Mouse Genome Informatics
hm1
    Cd4tm1Knw/Cd4tm1Knw
B6.129S-Cd4tm1Knw/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• significantly decreased CD4+ cell population in spleen and thymus as compared to control
• increased CD8+ cell population in spleen and thymus as compared to control
• significantly increased clearance time (24-50 days) after infection by Rickettsiales member (E. chaffeensis)
• granulomatous inflammation in liver is more extensive at 16 days post-infection in contrast to control
• delayed CTL response following second challenge with E. chaffeensis infection

hematopoietic system
• significantly decreased CD4+ cell population in spleen and thymus as compared to control
• increased CD8+ cell population in spleen and thymus as compared to control


Mouse Genome Informatics
hm2
    Cd4tm1Knw/Cd4tm1Knw
NOD.Cg-Cd4tm1Knw
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• Cd4-deficient mice are diabetes resistant (diabetes observed in 0/18 females by 30 weeks)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553


Mouse Genome Informatics
cx3
    Cd4tm1Knw/Cd4tm1Knw
Tgfb1tm1Doe/Tgfb1tm1Doe

involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• majority of double mutants die by 35 days of age


Mouse Genome Informatics
cx4
    Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0

NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• transgene-expressing female mice develop IDDM with an onset of about 7 weeks of age, whereas CD4-null NOD mice are resistant (no IDDM by 30 weeks of age)

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553