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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ncam1tm1Cgn
targeted mutation 1, University of Cologne
MGI:1857222
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ncam1tm1Cgn/Ncam1tm1Cgn B6.129P2-Ncam1tm1Cgn MGI:3762776
hm2
Ncam1tm1Cgn/Ncam1tm1Cgn involves: 129P2/OlaHsd MGI:2182567
hm3
Ncam1tm1Cgn/Ncam1tm1Cgn involves: 129P2/OlaHsd * C57BL/6J MGI:6383926
hm4
Ncam1tm1Cgn/Ncam1tm1Cgn involves: C57BL/6J MGI:3574807
cx5
Magtm1Mtg/Magtm1Mtg
Ncam1tm1Cgn/Ncam1tm1Cgn
involves: 129P2/OlaHsd * 129S2/SvPas MGI:4355933


Genotype
MGI:3762776
hm1
Allelic
Composition
Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic
Background
B6.129P2-Ncam1tm1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation (1 available); any Ncam1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• more neurospheres differentiate into GFAP+ cells when exposed to PDGF (44.1+/-7.5% compared to 33.0+/-4.5% of wild-type neurospheres)
• the number of GFAP+ cells is increased along the rostral migratory stream but these cells are not within the stream nor directed to the olfactory bulb

cellular
• more neurospheres differentiate into GFAP+ cells when exposed to PDGF (44.1+/-7.5% compared to 33.0+/-4.5% of wild-type neurospheres)




Genotype
MGI:2182567
hm2
Allelic
Composition
Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation (1 available); any Ncam1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• spatial learning impairment demonstrated in the Morris water maze test

nervous system




Genotype
MGI:6383926
hm3
Allelic
Composition
Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation (1 available); any Ncam1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 18 months
• however, the number of optic nerve axons is normal at 2 and 18 months
• at 2 months
• however, the number of optic nerve axons is normal at 2 and 18 months
• in middle and peripheral regions at 2 months
• loss of one third of thickness in the central areas at 18 months
• increased retinal thickness only in the peripheral temporal region at 2 months
• reduced retinal thickness in the central areas at 18 months
• however, mice exhibit normal thickness in the inner nuclear layer, outer plexiform layer and outer nuclear layer at 2 months
• a-wave Vmax is more than double wild-type before falling to normal levels by 10 months and older
• b-wave V-max is more than double at 2 months then falls to normal levels by 10 months or older with premature loss of light sensitivity at 18 months
• however, mice exhibit normal retinal sensitivity and b-wave to a-wave ratio
• premature loss of visual detection
• no ability to detect pattern at any age

nervous system
• at 18 months
• however, the number of optic nerve axons is normal at 2 and 18 months
• at 2 months
• however, the number of optic nerve axons is normal at 2 and 18 months




Genotype
MGI:3574807
hm4
Allelic
Composition
Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncam1tm1Cgn mutation (1 available); any Ncam1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in 50% of mutant in DD conditions aberrant activity rhythms make it impossible to determine a period
• these mutants also had a longer active period in DD conditions
• the circadian period in DD conditions is significantly shorter in 50% of mutants, 23.7 hours compared to 23.98 hours in wild-type littermates
• daily onset and offset of activity are irregular or lost




Genotype
MGI:4355933
cx5
Allelic
Composition
Magtm1Mtg/Magtm1Mtg
Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Magtm1Mtg mutation (0 available); any Mag mutation (17 available)
Ncam1tm1Cgn mutation (1 available); any Ncam1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 4 weeks of age, onion bulb like structures are seen in the pectineus and quadriceps nerves
• at 8 weeks of age in single fiber preparations many fibers show signs of myelin degeneration
• degeneration is preferentially associated with the paranodal regions of the fibers
• at 4 weeks of age, degenerating axons and degenerating myelin are seen in the femoral quadriceps nerve
• at 8 weeks of age the number of abnormal axons is increased compared to mice at 4 weeks of age





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory