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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfkb1tm1Bal
targeted mutation 1, David Baltimore
MGI:1857225
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nfkb1tm1Bal/Nfkb1tm1Bal B6.Cg-Nfkb1tm1Bal/J MGI:3841117
hm2
Nfkb1tm1Bal/Nfkb1tm1Bal B6;129P-Nfkb1tm1Bal/J MGI:3693806
hm3
Nfkb1tm1Bal/Nfkb1tm1Bal involves: 129P2/OlaHsd MGI:3799121
hm4
Nfkb1tm1Bal/Nfkb1tm1Bal involves: 129P2/OlaHsd * C57BL/6 MGI:3768245
cx5
Nfkb1tm1Bal/Nfkb1tm1Bal
Tg(Tnfsf13b)1Fma/?
B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma MGI:3841112
cx6
Nfkb1tm1Bal/Nfkb1tm1Bal
Reltm1Grd/Reltm1Grd
involves: 129P2/OlaHsd * 129S1/Sv MGI:3799119
cx7
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae MGI:3046863
cx8
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
involves: 129P2/OlaHsd * 129S4/SvJae MGI:3799122
cx9
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkb2tm1Sbn/Nfkb2tm1Sbn
involves: 129P2/OlaHsd * 129S4/SvJae MGI:3852643
cx10
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Rela+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3799208
cx11
Mir146tm1.1Bal/Mir146tm1.1Bal
Nfkb1tm1Bal/Nfkb1tm1Bal
involves: 129P2/OlaHsd * C57BL/6 MGI:5317801
cx12
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkbiatm1Bal/Nfkbiatm1Bal
involves: 129S4/SvJae * C57BL/6J MGI:3034094


Genotype
MGI:3841117
hm1
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic
Background
B6.Cg-Nfkb1tm1Bal/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• addition of Tnfsf13b (BAFF) to the in vitro B cell cultures does not elevate survival of B cells for the first 12 hours but provides benefits when present for 24 hours or longer

hematopoietic system
• addition of Tnfsf13b (BAFF) to the in vitro B cell cultures does not elevate survival of B cells for the first 12 hours but provides benefits when present for 24 hours or longer




Genotype
MGI:3693806
hm2
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic
Background
B6;129P-Nfkb1tm1Bal/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at 1 and 3 months, vacuole-like spaces replace the afferent terminals of the inner radial nerves while efferent inner spiral fibers appear intact
• at 1 and 3 months, edematous-appearing extracellular spaces are noted between the IHC and supporting cells; the cytoplasm in the base of IHCs consists of numerous small vesicles infiltrated with mitochondria and short profiles of cisternae
• in contrast, no major pathological changes are seen in mutant OHCs or stria vascularis at 1 or 3 months
• all homozygotes (6 of 6) exhibit excitotoxic pathologies of afferent dendrites under the IHCs compared with 4 of 9 in wild-type mice
• homozygotes show a significantly higher number of swollen dendritic terminals per IHC region relative to wild-type mice; only type I ganglion neurons are involved
• at 1 month of age, CAP thresholds in homozygotes are elevated by 6-20 dB SPL relative to wild-type mice at almost all frequencies
• at 3 months of age, mutant CAP thresholds are increased by ~20 dB SPL at low frequencies and by ~30 dB at high frequencies relative to wild-type
• by 8 months of age, most homozygotes no longer respond to auditory stimuli at high frequencies (90 dB SPL), whereas wild-type mice retain CAP responses at most test frequencies
• at 3 months, no sigificant loss of distorion product otoacoustic emissions (DPOAEs) is noted when primaries are presented at 70 dB SPL
• no significant differences in mean endocochlear potential values are observed at 1, 3, and 8 months of age relative to wild-type mice
• homozygotes exhibit accelerated age-related hearing loss at higher frequencies, as assessed by CAP threshold shifts at 1, 3, and 8 months of age
• accelerated hearing loss is highly associated with an exacerbated excitotoxic-like damage in afferent dendrites under IHCs and an accelerated loss of spiral ganglion neurons
• at 2 hrs after exposure to a wideband, low-level noise at 70 dB SPL, 1-month-old homozygotes display 7-15 dB SPL threshold shifts across most test frequencies whereas wild-type mice show no significant CAP threshold shifts

nervous system
• at 1 and 3 months, vacuole-like spaces replace the afferent terminals of the inner radial nerves while efferent inner spiral fibers appear intact
• at 1 and 3 months, edematous-appearing extracellular spaces are noted between the IHC and supporting cells; the cytoplasm in the base of IHCs consists of numerous small vesicles infiltrated with mitochondria and short profiles of cisternae
• in contrast, no major pathological changes are seen in mutant OHCs or stria vascularis at 1 or 3 months
• all homozygotes (6 of 6) exhibit excitotoxic pathologies of afferent dendrites under the IHCs compared with 4 of 9 in wild-type mice
• homozygotes show a significantly higher number of swollen dendritic terminals per IHC region relative to wild-type mice; only type I ganglion neurons are involved
• at 1 month of age, CAP thresholds in homozygotes are elevated by 6-20 dB SPL relative to wild-type mice at almost all frequencies
• at 3 months of age, mutant CAP thresholds are increased by ~20 dB SPL at low frequencies and by ~30 dB at high frequencies relative to wild-type
• by 8 months of age, most homozygotes no longer respond to auditory stimuli at high frequencies (90 dB SPL), whereas wild-type mice retain CAP responses at most test frequencies
• at 3 months, no sigificant loss of distorion product otoacoustic emissions (DPOAEs) is noted when primaries are presented at 70 dB SPL
• no significant differences in mean endocochlear potential values are observed at 1, 3, and 8 months of age relative to wild-type mice
• at 8 months, homozygotes show a 69% loss of SGNs in the basal cochlea relative to a ~28% loss observed in wild-type mice
• at 8 months, the numbers of afferent axons per habenular opening are significantly reduced relative to those of wild-type mice
• however, no significant differences in IHC or OHC loss are noted at 8 months relative to wild-type mice

homeostasis/metabolism
N
• despite altered expression of Trp53, neurons exhibit normal camptothecin-induced neuronal death
• at 8 months, the immunoreactivity for a set of calcium-buffering proteins is significantly increased in mutant spiral ganglion neurons, suggesting impaired calcium ion homeostasis

immune system
N
• most pancreatic islet cells appear normal in mutants not developing diabetes after streptozotocin treatment, while control pancreatic islets display insulitis; mutants developing diabetes after treatment display insulis in many islets
• splenocytes treated with anti-CD3 with or without anti-CD28 antibodies produce reduced levels of interferon gamma and Il-2 (Th1 cytokines) but increased levels of Il-4 and Il-10 (Th2 cytokines) while wild-type splenocytes produce both Th1 and Th2 cytokines
• peritoneal macrophages produce less Il-6, Il-12p40, TNF alpha, and nitric oxide compared to wild-type cells upon stimulation with interferon gamma and/or LPS
• bone marrow-derived dendritic cells stimulated with LPS produce significantly less Il-12p40 and TNF alpha than stimulated wild-type dendritic cells
• Il-4 secretion is impaired in cultured cells upon stimulation with MOG peptide
• >70% of control mice treated with low dose streptozotocin for 5 days develop diabetes starting ~8 and 12 days after the first injection, but only 23% of mutants develop diabetes

cellular
• growth factor withdrawal from cultured bone marrow dendritic cells enhances apoptosis of dendritic cells, but not granulocytes or macrophages

muscle
N
• myogenesis is normal

hematopoietic system
• splenocytes treated with anti-CD3 with or without anti-CD28 antibodies produce reduced levels of interferon gamma and Il-2 (Th1 cytokines) but increased levels of Il-4 and Il-10 (Th2 cytokines) while wild-type splenocytes produce both Th1 and Th2 cytokines
• peritoneal macrophages produce less Il-6, Il-12p40, TNF alpha, and nitric oxide compared to wild-type cells upon stimulation with interferon gamma and/or LPS




Genotype
MGI:3799121
hm3
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal dendritic cell development and maturation

hematopoietic system




Genotype
MGI:3768245
hm4
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• B cell proliferation following LPS and sCD40L stimulation is impaired (J:30268)
• however, B cells proliferate normally in response to CD40L, alpha-delta-dex and IL-4 + IL-5 (J:30268)
• B cells do not proliferate in response to LPS concentration that stimulate wild-type B cells to proliferate (J:37184)

mortality/aging
• mice die 24 hours after infection with Staphylococcus pneumoniae compared to wild-type mice that die between 36 and 72 hours after infection
• mice are more resistant to EMC virus infection than wild-type mice and exhibit mortality at a 10-fold higher titer with a slower progression towards fatal encephalopathy
• mice die more frequently at a young age compared to wild-type mice

immune system
• B cell proliferation following LPS and sCD40L stimulation is impaired (J:30268)
• however, B cells proliferate normally in response to CD40L, alpha-delta-dex and IL-4 + IL-5 (J:30268)
• B cells do not proliferate in response to LPS concentration that stimulate wild-type B cells to proliferate (J:37184)
• mice exhibit mild typhlocolitis
• mice exhibit mild typhlocolitis
• B cells are defective in IgG3, IgE and IgA class switching but undergo substantial IgG1 class switching
• low number of myeloid dendritic cells in Peyer's patches
• size of interfollicluar region is reduced
• slight increase of M cells in the follicle-associated epithelium (FAE)
• CD3+ T cell numbers are reduced and T-cell areas of Peyer's patches are underrepresented and small in size
• germinal centers are reduced in number and size with a low number of myeloid dentritic cells
• average of 2 to 4 Peyer's patches per mouse compared to an observed average of 7 to 10 per control mouse
• Peyer's patches are smaller and contain a range of no more than 1 to 2 follicles
• total NP-binding following exposure to NP15-CG is lower than in wild-type mice and NP-specific antibodies of all isotypes are decreased compared to in wild-type mice
• immunoglobin levels are 4-fold lower than in wild-type mice
• all isotypes except IgM are reduced
• IgA levels are decreased 5-fold
• IgE levels are decreased 50-fold
• IgG1 levels are reduced 10-fold
• proliferating B cells stimulated with alpha-delta-dex and IL-4 + IL-5 produce 32-fold less IgM than wild-type
• proliferating B cells stimulated wth mCD40L + IL-4 + IL-5 produce 41-fold less IgM than wild-type
• however, mlg and CD40 signaling restores B cell maturation to IgM secretion
• LPS-stimulated macrophages release 6-fold less IL-6
• mice are more prone to infection than wild-type mice (J:37184)
• while mice efficiently clear extracellular bacteria they fail to clear intracellular bacteria (J:37184)
• 6 days after infection with Listeria monocytogenes, mice exhibit no peritoneal bacterial but several thousand splenic bacteria compared to wild-type mice that exhibit neither (J:37184)
• mice die 24 hours after infection with Staphylococcus pneumoniae compared to wild-type mice that die between 36 and 72 hours after infection (J:37184)
• however, mice do not exhibit any abnormal response to H. influenzae and E. coli infection (J:37184)
• mice are more sensitive to typhlocolitis induced by H. hepaticus than wild-type mice but less sensitive than Nfkb1tm1Bal/Nfkb1tm1Bal Relatm1Bal/Rela+ (J:67107)
• mice die 24 hours after infection with Staphylococcus pneumoniae compared to wild-type mice that die between 36 and 72 hours after infection
• mice are more resistant to EMC virus infection than wild-type mice and exhibit mortality at a 10-fold higher titer with a slower progression towards fatal encephalopathy

digestive/alimentary system
• mice exhibit mild colonic perforations and typhlocolitis
• mild
• mice exhibit mild typhlocolitis
• mice exhibit mild typhlocolitis

hematopoietic system
• B cell proliferation following LPS and sCD40L stimulation is impaired (J:30268)
• however, B cells proliferate normally in response to CD40L, alpha-delta-dex and IL-4 + IL-5 (J:30268)
• B cells do not proliferate in response to LPS concentration that stimulate wild-type B cells to proliferate (J:37184)
• B cells are defective in IgG3, IgE and IgA class switching but undergo substantial IgG1 class switching
• low number of myeloid dendritic cells in Peyer's patches
• immunoglobin levels are 4-fold lower than in wild-type mice
• all isotypes except IgM are reduced
• IgA levels are decreased 5-fold
• IgE levels are decreased 50-fold
• IgG1 levels are reduced 10-fold
• proliferating B cells stimulated with alpha-delta-dex and IL-4 + IL-5 produce 32-fold less IgM than wild-type
• proliferating B cells stimulated wth mCD40L + IL-4 + IL-5 produce 41-fold less IgM than wild-type
• however, mlg and CD40 signaling restores B cell maturation to IgM secretion




Genotype
MGI:3841112
cx5
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Tg(Tnfsf13b)1Fma/?
Genetic
Background
B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• class switch recombination mediated by T cell independent antigens or by BAFF incubation is defective in these mice
• numbers of T1 B cells in the spleen are increased almost 3-fold while T2 numbers are almost about doubled
• marginal zone B cells are almost completely absent in the spleen
• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM class antibodies than wild-type controls
• the Nfkb1 null background significantly reduced the IgG2a and IgG2b responses and virtually abrogated the IgG3 and IgA responses compared to transgenic mice on a wild-type background

immune system
N
• there are no elevated levels of anti-dsDNA antibodies detected in circulation compared to transgenic mice on a wild-type background that have high levels of auto-antbodies
• class switch recombination mediated by T cell independent antigens or by BAFF incubation is defective in these mice
• numbers of T1 B cells in the spleen are increased almost 3-fold while T2 numbers are almost about doubled
• marginal zone B cells are almost completely absent in the spleen
• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM class antibodies than wild-type controls
• the Nfkb1 null background significantly reduced the IgG2a and IgG2b responses and virtually abrogated the IgG3 and IgA responses compared to transgenic mice on a wild-type background




Genotype
MGI:3799119
cx6
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Reltm1Grd/Reltm1Grd
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Reltm1Grd mutation (2 available); any Rel mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• despite normal development of dendritic cells, CD40LG and TNFSF11-induced survival and IL-12 production are abolished
• cells induced with LPS produce less IL-12 than similarly treated wild-type cells




Genotype
MGI:3046863
cx7
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Relatm1Bal mutation (1 available); any Rela mutation (24 available)
Tnftm1Ljo mutation (3 available); any Tnf mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• triple homozygous pups die within 12 hours of birth
• fewer than expected triple homozygous mutants are found at birth

integument
• the epidermis is marginally thinner




Genotype
MGI:3799122
cx8
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Relatm1Bal mutation (1 available); any Rela mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
• in culture, very few dendritic cells differentiate from bone marrow cells

immune system
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
• in culture, very few dendritic cells differentiate from bone marrow cells

cellular
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal




Genotype
MGI:3852643
cx9
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Nfkb2tm1Sbn mutation (0 available); any Nfkb2 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 3 and 4 weeks

immune system
• osteoclast differentiation is halted prior to TRAP expression
• B cell developmental block occurs at the immature IgM stage
• the block in B cell development is maintained when cells are adoptively transferred into in Rag1 null mice
• mice exhibit a higher proportional of granulocytes in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow granulocyte numbers are normal
• fewer M342+ interdigitating dendritic cells are present and are disorganized compared to in wild-type mice
• thymic medullary dendritic cells are reduced in number and disorganized compared to in wild-type mice
• B220+ B cells in the spleen are decreased 1.3- to 2.6-fold compared to in wild-type mice
• IgM+ B cells are reduced and IgD+ cells are undetected unlike in wild-type mice
• no T cells are detected in the spleen
• reduction in dull staining double positive T cells
• single positive T cells are low in the thymus and undetected in the periphery unlike in wild-type mice
• however, single T cells are produced when transferred into Rag1 null mice
• no TRAP+ osteoclasts are detected unlike in wild-type mice
• however, no abnormal apoptosis of osteoclasts is detected
• mice exhibit a higher proportional of macrophages in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow macrophage numbers are normal
• mature macrophage functions are impaired
• thymic cortical epithelial cells are randomly distributed unlike in wild-type mice
• medullary epithelial cells are absent
• 10- to 30-fold fewer cells
• B220+ B cells are diffusely distributed throughout the spleen with only a few rare T cells and macrophages present throughout the spleen unlike in wild-type mice

skeleton
• osteoclast differentiation is halted prior to TRAP expression
• incisors fail to erupt
• however, adoptive transfer with wild-type liver cells restores tooth eruption by 5 weeks
• no TRAP+ osteoclasts are detected unlike in wild-type mice
• however, no abnormal apoptosis of osteoclasts is detected
• long bones are shortened, radio-opaque, and lack proper bone marrow cavities unlike in wild-type mice
• long bones lack proper bone marrow cavities
• at 2 to 4 weeks, mice develop osteopetrosis
• however, adoptive transfer with wild-type bone marrow cells rescues osteopetrosis

growth/size/body
• incisors fail to erupt
• however, adoptive transfer with wild-type liver cells restores tooth eruption by 5 weeks
• within a week of birth

craniofacial
• incisors fail to erupt
• however, adoptive transfer with wild-type liver cells restores tooth eruption by 5 weeks

hematopoietic system
• osteoclast differentiation is halted prior to TRAP expression
• thymic cortical epithelial cells are randomly distributed unlike in wild-type mice
• medullary epithelial cells are absent
• 10- to 30-fold fewer cells
• B cell developmental block occurs at the immature IgM stage
• the block in B cell development is maintained when cells are adoptively transferred into in Rag1 null mice
• mice exhibit a higher proportional of granulocytes in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow granulocyte numbers are normal
• fewer M342+ interdigitating dendritic cells are present and are disorganized compared to in wild-type mice
• thymic medullary dendritic cells are reduced in number and disorganized compared to in wild-type mice
• B220+ B cells in the spleen are decreased 1.3- to 2.6-fold compared to in wild-type mice
• IgM+ B cells are reduced and IgD+ cells are undetected unlike in wild-type mice
• no T cells are detected in the spleen
• reduction in dull staining double positive T cells
• single positive T cells are low in the thymus and undetected in the periphery unlike in wild-type mice
• however, single T cells are produced when transferred into Rag1 null mice
• no TRAP+ osteoclasts are detected unlike in wild-type mice
• however, no abnormal apoptosis of osteoclasts is detected
• mice exhibit a higher proportional of macrophages in the spleen compared to in wild-type mice due to a decrease in other cell types
• however, bone marrow macrophage numbers are normal
• B220+ B cells are diffusely distributed throughout the spleen with only a few rare T cells and macrophages present throughout the spleen unlike in wild-type mice
• mature macrophage functions are impaired

cellular
• osteoclast differentiation is halted prior to TRAP expression

endocrine/exocrine glands
• thymic cortical epithelial cells are randomly distributed unlike in wild-type mice
• medullary epithelial cells are absent
• 10- to 30-fold fewer cells




Genotype
MGI:3799208
cx10
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Rela+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Relatm1Bal mutation (1 available); any Rela mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice exhibit colonic perforations and typhlocolitis
• severe
• mice exhibit typhlocolitis

immune system
• mice exhibit typhlocolitis
• mice are more sensitive to typhlocolitis induced by H. hepaticus than wild-type mice with a more rapid onset of diarrhea, enlargement and thickening of the colon, thickening of the mucosa characterized by extensive ulcerations, elongated irregularly shaped glands and crypt abscesses, lamina propria fibrosis and infiltration granulation tissue, dilated lymphatics, and multifocal necrotizing vasculitis with thrombosis, and expanded submucosa and serosa with infiltration




Genotype
MGI:5317801
cx11
Allelic
Composition
Mir146tm1.1Bal/Mir146tm1.1Bal
Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146tm1.1Bal mutation (2 available); any Mir146 mutation (9 available)
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• myeloproliferation and splenomegaly observed in Mir146tm1.1Bal knock-outs are rescued




Genotype
MGI:3034094
cx12
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkbiatm1Bal/Nfkbiatm1Bal
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (99 available)
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival prolonged until 2-4 weeks





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory