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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ldlrtm1Her
targeted mutation 1, Joachim Herz
MGI:1857212
Summary 95 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ldlrtm1Her/Ldlrtm1Her B6.129S7-Ldlrtm1Her MGI:3772339
hm2
Ldlrtm1Her/Ldlrtm1Her B6.129S7-Ldlrtm1Her/J MGI:3783837
hm3
Ldlrtm1Her/Ldlrtm1Her involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA MGI:4358710
hm4
Ldlrtm1Her/Ldlrtm1Her involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3719025
hm5
Ldlrtm1Her/Ldlrtm1Her involves: 129S7/SvEvBrd MGI:3691620
hm6
Ldlrtm1Her/Ldlrtm1Her involves: 129S7/SvEvBrd * C57BL/6 MGI:3611043
hm7
Ldlrtm1Her/Ldlrtm1Her involves: 129S7/SvEvBrd * C57BL/6J MGI:5661850
hm8
Ldlrtm1Her/Ldlrtm1Her involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:4367202
ht9
Ldlrtm1Her/Ldlr+ B6.129S7-Ldlrtm1Her MGI:4443062
ht10
Ldlrtm1Her/Ldlr+ involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3798392
cn11
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:4943551
cn12
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:4943737
cn13
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4943738
cn14
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
involves: 129S7/SvEvBrd MGI:4943555
cn15
Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tek-cre)12Flv/0
involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6N MGI:4946112
cn16
Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL MGI:4946109
cn17
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL MGI:3797226
cn18
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL MGI:4943557
cn19
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL MGI:4943553
cn20
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Vldlrtm1Her/Vldlrtm1Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:3797223
cn21
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:3797225
cn22
Ldlrtm1Her/Ldlrtm1Her
Nr1h3tm1.1Djm/Nr1h3tm1.1Djm
Tg(Alb-cre)21Mgn/0
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA MGI:5427004
cn23
Ldlrtm1Her/Ldlrtm1Her
Nr5a2tm2Sjns/Nr5a2tm2Sjns
Tg(Alb-cre)21Mgn/0
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA MGI:5607406
cx24
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
B6.129-Apobec1tm1Ddsn Ldlrtm1Her MGI:4367102
cx25
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Fggtm1Fjc/Fggtm1Fjc
Ldlrtm1Her/Ldlrtm1Her
B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her MGI:4367109
cx26
Agtr1atm1Unc/Agtr1atm1Unc
Ldlrtm1Her/Ldlrtm1Her
B6.129-Ldlrtm1Her Agtr1atm1Unc MGI:4946113
cx27
Apoa1tm1Unc/Apoa1tm1Unc
Ldlrtm1Her/Ldlrtm1Her
B6.129-Ldlrtm1Her Apoa1tm1Unc MGI:3783838
cx28
Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
B6.129-Ldlrtm1Her Gpr132tm1Witt MGI:3639678
cx29
Ldlrtm1Her/Ldlrtm1Her
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
B6.129-Ldlrtm1Her Tcra-Jtm1Tgi MGI:4839086
cx30
Ifngtm1Ts/Ifngtm1Ts
Ldlrtm1Her/Ldlrtm1Her
B6.129S7-Ldlrtm1Her Ifngtm1Ts MGI:4867042
cx31
Cd1d1tm1Luc/Cd1d1tm1Luc
Ldlrtm1Her/Ldlrtm1Her
B6.129S-Cd1d1tm1Luc Ldlrtm1Her MGI:4821420
cx32
Ctsstm1Hap/Ctsstm1Hap
Ldlrtm1Her/Ldlrtm1Her
B6.129S-Ctsstm1Hap Ldlrtm1Her MGI:5008733
cx33
Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc
Ldlrtm1Her/Ldlrtm1Her
B6.129S-Ldlrtm1Her Del(11Cxcl16-Zmynd15)1Ifc MGI:3721540
cx34
Ldlrtm1Her/Ldlrtm1Her
Pfn1tm1Wit/Pfn1+
B6.129S-Ldlrtm1Her Pfn1tm1Wit MGI:4367099
cx35
Ldlrtm1Her/Ldlrtm1Her
Serpine1tm1Mlg/Serpine1tm1Mlg
B6.129S-Serpine1tm1Mlg Ldlrtm1Her MGI:3811068
cx36
Ldlrtm1Her/Ldlrtm1Her
Vwftm1Wgr/Vwftm1Wgr
B6.129S-Vwftm1Wgr Ldlrtm1Her MGI:4834596
cx37
Ldlrtm1Her/Ldlrtm1Her
Tlr2tm1Kir/Tlr2tm1Kir
B6.129-Tlr2tm1Kir Ldlrtm1Her MGI:5428446
cx38
Ldlrtm1Her/Ldlrtm1Her
Mobq5CAST/Ei/Mobq5CAST/Ei
B6.CAST-Mobq5CAST/Ei MGI:3711207
cx39
Ldlrtm1Her/Ldlrtm1Her
Mobq6CAST/Ei/Mobq6CAST/Ei
B6.CAST-Mobq6CAST/Ei MGI:3711214
cx40
Crptm1Hjf/Crptm1Hjf
Ldlrtm1Her/Ldlrtm1Her
B6.Cg-Crptm1Hjf Ldlrtm1Her MGI:4947401
cx41
Ins2Akita/Ins2Akita
Ldlrtm1Her/Ldlrtm1Her
B6.Cg-Ins2Akita Ldlrtm1Her MGI:5286555
cx42
Ldlrtm1Her/Ldlrtm1Her
Scd1ab-2J/Scd1ab-2J
B6.Cg-Ldlrtm1Her Scd1ab-2J MGI:3794980
cx43
Ldlrtm1Her/Ldlrtm1Her
Scd1ab-J/Scd1ab-J
B6.Cg-Ldlrtm1Her Scd1ab-J MGI:3794981
cx44
Ldlrtm1Her/Ldlrtm1Her
Tg(CMV-Serpine1)1Dgi/0
B6.Cg-Ldlrtm1Her Tg(CMV-Serpine1)1Dgi MGI:3810981
cx45
Ldlrtm1Her/Ldlr+
Lepob/Lepob
B6.Cg-Lepob Ldlrtm1Her MGI:3622658
cx46
Ldlrtm1Her/Ldlrtm1Her
Lepob/Lepob
B6.Cg-Lepob Ldlrtm1Her MGI:3622656
cx47
Apoetm1Unc/Apoetm1Unc
Ldlrtm1Her/Ldlrtm1Her
involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:4367224
cx48
Ldlrtm1Her/Ldlrtm1Her
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4367112
cx49
Ldlrtm1Her/Ldlrtm1Her
Lipctm1Unc/Lipctm1Unc
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4367222
cx50
Lcattm1Hgc/Lcattm1Hgc
Ldlrtm1Her/Ldlrtm1Her
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA MGI:4358708
cx51
Apoetm1Unc/Apoetm1Unc
Ldlrtm1Her/Ldlrtm1Her
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:3789482
cx52
Ldlrtm1Her/Ldlrtm1Her
Pcsk9tm1.2Prat/Pcsk9tm1.2Prat
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:4943544
cx53
Ddr1tm1Wfv/Ddr1tm1Wfv
Ldlrtm1Her/Ldlrtm1Her
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:4367117
cx54
Cxcl1tm1Wabo/Cxcl1tm1Wabo
Ldlrtm1Her/Ldlrtm1Her
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3629493
cx55
Esr1tm1.1Mma/Esr1tm1.1Mma
Ldlrtm1Her/Ldlrtm1Her
involves: 129S2/SvPas * 129S7/SvEvBrd MGI:3833895
cx56
Itgb3tm1Hyn/Itgb3tm1Hyn
Ldlrtm1Her/Ldlrtm1Her
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4439281
cx57
Alox15tm1Fun/Alox15tm1Fun
Ldlrtm1Her/Ldlrtm1Her
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4367211
cx58
Apobec1tm1Chan/Apobec1tm1Chan
Ldlrtm1Her/Ldlrtm1Her
involves: 129S4/SvJae * 129S7/SvEvBrd MGI:3850551
cx59
Icam1tm1Jcgr/Icam1tm1Jcgr
Ldlrtm1Her/Ldlrtm1Her
involves: 129S4/SvJae * 129S7/SvEvBrd MGI:3620575
cx60
Ccl2tm1Rol/Ccl2tm1Rol
Ldlrtm1Her/Ldlrtm1Her
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:4418562
cx61
Ldlrtm1Her/Ldlrtm1Her
Vcam1tm1Dmil/Vcam1tm1Dmil
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3620572
cx62
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:4367101
cx63
Icam1tm1Jcgr/Icam1tm1Jcgr
Ldlrtm1Her/Ldlrtm1Her
Vcam1tm1Dmil/Vcam1tm1Dmil
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3620574
cx64
Ldlrtm1Her/Ldlrtm1Her
Pparatm1Gonz/Pparatm1Gonz
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:4367223
cx65
Ldlrtm1Her/Ldlrtm1Her
Soat1tm1Far/Soat1tm1Far
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3761833
cx66
Ldlrtm1Her/Ldlrtm1Her
Scarb1tm1Dhu/Scarb1tm1Dhu
involves: 129S4/SvJae * BALB/c * C57BL/6J MGI:3623224
cx67
Angptl3tm1Lex/Angptl3tm1Lex
Ldlrtm1Her/Ldlrtm1Her
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:3849585
cx68
Ldlrtm1Her/Ldlrtm1Her
Tbx21tm1Glm/Tbx21tm1Glm
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3719026
cx69
Esr1tm1Arnal/Esr1tm1Arnal
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd MGI:3833896
cx70
Ldlrtm1Her/Ldlrtm1Her
Olr1tm1Meht/Olr1tm1Meht
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3772340
cx71
Ldlrtm1Her/Ldlrtm1Her
Npc1m1N/Npc1m1N
involves: 129S7/SvEvBrd * BALB/c MGI:3785901
cx72
Ldlrtm1Her/Ldlrtm1Her
Npc1m1N/Npc1m1N
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:4367225
cx73
Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd * C57BL/6 MGI:4367110
cx74
Soat1tm1Ishi/Soat1tm1Ishi
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd * C57BL/6 MGI:3582203
cx75
Asgr2tm1Her/Asgr2tm1Her
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd * C57BL/6 MGI:3511248
cx76
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd * C57BL/6 MGI:3797227
cx77
Ldlrtm1Her/Ldlrtm1Her
Tg(APOC1)1Lmh/?
involves: 129S7/SvEvBrd * C57BL/6 MGI:3764683
cx78
Ldlrtm1Her/Ldlrtm1Her
Tg(APOM)NCchr/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA MGI:3772662
cx79
Ldlrtm1Her/Ldlrtm1Her
Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3574185
cx80
Ldlrtm1Her/Ldlr+
Tg(H2-K-AKR1B1)1Tj/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3798393
cx81
Ldlrtm1Her/Ldlrtm1Her
Tg(H2-K-AKR1B1)1Tj/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:3798391
cx82
Ldlrtm1Her/Ldlrtm1Her
Lipetm1Ishi/Lipetm1Ishi
Nceh1tm1Ishi/Nceh1tm1Ishi
involves: 129S7/SvEvBrd * C57BL/6J MGI:4359435
cx83
Ldlrtm1Her/Ldlrtm1Her
Lrpap1tm1Her/Lrpap1tm1Her
involves: 129S7/SvEvBrd * C57BL/6J MGI:3581865
cx84
Ldlrtm1Her/Ldlrtm1Her
Nceh1tm1Ishi/Nceh1tm1Ishi
involves: 129S7/SvEvBrd * C57BL/6J MGI:4359432
cx85
Ldlrtm1Her/Ldlrtm1Her
Lipetm1Ishi/Lipetm1Ishi
involves: 129S7/SvEvBrd * C57BL/6J MGI:4359433
cx86
Ldlrtm1Her/Ldlrtm1Her
Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N MGI:5607410
cx87
Ldlrtm1Her/Ldlrtm1Her
Tg(APOC3)3707Bres/?
Tg(Mt1-CETP)#Tall/?
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:4941579
cx88
Ldlrtm1Her/Ldlrtm1Her
Tg(APOC3)3707Bres/?
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:4367083
cx89
Apobtm2Sgy/Apobtm2Sgy
Ldlrtm1Her/Ldlrtm1Her
Tg(Ins-Igf2)1Fbos/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:4367111
cx90
Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:4367205
cx91
Ldlrtm1Her/Ldlrtm1Her
Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3847958
cx92
Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Ldlrtm1Her/Ldlrtm1Her
involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J MGI:3527874
cx93
Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Ldlrtm1Her/Ldlr+
involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J MGI:3527876
cx94
Ath38CAST/Ei/Ath38CAST/Ei
Ldlrtm1Her/Ldlrtm1Her
involves: CAST/Ei * C57BL/6J MGI:3639881
cx95
Ath37CAST/Ei/Ath37CAST/Ei
Ldlrtm1Her/Ldlrtm1Her
involves: CAST/Ei * C57BL/6J MGI:3639879


Genotype
MGI:3772339
hm1
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S7-Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Adiposity in Ldlrtm1Her/Ldlrtm1Her and Scd1ab-2J/Scd1ab-2J Ldlrtm1Her/Ldlrtm1Her mice

homeostasis/metabolism
• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet (J:100916)
• these high glucose levels persist for at least 12 weeks after STZ treatment (J:100916)
• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet (J:100916)
• these high glucose levels persist for at least 12 weeks after STZ treatment (J:100916)
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• streptozotocin (STZ) induced diabetes leads to blood cholesterol levels that are twice those of non-diabetic mice 6 weeks post-induction and three times greater 8 weeks post- induction (J:100916)
• streptozotocin (STZ) induced diabetes leads to blood cholesterol levels that are twice those of non-diabetic mice 6 weeks post-induction and three times greater 8 weeks post- induction (J:100916)
• when fed a western style diet for 12 weeks, male mice exhibit a higher circulating cholesterol level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice exhibit a higher circulating cholesterol level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• when fed a high-cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for HDL of 0.77 compared to 0.83 in wild-type mice (J:130794)
• when fed a high-cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for HDL of 0.77 compared to 0.83 in wild-type mice (J:130794)
• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks) (J:61287)
• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks) (J:61287)
• seen at 3-4 months of age (J:72027)
• seen at 3-4 months of age (J:72027)
• 10 fold increase in total cholesterol on a high fat diet compared to a 150% increase for controls (J:137264)
• 3 fold cholesterol elevation on a normal diet relative to controls (J:137264)
• 10 fold increase in total cholesterol on a high fat diet compared to a 150% increase for controls (J:137264)
• 3 fold cholesterol elevation on a normal diet relative to controls (J:137264)
• slightly elevated at 3 and 8 months of age (J:72027)
• slightly elevated at 3 and 8 months of age (J:72027)
• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for LDL of 0.88 compared to 0.84 in wild-type mice (J:130794)
• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for LDL of 0.88 compared to 0.84 in wild-type mice (J:130794)
• compared to in Ldlrtm1Her Scd1ab-2J homozygotes when fed a western style diet for 12 weeks (J:130278)
• compared to in Ldlrtm1Her Scd1ab-2J homozygotes when fed a western style diet for 12 weeks (J:130278)
• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for VLDL of 0.92 compared to 0.88 in wild-type mice (J:130794)
• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for VLDL of 0.92 compared to 0.88 in wild-type mice (J:130794)
• increased TNFalpha levels (J:137264)
• increased TNFalpha levels (J:137264)
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• seen at 3-4 months of age (J:72027)
• seen at 3-4 months of age (J:72027)
• when fed a western style diet for 12 weeks, female mice exhibit a higher circulating triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a higher circulating triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• elevated on a high fat diet (J:137264)
• elevated on a high fat diet (J:137264)
• compared to in Ldlrtm1Her Scd1ab-2J homozygotes when fed a western style diet for 12 weeks (J:130278)
• compared to in Ldlrtm1Her Scd1ab-2J homozygotes when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• increased amyloid beta 40 but not amyloid beta 42 on a high fat diet (J:137264)
• increased amyloid beta 40 but not amyloid beta 42 on a high fat diet (J:137264)

adipose tissue
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• increased when fed a western style diet for 12 weeks (J:130278)
• increased when fed a western style diet for 12 weeks (J:130278)

growth/size/body
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• lower body weight on a low cholesterol diet than controls on any diet (J:135078)
• lower body weight on a low cholesterol diet than controls on any diet (J:135078)
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)

cardiovascular system
• high-fat diet leads to atherosclerosis (J:100916)
• STZ-induced diabetes leads to an almost 3-fold greater size in total lesion area in the aorta compared to non-diabetic Ldlr tm1Her homozyogotes (J:100916)
• high-fat diet leads to atherosclerosis (J:100916)
• STZ-induced diabetes leads to an almost 3-fold greater size in total lesion area in the aorta compared to non-diabetic Ldlr tm1Her homozyogotes (J:100916)
• 4 weeks on the Western diet mice have lesions of small fatty streaks on the aorta (J:110061)
• 4 weeks on the Western diet mice have lesions of small fatty streaks on the aorta (J:110061)
• after 12 weeks on a high cholesterol diet, mice exhibit extensive intimal thickening and 60% to 80% of the aortic surface is sudanophilic unlike in wild-type mice (J:130794)
• after 12 weeks on a high cholesterol diet, mice exhibit endothelial disruption and an accumulation of macrophage and foam cells at the site of atherosclerotic plaques (J:130794)
• after 12 weeks on a high cholesterol diet, mice exhibit extensive intimal thickening and 60% to 80% of the aortic surface is sudanophilic unlike in wild-type mice (J:130794)
• after 12 weeks on a high cholesterol diet, mice exhibit endothelial disruption and an accumulation of macrophage and foam cells at the site of atherosclerotic plaques (J:130794)

immune system
• increased number of microglia in the hippocampus (J:137264)
• increased number of microglia in the hippocampus (J:137264)
• increased TNFalpha levels (J:137264)
• increased TNFalpha levels (J:137264)

liver/biliary system
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlrtm1Her Scd1ab-2J homozygotes (J:130278)
• when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks (J:130278)

behavior/neurological
• take longer to reach the target site in a Morris water maze when fed a high cholesterol diet (J:135078)
• take longer to reach the target site in a Morris water maze when fed a high cholesterol diet (J:135078)
• deficient performance in a water radial arm maze regardless of the diet (J:137264)
• deficient performance in a water radial arm maze regardless of the diet (J:137264)
• perform better than controls on a hanging bar test (J:135078)
• perform better than controls on a hanging bar test (J:135078)
• travel greater distances and spend more time in motion in an open field test (J:135078)
• travel greater distances and spend more time in motion in an open field test (J:135078)

nervous system
• increased amyloid beta 40 but not amyloid beta 42 on a high fat diet (J:137264)
• increased amyloid beta 40 but not amyloid beta 42 on a high fat diet (J:137264)
• increased number of microglia in the hippocampus (J:137264)
• increased number of microglia in the hippocampus (J:137264)
• increased numbers of reactive astrocytes (J:137264)
• further increase in reactive astrocytes on a high fat diet (J:137264)
• increased numbers of reactive astrocytes (J:137264)
• further increase in reactive astrocytes on a high fat diet (J:137264)

hematopoietic system
• increased number of microglia in the hippocampus (J:137264)
• increased number of microglia in the hippocampus (J:137264)




Genotype
MGI:3783837
hm2
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S7-Ldlrtm1Her/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice fed a Western diet exhibit normal HDL cholesterol (J:149005)
• mice fed a Western diet exhibit normal HDL cholesterol (J:149005)
• when fed regular chow or a high fat diet for 16 weeks, serum triglyceride levels are decreased compared to similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed regular chow or a high fat diet for 16 weeks, serum triglyceride levels are decreased compared to similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed a Western diet (J:149005)
• when fed a Western diet (J:149005)
• when fed a high fat diet, mice exhibit an increase in cholesterol content in the adrenal gland (J:85174)
• when fed a high fat diet, mice exhibit an increase in cholesterol content in the adrenal gland (J:85174)
• whether are fed a high fat diet or regular chow, plasma cholesterol levels are increased relative to similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlrtm1Her homozygotes (3-fold) (J:85174)
• whether are fed a high fat diet or regular chow, plasma cholesterol levels are increased relative to similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlrtm1Her homozygotes (3-fold) (J:85174)
• 15 fold higher on a normal diet than controls (J:104609)
• 40 fold higher than controls on a high fat diet (J:104609)
• 15 fold higher on a normal diet than controls (J:104609)
• 40 fold higher than controls on a high fat diet (J:104609)
• when fed regular chow or a high fat diet for 16 weeks, serum HDL levels are increased compared to similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed regular chow or a high fat diet for 16 weeks, serum HDL levels are increased compared to similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlrtm1Her homozygotes (3-fold) (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlrtm1Her homozygotes (3-fold) (J:85174)
• when fed a Western diet compared to Ldlrtm1Her homozygotes fed regular chow (J:149005)
• when fed a Western diet compared to Ldlrtm1Her homozygotes fed regular chow (J:149005)
• when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlrtm1Her homozygotes (3-fold) (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlrtm1Her homozygotes (3-fold) (J:85174)
• when fed a Western diet (J:149005)
• when fed a Western diet (J:149005)
• when fed a high fat diet, mice exhibit a greater increase in liver cholesterol content (11-fold) compared to in similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (2.5-fold) (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in liver cholesterol content (11-fold) compared to in similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (2.5-fold) (J:85174)

liver/biliary system
• when fed a high fat diet, mice exhibit a greater increase in liver cholesterol content (11-fold) compared to in similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (2.5-fold) (J:85174)
• when fed a high fat diet, mice exhibit a greater increase in liver cholesterol content (11-fold) compared to in similarly treated Apoa1tm1Unc Ldlrtm1Her homozygotes (2.5-fold) (J:85174)
• when fed a high fat diet, mice exhibit larger diameter and more frequent lipid droplets than in Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit larger diameter and more frequent lipid droplets than in Apoa1tm1Unc Ldlrtm1Her homozygotes (J:85174)
• LDL updake is decreased by about 2X (J:106146)
• LDL updake is decreased by about 2X (J:106146)

endocrine/exocrine glands
• when fed a high fat diet, mice exhibit an increase in cholesterol content in the adrenal gland (J:85174)
• when fed a high fat diet, mice exhibit an increase in cholesterol content in the adrenal gland (J:85174)

cardiovascular system
• after 8 or 20 weeks on a cholesterol diet aortic lesion size is increased compared to mice that are homozygous for both Ldlrtm1Her and Ifngtm1Ts (J:103072)
• after 8 or 20 weeks on a cholesterol diet aortic lesion size is increased compared to mice that are homozygous for both Ldlrtm1Her and Ifngtm1Ts (J:103072)

integument
• when fed a high fat diet (J:85174)
• when fed a high fat diet (J:85174)
• when fed a high fat diet (J:85174)
• when fed a high fat diet (J:85174)
• when fed a high fat diet (J:85174)
• when fed a high fat diet (J:85174)




Genotype
MGI:4358710
hm3
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increase in APOB-100 (J:75567)
• increase in APOB-100 (J:75567)
• the HDL phospholipid fraction contains less 16:0 and 18:0 species and is enriched for 20:4 and 22:6 species compared to Apoetm1Unc single mutants (J:75567)
• the HDL phospholipid fraction contains less 16:0 and 18:0 species and is enriched for 20:4 and 22:6 species compared to Apoetm1Unc single mutants (J:75567)
• plasma cholesterol is nearly equal distribution between the HDL and LDL fractions (J:75567)
• increase in the APOB lipoprotein cholesterol level compared to wild-type controls (J:75567)
• there is a 2.3 fold decrease in the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species compared to Apoetm1Unc single mutants (J:75567)
• the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species in the LDL fraction is significantly decreased compared to Apoetm1Unc single mutants (J:75567)
• plasma cholesterol is nearly equal distribution between the HDL and LDL fractions (J:75567)
• increase in the APOB lipoprotein cholesterol level compared to wild-type controls (J:75567)
• there is a 2.3 fold decrease in the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species compared to Apoetm1Unc single mutants (J:75567)
• the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species in the LDL fraction is significantly decreased compared to Apoetm1Unc single mutants (J:75567)




Genotype
MGI:3719025
hm4
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Phenotype of aortic arch atherosclerotic lesions in Tbx21tm1Glm/Tbx21tm1Glm Ldlrtm1Her/Ldlrtm1Her and Ldlrtm1Her/Ldlrtm1Her mice

cardiovascular system
• atherosclerosis in both aortic arch and descending aorta (J:96110)
• atherosclerosis in both aortic arch and descending aorta (J:96110)

homeostasis/metabolism
• hypercholesterolemic (J:96110)
• hypercholesterolemic (J:96110)




Genotype
MGI:3691620
hm5
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• circulating VLDL/LDL cholesterol levels are increased compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)
• circulating VLDL/LDL cholesterol levels are increased compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)
• LDL clearance is slowed (J:84694)
• LDL clearance is slowed (J:84694)
• when fed a chow diet or Western-type diet for 2 and 4 weeks, mice exhibit increased serum cholesterol levels compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)
• when fed a chow diet or Western-type diet for 2 and 4 weeks, mice exhibit increased serum cholesterol levels compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)
• plasma cholesterol level is 196mg/dl on a normal diet (J:84694)
• plasma cholesterol level is 196mg/dl on a normal diet (J:84694)
• on a chow diet, plasma LDL levels were higher than both those of wild-type mice and Ldlrap1tm1Her homozygous mutant mice (J:84694)
• plasma LDL levels become further elevated on high cholesterol diets (J:84694)
• on a chow diet, plasma LDL levels were higher than both those of wild-type mice and Ldlrap1tm1Her homozygous mutant mice (J:84694)
• plasma LDL levels become further elevated on high cholesterol diets (J:84694)
• male mice have a marked increase in plasma LDL cholesterol compared to wild-type (J:114949)
• in wild-type mice parabiosed with Ldlr-null mice (resulting in shared circulation), plasma total cholesterol levels did not increase significantly over pre-surgery levels (J:114949)
• male mice have a marked increase in plasma LDL cholesterol compared to wild-type (J:114949)
• in wild-type mice parabiosed with Ldlr-null mice (resulting in shared circulation), plasma total cholesterol levels did not increase significantly over pre-surgery levels (J:114949)
• plasma levels are increased 2.5 fold relative to controls (J:169834)
• plasma levels are increased 2.5 fold relative to controls (J:169834)
• when fed a chow diet or a Western-type diet for 2 and 4 weeks, mice exhibit increased serum triglyceride levels compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)
• when fed a chow diet or a Western-type diet for 2 and 4 weeks, mice exhibit increased serum triglyceride levels compared to in Apobec1tm1Chan homozygotes and wild-type mice (J:48202)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypercholesterolemia, Familial 143890 J:84694




Genotype
MGI:3611043
hm6
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice fed a diabetogenic high fat diet (35.5% carbohydrate and 36.6% fat) (DD diet) or a a diabetogenic high fat diet (35.5% carbohydrate and 36.6% fat) with 0.15% added cholesterol (DDC diet) exhibit weight gain leading to obesity; similar weight gain is seen regardless of diet (J:175559)
• mice fed a diabetogenic high fat diet (35.5% carbohydrate and 36.6% fat) (DD diet) or a a diabetogenic high fat diet (35.5% carbohydrate and 36.6% fat) with 0.15% added cholesterol (DDC diet) exhibit weight gain leading to obesity; similar weight gain is seen regardless of diet (J:175559)

homeostasis/metabolism
• mothers on a high fat diet have reduced plasma concentrations of phenylalanine, lysine, valine, isoleucine, and leucine (J:146932)
• levels of other amino acids are normal (J:146932)
• mothers on a high fat diet have reduced plasma concentrations of phenylalanine, lysine, valine, isoleucine, and leucine (J:146932)
• levels of other amino acids are normal (J:146932)
• levels in response to ACTH are significantly reduced (J:108412)
• levels in response to ACTH are significantly reduced (J:108412)
• similar levels of hypercholesterolemia are seen in mice fed the DD diet and those fed the DDC diet (J:175559)
• similar levels of hypercholesterolemia are seen in mice fed the DD diet and those fed the DDC diet (J:175559)
• clearance of 125I-LDL from circulation is retarded, uptake of DiI-LDL by hepatocytes is decreased, and uptake of 3H-CE-LDL by the liver is lower compared to wild-type (J:102291)
• clearance of 125I-LDL from circulation is retarded, uptake of DiI-LDL by hepatocytes is decreased, and uptake of 3H-CE-LDL by the liver is lower compared to wild-type (J:102291)
• circulating fatty free acids are increased in mice fed the DD or the DDC diet, however levels are higher in the mice on the DDC diet (J:175559)
• circulating fatty free acids are increased in mice fed the DD or the DDC diet, however levels are higher in the mice on the DDC diet (J:175559)
• similar levels of hypertriglyceridemia are seen in mice fed the DD diet and those fed the DDC diet (J:175559)
• similar levels of hypertriglyceridemia are seen in mice fed the DD diet and those fed the DDC diet (J:175559)
• ALT levels are increased in mice fed the DD diet and even more so in those fed the DDC diet (J:175559)
• ALT levels are increased in mice fed the DD diet and even more so in those fed the DDC diet (J:175559)
• increased fasting glucose levels after dexamethasone treatment (J:84844)
• increased fasting glucose levels after dexamethasone treatment (J:84844)
• after dexamethasone treatment (J:84844)
• after dexamethasone treatment (J:84844)
• glucose levels increase during a glucose tolerance test (J:84844)
• 30 minute insulin levels elevated (J:84844)
• glucose levels increase during a glucose tolerance test (J:84844)
• 30 minute insulin levels elevated (J:84844)
• less likely to become hypoglycemic during an insulin tolerance test (J:84844)
• less likely to become hypoglycemic during an insulin tolerance test (J:84844)
• hepatic cholesterol levels are increased only in the mice fed the DDC diet (J:175559)
• hepatic cholesterol levels are increased only in the mice fed the DDC diet (J:175559)
• hepatic triglyceride levels are increased in mice fed the DD or the DDC diet, but higher in those on the DDC diet (J:175559)
• hepatic triglyceride levels are increased in mice fed the DD or the DDC diet, but higher in those on the DDC diet (J:175559)

nervous system
• on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina (J:116493)
• 2X as many arterioles have microglia (J:116493)
• on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina (J:116493)
• 2X as many arterioles have microglia (J:116493)
• reduced cell proliferation in the hippocampus (J:127270)
• reduced cell proliferation in the hippocampus (J:127270)
• reduced density of synaptophysin-immunoreactive presynaptic boutons in the CA1 of the hippocampus (J:120389)
• normal density of synaptophysin-immunoreactive presynaptic boutons in the dentate gyrus (J:120389)
• reduced density of synaptophysin-immunoreactive presynaptic boutons in the CA1 of the hippocampus (J:120389)
• normal density of synaptophysin-immunoreactive presynaptic boutons in the dentate gyrus (J:120389)
• mild degeneration (J:132498)
• mild degeneration (J:132498)
• 32% of the cholesterol in the synaptic plasma membrane is in the exofacial leaflet as compared to 15% for controls (J:43043)
• cholesterol levels in the cytofacial leaflet are reduced (J:43043)
• cholesterol/phospholipid ratio in the synaptic plasma membrane is elevated (J:43043)
• fluidity of both the exofacial leaflet and the cytofacial leaflet of the synaptic plasma membrane are increased relative to controls (J:43043)
• 32% of the cholesterol in the synaptic plasma membrane is in the exofacial leaflet as compared to 15% for controls (J:43043)
• cholesterol levels in the cytofacial leaflet are reduced (J:43043)
• cholesterol/phospholipid ratio in the synaptic plasma membrane is elevated (J:43043)
• fluidity of both the exofacial leaflet and the cytofacial leaflet of the synaptic plasma membrane are increased relative to controls (J:43043)

cardiovascular system
• wall thickness of brain arterioles having a lumen diameter of 15-40 um is greater than controls (J:116493)
• wall thickness increases on a Western diet (J:116493)
• wall thickness is directly related to the number of associated microglia (J:116493)
• wall thickness of brain arterioles having a lumen diameter of 15-40 um is greater than controls (J:116493)
• wall thickness increases on a Western diet (J:116493)
• wall thickness is directly related to the number of associated microglia (J:116493)
• thickened endothelial basal lamina (J:132498)
• reduced number of fenestrations (J:132498)
• narrowing of lumina (J:132498)
• thickened endothelial basal lamina (J:132498)
• reduced number of fenestrations (J:132498)
• narrowing of lumina (J:132498)

behavior/neurological
• mice on a Western diet fail to show improved performance over time in a Morris water maze test (J:116493)
• mice on a Western diet fail to show improved performance over time in a Morris water maze test (J:116493)
• somewhat slower swimming speed in the acquisition phase of a Morris water maze test (J:120389)
• less time spent in the target quadrant during a probe test (J:120389)
• somewhat slower swimming speed in the acquisition phase of a Morris water maze test (J:120389)
• less time spent in the target quadrant during a probe test (J:120389)
• mice fed a Western diet and tested in a T-maze demonstrate reduced alternation returning more frequently to the blind arm of the maze (J:116493)
• mice fed a Western diet and tested in a T-maze demonstrate reduced alternation returning more frequently to the blind arm of the maze (J:116493)

vision/eye
• thickened endothelial basal lamina (J:132498)
• reduced number of fenestrations (J:132498)
• narrowing of lumina (J:132498)
• thickened endothelial basal lamina (J:132498)
• reduced number of fenestrations (J:132498)
• narrowing of lumina (J:132498)
• mild degeneration (J:132498)
• mild degeneration (J:132498)
• decreased and irregular height (J:132498)
• basal membrane infoldings are less regular (J:132498)
• numerous vacuoles in cytoplasm (J:132498)
• decreased and irregular height (J:132498)
• basal membrane infoldings are less regular (J:132498)
• numerous vacuoles in cytoplasm (J:132498)
• thickened (up to 0.8um on a high fat diet) (J:132498)
• enhanced condensation of collagenous and elastic fibers (J:132498)
• laminations disrupted and large vacuoles become diffusely distributed (J:132498)
• thickened (up to 0.8um on a high fat diet) (J:132498)
• enhanced condensation of collagenous and elastic fibers (J:132498)
• laminations disrupted and large vacuoles become diffusely distributed (J:132498)

other phenotype
• poor survival of pups from mothers on a high fat diet (J:146932)
• intrauterine growth restriction of pups from mothers on a high fat diet (J:146932)
• also reduced birth weight persisting to at least 90 days of age (J:146932)
• offspring with lower gonadal fat pad to body weight ratio (J:146932)
• offspring with larger atherosclerotic lesions (J:146932)
• poor survival of pups from mothers on a high fat diet (J:146932)
• intrauterine growth restriction of pups from mothers on a high fat diet (J:146932)
• also reduced birth weight persisting to at least 90 days of age (J:146932)
• offspring with lower gonadal fat pad to body weight ratio (J:146932)
• offspring with larger atherosclerotic lesions (J:146932)

hematopoietic system
• on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina (J:116493)
• 2X as many arterioles have microglia (J:116493)
• on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina (J:116493)
• 2X as many arterioles have microglia (J:116493)

immune system
• on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina (J:116493)
• 2X as many arterioles have microglia (J:116493)
• on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina (J:116493)
• 2X as many arterioles have microglia (J:116493)
• inflammatory cell foci is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet (J:175559)
• inflammatory cell foci is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet (J:175559)

pigmentation
• decreased and irregular height (J:132498)
• basal membrane infoldings are less regular (J:132498)
• numerous vacuoles in cytoplasm (J:132498)
• decreased and irregular height (J:132498)
• basal membrane infoldings are less regular (J:132498)
• numerous vacuoles in cytoplasm (J:132498)

cellular
• DD diet fed mice show some apoptotic cells in the liver while those on the DDC diet have a larger increase (J:175559)
• DD diet fed mice show some apoptotic cells in the liver while those on the DDC diet have a larger increase (J:175559)
• mice on the DDC diet exhibit an increase in hepatic oxidative stress (J:175559)
• mice on the DDC diet exhibit an increase in hepatic oxidative stress (J:175559)

liver/biliary system
• DD diet fed mice show some apoptotic cells in the liver while those on the DDC diet have a larger increase (J:175559)
• DD diet fed mice show some apoptotic cells in the liver while those on the DDC diet have a larger increase (J:175559)
• hepatic cholesterol levels are increased only in the mice fed the DDC diet (J:175559)
• hepatic cholesterol levels are increased only in the mice fed the DDC diet (J:175559)
• hepatic triglyceride levels are increased in mice fed the DD or the DDC diet, but higher in those on the DDC diet (J:175559)
• hepatic triglyceride levels are increased in mice fed the DD or the DDC diet, but higher in those on the DDC diet (J:175559)
• inflammatory cell foci is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet (J:175559)
• inflammatory cell foci is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet (J:175559)
• mice on the DD diet and on the DDC diet exhibit higher liver weights than regular chow-fed mice (J:175559)
• mice on the DD diet and on the DDC diet exhibit higher liver weights than regular chow-fed mice (J:175559)
• mice fed the DD diet exhibit diffuse macrovesicular steatosis with limited inflammation and fibrosis in the liver (J:175559)
• mice fed the DDC diet exhibit both macrovesicular and microvesicular steatosis in the liver (J:175559)
• mice fed the DD diet exhibit diffuse macrovesicular steatosis with limited inflammation and fibrosis in the liver (J:175559)
• mice fed the DDC diet exhibit both macrovesicular and microvesicular steatosis in the liver (J:175559)
• intrasinusoidal and pericellular fibrosis is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet (J:175559)
• intrasinusoidal and pericellular fibrosis is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet (J:175559)




Genotype
MGI:5661850
hm7
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice fed a cholate-free high-cholesterol diet (1%) for 6 months develop more extensive lesions throughout the aorta compared to controls which show smaller lesions that are almost exclusively in the aortic origin; the extent of atherosclerosis in the entire aorta correlates with the size of lesions in the aortic origin (J:29950)
• males show more aortic atherosclerosis than females, both in the arch and in the thoracic and abdominal aorta, whereas the average plasma cholesterol levels are similar in males and females (J:29950)
• mice fed a cholate-free high-cholesterol diet (1%) for 6 months develop more extensive lesions throughout the aorta compared to controls which show smaller lesions that are almost exclusively in the aortic origin; the extent of atherosclerosis in the entire aorta correlates with the size of lesions in the aortic origin (J:29950)
• males show more aortic atherosclerosis than females, both in the arch and in the thoracic and abdominal aorta, whereas the average plasma cholesterol levels are similar in males and females (J:29950)
• when fed a high-cholesterol diet, mice develop more extensive atherosclerotic lesions than similarly fed controls, with males more affected than females (J:29950)
• when fed a high-cholesterol diet, mice develop more extensive atherosclerotic lesions than similarly fed controls, with males more affected than females (J:29950)

homeostasis/metabolism
• mice fed a high-fat diet (1% cholesterol) exhibit increased average total plasma cholesterol levels (J:29950)
• mice fed a high-fat diet (1% cholesterol) exhibit increased average total plasma cholesterol levels (J:29950)




Genotype
MGI:4367202
hm8
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• total cholesterol greatly elevated (J:114480)
• total cholesterol greatly elevated (J:114480)
• greatly elevated (J:114480)
• greatly elevated (J:114480)




Genotype
MGI:4443062
ht9
Allelic
Composition
Ldlrtm1Her/Ldlr+
Genetic
Background
B6.129S7-Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• seen at 3-4 months of age (J:72027)
• seen at 3-4 months of age (J:72027)
• seen at 3-4 months of age (J:72027)
• seen at 3-4 months of age (J:72027)




Genotype
MGI:3798392
ht10
Allelic
Composition
Ldlrtm1Her/Ldlr+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet (J:100916)
• these high glucose levels persist for at least 12 weeks after STZ treatment (J:100916)
• streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet (J:100916)
• these high glucose levels persist for at least 12 weeks after STZ treatment (J:100916)




Genotype
MGI:4943551
cn11
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (64 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• the total macrophage and collagen lesion contents are increased (J:129557)
• the percentage (normalized for lesion size) of collagen in lesions is increased; however, the percentages of macrophages and smooth muscle cells in the lesions are similar (J:129557)
• the total macrophage and collagen lesion contents are increased (J:129557)
• the percentage (normalized for lesion size) of collagen in lesions is increased; however, the percentages of macrophages and smooth muscle cells in the lesions are similar (J:129557)
• total atherosclerotic lesion area and the proportion of advanced lesions are significantly increased compared to mutant mice expressing Lrp1 (J:129557)
• total atherosclerotic lesion area and the proportion of advanced lesions are significantly increased compared to mutant mice expressing Lrp1 (J:129557)




Genotype
MGI:4943737
cn12
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• impaired ability to internalize targets coated with LRP ligands (J:137404)
• however, phagocytosis of apoptotic cells in serum free conditions is similar to controls (J:137404)
• impaired ability to internalize targets coated with LRP ligands (J:137404)
• however, phagocytosis of apoptotic cells in serum free conditions is similar to controls (J:137404)

hematopoietic system
• impaired ability to internalize targets coated with LRP ligands (J:137404)
• however, phagocytosis of apoptotic cells in serum free conditions is similar to controls (J:137404)
• impaired ability to internalize targets coated with LRP ligands (J:137404)
• however, phagocytosis of apoptotic cells in serum free conditions is similar to controls (J:137404)




Genotype
MGI:4943738
cn13
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant reduction in the accumulation of nitrotyrosine in the ischemic tissue (J:144185)
• treatment with PLAT fails to restore nitrotyrosine accumulation unlike in mice null for Plat (J:144185)
• significant reduction in the accumulation of nitrotyrosine in the ischemic tissue (J:144185)
• treatment with PLAT fails to restore nitrotyrosine accumulation unlike in mice null for Plat (J:144185)
• 24 hours after transient middle cerebral artery occlusion (J:144185)
• 24 hours after transient middle cerebral artery occlusion (J:144185)

homeostasis/metabolism
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant reduction in the accumulation of nitrotyrosine in the ischemic tissue (J:144185)
• treatment with PLAT fails to restore nitrotyrosine accumulation unlike in mice null for Plat (J:144185)
• significant reduction in the accumulation of nitrotyrosine in the ischemic tissue (J:144185)
• treatment with PLAT fails to restore nitrotyrosine accumulation unlike in mice null for Plat (J:144185)
• 24 hours after transient middle cerebral artery occlusion (J:144185)
• 24 hours after transient middle cerebral artery occlusion (J:144185)

immune system
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)

hematopoietic system
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)
• significant decrease in the number of activated glial cells in ischemic tissue after transient middle cerebral artery occlusion (J:144185)




Genotype
MGI:4943555
cn14
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after adenoviral cre infection (J:67929)
• after adenoviral cre infection (J:67929)
• after adenoviral cre infection, concentrations of apoB48 are dramatically increased (J:67929)
• this increase is primarily responsible for the increase in plasma cholesterol and triglyceride levels (J:67929)
• after adenoviral cre infection, concentrations of apoB48 are dramatically increased (J:67929)
• this increase is primarily responsible for the increase in plasma cholesterol and triglyceride levels (J:67929)
• slightly increased after adenoviral cre infection (J:67929)
• slightly increased after adenoviral cre infection (J:67929)
• after adenoviral cre infection, the total cholesterol profile is dramatically changed (J:67929)
• after adenoviral cre infection, the total cholesterol profile is dramatically changed (J:67929)
• increase in total plasma cholesterol levels after adenoviral cre infection (J:67929)
• increase in total plasma cholesterol levels after adenoviral cre infection (J:67929)
• large increase of plasma lipoproteins in the LDL size range after adenoviral cre infection (J:67929)
• large increase of plasma lipoproteins in the LDL size range after adenoviral cre infection (J:67929)
• large increase of plasma lipoproteins in the chylomicron remnant/VLDL size range after adenoviral cre infection (J:67929)
• large increase of plasma lipoproteins in the chylomicron remnant/VLDL size range after adenoviral cre infection (J:67929)




Genotype
MGI:4946112
cn15
Allelic
Composition
Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Uky mutation (1 available); any Agtr1a mutation (12 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• angiotensin II-treated mice fed a high-fat diet exhibit decreased elastin breaks compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit decreased elastin breaks compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit decreased medial thickness compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit decreased medial thickness compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta lengthening compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta lengthening compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta ulcers compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta ulcers compared with similarly treated Ldlrtm1Her homozygotes (J:170230)




Genotype
MGI:4946109
cn16
Allelic
Composition
Agtr1atm1Uky/Agtr1atm1Uky
Ldlrtm1Her/Ldlrtm1Her
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Uky mutation (1 available); any Agtr1a mutation (12 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice fed a high-fat diet exhibit the same amount of angiotensin-induced expansion of ascending aortas and aneurysms as in similarly treated Ldlrtm1Her homozygotes (J:170230)
• mice fed a high-fat diet exhibit the same amount of angiotensin-induced expansion of ascending aortas and aneurysms as in similarly treated Ldlrtm1Her homozygotes (J:170230)




Genotype
MGI:3797226
cn17
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (64 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(Mx1-cre)29-4Her mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following pIpC treatment, plasma cholesterol level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma cholesterol level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma LDL cholesterol level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma LDL cholesterol level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma VLDL cholesterol level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma VLDL cholesterol level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma triglyceride level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• following pIpC treatment, plasma triglyceride level is lower compared to mutant mice wild-type for Lrp1 (J:90547)
• increase in Factor VIII, von Willebrand factor, and tissue type plasminogen activator levels by 4 weeks after pIpC treatment (J:90547)
• increase in Factor VIII, von Willebrand factor, and tissue type plasminogen activator levels by 4 weeks after pIpC treatment (J:90547)
• mice show elevated FVIII (Factor 8) levels (J:117317)
• mice show elevated FVIII (Factor 8) levels (J:117317)
• following pIpC treatment, plasma lipoprotein lipase level is higher compared to mutant mice wild-type for Lrp1 (J:90547)
• however, no increase in lipoprotein lipase activity is detected (J:90547)
• following pIpC treatment, plasma lipoprotein lipase level is higher compared to mutant mice wild-type for Lrp1 (J:90547)
• however, no increase in lipoprotein lipase activity is detected (J:90547)

cardiovascular system
• increase in lesion size in pIpC treated mice compared to untreated controls (J:90547)
• however, no change in lesion composition is detected (J:90547)
• increase in lesion size in pIpC treated mice compared to untreated controls (J:90547)
• however, no change in lesion composition is detected (J:90547)




Genotype
MGI:4943557
cn18
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• grossly disrupted (J:82871)
• grossly disrupted (J:82871)
• progressive thickening of the aorta wall with age (J:82871)
• thickening is primarily caused by increased smooth muscle cell proliferation (J:82871)
• progressive thickening of the aorta wall with age (J:82871)
• thickening is primarily caused by increased smooth muscle cell proliferation (J:82871)
• aortas are consistently distended and dilated (J:82871)
• aortas are consistently distended and dilated (J:82871)
• pronounced atherosclerosis is seen in the aorta (J:82871)
• pronounced atherosclerosis is seen in the aorta (J:82871)
• on a high cholesterol diet (J:82871)
• addition of Gleevec to the diet protects against atherosclerotic lesion formation (J:82871)
• on a high cholesterol diet (J:82871)
• addition of Gleevec to the diet protects against atherosclerotic lesion formation (J:82871)
• almost complete occlusion of the mesenteric arteries (J:82871)
• almost complete occlusion of the mesenteric arteries (J:82871)
• increase in vascular smooth muscle cell proliferation (J:82871)
• increase in vascular smooth muscle cell proliferation (J:82871)

homeostasis/metabolism
N
• no changes in cholesterol or triglyceride levels are detected compared to mice homozygous for Ldlrtm1Her alone (J:82871)
• no changes in cholesterol or triglyceride levels are detected compared to mice homozygous for Ldlrtm1Her alone (J:82871)

muscle
• increase in vascular smooth muscle cell proliferation (J:82871)
• increase in vascular smooth muscle cell proliferation (J:82871)




Genotype
MGI:4943553
cn19
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(Mx1-cre)29-4Her mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increase in total plasma cholesterol levels within 10 days of pIpC injection (J:67929)
• increase in total plasma cholesterol levels within 10 days of pIpC injection (J:67929)
• large increase of plasma lipoproteins in the LDL size range within 10 days of pIpC injection (J:67929)
• large increase of plasma lipoproteins in the LDL size range within 10 days of pIpC injection (J:67929)
• large increase of plasma lipoproteins in the chylomicron remnant/VLDL size range within 10 days of pIpC injection (J:67929)
• large increase of plasma lipoproteins in the chylomicron remnant/VLDL size range within 10 days of pIpC injection (J:67929)
• within 10 days of pIpC injection (J:67929)
• within 10 days of pIpC injection (J:67929)
• within 10 days of pIpC injection, concentrations of apoB48 are dramatically increased (J:67929)
• this increase is primarily responsible for the increase in plasma cholesterol and triglyceride levels (J:67929)
• within 10 days of pIpC injection, concentrations of apoB48 are dramatically increased (J:67929)
• this increase is primarily responsible for the increase in plasma cholesterol and triglyceride levels (J:67929)




Genotype
MGI:3797223
cn20
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Vldlrtm1Her/Vldlrtm1Her
Tg(Mx1-cre)29-4Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(Mx1-cre)29-4Her mutation (0 available)
Vldlrtm1Her mutation (1 available); any Vldlr mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show significantly elevated FVIII (Factor 8), similar to Ldlr/Lrp double mutants (J:117317)
• mice show significantly elevated FVIII (Factor 8), similar to Ldlr/Lrp double mutants (J:117317)




Genotype
MGI:3797225
cn21
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(Mx1-cre)29-4Her mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• levels are significantly increased (>10-fold) compared to controls (J:117317)
• levels are significantly increased (>10-fold) compared to controls (J:117317)
• levels are significantly increased (>10-fold) compared to controls (J:117317)
• levels are significantly increased (>10-fold) compared to controls (J:117317)
• mice show significantly elevated FVIII (Factor 8) and VWF (von Willebrand factor) levels, by 4.2- and 3.3-fold respectively (J:117317)
• mice show significantly elevated FVIII (Factor 8) and VWF (von Willebrand factor) levels, by 4.2- and 3.3-fold respectively (J:117317)




Genotype
MGI:5427004
cn22
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Nr1h3tm1.1Djm/Nr1h3tm1.1Djm
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Nr1h3tm1.1Djm mutation (0 available); any Nr1h3 mutation (10 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Atherosclerosis lesion area is increased in Ldlrtm1Her/Ldlrtm1Her Nr1h3tm1.1Djm/Nr1h3tm1.1Djm Tg(Alb-cre)21Mgn/0 mice and TO901317 treatment reduces these lesions

homeostasis/metabolism
• by 4 weeks in mice fed a western diet (J:184536)
• by 4 weeks in mice fed a western diet (J:184536)
• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit impaired reverse cholesterol transport compared with control mice (J:184536)
• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit impaired reverse cholesterol transport compared with control mice (J:184536)
• by 4 weeks in mice fed a western diet (J:184536)
• by 4 weeks in mice fed a western diet (J:184536)
• in mice fed a western diet at the conclusion of the experiment (J:184536)
• in mice fed a western diet at the conclusion of the experiment (J:184536)
• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) fail to exhibit a change in plasma lipid levels or an increase in fecal excretion of macrophage-derived sterols but an increase in hepatic sterols compared with control mice (J:184536)
• however, treatment with T0901317 reduces atherosclerosis as in controls (J:184536)
• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) fail to exhibit a change in plasma lipid levels or an increase in fecal excretion of macrophage-derived sterols but an increase in hepatic sterols compared with control mice (J:184536)
• however, treatment with T0901317 reduces atherosclerosis as in controls (J:184536)

liver/biliary system
• in mice fed a western diet at the conclusion of the experiment (J:184536)
• in mice fed a western diet at the conclusion of the experiment (J:184536)

cardiovascular system
• mice fed a western diet exhibit increase in lesion size as detected by macrophage staining compared with control mice (J:184536)
• however, collagen staining or lesions is normal and treatment with T0901317 reduces atherosclerosis as in controls (J:184536)
• mice fed a western diet exhibit increase in lesion size as detected by macrophage staining compared with control mice (J:184536)
• however, collagen staining or lesions is normal and treatment with T0901317 reduces atherosclerosis as in controls (J:184536)




Genotype
MGI:5607406
cn23
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Nr5a2tm2Sjns/Nr5a2tm2Sjns
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Nr5a2tm2Sjns mutation (0 available); any Nr5a2 mutation (66 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice fed a high-cholesterol diet for 12 weeks exhibit a similar body and liver weight as single Ldlr homozygotes and do not develop increased atherosclerosis (J:215556)
• mice fed a high-cholesterol diet for 12 weeks exhibit a similar body and liver weight as single Ldlr homozygotes and do not develop increased atherosclerosis (J:215556)

digestive/alimentary system
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygote (J:215556)
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygote (J:215556)

homeostasis/metabolism
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygotes (J:215556)
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygotes (J:215556)




Genotype
MGI:4367102
cx24
Allelic
Composition
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (9 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction (J:132734)
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction (J:132734)
• shortened prothrombin times and activated thromboplastin times (J:132734)
• elevated thrombin and antithrombin levels (J:132734)
• shortened prothrombin times and activated thromboplastin times (J:132734)
• elevated thrombin and antithrombin levels (J:132734)

cardiovascular system
• plaque surface area increases from 24 to 72 weeks of age (J:132734)
• plaques composed of a fibrous cap over a foam cell core (J:132734)
• multilayered smooth muscle cell regions associated with collagen deposition at 24 weeks (J:132734)
• smooth muscle cell numbers diminished after 36 weeks (J:132734)
• collagen throughout the plaque core at 48 weeks (J:132734)
• plaque surface area increases from 24 to 72 weeks of age (J:132734)
• plaques composed of a fibrous cap over a foam cell core (J:132734)
• multilayered smooth muscle cell regions associated with collagen deposition at 24 weeks (J:132734)
• smooth muscle cell numbers diminished after 36 weeks (J:132734)
• collagen throughout the plaque core at 48 weeks (J:132734)




Genotype
MGI:4367109
cx25
Allelic
Composition
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Fggtm1Fjc/Fggtm1Fjc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (9 available)
Fggtm1Fjc mutation (0 available); any Fgg mutation (3 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• display better survival to 3 weeks than do mice only deficient for Fgg (J:135942)
• display better survival to 3 weeks than do mice only deficient for Fgg (J:135942)

homeostasis/metabolism
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction (J:132734)
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction (J:132734)
• thrombin and antithrombin levels very highly elevated (J:132734)
• thrombin and antithrombin levels very highly elevated (J:132734)

cardiovascular system
• plaque surface area increases beyond what is seen in double homozygotes lacking fibrinogen gamma chain deficiency (J:132734)
• fibrous cap thinner than is seen in double homozygotes lacking fibrinogen gamma chain deficiency (J:132734)
• collagen deposition in plaques develops more rapidly than in double homozygotes lacking fibrinogen gamma chain deficiency (J:132734)
• plaque surface area increases beyond what is seen in double homozygotes lacking fibrinogen gamma chain deficiency (J:132734)
• fibrous cap thinner than is seen in double homozygotes lacking fibrinogen gamma chain deficiency (J:132734)
• collagen deposition in plaques develops more rapidly than in double homozygotes lacking fibrinogen gamma chain deficiency (J:132734)




Genotype
MGI:4946113
cx26
Allelic
Composition
Agtr1atm1Unc/Agtr1atm1Unc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Ldlrtm1Her Agtr1atm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (12 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• angiotensin II-treated mice fed a high-fat diet do not exhibit ascending aortic aneurysms unlike similarly treated Ldlrtm1Her homozygotes (J:170230)
• bone marrow transplant do not alter incidence of angiotensin II-induced ascending aortic aneurysms compared with similarly treated Ldlrtm1Her homozygotes (J:170230)
• angiotensin II-treated mice fed a high-fat diet do not exhibit ascending aortic aneurysms unlike similarly treated Ldlrtm1Her homozygotes (J:170230)
• bone marrow transplant do not alter incidence of angiotensin II-induced ascending aortic aneurysms compared with similarly treated Ldlrtm1Her homozygotes (J:170230)




Genotype
MGI:3783838
cx27
Allelic
Composition
Apoa1tm1Unc/Apoa1tm1Unc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Ldlrtm1Her Apoa1tm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1tm1Unc mutation (2 available); any Apoa1 mutation (3 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• when fed regular chow or a high fat diet for 16 weeks, serum triglyceride levels are increased compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed regular chow or a high fat diet for 16 weeks, serum triglyceride levels are increased compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, female mice exhibit a decrease in aortic cholesterol compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• however, aortic cholesterol levels in male mice fed a high fat diet are equivalent to in similarly treated Ldlrtm1Her homozygotes and female mice die before completion of the study (J:85174)
• when fed a high fat diet, mice exhibit a decrease in cholesterol content, specifically esterified cholesterol, in the adrenal gland compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, female mice exhibit a decrease in aortic cholesterol compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• however, aortic cholesterol levels in male mice fed a high fat diet are equivalent to in similarly treated Ldlrtm1Her homozygotes and female mice die before completion of the study (J:85174)
• when fed a high fat diet, mice exhibit a decrease in cholesterol content, specifically esterified cholesterol, in the adrenal gland compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• when mice are fed a high fat diet or regular chow, plasma cholesterol levels are decreased relative to similarly treated Ldlrtm1Her homozygotes (J:85174)
• unlike male Ldlrtm1Her homozygotes, plasma cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet (J:85174)
• when fed a high fat diet, free cholesterol levels fail to increase as much as in similarly treated Ldlrtm1Her homozygotes (J:85174)
• unlike Ldlrtm1Her homozygotes, free cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet (J:85174)
• when mice are fed a high fat diet or regular chow, esterified cholesterol levels are decreased relative to similarly treated Ldlrtm1Her homozygotes (J:85174)
• unlike male Ldlrtm1Her homozygotes, esterified cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet (J:85174)
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold) (J:85174)
• when mice are fed a high fat diet or regular chow, plasma cholesterol levels are decreased relative to similarly treated Ldlrtm1Her homozygotes (J:85174)
• unlike male Ldlrtm1Her homozygotes, plasma cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet (J:85174)
• when fed a high fat diet, free cholesterol levels fail to increase as much as in similarly treated Ldlrtm1Her homozygotes (J:85174)
• unlike Ldlrtm1Her homozygotes, free cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet (J:85174)
• when mice are fed a high fat diet or regular chow, esterified cholesterol levels are decreased relative to similarly treated Ldlrtm1Her homozygotes (J:85174)
• unlike male Ldlrtm1Her homozygotes, esterified cholesterol levels fail to increased from weeks 8 to 16 on a high fat diet (J:85174)
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold) (J:85174)
• when fed regular chow or a high fat diet for 16 weeks, serum HDL levels are decreased compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed regular chow or a high fat diet for 16 weeks, serum HDL levels are decreased compared to similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold) (J:85174)
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold) (J:85174)
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold) (J:85174)
• when fed a high fat diet, mice exhibit a lesser increase in VLDL and LDL (3-fold) compared to Ldlrtm1Her homozygotes (6-fold) (J:85174)
• when fed a high fat diet, mice exhibit a reduced increase of 2.5-fold in liver cholesterol content compared to 11-fold in similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a reduced increase of 2.5-fold in liver cholesterol content compared to 11-fold in similarly treated Ldlrtm1Her homozygotes (J:85174)
• female mice develop skin lesions when fed a high fat diet (J:85174)
• total skin cholesterol content is increased 12- to 13-fold and 5.5-fold for free cholesterol compared to in Ldlrtm1Her homozygotes (J:85174)
• female mice develop skin lesions when fed a high fat diet (J:85174)
• total skin cholesterol content is increased 12- to 13-fold and 5.5-fold for free cholesterol compared to in Ldlrtm1Her homozygotes (J:85174)

liver/biliary system
• when fed a high fat diet, mice exhibit smaller diameter lipid droplets than in Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit an accumulation of inflammatory cells such as neutrophils and leukocytes around the hepatic vein unlike in Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit smaller diameter lipid droplets than in Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit an accumulation of inflammatory cells such as neutrophils and leukocytes around the hepatic vein unlike in Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a reduced increase of 2.5-fold in liver cholesterol content compared to 11-fold in similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a reduced increase of 2.5-fold in liver cholesterol content compared to 11-fold in similarly treated Ldlrtm1Her homozygotes (J:85174)

endocrine/exocrine glands
• when fed a high fat diet, mice exhibit an decrease in cholesterol content, specifically esterified cholesterol, in the adrenal gland compared to in similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit an decrease in cholesterol content, specifically esterified cholesterol, in the adrenal gland compared to in similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a severe depletion of cytoplasmic lipid droplets unlike in Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, mice exhibit a severe depletion of cytoplasmic lipid droplets unlike in Ldlrtm1Her homozygotes (J:85174)

integument
• when fed a high fat diet, mice develop a thickened dermal layer with macrophage infiltrate and cholesterol deposits (J:85174)
• dermal thickening associated with a high fat diet is more severe in female mice than male mice (J:85174)
• when fed a high fat diet, mice develop a thickened dermal layer with macrophage infiltrate and cholesterol deposits (J:85174)
• dermal thickening associated with a high fat diet is more severe in female mice than male mice (J:85174)
• when fed a high fat diet, female mice develop skin lesions beginning at 9 weeks with scratching and lesion areas that progress until animals cease eating and drinking (J:85174)
• skin lesions observed in mice fed a high fat diet are different than the non-fatal skin thickening observed in similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, female mice develop skin lesions beginning at 9 weeks with scratching and lesion areas that progress until animals cease eating and drinking (J:85174)
• skin lesions observed in mice fed a high fat diet are different than the non-fatal skin thickening observed in similarly treated Ldlrtm1Her homozygotes (J:85174)
• when fed a high fat diet, female mice exhibit severe ulcerations on thickened skin of the abdomen, neck and front limbs (J:85174)
• when fed a high fat diet, female mice exhibit severe ulcerations on thickened skin of the abdomen, neck and front limbs (J:85174)
• when fed a high fat diet, female mice develop pruritus (itching) and must be euthanized before the end of the 16 week study period (J:85174)
• when fed a high fat diet, female mice develop pruritus (itching) and must be euthanized before the end of the 16 week study period (J:85174)




Genotype
MGI:3639678
cx28
Allelic
Composition
Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Ldlrtm1Her Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (2 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• area in lesions occupied by macrophage is significantly increased (J:100498)
• reduced collagen content (J:100498)
• decreased apoptosis of macrophage in lesions (J:100498)
• area in lesions occupied by macrophage is significantly increased (J:100498)
• reduced collagen content (J:100498)
• decreased apoptosis of macrophage in lesions (J:100498)

immune system
• decreased apoptosis of macrophage in atherosclerotic lesions (J:100498)
• decreased apoptosis of macrophage in atherosclerotic lesions (J:100498)

cellular
• decreased apoptosis of macrophage in atherosclerotic lesions (J:100498)
• decreased apoptosis of macrophage in atherosclerotic lesions (J:100498)

hematopoietic system
• decreased apoptosis of macrophage in atherosclerotic lesions (J:100498)
• decreased apoptosis of macrophage in atherosclerotic lesions (J:100498)




Genotype
MGI:4839086
cx29
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Genetic
Background
B6.129-Ldlrtm1Her Tcra-Jtm1Tgi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Tcra-Jtm1Tgi mutation (0 available); any Tcra-J mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• lesions in the ascending aorta are reduced 20% in males and 28% in females relative to homozygous Ldlrtm1Her (J:140276)
• considerable reduction of lipid containing areas in the lesions (J:140276)
• less IFN-gamma in the lesions (J:140276)
• lesions in the ascending aorta are reduced 20% in males and 28% in females relative to homozygous Ldlrtm1Her (J:140276)
• considerable reduction of lipid containing areas in the lesions (J:140276)
• less IFN-gamma in the lesions (J:140276)

immune system
• less IFN-gamma in atherosclerotic lesions (J:140276)
• less IFN-gamma in atherosclerotic lesions (J:140276)




Genotype
MGI:4867042
cx30
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S7-Ldlrtm1Her Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after 8 or 20 weeks on a cholesterol diet aortic lesion size is reduced compared to mice homozygous for Ldlrtm1Her alone (J:103072)
• after 8 or 20 weeks on a cholesterol diet aortic lesion size is reduced compared to mice homozygous for Ldlrtm1Her alone (J:103072)

hematopoietic system
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)

immune system
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)




Genotype
MGI:4821420
cx31
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S-Cd1d1tm1Luc Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (7 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• male mice after 4 weeks on the Western diet have lesions of small fatty streaks on the aorta were 40.4% smaller than Ldlrtm1Her (J:110061)
• Oil red O stained serial sections of 4-week-old mice fed a western diet, revealed had 31.7% less lipid staining than Ldlrtm1Her (J:110061)
• male mice after 4 weeks on the Western diet have lesions of small fatty streaks on the aorta were 40.4% smaller than Ldlrtm1Her (J:110061)
• Oil red O stained serial sections of 4-week-old mice fed a western diet, revealed had 31.7% less lipid staining than Ldlrtm1Her (J:110061)

homeostasis/metabolism
• slightly lower levels of very low density lipoprotein (J:110061)
• slightly lower levels of very low density lipoprotein (J:110061)




Genotype
MGI:5008733
cx32
Allelic
Composition
Ctsstm1Hap/Ctsstm1Hap
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S-Ctsstm1Hap Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Hap mutation (0 available); any Ctss mutation (7 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after 12 and 26 weeks on an atherogenic diet with decreased macrophage, leukocyte, and CD4+ T cells within lesions (J:82520)
• after 12 and 26 weeks on an atherogenic diet with decreased macrophage, leukocyte, and CD4+ T cells within lesions (J:82520)

immune system
• leukocytes exhibit impaired leukocyte transmigration compared with wild-type cells (J:82520)
• leukocytes exhibit impaired leukocyte transmigration compared with wild-type cells (J:82520)

homeostasis/metabolism
• when fed standard chow (J:82520)
• when fed standard chow (J:82520)
• when fed standard chow (J:82520)
• when fed standard chow (J:82520)

muscle

cellular
• leukocytes exhibit impaired leukocyte transmigration compared with wild-type cells (J:82520)
• leukocytes exhibit impaired leukocyte transmigration compared with wild-type cells (J:82520)

hematopoietic system
• leukocytes exhibit impaired leukocyte transmigration compared with wild-type cells (J:82520)
• leukocytes exhibit impaired leukocyte transmigration compared with wild-type cells (J:82520)




Genotype
MGI:3721540
cx33
Allelic
Composition
Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S-Ldlrtm1Her Del(11Cxcl16-Zmynd15)1Ifc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Cxcl16-Zmynd15)1Ifc mutation (0 available); any Del(11Cxcl16-Zmynd15)1Ifc mutation (0 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after 6 weeks, atherosclerosis lesions are 46% larger than in Ldlrtm1Her homozygotes (J:123851)
• after 10 weeks, atherosclerosis lesions are 27% and 56% (when assessed with serial sections of the aortic root stained with oil red O) larger than in Ldlrtm1Her homozygotes (J:123851)
• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlrtm1Her homozygotes (J:123851)
• after 6 weeks, atherosclerosis lesions are 46% larger than in Ldlrtm1Her homozygotes (J:123851)
• after 10 weeks, atherosclerosis lesions are 27% and 56% (when assessed with serial sections of the aortic root stained with oil red O) larger than in Ldlrtm1Her homozygotes (J:123851)
• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlrtm1Her homozygotes (J:123851)

cellular
• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlrtm1Her homozygotes (J:123851)
• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlrtm1Her homozygotes (J:123851)




Genotype
MGI:4367099
cx34
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Pfn1tm1Wit/Pfn1+
Genetic
Background
B6.129S-Ldlrtm1Her Pfn1tm1Wit
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Pfn1tm1Wit mutation (0 available); any Pfn1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• produced at a lower than expected ratio (J:140294)
• mice surviving to adulthood are healthy and normal regardless of diet fed (J:140294)
• produced at a lower than expected ratio (J:140294)
• mice surviving to adulthood are healthy and normal regardless of diet fed (J:140294)

cardiovascular system
• lesions are reduced by 60% in males and 75% in females after 2 months on a high cholesterol diet as compared to Ldlr deficient mice (J:140294)
• less area in lesions is occupied by macrophage (J:140294)
• macrophage recruitment to lesion sites is reduced early in lesion formation (J:140294)
• lesions are reduced by 60% in males and 75% in females after 2 months on a high cholesterol diet as compared to Ldlr deficient mice (J:140294)
• less area in lesions is occupied by macrophage (J:140294)
• macrophage recruitment to lesion sites is reduced early in lesion formation (J:140294)

immune system
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation (J:140294)
• ess area in lesions is occupied by macrophage (J:140294)
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation (J:140294)
• ess area in lesions is occupied by macrophage (J:140294)

cellular
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation (J:140294)
• ess area in lesions is occupied by macrophage (J:140294)
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation (J:140294)
• ess area in lesions is occupied by macrophage (J:140294)

hematopoietic system
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation (J:140294)
• ess area in lesions is occupied by macrophage (J:140294)
• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation (J:140294)
• ess area in lesions is occupied by macrophage (J:140294)




Genotype
MGI:3811068
cx35
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic
Background
B6.129S-Serpine1tm1Mlg Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Serpine1tm1Mlg mutation (4 available); any Serpine1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Ldlr-deficient genotypes (J:61287)
• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Ldlr-deficient genotypes (J:61287)

homeostasis/metabolism
• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks) (J:61287)
• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks) (J:61287)




Genotype
MGI:4834596
cx36
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Vwftm1Wgr/Vwftm1Wgr
Genetic
Background
B6.129S-Vwftm1Wgr Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Vwftm1Wgr mutation (1 available); any Vwf mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at 22 weeks, mice fed an atherogenic diet exhibit decreased atherosclerotic lesions size with fewer macrophages and reduced calcification compared with similarly treated Ldlrtm1Her homozygotes (J:106677)
• lesions in mice fed an atherogenic diet are uniformly distributed unlike in similarly treated Ldlrtm1Her homozygotes that exhibit formation hot spots (J:106677)
• however, mice exhibit normal atherosclerotic lesions at 37 weeks (J:106677)
• at 22 weeks, mice fed an atherogenic diet exhibit decreased atherosclerotic lesions size with fewer macrophages and reduced calcification compared with similarly treated Ldlrtm1Her homozygotes (J:106677)
• lesions in mice fed an atherogenic diet are uniformly distributed unlike in similarly treated Ldlrtm1Her homozygotes that exhibit formation hot spots (J:106677)
• however, mice exhibit normal atherosclerotic lesions at 37 weeks (J:106677)

immune system
• leukocyte rolling on a chow diet is decreased compared to in wild-type mice (J:106677)
• however, rolling on an atherogenic diet is normal (J:106677)
• leukocyte rolling on a chow diet is decreased compared to in wild-type mice (J:106677)
• however, rolling on an atherogenic diet is normal (J:106677)

cellular
• leukocyte rolling on a chow diet is decreased compared to in wild-type mice (J:106677)
• however, rolling on an atherogenic diet is normal (J:106677)
• however, rolling on an atherogenic diet is normal (J:106677)
• leukocyte rolling on a chow diet is decreased compared to in wild-type mice (J:106677)

hematopoietic system
• leukocyte rolling on a chow diet is decreased compared to in wild-type mice (J:106677)
• however, rolling on an atherogenic diet is normal (J:106677)
• leukocyte rolling on a chow diet is decreased compared to in wild-type mice (J:106677)
• however, rolling on an atherogenic diet is normal (J:106677)




Genotype
MGI:5428446
cx37
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Tlr2tm1Kir/Tlr2tm1Kir
Genetic
Background
B6.129-Tlr2tm1Kir Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Tlr2tm1Kir mutation (2 available); any Tlr2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• reduced total plasma cholesterol on a high fat diet relative to Ldlrtm1Her/tm1Her controls (J:102502)
• reduced total plasma cholesterol on a high fat diet relative to Ldlrtm1Her/tm1Her controls (J:102502)

growth/size/body
• increased body weight on a high fat diet relative to Ldlrtm1Her/tm1Her controls (J:102502)
• increased body weight on a high fat diet relative to Ldlrtm1Her/tm1Her controls (J:102502)

cardiovascular system
• aortic lesion area and aortic valve lesion volume are significantly reduced relative to Ldlrtm1Her/tm1Her controls (J:102502)
• aortic lesion area and aortic valve lesion volume are significantly reduced relative to Ldlrtm1Her/tm1Her controls (J:102502)
• less lipid accumulation in the lesser aortic curvature on a high fat diet than in Ldlrtm1Her/tm1Her controls (J:131783)
• less lipid accumulation in the lesser aortic curvature on a high fat diet than in Ldlrtm1Her/tm1Her controls (J:131783)

immune system
• leukocyte accumulation under the aortic endothelium is less than in Ldlrtm1Her/tm1Her controls (J:131783)
• leukocyte accumulation under the aortic endothelium is less than in Ldlrtm1Her/tm1Her controls (J:131783)
• significantly reduced response to LPS challenge (J:131783)
• significantly reduced response to LPS challenge (J:131783)

cellular
• leukocyte accumulation under the aortic endothelium is less than in Ldlrtm1Her/tm1Her controls (J:131783)
• leukocyte accumulation under the aortic endothelium is less than in Ldlrtm1Her/tm1Her controls (J:131783)

hematopoietic system
• leukocyte accumulation under the aortic endothelium is less than in Ldlrtm1Her/tm1Her controls (J:131783)
• leukocyte accumulation under the aortic endothelium is less than in Ldlrtm1Her/tm1Her controls (J:131783)




Genotype
MGI:3711207
cx38
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Mobq5CAST/Ei/Mobq5CAST/Ei
Genetic
Background
B6.CAST-Mobq5CAST/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Mobq5CAST/Ei mutation (0 available); any Mobq5 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased plasma cholesterol (J:116503)
• decreased unesterified cholesterol (J:116503)
• decreased plasma cholesterol (J:116503)
• decreased unesterified cholesterol (J:116503)




Genotype
MGI:3711214
cx39
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Mobq6CAST/Ei/Mobq6CAST/Ei
Genetic
Background
B6.CAST-Mobq6CAST/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Mobq6CAST/Ei mutation (0 available); any Mobq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased obesity on a Western diet (J:116503)
• decreased obesity on a Western diet (J:116503)
• decreased plasma cholesterol (J:116503)
• decreased unesterified cholesterol (J:116503)
• decreased plasma cholesterol (J:116503)
• decreased unesterified cholesterol (J:116503)
• improved glucose tolerance on a Western diet (J:116503)
• improved glucose tolerance on a Western diet (J:116503)

cardiovascular system
• reduced aortic root lesion size (2-3 fold smaller) (J:116503)
• reduced aortic root lesion size (2-3 fold smaller) (J:116503)

behavior/neurological
• increased food efficiency (J:116503)
• increased food efficiency (J:116503)

growth/size/body
• decreased obesity on a Western diet (J:116503)
• decreased obesity on a Western diet (J:116503)




Genotype
MGI:4947401
cx40
Allelic
Composition
Crptm1Hjf/Crptm1Hjf
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.Cg-Crptm1Hjf Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crptm1Hjf mutation (1 available); any Crp mutation (3 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)
• in male mice at 20 weeks (J:170409)

cardiovascular system
• female mice exhibit an increase in macrophage content in lesions compared with Ldlrtm1Her homozygotes (J:170409)
• however, lesion size and susceptibility do not differ from Ldlrtm1Her homozygotes (J:170409)
• female mice exhibit an increase in macrophage content in lesions compared with Ldlrtm1Her homozygotes (J:170409)
• however, lesion size and susceptibility do not differ from Ldlrtm1Her homozygotes (J:170409)




Genotype
MGI:5286555
cx41
Allelic
Composition
Ins2Akita/Ins2Akita
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.Cg-Ins2Akita Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (25 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with Ldlrtm1Her homozygotes (J:174983)
• compared with Ldlrtm1Her homozygotes (J:174983)

homeostasis/metabolism
• severe compared with Ldlrtm1Her homozygotes (J:174983)
• severe compared with Ldlrtm1Her homozygotes (J:174983)
• in fasting mice compared with Ldlrtm1Her homozygotes (J:174983)
• in fasting mice compared with Ldlrtm1Her homozygotes (J:174983)
• in fasting mice compared with Ldlrtm1Her homozygotes (J:174983)
• in fasting mice compared with Ldlrtm1Her homozygotes (J:174983)
• in female mice compared with Ldlrtm1Her homozygotes (J:174983)
• in female mice compared with Ldlrtm1Her homozygotes (J:174983)
• 2-fold in male mice and 24% in female mice compared with Ldlrtm1Her homozygotes (J:174983)
• 2-fold in male mice and 24% in female mice compared with Ldlrtm1Her homozygotes (J:174983)
• 7-fold in male mice and 1.8-fold in female mice compared with Ldlrtm1Her homozygotes (J:174983)
• 7-fold in male mice and 1.8-fold in female mice compared with Ldlrtm1Her homozygotes (J:174983)
• in fasting mice compared with Ldlrtm1Her homozygotes (J:174983)
• in fasting mice compared with Ldlrtm1Her homozygotes (J:174983)
• compared with Ldlrtm1Her homozygotes (J:174983)
• compared with Ldlrtm1Her homozygotes (J:174983)

growth/size/body
• in male, but not female, mice at 20 weeks of age compared with Ldlrtm1Her homozygotes (J:174983)
• in male, but not female, mice at 20 weeks of age compared with Ldlrtm1Her homozygotes (J:174983)

cardiovascular system
• accelerated in mice fed a high-fat diet compared with similarly treated Ldlrtm1Her homozygotes (J:174983)
• accelerated in mice fed a high-fat diet compared with similarly treated Ldlrtm1Her homozygotes (J:174983)




Genotype
MGI:3794980
cx42
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Scd1ab-2J/Scd1ab-2J
Genetic
Background
B6.Cg-Ldlrtm1Her Scd1ab-2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Scd1ab-2J mutation (2 available); any Scd1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Adiposity in Ldlrtm1Her/Ldlrtm1Her and Scd1ab-2J/Scd1ab-2J Ldlrtm1Her/Ldlrtm1Her mice

adipose tissue
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice have smaller periepididymal fat pads than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice have smaller periepididymal fat pads than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice have smaller periuterine fat pads than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice have smaller periuterine fat pads than Ldlrtm1Her homozygotes (J:130278)

homeostasis/metabolism
N
• when fed a western style diet for 12 weeks, mice are protected from impaired glucose tolerance, hyperglycemia, and increased plasma insulin levels observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice are protected from impaired glucose tolerance, hyperglycemia, and increased plasma insulin levels observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a decrease in visceral and subcutaneous lipid compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a decrease in visceral and subcutaneous lipid compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice exhibit a lower circulating cholesterol level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice exhibit a lower circulating cholesterol level than in Ldlrtm1Her homozygotes (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)

behavior/neurological
• when fed a western style diet for 12 weeks, mice consuming more food than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice consuming more food than Ldlrtm1Her homozygotes (J:130278)

growth/size/body
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice gain less weight than Ldlrtm1Her homozygotes despite consuming more food (J:130278)
• when fed a western style diet for 12 weeks, mice gain less weight than Ldlrtm1Her homozygotes despite consuming more food (J:130278)

liver/biliary system
N
• when fed a western style diet for 12 weeks, mice are protected from the hepatic steatosis observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice are protected from the hepatic steatosis observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)




Genotype
MGI:3794981
cx43
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Scd1ab-J/Scd1ab-J
Genetic
Background
B6.Cg-Ldlrtm1Her Scd1ab-J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Scd1ab-J mutation (0 available); any Scd1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice have smaller periepididymal fat pads than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice have smaller periepididymal fat pads than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice have smaller periuterine fat pads than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice have smaller periuterine fat pads than Ldlrtm1Her homozygotes (J:130278)

homeostasis/metabolism
N
• when fed a western style diet for 12 weeks, mice are protected from impaired glucose tolerance, hyperglycemia and increased plasma insulin levels observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice are protected from impaired glucose tolerance, hyperglycemia and increased plasma insulin levels observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a decrease in visceral and subcutaneous lipid compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a decrease in visceral and subcutaneous lipid compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice exhibit a lower circulating cholesterol level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, male mice exhibit a lower circulating cholesterol level than in Ldlrtm1Her homozygotes (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, female mice exhibit a lower circulating triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• compared to in Ldlrtm1Her homozygotes when fed a western style diet for 12 weeks (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)

behavior/neurological
• when fed a western style diet for 12 weeks, mice consuming more food than Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice consuming more food than Ldlrtm1Her homozygotes (J:130278)

growth/size/body
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 50% reduction in total fat mass compared to in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice gain less weight than Ldlrtm1Her homozygotes despite consuming more food (J:130278)
• when fed a western style diet for 12 weeks, mice gain less weight than Ldlrtm1Her homozygotes despite consuming more food (J:130278)

liver/biliary system
N
• when fed a western style diet for 12 weeks, mice are protected from the hepatic steatosis observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice are protected from the hepatic steatosis observed in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)
• when fed a western style diet for 12 weeks, mice exhibit a 5-fold lower hepatic triglyceride level than in Ldlrtm1Her homozygotes (J:130278)




Genotype
MGI:3810981
cx44
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Tg(CMV-Serpine1)1Dgi/0
Genetic
Background
B6.Cg-Ldlrtm1Her Tg(CMV-Serpine1)1Dgi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Tg(CMV-Serpine1)1Dgi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Ldlr-deficient genotypes (J:61287)
• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Ldlr-deficient genotypes (J:61287)

homeostasis/metabolism
• mice develop severe cholesterolemia receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks) (J:61287)
• mice develop severe cholesterolemia receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks) (J:61287)




Genotype
MGI:3622658
cx45
Allelic
Composition
Ldlrtm1Her/Ldlr+
Lepob/Lepob
Genetic
Background
B6.Cg-Lepob Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lepob mutation (6 available); any Lep mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• age dependent increase in cholesterol levels between 1 and 4 months of age, with maximal values at 3-4 months of age (282 mg/dl vs 81 md/dl in wild-type) that are maintained thereafter (J:72027)
• age dependent increase in cholesterol levels between 1 and 4 months of age, with maximal values at 3-4 months of age (282 mg/dl vs 81 md/dl in wild-type) that are maintained thereafter (J:72027)
• slightly elevated at 3 and 8 months of age (J:72027)
• slightly elevated at 3 and 8 months of age (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit about 10x higher levels of triglyceride, however no increase in plasma triglyceride levels (J:72027)
• livers exhibit about 10x higher levels of triglyceride, however no increase in plasma triglyceride levels (J:72027)

liver/biliary system
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit about 10x higher levels of triglyceride, however no increase in plasma triglyceride levels (J:72027)
• livers exhibit about 10x higher levels of triglyceride, however no increase in plasma triglyceride levels (J:72027)




Genotype
MGI:3622656
cx46
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lepob/Lepob
Genetic
Background
B6.Cg-Lepob Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lepob mutation (6 available); any Lep mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• extensive atherosclerotic lesions throughout the aorta by 6 months of age (J:72027)
• extensive atherosclerotic lesions throughout the aorta by 6 months of age (J:72027)

homeostasis/metabolism
• plasma contains severely elevated and broadened lipoprotein peak, ranging from VLDL/LDL-sized particles to LDL-sized particles (J:72027)
• plasma contains severely elevated and broadened lipoprotein peak, ranging from VLDL/LDL-sized particles to LDL-sized particles (J:72027)
• age dependent increase in cholesterol levels between 1 and 4 months of age, with maximal values at 3-4 months of age (1715 mg/dl vs. 81 mg/dl in wild-type), followed by a gradual decrease by 8 months (J:72027)
• fasting, diet restriction, and low-level leptin treatment only slightly lowers plasma cholesterol levels (J:72027)
• age dependent increase in cholesterol levels between 1 and 4 months of age, with maximal values at 3-4 months of age (1715 mg/dl vs. 81 mg/dl in wild-type), followed by a gradual decrease by 8 months (J:72027)
• fasting, diet restriction, and low-level leptin treatment only slightly lowers plasma cholesterol levels (J:72027)
• elevated at 3 and 8 months of age (J:72027)
• elevated at 3 and 8 months of age (J:72027)
• age dependent increase in triglyceride levels between 1 and 4 months of age, with maximal values at 3-4 months of age, followed by a gradual decrease by 8 months (J:72027)
• fasting, diet restriction, and low-level leptin treatment significantly lowers plasma triglyceride levels (J:72027)
• age dependent increase in triglyceride levels between 1 and 4 months of age, with maximal values at 3-4 months of age, followed by a gradual decrease by 8 months (J:72027)
• fasting, diet restriction, and low-level leptin treatment significantly lowers plasma triglyceride levels (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit about 10x higher levels of triglyceride (J:72027)
• livers exhibit about 10x higher levels of triglyceride (J:72027)

liver/biliary system
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit slightly, but significantly, higher levels of cholesterol (J:72027)
• livers exhibit about 10x higher levels of triglyceride (J:72027)
• livers exhibit about 10x higher levels of triglyceride (J:72027)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypercholesterolemia, Familial 143890 J:72027




Genotype
MGI:4367224
cx47
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (64 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma cholesterol on a high fat diet reaches 4120 mg/dl (J:59491)
• triglyceride levels are unaffected by diet (J:59491)
• plasma cholesterol on a high fat diet reaches 4120 mg/dl (J:59491)
• triglyceride levels are unaffected by diet (J:59491)




Genotype
MGI:4367112
cx48
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Mapkapk2tm1Mgl mutation (0 available); any Mapkapk2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced development of atherosclerosis after 8-16 weeks on an atherogenic diet (J:142788)
• reduced development of atherosclerosis after 8-16 weeks on an atherogenic diet (J:142788)

hematopoietic system
• reduced in number among peritoneal macrophage in mice fed an atherogenic diet for 10 weeks (J:142788)
• reduced in number among peritoneal macrophage in mice fed an atherogenic diet for 10 weeks (J:142788)
• decreased macrophage content in longitudinal sections of the aortic arch (J:142788)
• decreased macrophage content in longitudinal sections of the aortic arch (J:142788)

homeostasis/metabolism
• increased plasma cholesterol relative to mice deficient only in Ldlr (J:142788)
• increased non-HDL cholesterol relative to mice deficient only in Ldlr (J:142788)
• increased plasma cholesterol relative to mice deficient only in Ldlr (J:142788)
• increased non-HDL cholesterol relative to mice deficient only in Ldlr (J:142788)

immune system
• reduced in number among peritoneal macrophage in mice fed an atherogenic diet for 10 weeks (J:142788)
• reduced in number among peritoneal macrophage in mice fed an atherogenic diet for 10 weeks (J:142788)
• decreased macrophage content in longitudinal sections of the aortic arch (J:142788)
• decreased macrophage content in longitudinal sections of the aortic arch (J:142788)

cellular
• reduced in number among peritoneal macrophage in mice fed an atherogenic diet for 10 weeks (J:142788)
• reduced in number among peritoneal macrophage in mice fed an atherogenic diet for 10 weeks (J:142788)




Genotype
MGI:4367222
cx49
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Lipctm1Unc/Lipctm1Unc
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
Lipctm1Unc mutation (3 available); any Lipc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• levels in response to ACTH are significantly reduced (J:108412)
• levels in response to ACTH are significantly reduced (J:108412)
• levels markedly increased (J:108412)
• primarily in HDL and LDL fractions (J:108412)
• levels markedly increased (J:108412)
• primarily in HDL and LDL fractions (J:108412)




Genotype
MGI:4358708
cx50
Allelic
Composition
Lcattm1Hgc/Lcattm1Hgc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcattm1Hgc mutation (0 available); any Lcat mutation (3 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• unlike Lcat single mutants, the free cholesterol/esterfied cholesterol ratio is not significantly different from controls (J:75567)
• unlike Lcat single mutants, the free cholesterol/esterfied cholesterol ratio is not significantly different from controls (J:75567)
• fasting glucose levels are 31% lower than the single mutant controls (J:89015)
• fasting glucose levels are 31% lower than the single mutant controls (J:89015)
• fasting insulin levels are 42% lower than the single mutant controls (J:89015)