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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd4tm1Knw
targeted mutation 1, Barbara B Knowles
MGI:1857143
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd4tm1Knw/Cd4tm1Knw B6.129S-Cd4tm1Knw/J MGI:3580328
hm2
Cd4tm1Knw/Cd4tm1Knw NOD.Cg-Cd4tm1Knw MGI:3623373
cx3
Cd4tm1Knw/Cd4tm1Knw
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1 MGI:3622474
cx4
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs MGI:3618705


Genotype
MGI:3580328
hm1
Allelic
Composition
Cd4tm1Knw/Cd4tm1Knw
Genetic
Background
B6.129S-Cd4tm1Knw/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significantly decreased CD4+ cell population in spleen and thymus as compared to control
• increased CD8+ cell population in spleen and thymus as compared to control
• significantly increased clearance time (24-50 days) after infection by Rickettsiales member (E. chaffeensis)
• granulomatous inflammation in liver is more extensive at 16 days post-infection in contrast to control
• delayed CTL response following second challenge with E. chaffeensis infection

hematopoietic system
• significantly decreased CD4+ cell population in spleen and thymus as compared to control
• increased CD8+ cell population in spleen and thymus as compared to control




Genotype
MGI:3623373
hm2
Allelic
Composition
Cd4tm1Knw/Cd4tm1Knw
Genetic
Background
NOD.Cg-Cd4tm1Knw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Cd4-deficient mice are diabetes resistant (diabetes observed in 0/18 females by 30 weeks)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553




Genotype
MGI:3622474
cx3
Allelic
Composition
Cd4tm1Knw/Cd4tm1Knw
Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (51 available)
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• majority of double mutants die by 35 days of age




Genotype
MGI:3618705
cx4
Allelic
Composition
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (51 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• transgene-expressing female mice develop IDDM with an onset of about 7 weeks of age, whereas CD4-null NOD mice are resistant (no IDDM by 30 weeks of age)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory