Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation
(1 available);
any
Ncam1 mutation
(65 available)
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nervous system
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• more neurospheres differentiate into GFAP+ cells when exposed to PDGF (44.1+/-7.5% compared to 33.0+/-4.5% of wild-type neurospheres)
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• the number of GFAP+ cells is increased along the rostral migratory stream but these cells are not within the stream nor directed to the olfactory bulb
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cellular
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• more neurospheres differentiate into GFAP+ cells when exposed to PDGF (44.1+/-7.5% compared to 33.0+/-4.5% of wild-type neurospheres)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation
(1 available);
any
Ncam1 mutation
(65 available)
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behavior/neurological
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• spatial learning impairment demonstrated in the Morris water maze test
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nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation
(1 available);
any
Ncam1 mutation
(65 available)
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vision/eye
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• at 18 months
• however, the number of optic nerve axons is normal at 2 and 18 months
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• at 2 months
• however, the number of optic nerve axons is normal at 2 and 18 months
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• in middle and peripheral regions at 2 months
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• loss of one third of thickness in the central areas at 18 months
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• increased retinal thickness only in the peripheral temporal region at 2 months
• reduced retinal thickness in the central areas at 18 months
• however, mice exhibit normal thickness in the inner nuclear layer, outer plexiform layer and outer nuclear layer at 2 months
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• a-wave Vmax is more than double wild-type before falling to normal levels by 10 months and older
• b-wave V-max is more than double at 2 months then falls to normal levels by 10 months or older with premature loss of light sensitivity at 18 months
• however, mice exhibit normal retinal sensitivity and b-wave to a-wave ratio
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• premature loss of visual detection
• no ability to detect pattern at any age
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nervous system
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• at 18 months
• however, the number of optic nerve axons is normal at 2 and 18 months
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• at 2 months
• however, the number of optic nerve axons is normal at 2 and 18 months
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation
(1 available);
any
Ncam1 mutation
(65 available)
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behavior/neurological
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• in 50% of mutant in DD conditions aberrant activity rhythms make it impossible to determine a period
• these mutants also had a longer active period in DD conditions
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• the circadian period in DD conditions is significantly shorter in 50% of mutants, 23.7 hours compared to 23.98 hours in wild-type littermates
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• daily onset and offset of activity are irregular or lost
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magtm1Mtg mutation
(0 available);
any
Mag mutation
(24 available)
Ncam1tm1Cgn mutation
(1 available);
any
Ncam1 mutation
(65 available)
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nervous system
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• at 4 weeks of age, onion bulb like structures are seen in the pectineus and quadriceps nerves
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• at 8 weeks of age in single fiber preparations many fibers show signs of myelin degeneration
• degeneration is preferentially associated with the paranodal regions of the fibers
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• at 4 weeks of age, degenerating axons and degenerating myelin are seen in the femoral quadriceps nerve
• at 8 weeks of age the number of abnormal axons is increased compared to mice at 4 weeks of age
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Analysis Tools