All Phenotypes En1<tm1Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

En1^tm1Alj
targeted mutation 1, Alexandra L Joyner
MGI:1857163

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	En1^tm1Alj/En1^tm1Alj	B6.129-En1^tm1Alj	MGI:3718798
hm2	En1^tm1Alj/En1^tm1Alj	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:2175847
hm3	En1^tm1Alj/En1^tm1Alj	involves: 129 * C57BL/6J	MGI:2171880
ht4	En1^tm1Alj/En1^tm3(En2)Alj	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:2175850
cn5	En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm7.1Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:4421427
cn6	En1^tm1Alj/En1^tm8.1Alj En2^tm6Alj/En2⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:4421456
cn7	En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm6Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺	involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster	MGI:4421433
cx8	En1^tm1Alj/En1^tm1Alj Wnt7a^tm1Amc/Wnt7a^tm1Amc Tg(Wnt1-En1)1Amc/0	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3718802
cx9	En1^tm1Alj/En1^tm1Alj Tg(Wnt1-En1)1Amc/0	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3718801
cx10	En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm7.1Alj	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:4421431
cx11	En1^tm1Alj/En1⁺ En2^tm1Alj/En2^tm1Alj	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3718800
cx12	En1^tm1Alj/En1^tm1Alj En2^tm1Alj/En2⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3718799
cx13	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3849436
cx14	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng^tm1Tfv	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3849435
cx15	En1^tm1Alj/En1^tm1Alj Moen3^C57BL/6/Moen3^C57BL/6	involves: 129S1/Sv * C57BL/6	MGI:3715514
cx16	En1^tm1Alj/En1^tm1Alj Moen2^C57BL/6/Moen2^C57BL/6	involves: 129S1/Sv * C57BL/6	MGI:3715513
cx17	En1^tm1Alj/En1^tm1Alj Moen1^C57BL/6/Moen1^C57BL/6	involves: 129S1/Sv * C57BL/6	MGI:3715512

Allelic Composition	En1^tm1Alj/En1^tm1Alj
Genetic Background	B6.129-En1^tm1Alj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:84363 )

• born in normal numbers

• reduced vitality and frequently die before weaning

growth/size/body

decreased body size ( J:84363 )

• smaller than littermates within a few days of birth

nervous system

abnormal cerebellar lobule formation ( J:84363 )

• fusion of cerebellar lobules IV and V

• Background Sensitivity: otherwise phenotypically normal cerebellum is seen as early as the third backcross generation to C57BL/6 and thereafter

decreased inferior colliculus size ( J:84363 )

• mild truncation seen in the midbrain in the area of the inferior colliculi

limbs/digits/tail

abnormal autopod morphology ( J:84363 )

• fur growth on the ventral surface of the forepaws

abnormal digit morphology ( J:84363 )

• circumferential nails on all digits

polydactyly ( J:84363 )

• 6th postaxial digit

• ectopic digits

syndactyly ( J:84363 )

integument

deformed nails ( J:84363 )

• circumferential nails on all digits

Allelic Composition	En1^tm1Alj/En1^tm1Alj
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:19212 )

• Background Sensitivity: death usually within 24 hours of birth

• one mouse with a less severe phenotype survived to 7 days

embryo

thin apical ectodermal ridge ( J:34307 )

• thinner than in controls at E10.5

limbs/digits/tail

abnormal limb morphology ( J:34307 )

• in limbs examined, ventral tendons of digit flexor muscles are absent or poorly developed

• ventral skeletal elements such as falciform and sesamoid cartilages are absent or incompletely formed

thin apical ectodermal ridge ( J:34307 )

• thinner than in controls at E10.5

abnormal autopod morphology ( J:34307 )

• dorsal transformation of ventral structures and ventral duplication of distal structures is observed in neonatal limbs

• paws display aspects of double dorsal paws

abnormal eccrine sweat gland morphology ( J:34307 )

• ventrally restricted eccrine glands are largely absent

abnormal digit morphology ( J:19212 , J:34307 )

• outward splayed digits (J:19212)

• skin wrinkles on digits (J:19212)

• digits flex dorsally rather than ventrally (J:34307)

ectopic digits ( J:34307 )

• occasional ectopic ventral digits (digits 6, 7) are seen emanating from proximal paw pads in 10-15% of neonates

polydactyly ( J:19212 )

• 6th postaxial digit

• often with only one phalange

• usually involves only one forelimb

• one example of a preaxial supernumary digit on one paw (7 digits)

syndactyly ( J:19212 )

truncated digits ( J:19212 )

• mild truncation

abnormal foot pad morphology ( J:34307 )

• circumferential nails supplant distal, ventral foot pads; proximal metatarsal pads are present but possess few is any eccrine glands

skeleton

abnormal axial skeleton morphology ( J:19212 )

short sternum ( J:19212 )

• length reduced by 25%

• ossification centers reduced rostrally to caudally by 40-80%

• ossification centers asymmetric and abnormally fused in the midline

• fourth ossification center absent or rudimentary

decreased rib number ( J:19212 )

• 13th rib pair missing or severely truncated in about 43% of animals

delayed bone ossification ( J:19212 )

• delayed ossification of phalanges

behavior/neurological

aphagia ( J:19212 )

• most mice fail to eat

• only one, with a less severe phenotype actually ate

abnormal suckling behavior ( J:19212 )

• pups fail to eat

nervous system

abnormal brain morphology ( J:19212 )

abnormal brain development ( J:19212 )

• abnormalities in the brain are apparent by E12.5, before primordia for the cerebellum and colliculi form

abnormal midbrain development ( J:19212 )

• Background Sensitivity: reduced in size by E9.5

• Background Sensitivity: abnormalities less obvious at E8.5

abnormal choroid plexus morphology ( J:19212 )

• fused to the truncated colliculi

decreased inferior colliculus size ( J:19212 )

• truncated

abnormal cerebellum morphology ( J:19212 )

• Background Sensitivity: variable reduction in size

absent cerebellum ( J:19212 )

• Background Sensitivity: in extreme examples, the cerebellum can be absent

abnormal cranial nerve morphology ( J:19212 )

absent oculomotor nerve ( J:19212 )

• missing at E10.5 and E12.5

absent trochlear nerve ( J:19212 )

• missing at E10.5 and E12.5

endocrine/exocrine glands

abnormal eccrine sweat gland morphology ( J:34307 )

• ventrally restricted eccrine glands are largely absent

integument

abnormal eccrine sweat gland morphology ( J:34307 )

• ventrally restricted eccrine glands are largely absent

abnormal nail morphology ( J:34307 )

• in newborn mice, nails on digits 1-4 are circumferential in contrast to dorsally-positioned nails in wild-type neonates; nail plates are found on ventral and dorsal digit surfaces

abnormal hair follicle dermal papilla morphology ( J:34307 )

• present at base of epithelial structures in ventral and dorsal dermis

abnormal hair follicle development ( J:34307 )

• dorsally restricted follicles are seen along ventral as well as dorsal digit surfaces; ectopic ventral hairs on distal limbs

wrinkled skin ( J:19212 )

• skin wrinkles on digits

Allelic Composition	En1^tm1Alj/En1^tm1Alj
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal apical ectodermal ridge morphology ( J:45301 )

• ectopic expression ventrally of markers for the apical ectodermal ridge

embryo

abnormal apical ectodermal ridge morphology ( J:45301 )

• ectopic expression ventrally of markers for the apical ectodermal ridge

Allelic Composition	En1^tm1Alj/En1^tm3(En2)Alj
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
En1^tm3(En2)Alj mutation (0 available); any En1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:27767 )

• brain, limbs, and sternum normal

Allelic Composition	En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm7.1Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
En1^tm8.1Alj mutation (1 available); any En1 mutation (32 available)
En2^tm1Alj mutation (1 available); any En2 mutation (104 available)
En2^tm7.1Alj mutation (0 available); any En2 mutation (104 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:156169 )

abnormal cerebellum hemisphere lobule morphology ( J:156169 )

• when given tamoxifen at E13.5 or E14. the hemisphere phenotype is more severe than in double mutants that do not express Cre

abnormal cerebellum vermis lobule morphology ( J:156169 )

• when given tamoxifen at E13.5 or E14. the vermis phenotype is more severe than in double mutants that do not express Cre

Allelic Composition	En1^tm1Alj/En1^tm8.1Alj En2^tm6Alj/En2⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
En1^tm8.1Alj mutation (1 available); any En1 mutation (32 available)
En2^tm6Alj mutation (1 available); any En2 mutation (104 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:156169 )

decreased anterior vermis size ( J:156169 )

• when given tamoxifen at E10.5, at P21 the anterior region (lobules I-V) is reduced and the central region (lobules VI-VII) is preferentially expanded.

abnormal cerebellum vermis lobule morphology ( J:156169 )

• when tamoxifen is given at E10.5, at P21 lobule VIII extends more laterally than normal, as do lobules I-V but only on one side

Allelic Composition	En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm6Alj Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
En1^tm8.1Alj mutation (1 available); any En1 mutation (32 available)
En2^tm1Alj mutation (1 available); any En2 mutation (104 available)
En2^tm6Alj mutation (1 available); any En2 mutation (104 available)
Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156169 )

• tamoxifen treatment at E9.5, but not at E10.5, results in death at birth

nervous system

abnormal cerebellar granule cell precursor proliferation ( J:156169 )

• when tamoxifen treated at E10.5, at P2 proliferation is similar in the anterior and central lobules, unlike in wild-type mice

abnormal midbrain morphology ( J:156169 )

• a major deletion of the midbrain is seen when tamoxifen is given at E9.5, but not when given at E10.5

abnormal cerebellum morphology ( J:156169 )

• a major deletion of the medial cerebellum is seen when tamoxifen is given at E9.5 but not when given at E10.5

• when given tamoxifen at E10.5, at P14 the distinction between the vermis and the hemispheres is not apparent

abnormal cerebellum development ( J:156169 )

• when given tamoxifen at E10.5, at E12.5 the cerebellar primordium is reduced in size

• when tamoxifen treated at E10.5, development of the vermis prepyramidal fissure is delayed and the order of fissure initiation is altered

abnormal cerebellar foliation ( J:156169 )

• when given tamoxifen at E10.5, at P14 cerebellar foliation patterns are disrupted

• when given tamoxifen at E13.5 or E14.5, foliation defects in adults are less severe than when tamoxifen is given at E10.5

abnormal cerebellum external granule cell layer morphology ( J:156169 )

• when tamoxifen treated at E10.5, at E18.5 the thickness of the external granule layer was 1.5-2 times greater in the mutants than in wild types

• when tamoxifen treated at E10.5, at P2 the thickness of the external granule layer is similar in the lobules IV/V and VI unlike in wild-type mice

thin external granule cell layer ( J:156169 )

• when tamoxifen treated at E10.5, at P2 thickness is similar to that at E18.5 and thinner than in the controls.

abnormal cerebellum fissure morphology ( J:156169 )

• when given tamoxifen at E13.5 or E14.5, in adults the preculminate fissure is absent (between I-II and III) as lobules I-III are fused

• when given tamoxifen at E10.5, at P3 the depth of the primary fissure is increased relative to the intercrural fissure

abnormal cerebellum vermis morphology ( J:156169 )

decreased anterior vermis size ( J:156169 )

• when given tamoxifen at E10.5, at P14 the anterior region (lobules I-V) is reduced and the central region (lobules VI-VII) is preferentially expanded

abnormal cerebellum vermis lobule morphology ( J:156169 )

• when tamoxifen is given at E10.5, at P14, unlike in wild type, the remnants of lobules I-V extend into the hemispheres

• when tamoxifen is given at E10.5, at P14 remnants of the vermis, specific anterior and posterior regions, are maintained more laterally than in wild-type

• when given tamoxifen at E10.5, at P14 in some mutants lobule VIII is diminished more medially than lobule IX rather than the opposite as occurs in wild-type

• when tamoxifen treated at E10.5, at P2 lobules I - V are smaller and lobule VI is much larger than in wild-type

• when tamoxifen is given at E13.5 or E14.5, in adults lobule VIII is shifted posterior and fused with dorsal lobule IX

• when tamoxifen treated at E10.5, at P2 the thickness of the external granule layer is similar in the lobules IV/V and VI unlike in wild-type mice

abnormal cerebellum posterior vermis morphology ( J:156169 )

• when given tamoxifen at E10.5, at P14 lobules VI-VII occupy a greater proportion of the vermis than in wild-type

• when given tamoxifen at E10.5, at P14 lobules VIII-IX occupy a smaller proportion of the vermis than in wild-type

• when given tamoxifen at E13.5 or E14.5, in adults lobules I-III are fused into one lobule

cerebellum vermis hypoplasia ( J:156169 )

• when tamoxifen treated at E10.5, at P2 overall size of each region, and thus total number of cells, is greatly reduced

small cerebellum ( J:156169 )

• when given tamoxifen, at P3 the cerebellum is smaller compared to controls

cellular

abnormal cerebellar granule cell precursor proliferation ( J:156169 )

• when tamoxifen treated at E10.5, at P2 proliferation is similar in the anterior and central lobules, unlike in wild-type mice

Allelic Composition	En1^tm1Alj/En1^tm1Alj Wnt7a^tm1Amc/Wnt7a^tm1Amc Tg(Wnt1-En1)1Amc/0
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Tg(Wnt1-En1)1Amc mutation (0 available)
Wnt7a^tm1Amc mutation (1 available); any Wnt7a mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:45301 )

• viability ranged from 3 weeks to beyond 4 months

perinatal lethality, incomplete penetrance ( J:45301 )

• born in lower numbers than expected

limbs/digits/tail

abnormal autopod morphology ( J:45301 )

• ventral surface of autopods is pigmented

abnormal digit morphology ( J:45301 )

• dorsal sesamoid processes in the 3rd digit

• no polydactyly

oligodactyly ( J:45301 )

• some mice lack digit 5

abnormal foot pad morphology ( J:45301 )

• ectopic foot pads on digits 2, 3, and 4

• striations on the tips of digits 2, 3, and 5

• hardened foot pads

abnormal forelimb morphology ( J:45301 )

• dorsal surface of forelimbs with ventral surface characteristics

Allelic Composition	En1^tm1Alj/En1^tm1Alj Tg(Wnt1-En1)1Amc/0
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Tg(Wnt1-En1)1Amc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:45301 )

• perinatal brain lethality is rescued

nervous system

abnormal brain morphology ( J:45301 )

• brain abnormalities rescued

limbs/digits/tail

abnormal digit morphology ( J:45301 )

• ectopic hair growth on the ventral surface of the anterior digits

• related to ectopic ventral expression of Lmx-1B

abnormal foot pad morphology ( J:45301 )

• dorsal foot pads at the distal tips of digits 2 and 3 in 3 of 7 mice

Allelic Composition	En1^tm1Alj/En1^tm8.1Alj En2^tm1Alj/En2^tm7.1Alj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:156169 )

abnormal cerebellum hemisphere lobule morphology ( J:156169 )

• in the hemispheres, CrusII and Paramedian are only partially separated.

abnormal cerebellum vermis lobule morphology ( J:156169 )

• in adults, only one or two major anterior lobules are present, and lobule VIII is very small and fused with dorsal lobule IX.

Allelic Composition	En1^tm1Alj/En1⁺ En2^tm1Alj/En2^tm1Alj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
En2^tm1Alj mutation (1 available); any En2 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:84363 )

N	• normal cerebellum

Allelic Composition	En1^tm1Alj/En1^tm1Alj En2^tm1Alj/En2⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent cerebellum ( J:84363 )

Allelic Composition	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Rfng^tm1Tfv mutation (0 available); any Rfng mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

embryo

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

Allelic Composition	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng^tm1Tfv
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb development ( J:149312 )

• indistinguishable from mice with one wild-type Rfng allele at all stages examined

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

embryo

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

Allelic Composition	En1^tm1Alj/En1^tm1Alj Moen3^C57BL/6/Moen3^C57BL/6
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Moen3^C57BL/6 mutation (0 available); any Moen3 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum development ( J:120598 )

• promotes normal cerebellar development despite the presence of the En1^tm1Alj mutation

Allelic Composition	En1^tm1Alj/En1^tm1Alj Moen2^C57BL/6/Moen2^C57BL/6
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Moen2^C57BL/6 mutation (0 available); any Moen2 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum development ( J:120598 )

• promotes normal cerebellar development despite the presence of the En1^tm1Alj mutation

Allelic Composition	En1^tm1Alj/En1^tm1Alj Moen1^C57BL/6/Moen1^C57BL/6
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (32 available)
Moen1^C57BL/6 mutation (0 available); any Moen1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum development ( J:120598 )

• promotes normal cerebellar development despite the presence of the En1^tm1Alj mutation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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