All Phenotypes Ptgs2<tm1Jed> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs2^tm1Jed/Ptgs2^tm1Jed	B6;129S-Ptgs2^tm1Jed/J	MGI:3604082
hm2	Ptgs2^tm1Jed/Ptgs2^tm1Jed	involves: 129S7/SvEvBrd	MGI:2177809
hm3	Ptgs2^tm1Jed/Ptgs2^tm1Jed	involves: 129S7/SvEvBrd * C57BL/6	MGI:3603952
hm4	Ptgs2^tm1Jed/Ptgs2^tm1Jed	involves: 129S7/SvEvBrd * CD-1	MGI:4834871
cx5	Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2⁺	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3603949
cx6	Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2^tm1Jed	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3603950
cx7	Ptgs2^tm1Jed/Ptgs2^tm1Jed Stk11^tm1Tpm/Stk11⁺	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3790956
cx8	Ptgs2^tm1Jed/Ptgs2⁺ Stk11^tm1Tpm/Stk11⁺	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3790958

Allelic Composition	Ptgs2^tm1Jed/Ptgs2^tm1Jed
Genetic Background	B6;129S-Ptgs2^tm1Jed/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

pulmonary interstitial fibrosis ( J:68669 )

• in response to bleomycin-induced lung injury, homozygotes exhibit an aggressive fibroproliferative response, widespread inflammation, loss of alveolar architecture, and increased extracellular matrix protein deposition relative to wild-type mice

digestive/alimentary system

abnormal stomach pH ( J:103642 )

• indomethacin-treated mice exhibit a less prominent disruption in pH gradient in the stomach compared with similarly treated wild-type mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:103642 )

• indomethacin-treated mice exhibit a less prominent disruption in pH gradient in the stomach compared with similarly treated wild-type mice

Allelic Composition	Ptgs2^tm1Jed/Ptgs2^tm1Jed
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:29974 )

• homozygotes that reach weaning have an average lifespan of ~3.5 months, with a few animals surviving beyond 6 months

neonatal lethality, incomplete penetrance ( J:29974 )

• ~65% of homozygous mutant mice die neonatally

renal/urinary system

pyelonephritis ( J:29974 )

• all adult homozygotes with renal histopathology are susceptible to development of secondary pyelonephritis

abnormal kidney morphology ( J:29974 )

• all adult homozygotes exhibit renal dysplasia

abnormal kidney collecting duct morphology ( J:29974 )

• homozygous newborns show poor collecting duct development

abnormal kidney cortex morphology ( J:29974 )

abnormal renal glomerulus morphology ( J:29974 )

• all adult homozygotes exhibit mild to moderate renal lesions typified by numerous immature small glomeruli found subcapsularly

abnormal kidney corticomedullary boundary morphology ( J:29974 )

• homozygous newborns exhibit corticomedullary atrophy

kidney corticomedullary cyst ( J:29974 )

• all adult homozygotes display corticomedullary microcysts

abnormal kidney development ( J:29974 )

• although fetal metanephri appear normal at E14, kidneys of homozygous newborns appear severely underdeveloped relative to wild-type kidneys

abnormal kidney mesenchyme morphology ( J:29974 )

• homozygous newborns show abundant undifferentiated mesenchyme

kidney medulla hypoplasia ( J:29974 )

• all adult homozygotes display mild medullary hypoplasia or atrophy

abnormal renal tubule morphology ( J:29974 )

• all adult homozygotes exhibit mild to moderate renal lesions typified by multiple foci of dysplastic tubules

kidney failure ( J:29974 )

• adult homozygotes die of chronic renal failure of developmental origin

reproductive system

absent corpus luteum ( J:29974 )

• mutant ovaries show virtual absence of corpora lutea, despite normal ovarian follicular development

small ovary ( J:29974 )

decreased ovulation rate ( J:29974 )

female infertility ( J:29974 )

• homozygous females are largely infertile, rarely giving birth to live offspring

endocrine/exocrine glands

absent corpus luteum ( J:29974 )

• mutant ovaries show virtual absence of corpora lutea, despite normal ovarian follicular development

small ovary ( J:29974 )

cardiovascular system

cardiac fibrosis ( J:29974 )

• 50% of adult homozygotes exhibit diffuse myocardial fibrosis of variable severity involving both right and left ventricles

homeostasis/metabolism

increased circulating creatinine level ( J:29974 )

increased blood urea nitrogen level ( J:29974 )

immune system

immune system phenotype ( J:29974 )

N	• homozygotes exhibit normal immune responses to carrageenan-induced paw edema, TPA-induced edema and arachidonic acid-induced edema

pyelonephritis ( J:29974 )

• all adult homozygotes with renal histopathology are susceptible to development of secondary pyelonephritis

hematopoietic system

hematopoietic system phenotype ( J:29974 )

N	• homozygotes exhibit normal hematologic parameters

growth/size/body

kidney corticomedullary cyst ( J:29974 )

• all adult homozygotes display corticomedullary microcysts

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:104002 )

• about 20% of mice die between 7 and 23 weeks of age

reproductive system

reproductive system phenotype ( J:69034 )

N	• in vitro, oocyte-cumulus cell complexes retrieved from eCG-primed ovaries of adult homozygotes display normal follicular growth and oocyte maturation • in vitro-matured oocytes obtained from adult female homozygotes show no significant differences in fertilization or preimplantation development

abnormal primary polar body morphology ( J:43609 )

• extrusion of the first polar body is rarely noted

abnormal decidualization ( J:43609 )

• pseudopregnant female homozygotes fail to exhibit an increase in uterine weight in response to intraluminal infusion of oil (a deciduogenic stimulus)

• intraluminal infusion of PGI2 (but not PGE2) or cholera toxin as the deciduogenic stimulus partially restores decidualization in ovaroectomized steroid hormonally prepared mutant mice

decreased superovulation rate ( J:43609 , J:69034 )

• females homozygotes exhibit significantly reduced superovulation, despite normal ovarian response to gonadotropins (J:43609)

• any recovered eggs appear developmentally abnormal, with virtually no extrusion of the first polar body (J:43609)

• adult (2- to 8-month-old) female homozygotes exhibit a poor ovulation rate upon induction with eCG and hCG (J:69034)

• immature (3-week-old) female homozygotes exhibit a superior ovulation rate relative to adult homozygotes, suggesting that the ovulatory process becomes defective with aging (J:69034)

failure of embryo implantation ( J:43609 )

• in blastocyst transfer experiments, wild-type blastocysts fail to exhibit the initial attachment reaction and do not implant into uteri of pseudopregnant female homozygous mutant mice

• failure of implantation and subsequent decidualization occur despite normal uterine responsiveness to steroid hormones

reduced female fertility ( J:109548 , J:118171 )

• number of term pregnancies reduced (J:109548)

• only 20% of homozygous females can sustain term pregnancy (J:118171)

decreased litter size ( J:118171 )

• homozygous females produce small litters compared to wild-type

impaired fertilization ( J:43609 )

• female homozygotes display complete failure of fertilization, despite the presence of numerous sperm at the fertilization site

embryo

abnormal decidualization ( J:43609 )

• pseudopregnant female homozygotes fail to exhibit an increase in uterine weight in response to intraluminal infusion of oil (a deciduogenic stimulus)

• intraluminal infusion of PGI2 (but not PGE2) or cholera toxin as the deciduogenic stimulus partially restores decidualization in ovaroectomized steroid hormonally prepared mutant mice

renal/urinary system

renal/urinary system phenotype ( J:104002 )

N	• adult mice exhibit normal urinalysis and 24-hr urine output under non-stressed conditions • no significant differences in urine osmolarity or in daily urinary excretion of sodium, potassium and chloride are observed

kidney cyst ( J:104002 )

• early cystic changes affecting different tubule sections and glomeruli at P10, with slightly variable pathologic progression

• severe cyst formation by P28

kidney cortex cyst ( J:104002 )

• massive tubular cysts in severely affected kidneys at P14

renal glomerulus cyst ( J:104002 )

• by P14, all mice exhibit cystic subcapsular glomeruli

abnormal kidney cortex morphology ( J:104002 )

• by P14, all mice exhibit outer cortical dysplasia

• inner cortical nephron hypertrophy by P42

abnormal renal glomerulus morphology ( J:104002 , J:109548 , J:118171 )

• small, crowded glomeruli in subcapsular region at P10 (J:104002)

• outer cortical glomerular hypoplasia at P42 (J:104002)

• hypoplastic (J:109548)

• average glomerular diameter is reduced to 29.4 um from 39.2 um in wild-type (J:118171)

cortical renal glomerulopathies ( J:118171 )

• at >6 weeks of age, renal cortex is abnormal with small immature glomeruli and deteriorating tubules; these changes are not seen in 2-month old COX-1 knockin mice

glomerulosclerosis ( J:104002 , J:109548 )

• focally variable glomerular sclerosis by P42 (J:104002)

• however, no inflammatory infiltrate or vascular pathology is observed at any age (J:104002)

• moderate (J:109548)

renal glomerulus fibrosis ( J:104002 )

• peri-glomerular fibrosis by P42

renal glomerulus hypertrophy ( J:104002 )

• hypertrophy of juxtamedullary glomeruli at P28

• inner cortical glomerular hypertrophy by P42

abnormal kidney development ( J:104002 )

• mice exhibit progressive cystic dysplasia during the later stages of kidney development

• however, prenatal and early postnatal kidney development appears normal

renal interstitial fibrosis ( J:104002 )

• diffuse interstitial fibrosis by P42

small kidney ( J:109548 )

kidney cortex atrophy ( J:109548 )

decreased kidney weight ( J:104002 )

• starting at P10, total kidney mass is significantly reduced relative to that in wild-type controls

• kidney-specific growth suppression persists to P42 with no significant change

renal tubule atrophy ( J:104002 )

• by P14, all mice exhibit loss of proximal tubular mass

abnormal proximal convoluted tubule morphology ( J:104002 )

• variable loss of normal proximal tubule mantle at P10

proximal convoluted tubule brush border loss ( J:104002 )

• by P14, all mice exhibit loss of brush border definition

dilated renal tubule ( J:104002 )

• variable tubular dilation at P10

• severe diffuse tubular dilation by P42

renal tubule hypertrophy ( J:104002 )

• hypertrophy of juxtamedullary tubules by P28

kidney degeneration ( J:104002 )

• at 8 weeks of age, some mice exhibit more severe cystic degeneration than others

pale kidney ( J:109548 )

decreased renal glomerular filtration rate ( J:104002 )

• adult mice exhibit a ~50% reduction in GFR relative to wild-type controls, as measured by inulin clearance

kidney failure ( J:104002 )

• mice exhibit progressive renal insufficiency

cardiovascular system

cardiovascular system phenotype ( J:104002 )

N	• normal systolic blood pressure in awake or anesthetized mice relative to wild-type controls

patent ductus arteriosus ( J:109548 )

• fails to close in 40% of mice

increased heart weight ( J:104002 )

• at birth, mice exhibit a significantly higher heart weight:body weight ratio relative to control mice

• however, a normal ratio is observed during postnatal growth and early adulthood

decreased vascular permeability ( J:118171 )

• dye extravasation in the ear vasculature is decreased by 50-60% with bradykinin challenge compared to wild-type

digestive/alimentary system

peritoneal inflammation ( J:118171 )

• at 5 months of age, mice show chronic peritonitis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:104002 )

N	• adult mice exhibit normal plasma sodium, potassium, bicarbonate and chloride levels relative to wild-type controls

increased circulating creatinine level ( J:104002 )

• adult mice exhibit a 1.5-fold increase in plasma creatinine levels relative to controls

increased blood urea nitrogen level ( J:104002 , J:118171 )

• adult mice exhibit a 2.5-fold increase in plasma BUN levels relative to controls (J:104002)

• BUN levels are increased ~2-fold vs wild-type at 6 months of age (J:118171)

decreased prostaglandin level ( J:109548 )

• near absence of LPS induced synthesis

immune system

peritoneal inflammation ( J:118171 )

• at 5 months of age, mice show chronic peritonitis

behavior/neurological

behavior/neurological phenotype ( J:104002 )

N	• mice exhibit normal daily water intake under non-stressed conditions

growth/size/body

growth/size/body region phenotype ( J:104002 )

N	• mice display normal somatic growth from birth to 42 days of age

increased heart weight ( J:104002 )

• at birth, mice exhibit a significantly higher heart weight:body weight ratio relative to control mice

• however, a normal ratio is observed during postnatal growth and early adulthood

kidney cyst ( J:104002 )

• early cystic changes affecting different tubule sections and glomeruli at P10, with slightly variable pathologic progression

• severe cyst formation by P28

kidney cortex cyst ( J:104002 )

• massive tubular cysts in severely affected kidneys at P14

renal glomerulus cyst ( J:104002 )

• by P14, all mice exhibit cystic subcapsular glomeruli

cellular

patent ductus arteriosus ( J:109548 )

• fails to close in 40% of mice

abnormal primary polar body morphology ( J:43609 )

• extrusion of the first polar body is rarely noted

Allelic Composition	Ptgs2^tm1Jed/Ptgs2^tm1Jed
Genetic Background	involves: 129S7/SvEvBrd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to infection ( J:120725 )

• following infection with Pseudomonas aeruginosa (PA103) bacterila counts in the right lung are lower compared to wild-type controls

• improved clearance is not the result of increased macrophage or neutrophil recruitment or cytokine production as these measures are similar to wild-type controls

Allelic Composition	Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2⁺
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Mmt mutation (0 available); any Apc mutation (154 available)
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:36816 )

• at 10 weeks, double heterozygotes develop only ~34% of the polyp number detected in the intestinal tracts of mice heterozygous for Apc^tm1Mmt alone

colon polyps ( J:36816 )

• at 10 weeks, double heterozygotes exhibit only 1.5 1.9 colonic polyps versus 6.8 7.2 detected in mice heterozygous for Apc^tm1Mmt alone

Allelic Composition	Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2^tm1Jed
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:36816 )

• at 10 weeks, these mutants develop only ~14% of the polyp number detected in the intestinal tracts of mice heterozygous for Apc^tm1Mmt alone

• the size of intestinal polyps is significantly smaller (<1.0 mm) than that observed in mice heterozygous for Apc^tm1Mmt alone, with no polyps larger than 2.0 mm in diameter

• histologically, well-developed polyps are not covered with the normal intestinal epithelium and appear flatter than polyps found in Apc^tm1Mmt heterozygous controls

• notably, no colonic polyps are observed

Allelic Composition	Ptgs2^tm1Jed/Ptgs2^tm1Jed Stk11^tm1Tpm/Stk11⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (72 available)
Stk11^tm1Tpm mutation (0 available); any Stk11 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

gastric polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

neoplasm

decreased tumor incidence ( J:93361 )

• 53-54% decrease in tumor burden is seen at 10 months in mice treated with celecoxib between 3.5 and 10 months compared to untreated controls

Allelic Composition	Ptgs2^tm1Jed/Ptgs2⁺ Stk11^tm1Tpm/Stk11⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

gastric polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

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