Mouse Genome Informatics
hm1
    B2mtm1Unc/B2mtm1Unc
B6.129P2-B2mtm1Unc/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose

immune system
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)
• in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice
• mice do not develop spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for about 17 weeks before developing hyperglycemia/diabetes; kinetics are much slower than in B2m-null, Tg(GFAP-B2m)Mdos (line 9 or 14) transgenic mice
• mice are highly resistant to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) following infection with either a low or high dose of IOE, 90% of mice survive a low dose with mild illness and all mice succumb to a high dose
• following infection with IEO, CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)
• mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice
• at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity
• following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose

hematopoietic system
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)
• in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice

endocrine/exocrine glands
• mice develop peri-islet T cell aggregates >30 weeks of age

homeostasis/metabolism
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice


Mouse Genome Informatics
hm2
    B2mtm1Unc/B2mtm1Unc
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
• when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut
• when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts
• deficient in CD4-CD8+ T cells
• CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control
• surface expression of class I molecules in cells from lymph nodes, spleen and thymus cannot be detected by flow cytometry

hematopoietic system
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
• when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut
• when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts
• deficient in CD4-CD8+ T cells
• CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control


Mouse Genome Informatics
hm3
    B2mtm1Unc/B2mtm1Unc
involves: 129P2/OlaHsd * NOD/Lt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks

immune system
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks


Mouse Genome Informatics
hm4
    B2mtm1Unc/B2mtm1Unc
NOD.129P2-B2mtm1Unc
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• homozygous-null NOD mice show almost no insulitis and still possess normal beta cells; control NOD mice show insulitis and a high degree of beta cell destruction

immune system
• mice lack CD8+ T cells
• no homozygous mice become diabetic by 4 months of age, while over 70% of control NOD mice become diabetic (blood glucose >16.7 mM; positive urine glucose test) by 4 months of age (J:17000)
• females remain disease-free compared (J:121685)

hematopoietic system
• mice lack CD8+ T cells

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:17000


Mouse Genome Informatics
ht5
    B2mtm1Unc/B2m+
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control
• surface expression of class I molecules in cells from lymph nodes are reduced in comparison to control

hematopoietic system
• numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control


Mouse Genome Informatics
cn6
    B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)#Asin/0

involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system

hematopoietic system


Mouse Genome Informatics
cn7
    B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)#Asin/0

involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system

hematopoietic system


Mouse Genome Informatics
cx8
    B2mtm1Unc/B2mtm1Unc
Tespa1tm1Lrgl/Tespa1tm1Lrgl

involves: 129 * 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• unlike in B2mtm1Unc homozygotes, CD8+ single positive thymocytes are detected in the thymus and spleen

hematopoietic system
• unlike in B2mtm1Unc homozygotes, CD8+ single positive thymocytes are detected in the thymus and spleen


Mouse Genome Informatics
cx9
    B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• colitis progresses faster in these mice compared to mice with targeted mutations of just the Il2 gene (J:39981)
• 75% have colitis at 6-12 months of age (J:51450)
• T cells isolated from lymph nodes and the colon have markers indicating an activated or memory-like phenotype
• mesenteric lymph nodes do not contain CD8+ T cells
• <1% of CD8 T cells found in the intestinal mucosa
• chronically activated CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments
• increased IFN-gamma production by CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments of colitic double mutants

digestive/alimentary system
• several mutants develop rectal prolapse
• 70% of mice exhibit this by 15 weeks of age, compared to 25% of mice to mice with targeted mutations of just the Il2 gene (J:39981)
• colitis progresses faster in these mice compared to mice with targeted mutations of just the Il2 gene (J:39981)
• 75% have colitis at 6-12 months of age (J:51450)

tumorigenesis
• 29% incidence of adenocarcinomas in the proximal half of the colon
• most mutants with tumors were between 6-8 months old and no tumors seen at 6 months or younger
• tumors are well to moderately differentiated, invading into or through the muscularis propria with a surrounding desmoplastic stromal response

growth/size
• 70% of mice exhibit this by 15 weeks of age, compared to 25% of homozygote mice with targeted mutations of just the Il2 gene (J:39981)

hematopoietic system
• T cells isolated from lymph nodes and the colon have markers indicating an activated or memory-like phenotype
• mesenteric lymph nodes do not contain CD8+ T cells
• <1% of CD8 T cells found in the intestinal mucosa
• chronically activated CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments
• increased IFN-gamma production by CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments of colitic double mutants


Mouse Genome Informatics
cx10
    B2mtm1Unc/B2mtm1Unc
Cd4tm1Mak/Cd4tm1Mak
Cd8atm2.1(Cd4)Asin/Cd8atm2.1(Cd4)Asin

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• lack of helper T cell function
• retain cytotoxic T cell functions

hematopoietic system
• lack of helper T cell function
• retain cytotoxic T cell functions


Mouse Genome Informatics
cx11
    B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor

involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
N
• there are no abnormalities of the placenta, the mesometrial triangle, and differentiation of granulated metrial gland cells (aka uterine NK cells) in the uteri of pregnant mice at day 14 of gestation (J:134589)


Mouse Genome Informatics
cx12
    B2mtm1Unc/B2mtm1Unc
Zbtb7btm4.1Itan/Zbtb7btm4.1Itan

involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mature CD8+ T cells are increased unlike controls

hematopoietic system
• mature CD8+ T cells are increased unlike controls


Mouse Genome Informatics
cx13
    B2mtm1Unc/B2mtm1Unc
Lattm1Mal/Lattm1Mal

involves: 129P2/OlaHsd * 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• same phenotype as Lattm1Mal homozygotes


Mouse Genome Informatics
cx14
    B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Lattm1Mal/Lattm1Mal

involves: 129P2/OlaHsd * 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• pathological inflammatory phenotype of Lattm1Mal homozygotes is absent in these mice (J:77098)
• in both the thymus and spleen
• in both the thymus and spleen

hematopoietic system
• in both the thymus and spleen
• in both the thymus and spleen


Mouse Genome Informatics
cx15
    B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi

involves: 129P2/OlaHsd * 129S2/SvPas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• decrease in hippocampal neurogenesis

cellular
• decrease in hippocampal neurogenesis


Mouse Genome Informatics
cx16
    B2mtm1Unc/B2mtm1Unc
Irf2tm1Mak/Irf2tm1Mak

involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
integument
• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice


Mouse Genome Informatics
cx17
    B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees

involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 6-fold more embryos survive than in Tbptm1.1Ees homozygotes


Mouse Genome Informatics
cx18
    B2mtm1Unc/B2mtm1Unc
H2-D1tm1Bpe/H2-D1tm1Bpe

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• almost no CD8+ T lymphocytes

hematopoietic system
• almost no CD8+ T lymphocytes


Mouse Genome Informatics
cx19
    B2mtm1Unc/B2mtm1Unc
Tg(GFAP-B2m)9Mdos/?

involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• cells are absent from spleen
• mice resist development of spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for 14 weeks before developing hyperglycemia/diabetes; kinetics of disease development are much slower than wild-type recipients which maintain normoglycemia for <5 weeks post-transfer
• adoptive transfer of splenocytes from TCR-AI4 transgenic mice does not result in rapid disease development in contrast to wild-type controls

hematopoietic system
• cells are absent from spleen


Mouse Genome Informatics
cx20
    B2mtm1Unc/B2mtm1Unc
Tg(GFAP-B2m)#Mdos/?

involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• cells are absent from spleen
• mice resist development of spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for 14 weeks before developing hyperglycemia/diabetes; kinetics of disease development are much slower than wild-type recipients which maintain normoglycemia for <5 weeks post-transfer
• adoptive transfer of splenocytes from TCR-AI4 transgenic mice does not result in rapid disease development in contrast to wild-type controls

hematopoietic system
• cells are absent from spleen


Mouse Genome Informatics
cx21
    B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca

involves: 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant

liver/biliary system
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant


Mouse Genome Informatics
cx22
    B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum

NOD.Cg-B2mtm1Unc Ciitatm1Ccum
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• NOD diabetic female mice which receive islet grafts from these classI/II-deficient NOD mice remain euglycemic for up to 147 days, compared to mice receiving islet grafts from NOD or class II-deficient NOD mice which maintain euglycemia for only 6-8 days after transplant; upon removal of the graft-bearing kidney, hyperglycemia returned within 24 hours

hematopoietic system
• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals

immune system
• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals
• mice monitored to 30 weeks of age do not develop type I diabetes (2 consecutive blood glucose readings >16.5nM) while 70% of wild-type NOD mice develop diabetes

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:107051


Mouse Genome Informatics
cx23
    B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
N
• at 22 weeks, no animals show cardiac enlargement or significant mononuclear cell infiltrates (J:113267)
• only animal developed first degree heart block by 24 weeks of age, and no animals develop complete heart block


Mouse Genome Informatics
cx24
    B2mtm1Unc/B2mtm1Unc
Prkdcscid/Prkdcscid

NOD.Cg-B2mtm1Unc Prkdcscid
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mean life span is 191+11 days

immune system
• lacks lymphoid cells in the spleen, lymph nodes and thymus
• absence of mature B cells in spleen, very little serum Ig
• few CD4+ and CD8+ cells in spleen and no mature T cells
• lacks detectable NK cell activity after pretreatment with NK cell inducer
• mouse supports high levels of human CD4+ T cell engraftment in spleen and peripheral blood following human PBMC injection
• minimal engraftment of human CD19+ B cells (less than 2%) following human PBMC injection
• rapid clearance of human IgG

tumorigenesis
• associated with shortened lifespan

homeostasis/metabolism
• intracytoplasmic iron deposition in liver

hematopoietic system
• lacks lymphoid cells in the spleen, lymph nodes and thymus
• absence of mature B cells in spleen, very little serum Ig
• few CD4+ and CD8+ cells in spleen and no mature T cells
• lacks detectable NK cell activity after pretreatment with NK cell inducer

liver/biliary system
• intracytoplasmic iron deposition in liver


Mouse Genome Informatics
cx25
    B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Tg(HLA-A2.1)1Enge/Tg(HLA-A2.1)1Enge

NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice develop diabetes at a rate similar to NOD control females, whereas transgenic animals not expressing Tg(HLA-A2.1)1Enge are normally diabetes-resistant


Mouse Genome Informatics
cx26
    B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/0

NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• mice exhibit normal class I disparate skin graft rejection and viral infection clearance (J:71837)

endocrine/exocrine glands
N
• mice fail to develop insulitis unlike NOD mice (J:71837)


Mouse Genome Informatics
cx27
    B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0

NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
• HLA-A2.1-restricted T cells from mice as young as 5 weeks of age respond to IGRP (islet-specific glucose-6-phophatase catalytic subunit-related protein) peptides
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets
• 55% of females develop type I diabetes by 30 weeks of age, with significantly accelerated onset compared with non transgenic littermates

hematopoietic system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:121685


Mouse Genome Informatics
cx28
    B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0

NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present

immune system
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present
• B2m-deficient female transgenic NOD mice are completely diabetes resistant compared to transgenic NOD controls

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553