• partial arrest of B cell development (J:28968)

• defective B cell activation after immunization with T-independent type II antigens (J:28968)

• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)

• increased numbers of pro-B cells (J:28968)

• decreased numbers of mature B cells (J:28968)

• numbers of mature recirculating B cells (B220^highIgM+, HSA^lowIgM+, and B220+IgD+) are reduced (J:82298)

• germinal centers are infrequent in TNP-LPS immunized mutants (J:82298)

• germinal centers are smaller in TNP-LPS immunized mutants (J:82298)

• partial arrest of B cell development (J:28968)

• defective B cell activation after immunization with T-independent type II antigens (J:28968)

• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)

• increased numbers of pro-B cells (J:28968)

• decreased numbers of mature B cells (J:28968)

• numbers of mature recirculating B cells (B220^highIgM+, HSA^lowIgM+, and B220+IgD+) are reduced (J:82298)

• germinal centers are infrequent in TNP-LPS immunized mutants (J:82298)

• germinal centers are smaller in TNP-LPS immunized mutants (J:82298)

• smaller and fewer germinal centers are observed in response to TI-I antigen, TNP-LPS (J:82298)

• decreased serum IgG3 concentration (J:28968)

• decreased serum IgM concentration (J:28968)

• partial arrest of B cell development (J:28968)

• defective B cell activation after immunization with T-independent type II antigens (J:28968)

• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)

• increased numbers of pro-B cells (J:28968)

• B cell development and activation are normal and no other obvious abnormalities are seen (J:104167)

• partial block at large pre-B cell stage (J:66080)

• failure to respond to IgM (J:66080)

• attenuated response to LPS (J:66080)

• accumulation of CD43+ B cell precursors, indicating partial developmental block (J:66080)

• reduced platelet spreading on collagen, but not fibrinogen, monolayer (J:86448)

• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen (J:86448)

• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen (J:86448)

• no alterations in aggregation in response to ADP (J:86448)

• partial block at large pre-B cell stage (J:66080)

• failure to respond to IgM (J:66080)

• attenuated response to LPS (J:66080)

• accumulation of CD43+ B cell precursors, indicating partial developmental block (J:66080)

• failure to respond to thymus-independent antigen (TNP-Ficoll) (J:66080)

• failure to respond to thymus-dependent antigen (TNP-KLH adsorbed on aluminum hydroxide) (J:66080)

• reduced platelet spreading on collagen, but not fibrinogen, monolayer (J:86448)

• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen (J:86448)

• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen (J:86448)

• no alterations in aggregation in response to ADP (J:86448)

• partial block at large pre-B cell stage (J:66080)

• failure to respond to IgM (J:66080)

• attenuated response to LPS (J:66080)

• accumulation of CD43+ B cell precursors, indicating partial developmental block (J:66080)

• impairment in the early and late phases of Ca²⁺ mobilization following BCR stimulation (J:82430)

• fail to proliferate after BCR cross linking (J:82430)

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased (J:82430)

• fail to proliferate after BCR cross linking (J:82430)

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased (J:82430)

• fail to proliferate after BCR cross linking (J:82430)

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased (J:82430)

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased (J:82430)

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased (J:82430)

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased (J:82430)

• arrested B cell development at the pre-B stage (J:70406)

• arrested B cell development at the pre-B stage (J:70406)

• arrested B cell development at the pre-B stage (J:70406)

• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)

• severe deficiency of B cells in the spleen and lymph nodes compared to single Btk homozygotes; total numbers of B220+IgM+ B cells in the spleen are 3-4 fold reduced relative to single Btk homozygotes and 7-8 fold reduced relative to wild-type or single Cd40 homozygotes (J:82298)

• B cell deficiency is more severe in the lymph node than in spleen (J:82298)

• mature recirculating B cells (B220^highIgM+, HSA^lowIgM+, and B220+IgD+) are reduced more than in single Btk homozygotes (J:82298)

• absence of germinal center formation in response to TI-I antigen stimulation (J:82298)

• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)

• severe deficiency of B cells in the spleen and lymph nodes compared to single Btk homozygotes; total numbers of B220+IgM+ B cells in the spleen are 3-4 fold reduced relative to single Btk homozygotes and 7-8 fold reduced relative to wild-type or single Cd40 homozygotes (J:82298)

• B cell deficiency is more severe in the lymph node than in spleen (J:82298)

• mature recirculating B cells (B220^highIgM+, HSA^lowIgM+, and B220+IgD+) are reduced more than in single Btk homozygotes (J:82298)

• absence of germinal center formation in response to TI-I antigen stimulation (J:82298)

• absence of germinal center formation in response to TI-I antigen stimulation (J:82298)

• defective IgM and IgG response to TI antigen and TD antigen stimulation (J:82298)

• 40-fold reduction compared to single CD40 homozygote (J:82298)

• similar decrease to that seen in single CD40 homozygotes (J:82298)

• 10-fold reduction compared to single CD40 homozygote (J:82298)

• similar decrease to that seen in single Btk homozygotes (J:82298)

• 7-fold reduction compared to single Btk homozygote (J:82298)

• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type (J:82298)