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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd5tm1Cgn
targeted mutation 1, University of Cologne
MGI:1857148
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd5tm1Cgn/Cd5tm1Cgn B6.129P2-Cd5tm1Cgn MGI:5447722
hm2
 		Cd5tm1Cgn/Cd5tm1Cgn involves: 129P2/OlaHsd * C57BL/6 MGI:2662100
cx3
 		Cd28tm1Mak/Cd28+
Cd5tm1Cgn/Cd5tm1Cgn 		either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP) MGI:3652974
cx4
 		Cd28tm1Mak/Cd28tm1Mak
Cd5tm1Cgn/Cd5+ 		either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP) MGI:3652975
cx5
 		Cd28tm1Mak/Cd28tm1Mak
Cd5tm1Cgn/Cd5tm1Cgn 		either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP) MGI:3652976


Genotype
MGI:5447722
hm1
Allelic
Composition		 Cd5tm1Cgn/Cd5tm1Cgn
Genetic
Background		 B6.129P2-Cd5tm1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd5tm1Cgn mutation (1 available); any Cd5 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:189919 )
• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55
• in CD8+ T cells when restimulated
abnormal T cell anergy ( J:189919 )
• T cells treated with anti-CD3 or MOG35-55 are resistant to development of anergy
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:189919 )
• delayed onset and reduced severity of MOG-induced experimental autoimmune encephalomyelitis

hematopoietic system
increased T cell proliferation ( J:189919 )
• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55
• in CD8+ T cells when restimulated

cellular
increased T cell proliferation ( J:189919 )
• in CD4+ T cells stimulated with anti-CD3 or cognate peptide, rested then restimulated with anti-CD3 or MOG35-55
• in CD8+ T cells when restimulated




Genotype
MGI:2662100
hm2
Allelic
Composition		 Cd5tm1Cgn/Cd5tm1Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd5tm1Cgn mutation (1 available); any Cd5 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:19317 )
• mutant mice are viable, healthy and exhibit no changes in B and T cell populations, serum Ig content, and are able to mount effective T-cell dependent immune responses




Genotype
MGI:3652974
cx3
Allelic
Composition		 Cd28tm1Mak/Cd28+
Cd5tm1Cgn/Cd5tm1Cgn
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (12 available); any Cd28 mutation (53 available)
Cd5tm1Cgn mutation (1 available); any Cd5 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell clonal deletion ( J:110925 )
• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection

hematopoietic system
abnormal T cell clonal deletion ( J:110925 )
• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection




Genotype
MGI:3652975
cx4
Allelic
Composition		 Cd28tm1Mak/Cd28tm1Mak
Cd5tm1Cgn/Cd5+
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (12 available); any Cd28 mutation (53 available)
Cd5tm1Cgn mutation (1 available); any Cd5 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell clonal deletion ( J:110925 )
• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection

hematopoietic system
abnormal T cell clonal deletion ( J:110925 )
• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection




Genotype
MGI:3652976
cx5
Allelic
Composition		 Cd28tm1Mak/Cd28tm1Mak
Cd5tm1Cgn/Cd5tm1Cgn
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (12 available); any Cd28 mutation (53 available)
Cd5tm1Cgn mutation (1 available); any Cd5 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell clonal deletion ( J:110925 )
• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection
increased CD4-positive, alpha-beta T cell number ( J:110925 )
• CD4+ thymocytes are increased to a greater extent than in CD5 knockouts
increased CD8-positive, alpha-beta T cell number ( J:110925 )
• Cd8+ thymocytes are increased

hematopoietic system
abnormal T cell clonal deletion ( J:110925 )
• mice show partial rescue of Vbeta11+CD4+ thymocytes from negative selection
increased CD4-positive, alpha-beta T cell number ( J:110925 )
• CD4+ thymocytes are increased to a greater extent than in CD5 knockouts
increased CD8-positive, alpha-beta T cell number ( J:110925 )
• Cd8+ thymocytes are increased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory