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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atmtm1Awb
targeted mutation 1, Anthony Wynshaw Boris
MGI:1857132
Summary 19 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atmtm1Awb/Atmtm1Awb 129S6/SvEvTac-Atmtm1Awb MGI:5565477
hm2
Atmtm1Awb/Atmtm1Awb A.129S6-Atmtm1Awb MGI:5565476
hm3
Atmtm1Awb/Atmtm1Awb B6.129S6-Atmtm1Awb MGI:5565475
hm4
Atmtm1Awb/Atmtm1Awb CByJ.129S6-Atmtm1Awb MGI:5565474
hm5
Atmtm1Awb/Atmtm1Awb either: 129S6/SvEvTac-Atmtm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss) MGI:2175703
hm6
Atmtm1Awb/Atmtm1Awb either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1 MGI:5565479
hm7
Atmtm1Awb/Atmtm1Awb either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1 MGI:5565478
hm8
Atmtm1Awb/Atmtm1Awb either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 MGI:5565480
hm9
Atmtm1Awb/Atmtm1Awb involves: 129S6/SvEvTac MGI:3761095
hm10
Atmtm1Awb/Atmtm1Awb involves: 129S6/SvEvTac * C57BL/6 MGI:3615662
cx11
Atmtm1Awb/Atmtm1Awb
Pim1tm1Mjn/Pim1+
involves: 129 * 129S6/SvEvTac * C57BL/6J MGI:5491072
cx12
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129 * C57BL * FVB/N * SJL MGI:3710183
cx13
Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3850721
cx14
Atmtm1Awb/Atmtm1Awb
Nbntm1Jpt/Nbntm1Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:3615888
cx15
Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3615669
cx16
Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3615663
cx17
Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129S6/SvEvTac * 129/Sv MGI:3771170
cx18
Atmtm1Awb/Atm+
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:5614077
cx19
Atmtm1Awb/Atmtm1Awb
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:5614078


Genotype
MGI:5565477
hm1
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
129S6/SvEvTac-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 113 days
• one mouse out of 40 survives to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:5565476
hm2
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
A.129S6-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• 4 out of 40 mice develop hepatocellular carcinomas as compared to 0 in wild type controls
• tumors were only found in male mice

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
• heterozygote x heterozygote matings produced fewer homozygotes than the expected Mendelian ratio
• Background Sensitivity: the number of homozygous pups produced from heterozygotes on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1
• median survival time is 385 days
• 4 mice out of 40 survive to 18 months of age

neoplasm
• Background Sensitivity: mice are resistant to thymic lymphomas as compared to mice on the BALB/c, 129S6/SvEvTac, C57BL/6, B6AF1, 129S6B6F1, 129S6AF1 backgrounds
• 3 out of 40 mice develop thymic lymphomas by 18 months of age
• 4 out of 40 mice develop hepatocellular carcinomas as compared to 0 in wild type controls
• tumors were only found in male mice




Genotype
MGI:5565475
hm3
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
B6.129S6-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
• heterozygote x heterozygote matings produced fewer homozygotes than the expected Mendelian ratio
• Background Sensitivity: the number of homozygous pups produced from heterozygotes on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio
• median survival time is 353 days
• 8 mice out of 40 survive to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• Background Sensitivity: mice are less susceptible to thymic lymphomas than on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 backgrounds
• 21 out of 40 mice die of thymic lymphomas




Genotype
MGI:5565474
hm4
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
CByJ.129S6-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 74 days, no mice survive beyond 109 days
• Background Sensitivity: survival time is shortest on this background as compared to the A/J, C57BL/6, 129S6B6F1, B6AF1 and 129S6AF1 backgrounds

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:2175703
hm5
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: 129S6/SvEvTac-Atmtm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Oxidated stress in the brain of Atmtm1Awb/Atmtm1Awb mice indicated by increased levels of heme oxygenase

mortality/aging
• mutant mice die from radiation induced toxicity to the gastrointestinal tract at doses that do not kill control mice
• many mice die from thymic lymphoma; none survived greater than 4.5 months of age without a thymic lymphoma

growth/size/body
• homozygotes appear smaller at birth
• female and male homozygotes weigh less that control littermates from P8 to 3 months of age

immune system
N
• no abnormalities in B lymphocytes, granulocytes or myeloid cells observed
• increased number of immature double positive cells
• reduced number of mature single-positive Cd4+ and Cd8+ T lymphocytes
• 59% reduction in Cd3/Cd4 double positive T lymphocytes
• 67% reduction in Cd3/Cd8 double positive T lymphocytes
• reduction in Cd5, Cd4, and Cd8 positive T lymphocytes
• using Cd69 as a marker of activation, the number of Cd3/Cd69 or Cd8/Cd69 positive cells is reduced, but still present

reproductive system
• absence of primordial and mature ovarian follicles
• no proliferation or degeneration in as part of the estrous cycle
• complete absence of mature gametes
• absence of mature sperm
• reduced number of cells
• degeneration of cells evident
• some barren of all cells except Sertoli cells
• females never enter estrous
• females never exhibit copulation plugs
• normal mating behavior evident by the presence of copulation plugs in control females; however, pregnancy never results

neoplasm
• thymic lymphomas are highly metastatic and consist of immature T cells

cellular
• significant increase in the number of lysosomes in cerebellar Purkinje cells and in pyramidal cells of the hippocampus in the absence of any neuronal degeneration at 4-12 weeks of age, before the onset of T cell lymphoma
• mutant fibroblasts show increased radioresistant DNA synthesis (RDS) after 5 to 15 Gy of gamma-irradiation compared to controls, indicating that cell cycle checkpoints are abnormal
• mutant fibroblasts grew more slowly in culture than control cells
• tissues from mutants are under oxidative stress and suffer oxidative damage, especially in the brain
• oxidative damage to proteins and lipids as indicated by elevated nitrotyrosine levels in the brain (but not the liver) and elevated F2-isoprostanes in the testes (indicative of lipid damage)
• activity of the isozyme, heme oxygenase, is increased 600% in the cerebellum (but not in the cortex)

behavior/neurological
• mutant mice were not able to stay on a rota-rod as long as controls
• impaired performance was not due to decreased strength since mice were able to suspend from a wire lid as long as controls
• mutant mice reared less often than controls
• reduced horizontal activity was shown by reduced movement around an open field
• in addition, the maximum difference in stride lengths was greater in mutant mice, suggestive of ataxia

nervous system
N
• no defects in brain architecture
• no evidence of neurodegeneration
• heme oxygenase 1 is increase in Purkinje cells, indicating oxidative damage particularly in these cells

hematopoietic system
• increased number of immature double positive cells
• reduced number of mature single-positive Cd4+ and Cd8+ T lymphocytes
• 59% reduction in Cd3/Cd4 double positive T lymphocytes
• 67% reduction in Cd3/Cd8 double positive T lymphocytes
• reduction in Cd5, Cd4, and Cd8 positive T lymphocytes
• using Cd69 as a marker of activation, the number of Cd3/Cd69 or Cd8/Cd69 positive cells is reduced, but still present

endocrine/exocrine glands
• absence of primordial and mature ovarian follicles
• reduced number of cells
• degeneration of cells evident
• some barren of all cells except Sertoli cells
• thymic lymphomas are highly metastatic and consist of immature T cells

homeostasis/metabolism
• mutant mice die from radiation induced toxicity to the gastrointestinal tract at doses that do not kill control mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Ataxia-Telangiectasia; AT 208900 J:34193 , J:57115




Genotype
MGI:5565479
hm6
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 139 days
• 4 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:5565478
hm7
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 200 days
• 5 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:5565480
hm8
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 451 days
• 6 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time is longest on this background as compared to A/J, BALB/c, 129S6/SvEvTac, C57BL/6, 129S6B6F1 and 129S6AF1 backgrounds

neoplasm
• Background Sensitivity: mice are less susceptible to thymic lymphomas than on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 backgrounds
• 5 out of 20 males and 13 out of 20 mice die of thymic lymphomas




Genotype
MGI:3761095
hm9
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

mortality/aging
• median survival is 16 weeks

immune system
N
• thymic apoptosis following exposure to radiation is normal
• B cells have about a 5-fold reduction in class switch recombination to IgG1
• there is small increase in switch junctions showing three or more nucleotide insertions

cellular
N
• mouse embryonic fibroblast cells arrest and undergo apoptosis following exposure to ionizing radiation
• lymphoma cells show Chromosome 14 translocations at the TCR alpha/delta locus
• DNA losses in distal Chromosome 12 near the Igh locus
• mouse embryonic fibroblasts exposed to radiation fail to arrest at the G1/S transition unlike similarly treated wild-type cells
• 10%-20% of B cells harbored IgH-specific breaks, 0.5%-3.5% carried IgH translocations, and 20%-30% had non-IgH associated instability
• incubation with DNA-PKcs kinase inhibitors dramatically increases genomic instability and almost doubles the frequency of myc/IgH translocations

growth/size/body

hematopoietic system
• B cells have about a 5-fold reduction in class switch recombination to IgG1
• there is small increase in switch junctions showing three or more nucleotide insertions

neoplasm

homeostasis/metabolism




Genotype
MGI:3615662
hm10
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• majority die with thymic lymphomas

mortality/aging
• majority die with thymic lymphomas by 5 months of age, 2.9% live up to 10 months, and none live beyond 15 months

neoplasm
• majority die with thymic lymphomas

cellular
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage




Genotype
MGI:5491072
cx11
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Pim1tm1Mjn/Pim1+
Genetic
Background
involves: 129 * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Pim1tm1Mjn mutation (0 available); any Pim1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• no defect in homology directed repair is detected in MEFs or ear fibroblasts




Genotype
MGI:3710183
cx12
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129 * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Ppm1dtm1Lad mutation (0 available); any Ppm1d mutation (10 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 69 days

neoplasm
• based on median survival time, mice carrying double Atmtm1Awb allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele




Genotype
MGI:3850721
cx13
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Rad52tm1Aps mutation (1 available); any Rad52 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice develop thymic tumors

mortality/aging
• median survival is 33 weeks compared to 16 weeks for Atmtm1Awb homozygotes

neoplasm
• mice develop thymic tumors
• unlike in Atmtm1Awb homozygotes, mice rarely develop T cell lymphomas

immune system

growth/size/body

hematopoietic system

homeostasis/metabolism




Genotype
MGI:3615888
cx14
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Nbntm1Jpt/Nbntm1Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Nbntm1Jpt mutation (1 available); any Nbn mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no embryos detected at E10, stage of death not determined




Genotype
MGI:3615669
cx15
Allelic
Composition
Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although most succumb to anemia, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 85% living longer than 5 months of age

neoplasm
• 16 of 67 develop lymphoma

hematopoietic system
• most succumb to anemia
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

immune system
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice




Genotype
MGI:3615663
cx16
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although die of malignancy, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 42% living longer than 5 months, 20.5% surviving to 10 months and 18% surviving to 15 months

neoplasm
• although mutants develop lymphomas, the latency of lymphomagenesis is increased compared to homozygous Atmtm1Awb mice

cellular
N
• growth of MEFs and sensitivity to irradiation is comparable to wild-type indicating rescue of the slower growth of MEFs and increased sensitivity to gamma-irradiation that is seen in homozygous Atmtm1Awb mice
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage
• exhibit some chromosomal instability, however it is slightly reduced relative to homozygous Atm mice

hematopoietic system
• 4 of 42 develop anemia




Genotype
MGI:3771170
cx17
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cells undergo fail to exhibit increased levels of apoptosis following exposure to ionizing radiation




Genotype
MGI:5614077
cx18
Allelic
Composition
Atmtm1Awb/Atm+
Rad50tm4.1Jpt/Rad50+
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• cellularity is increased compared to mutant mice wild-type for Atm
• 2-fold larger than in mutant mice wild-type for Atm

hematopoietic system
N
• unlike mutant mice wild-type for Atm, the LSK population is similar to wild-type controls

nervous system
N
• unlike mutant mice wild-type for Atm, no mice with hydrocephaly are seen

endocrine/exocrine glands
• cellularity is increased compared to mutant mice wild-type for Atm
• 2-fold larger than in mutant mice wild-type for Atm




Genotype
MGI:5614078
cx19
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Rad50tm4.1Jpt/Rad50+
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (81 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• marked increase in the latency of thymic lymphomas compared to mutant mice wild-type for Rad50





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory