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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
B2mtm1Unc
targeted mutation 1, University of North Carolina
MGI:1857133
Summary 29 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
B2mtm1Unc/B2mtm1Unc B6.129P2-B2mtm1Unc/J MGI:3722074
hm2
B2mtm1Unc/B2mtm1Unc involves: 129P2/OlaHsd * C57BL/6 MGI:3576257
hm3
B2mtm1Unc/B2mtm1Unc involves: 129P2/OlaHsd * NOD/Lt MGI:3640344
hm4
B2mtm1Unc/B2mtm1Unc NOD.129P2-B2mtm1Unc MGI:3623523
ht5
B2mtm1Unc/B2m+ involves: 129P2/OlaHsd * C57BL/6 MGI:3762580
cn6
B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)#Asin/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5469014
cn7
B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)#Asin/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5469010
cx8
B2mtm1Unc/B2mtm1Unc
Tespa1tm1Lrgl/Tespa1tm1Lrgl
involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:5432920
cx9
B2mtm1Unc/B2mtm1Unc
Cd4tm1Mak/Cd4tm1Mak
Cd8atm2.1(Cd4)Asin/Cd8atm2.1(Cd4)Asin
involves: 129 * C57BL/6 MGI:5309023
cx10
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129 * C57BL/6 MGI:3576258
cx11
B2mtm1Unc/B2mtm1Unc
Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
involves: 129P2/OlaHsd MGI:5486340
cx12
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129P2/OlaHsd MGI:3798945
cx13
B2mtm1Unc/B2mtm1Unc
Lattm1Mal/Lattm1Mal
involves: 129P2/OlaHsd * 129S2/SvPas MGI:3770643
cx14
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Lattm1Mal/Lattm1Mal
involves: 129P2/OlaHsd * 129S2/SvPas MGI:3770644
cx15
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
involves: 129P2/OlaHsd * 129S2/SvPas MGI:4949108
cx16
B2mtm1Unc/B2mtm1Unc
Irf2tm1Mak/Irf2tm1Mak
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3630269
cx17
B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3720051
cx18
B2mtm1Unc/B2mtm1Unc
H2-D1tm1Bpe/H2-D1tm1Bpe
involves: 129P2/OlaHsd * C57BL/6 MGI:3623482
cx19
B2mtm1Unc/B2mtm1Unc
Tg(GFAP-B2m)9Mdos/?
involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ MGI:3790777
cx20
B2mtm1Unc/B2mtm1Unc
Tg(GFAP-B2m)#Mdos/?
involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ MGI:3790780
cx21
B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca
involves: 129S6/SvEvTac * C57BL/6J MGI:2655484
cx22
B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum
NOD.Cg-B2mtm1Unc Ciitatm1Ccum MGI:3620137
cx23
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell MGI:3687124
cx24
B2mtm1Unc/B2mtm1Unc
Prkdcscid/Prkdcscid
NOD.Cg-B2mtm1Unc Prkdcscid MGI:3607137
cx25
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/0
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs MGI:3844912
cx26
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Tg(HLA-A2.1)1Enge/Tg(HLA-A2.1)1Enge
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge MGI:3723607
cx27
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs MGI:3711109
cx28
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs MGI:3618703
cx29
B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Tg(HLA-A2.1)1Enge/?
NOD.Cg-Prkdcscid Emv30b B2mtm1Unc Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl/Dvs MGI:5707036


Genotype
MGI:3722074
hm1
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Genetic
Background
B6.129P2-B2mtm1Unc/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose

immune system
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)
• in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice
• mice do not develop spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for about 17 weeks before developing hyperglycemia/diabetes; kinetics are much slower than in B2m-null, Tg(GFAP-B2m)Mdos (line 9 or 14) transgenic mice
• mice are highly resistant to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) following infection with either a low or high dose of IOE, 90% of mice survive a low dose with mild illness and all mice succumb to a high dose
• following infection with IEO, CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)
• mice have lower burdens of Ehrlichia bacteria in the lungs and spleen following infection than do wild-type mice
• at day 12 and 14 post-infection with a lethal low dose of IEO, mice exhibit only mild liver pathology, few apoptotic foci in the liver and preserved lymphoid tissue cellularity
• following infection with either a low or high dose of IOE, 90% of mice survive a low dose and all mice succumb to a high dose

hematopoietic system
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), the number of interferon-gamma producing CD4+ Th1 cells in the spleen on day 8 and day 12 is increased relative to in infected wild-type mice
• following infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), CD8+ T cells in the spleen are reduced (1.5%+/-0.1% of splenocytes compared to 9.7%+/-0.7% of splenocytes in wild-type mice)
• in uninfected mice the number of CD8+ T cells in the spleen is reduced compared to in wild-type mice

endocrine/exocrine glands
• mice develop peri-islet T cell aggregates >30 weeks of age

homeostasis/metabolism
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less IL-10 than in infected wild-type mice
• following infection with a lethal low dose of a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE), induces less TNF-alpha than in infected wild-type mice




Genotype
MGI:3576257
hm2
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
• when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut
• when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts
• deficient in CD4-CD8+ T cells
• CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control
• surface expression of class I molecules in cells from lymph nodes, spleen and thymus cannot be detected by flow cytometry

hematopoietic system
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
• when wild-type bone marrow is transferred into these mice, MAIT T cells are found in the gut
• when these mice serve as bone marrow donors, MAIT T cells are absent in the gut of irradiated hosts
• deficient in CD4-CD8+ T cells
• CD8+CD4- T cells from the thymus of five week old mice are almost non-existent in comparison to control (0.8% vs. 6.7%), however, total numbers of alpha beta T cells and CD8-CD4+ T cells do not differ significantly from control




Genotype
MGI:3640344
hm3
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Genetic
Background
involves: 129P2/OlaHsd * NOD/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks

immune system
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks




Genotype
MGI:3623523
hm4
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Genetic
Background
NOD.129P2-B2mtm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• homozygous-null NOD mice show almost no insulitis and still possess normal beta cells; control NOD mice show insulitis and a high degree of beta cell destruction

immune system
• mice lack CD8+ T cells
• no homozygous mice become diabetic by 4 months of age, while over 70% of control NOD mice become diabetic (blood glucose >16.7 mM; positive urine glucose test) by 4 months of age (J:17000)
• females remain disease-free compared (J:121685)

hematopoietic system
• mice lack CD8+ T cells

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:17000




Genotype
MGI:3762580
ht5
Allelic
Composition
B2mtm1Unc/B2m+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control
• surface expression of class I molecules in cells from lymph nodes are reduced in comparison to control

hematopoietic system
• numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control




Genotype
MGI:5469014
cn6
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)#Asin/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (56 available)
Il2rgtm1Wjl mutation (26 available); any Il2rg mutation (56 available)
Tg(Cd8a*-cre)#Asin mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469010
cn7
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)#Asin/0
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (9 available)
Il7rtm1Imx mutation (3 available); any Il7r mutation (9 available)
Tg(Cd8a*-cre)#Asin mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5432920
cx8
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic
Background
involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tespa1tm1Lrgl mutation (0 available); any Tespa1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• unlike in B2mtm1Unc homozygotes, CD8+ single positive thymocytes are detected in the thymus and spleen

hematopoietic system
• unlike in B2mtm1Unc homozygotes, CD8+ single positive thymocytes are detected in the thymus and spleen




Genotype
MGI:5309023
cx9
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Cd4tm1Mak/Cd4tm1Mak
Cd8atm2.1(Cd4)Asin/Cd8atm2.1(Cd4)Asin
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Cd4tm1Mak mutation (3 available); any Cd4 mutation (51 available)
Cd8atm2.1(Cd4)Asin mutation (0 available); any Cd8a mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• lack of helper T cell function
• retain cytotoxic T cell functions

hematopoietic system
• lack of helper T cell function
• retain cytotoxic T cell functions




Genotype
MGI:3576258
cx10
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Il2tm1Hor mutation (4 available); any Il2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• colitis progresses faster in these mice compared to mice with targeted mutations of just the Il2 gene (J:39981)
• 75% have colitis at 6-12 months of age (J:51450)
• T cells isolated from lymph nodes and the colon have markers indicating an activated or memory-like phenotype
• mesenteric lymph nodes do not contain CD8+ T cells
• <1% of CD8 T cells found in the intestinal mucosa
• chronically activated CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments
• increased IFN-gamma production by CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments of colitic double mutants

digestive/alimentary system
• several mutants develop rectal prolapse
• 29% incidence of adenocarcinomas in the proximal half of the colon
• most mutants with tumors were between 6-8 months old and no tumors seen at 6 months or younger
• tumors are well to moderately differentiated, invading into or through the muscularis propria with a surrounding desmoplastic stromal response
• 70% of mice exhibit this by 15 weeks of age, compared to 25% of mice to mice with targeted mutations of just the Il2 gene (J:39981)
• colitis progresses faster in these mice compared to mice with targeted mutations of just the Il2 gene (J:39981)
• 75% have colitis at 6-12 months of age (J:51450)

neoplasm
• 29% incidence of adenocarcinomas in the proximal half of the colon
• most mutants with tumors were between 6-8 months old and no tumors seen at 6 months or younger
• tumors are well to moderately differentiated, invading into or through the muscularis propria with a surrounding desmoplastic stromal response

growth/size/body
• 70% of mice exhibit this by 15 weeks of age, compared to 25% of homozygote mice with targeted mutations of just the Il2 gene (J:39981)

hematopoietic system
• T cells isolated from lymph nodes and the colon have markers indicating an activated or memory-like phenotype
• mesenteric lymph nodes do not contain CD8+ T cells
• <1% of CD8 T cells found in the intestinal mucosa
• chronically activated CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments
• increased IFN-gamma production by CD4+ T cells in the mesenteric lymph node and lamina propria lymphocyte compartments of colitic double mutants




Genotype
MGI:5486340
cx11
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Zbtb7btm4.1Itan/Zbtb7btm4.1Itan
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Zbtb7btm4.1Itan mutation (0 available); any Zbtb7b mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mature CD8+ T cells are increased unlike controls

hematopoietic system
• mature CD8+ T cells are increased unlike controls




Genotype
MGI:3798945
cx12
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Il2tm1Hor mutation (4 available); any Il2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• there are no abnormalities of the placenta, the mesometrial triangle, and differentiation of granulated metrial gland cells (aka uterine NK cells) in the uteri of pregnant mice at day 14 of gestation




Genotype
MGI:3770643
cx13
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Lattm1Mal/Lattm1Mal
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Lattm1Mal mutation (0 available); any Lat mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• same phenotype as Lattm1Mal homozygotes




Genotype
MGI:3770644
cx14
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Lattm1Mal/Lattm1Mal
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
H2-Ab1tm1Doi mutation (11 available); any H2-Ab1 mutation (37 available)
Lattm1Mal mutation (0 available); any Lat mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• pathological inflammatory phenotype of Lattm1Mal homozygotes is absent in these mice
• in both the thymus and spleen
• in both the thymus and spleen

hematopoietic system
• in both the thymus and spleen
• in both the thymus and spleen




Genotype
MGI:4949108
cx15
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
H2-Ab1tm1Doi mutation (11 available); any H2-Ab1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in hippocampal neurogenesis

cellular
• decrease in hippocampal neurogenesis




Genotype
MGI:3630269
cx16
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Irf2tm1Mak/Irf2tm1Mak
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Irf2tm1Mak mutation (0 available); any Irf2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice




Genotype
MGI:3720051
cx17
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tbptm1.1Ees/Tbptm1.1Ees
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tbptm1.1Ees mutation (0 available); any Tbp mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 6-fold more embryos survive than in Tbptm1.1Ees homozygotes




Genotype
MGI:3623482
cx18
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
H2-D1tm1Bpe/H2-D1tm1Bpe
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
H2-D1tm1Bpe mutation (5 available); any H2-D1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• almost no CD8+ T lymphocytes

hematopoietic system
• almost no CD8+ T lymphocytes




Genotype
MGI:3790777
cx19
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(GFAP-B2m)9Mdos/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tg(GFAP-B2m)9Mdos mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cells are absent from spleen
• mice resist development of spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for 14 weeks before developing hyperglycemia/diabetes; kinetics of disease development are much slower than wild-type recipients which maintain normoglycemia for <5 weeks post-transfer
• adoptive transfer of splenocytes from TCR-AI4 transgenic mice does not result in rapid disease development in contrast to wild-type controls

hematopoietic system
• cells are absent from spleen




Genotype
MGI:3790780
cx20
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(GFAP-B2m)#Mdos/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * NOD/ShiLtJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tg(GFAP-B2m)#Mdos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cells are absent from spleen
• mice resist development of spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for 14 weeks before developing hyperglycemia/diabetes; kinetics of disease development are much slower than wild-type recipients which maintain normoglycemia for <5 weeks post-transfer
• adoptive transfer of splenocytes from TCR-AI4 transgenic mice does not result in rapid disease development in contrast to wild-type controls

hematopoietic system
• cells are absent from spleen




Genotype
MGI:2655484
cx21
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant

liver/biliary system
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:3620137
cx22
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Ciitatm1Ccum/Ciitatm1Ccum
Genetic
Background
NOD.Cg-B2mtm1Unc Ciitatm1Ccum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Ciitatm1Ccum mutation (4 available); any Ciita mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• NOD diabetic female mice which receive islet grafts from these classI/II-deficient NOD mice remain euglycemic for up to 147 days, compared to mice receiving islet grafts from NOD or class II-deficient NOD mice which maintain euglycemia for only 6-8 days after transplant; upon removal of the graft-bearing kidney, hyperglycemia returned within 24 hours

hematopoietic system
• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals

immune system
• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals
• mice monitored to 30 weeks of age do not develop type I diabetes (2 consecutive blood glucose readings >16.5nM) while 70% of wild-type NOD mice develop diabetes

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:107051




Genotype
MGI:3687124
cx23
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic
Background
NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
H2-Ab1tm1Gru mutation (12 available); any H2-Ab1 mutation (37 available)
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• at 22 weeks, no animals show cardiac enlargement or significant mononuclear cell infiltrates
• only animal developed first degree heart block by 24 weeks of age, and no animals develop complete heart block




Genotype
MGI:3607137
cx24
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Prkdcscid/Prkdcscid
Genetic
Background
NOD.Cg-B2mtm1Unc Prkdcscid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Prkdcscid mutation (72 available); any Prkdc mutation (188 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• associated with shortened lifespan

mortality/aging
• mean life span is 191+11 days

immune system
• absence of mature B cells in spleen, very little serum Ig
• few CD4+ and CD8+ cells in spleen and no mature T cells
• lacks lymphoid cells in the spleen, lymph nodes and thymus
• lacks detectable NK cell activity after pretreatment with NK cell inducer
• mouse supports high levels of human CD4+ T cell engraftment in spleen and peripheral blood following human PBMC injection
• minimal engraftment of human CD19+ B cells (less than 2%) following human PBMC injection
• rapid clearance of human IgG

neoplasm
• associated with shortened lifespan

homeostasis/metabolism
• intracytoplasmic iron deposition in liver

hematopoietic system
• absence of mature B cells in spleen, very little serum Ig
• few CD4+ and CD8+ cells in spleen and no mature T cells
• lacks lymphoid cells in the spleen, lymph nodes and thymus
• lacks detectable NK cell activity after pretreatment with NK cell inducer

liver/biliary system
• intracytoplasmic iron deposition in liver




Genotype
MGI:3844912
cx25
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/0
Genetic
Background
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tg(B2M)55Hpl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal class I disparate skin graft rejection and viral infection clearance

endocrine/exocrine glands
N
• mice fail to develop insulitis unlike NOD mice




Genotype
MGI:3723607
cx26
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Tg(HLA-A2.1)1Enge/Tg(HLA-A2.1)1Enge
Genetic
Background
NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl Tg(HLA-A2.1)1Enge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tg(B2M)55Hpl mutation (6 available)
Tg(HLA-A2.1)1Enge mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop diabetes at a rate similar to NOD control females, whereas transgenic animals not expressing Tg(HLA-A2.1)1Enge are normally diabetes-resistant




Genotype
MGI:3711109
cx27
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic
Background
NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tg(HLA-A/H2-D/B2M)1Dvs mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
• HLA-A2.1-restricted T cells from mice as young as 5 weeks of age respond to IGRP (islet-specific glucose-6-phophatase catalytic subunit-related protein) peptides
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets
• 55% of females develop type I diabetes by 30 weeks of age, with significantly accelerated onset compared with non transgenic littermates

hematopoietic system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:121685




Genotype
MGI:3618703
cx28
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present

immune system
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present
• B2m-deficient female transgenic NOD mice are completely diabetes resistant compared to transgenic NOD controls

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553




Genotype
MGI:5707036
cx29
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Tg(HLA-A2.1)1Enge/?
Genetic
Background
NOD.Cg-Prkdcscid Emv30b B2mtm1Unc Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (32 available); any B2m mutation (42 available)
Emv30b mutation (2 available); any Emv30 mutation (2 available)
Prkdcscid mutation (72 available); any Prkdc mutation (188 available)
Tg(B2M)55Hpl mutation (6 available)
Tg(HLA-A2.1)1Enge mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory