Mouse Genome Informatics
hm1
    Lrpap1tm1Her/Lrpap1tm1Her
B6.129S7-Lrpap1tm1Her
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• endocytotic machinery in the proximal tubule is disturbed athough the ability to adjust to dietary phosphate levels is unaffected

endocrine/exocrine glands
• slight thyrocyte and nuclear hypertrophy but no goiter
• slightly reduced thyroglobulin in thyroid follicles but intracellular levels and levels on the apical membrane of thyrocytes are increased
• T4 levels in thyroglobulin are normal or slightly elevated
• free T4 levels unchanged
• TSH levels are elevated but not to the point of statistical significance

nervous system
• levels of somatostatin in neurons reduced
• number of neurons expressing somatostatin is reduced

behavior/neurological
• poorer performance in a Morris water maze
• after 6 days of training, swim a greater distance to find target than do controls


Mouse Genome Informatics
hm2
    Lrpap1tm1Her/Lrpap1tm1Her
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• alpha2 macroglobulin is removed from the circulation at about 25% of the normal rate
• no effect is seen on blood lipoproteins regardless of diet
• homozygotes thrived well and are superficially normal

other phenotype
• reduces expression of lipoprotein receptor related protein by 75% but has no effect on the LDL receptor


Mouse Genome Informatics
cx3
    Lrp1btm1Her/Lrp1btm1Her
Lrpap1tm1Her/Lrpap1tm1Her

involves: 129S/SvEv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• homozygous mutants appear normal and have normal brain physiology


Mouse Genome Informatics
cx4
    Lrpap1tm1Her/Lrpap1tm1Her
Tg(APPV717F)109Ili/0

involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• develop reactive astrocytosis
• elevated amyloid deposits over controls

other phenotype
• elevated amyloid deposits over controls


Mouse Genome Informatics
cx5
    Ldlrtm1Her/Ldlrtm1Her
Lrpap1tm1Her/Lrpap1tm1Her

involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• chylomicron reminent and LDL levels increased in blood
• 2 fold increase in total plasma cholesterol
• moderately increased plasma triglyceride levels