as early as 3 weeks of age in nearly all mice
• male mice show greater susceptibility to develop hyperglycemia than females




Genotype
MGI:3817776
cx61
Allelic
Composition
Ins2Akita/Ins2Akita
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (28 available)
Prf1tm1Sdz mutation (12 available); any Prf1 mutation (40 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to weaning




Genotype
MGI:3580416
cx62
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Prf1tm1Sdz/Prf1tm1Sdz
Genetic
Background
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Sdz mutation (12 available); any Prf1 mutation (40 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean lifespan is 262+/-21 days

immune system
• thymus lacks a clearly defined cortex
• lymphoid cells are severely reduced in thymuses
• IgLkappa- B220+ immature B cells are increased six-fold as compared to NOD controls
• numbers of granulocytes are increased in comparison to NOD controls, however, in comparison to NOD-Ragnull numbers are decreased
• spleens of 8-11 week old mice are deficient in Igkappa+ B220+ T cells
• numbers of NK cells are increased in comparison to NOD controls
• spleens of 8-11 week old mice are deficient in CD3+ CD4+ T cells
• spleens of 8-11 week old mice are deficient in CD3+ CD8+ T cells
• numbers of macrophages are increased in comparison to NOD controls
• nucleated spleen cells are reduced 14 fold in 8-11 week old mice as compared to NOD control
• spleen lacks lymphoid follicles
• no serum immunoglobulin is detected in 176-362 day old mice
• poly I:C stimulated spleen cells exhibit extremely low levels of NK cell cyotoxic activity
• lymph nodes lack follicles
• four to five-fold decrease in cells expressing I-Ag7 as compared to NOD control
• following IP injection of human PMBC, peripheral blood has a fivefold increase in the percentage of human lymphoid cells as compared to NOD-Ragnull controls
• peripheral blood has a 13-fold increase in engraftment of human CD4+ T cells
• spleens have a 9-fold increase in engraftment of human CD45+ cells and a 20-fold increase in human CD4+ cells as compared to control, although there is no significant difference in engraftment of human CD8+ cells
• 6-8 weeks after IP injection, bone marrow exhibits a 12-fold increase in engraftment of human cord blood cells

neoplasm

hematopoietic system
• thymus lacks a clearly defined cortex
• lymphoid cells are severely reduced in thymuses
• IgLkappa- B220+ immature B cells are increased six-fold as compared to NOD controls
• numbers of granulocytes are increased in comparison to NOD controls, however, in comparison to NOD-Ragnull numbers are decreased
• spleens of 8-11 week old mice are deficient in Igkappa+ B220+ T cells
• numbers of NK cells are increased in comparison to NOD controls
• spleens of 8-11 week old mice are deficient in CD3+ CD4+ T cells
• spleens of 8-11 week old mice are deficient in CD3+ CD8+ T cells
• numbers of macrophages are increased in comparison to NOD controls
• nucleated spleen cells are reduced 14 fold in 8-11 week old mice as compared to NOD control
• spleen lacks lymphoid follicles
• no serum immunoglobulin is detected in 176-362 day old mice
• poly I:C stimulated spleen cells exhibit extremely low levels of NK cell cyotoxic activity

endocrine/exocrine glands
• thymus lacks a clearly defined cortex
• lymphoid cells are severely reduced in thymuses




Genotype
MGI:3844697
cx63
Allelic
Composition
Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Sdz mutation (12 available); any Prf1 mutation (40 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• streptozotocin-treated mice exhibit increased serum glucose levels that can be restored transiently to euglycemia by transplanting islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice
• 70% of streptozotocin-treated mice transplanted with islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice and HLA-A2 negative human peripheral blood mononuclear cells exhibit increased glucose serum levels
• however, all of streptozotocin-treated mice transplanted with islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice and HLA-A2 positive human peripheral blood mononuclear cells exhibit euglycemia

immune system
• streptozotocin-treated mice transplanted with islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice and HLA-A2 negative human peripheral blood mononuclear cells exhibit destruction of engrafted islet cells




Genotype
MGI:3618788
cx64
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraAI4)1Dvs mutation (4 available)
Tg(TcrbAI4)1Dvs mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• females have a greatly increased rate of diabetes development compared to non-transgenic NOD controls (100% incidence by 6 weeks of age)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:94192




Genotype
MGI:3574972
cx65
Allelic
Composition
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation (0 available); any Foxp3 mutation (42 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit no differences in thymocyte and peripheral T cell subpopulations and normal antigen sensitivity, costimulation requirement and proliferative capacity of nonregulatory CD4+ T cells

normal phenotype
• mice were healthy and phenotypically indistinguishable from controls





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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory