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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mgat1tm1Jxm
targeted mutation 1, Jamey Marth
MGI:1857217
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mgat1tm1Jxm/Mgat1tm1Jxm involves: 129S2/SvPas * C57BL/6J MGI:2175108


Genotype
MGI:2175108
hm1
Allelic
Composition
Mgat1tm1Jxm/Mgat1tm1Jxm
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat1tm1Jxm mutation (1 available); any Mgat1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are still viable at E9.5 but die by ~E10.5

embryo
• at E9.5, homozygotes often fail to complete axial turning
• at E9.5, homozygotes frequently display inverted left-right asymmetry
• homozygous mutant embryos fail to develop beyond ~E9.0 but show normal formation of fore- , mid-, and hindbrain regions, branchial arches and myocardium
• at E9.5, homozygotes are 50%-66% the size of wild-type or heterozygous embryos
• at E9.5, homozygotes exhibit a highly convoluted neural tube with a staggered suture line
• at E9.5, homozygotes display a convoluted neural epithelium with increased numbers of mitotic figures in neural epithelial cells
• at E9.5, homozygotes exhibit only 20-22 somite pairs vs 26 pairs found in wild-type embryos; those somites that form appear less well developed

growth/size/body
• at E9.5, homozygotes are 50%-66% the size of wild-type or heterozygous embryos
• at E9.5, homozygotes display situs inversus with an inverted tail and heart structure

cardiovascular system
• at E9.5, homozygotes exhibit an expanded endothelial cell vasculature with multiple nucleated red blood cells in the fore- and midbrain regions
• at E9.5, many homozygotes show vascular hypertrophy, with aberrant accumulation of red blood cells within dilated vessels in the primitive head region and in proximity to the dorsal aorta and primary head vein
• at E9.5, most homozygotes exhibit an inverted heart loop structure
• by E10.5, homozygotes exhibit multiple hemorrhages

nervous system
• at E9.5, homozygotes exhibit a highly convoluted neural tube with a staggered suture line
• at E9.5, homozygotes display a convoluted neural epithelium with increased numbers of mitotic figures in neural epithelial cells

hematopoietic system
• at E9.5, some homozygotes appear anemic

limbs/digits/tail
• at E9.5, the mutant tail is abnormally oriented towards the left side of the embryo





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory