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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lrpap1tm1Her
targeted mutation 1, Joachim Herz
MGI:1857214
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lrpap1tm1Her/Lrpap1tm1Her B6.129S7-Lrpap1tm1Her MGI:3622695
hm2
Lrpap1tm1Her/Lrpap1tm1Her involves: 129S7/SvEvBrd * C57BL/6J MGI:3581862
cx3
Lrp1btm1Her/Lrp1btm1Her
Lrpap1tm1Her/Lrpap1tm1Her
involves: 129S/SvEv * C57BL/6 MGI:3045503
cx4
Lrpap1tm1Her/Lrpap1tm1Her
Tg(APPV717F)109Ili/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3622696
cx5
Ldlrtm1Her/Ldlrtm1Her
Lrpap1tm1Her/Lrpap1tm1Her
involves: 129S7/SvEvBrd * C57BL/6J MGI:3581865


Genotype
MGI:3622695
hm1
Allelic
Composition
Lrpap1tm1Her/Lrpap1tm1Her
Genetic
Background
B6.129S7-Lrpap1tm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• endocytotic machinery in the proximal tubule is disturbed athough the ability to adjust to dietary phosphate levels is unaffected

endocrine/exocrine glands
• slight thyrocyte and nuclear hypertrophy but no goiter
• slightly reduced thyroglobulin in thyroid follicles but intracellular levels and levels on the apical membrane of thyrocytes are increased
• T4 levels in thyroglobulin are normal or slightly elevated
• free T4 levels unchanged
• TSH levels are elevated but not to the point of statistical significance

nervous system
• levels of somatostatin in neurons reduced
• number of neurons expressing somatostatin is reduced

behavior/neurological
• poorer performance in a Morris water maze
• after 6 days of training, swim a greater distance to find target than do controls




Genotype
MGI:3581862
hm2
Allelic
Composition
Lrpap1tm1Her/Lrpap1tm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• alpha2 macroglobulin is removed from the circulation at about 25% of the normal rate
• no effect is seen on blood lipoproteins regardless of diet
• homozygotes thrived well and are superficially normal

cellular
• reduces expression of lipoprotein receptor related protein by 75% but has no effect on the LDL receptor




Genotype
MGI:3045503
cx3
Allelic
Composition
Lrp1btm1Her/Lrp1btm1Her
Lrpap1tm1Her/Lrpap1tm1Her
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1btm1Her mutation (0 available); any Lrp1b mutation (110 available)
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygous mutants appear normal and have normal brain physiology




Genotype
MGI:3622696
cx4
Allelic
Composition
Lrpap1tm1Her/Lrpap1tm1Her
Tg(APPV717F)109Ili/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (10 available)
Tg(APPV717F)109Ili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• elevated amyloid deposits over controls
• develop reactive astrocytosis

homeostasis/metabolism
• elevated amyloid deposits over controls




Genotype
MGI:3581865
cx5
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrpap1tm1Her/Lrpap1tm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• chylomicron reminent and LDL levels increased in blood
• 2 fold increase in total plasma cholesterol
• moderately increased plasma triglyceride levels





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory