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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atmtm1Awb
targeted mutation 1, Anthony Wynshaw Boris
MGI:1857132
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atmtm1Awb/Atmtm1Awb 129S6/SvEvTac-Atmtm1Awb MGI:5565477
hm2
Atmtm1Awb/Atmtm1Awb A.129S6-Atmtm1Awb MGI:5565476
hm3
Atmtm1Awb/Atmtm1Awb A.129S6-Atmtm1Awb/J MGI:5829788
hm4
Atmtm1Awb/Atmtm1Awb B6.129S6-Atmtm1Awb MGI:5565475
hm5
Atmtm1Awb/Atmtm1Awb CByJ.129S6-Atmtm1Awb MGI:5565474
hm6
Atmtm1Awb/Atmtm1Awb either: 129S6/SvEvTac-Atmtm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss) MGI:2175703
hm7
Atmtm1Awb/Atmtm1Awb either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1 MGI:5565479
hm8
Atmtm1Awb/Atmtm1Awb either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1 MGI:5565478
hm9
Atmtm1Awb/Atmtm1Awb either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 MGI:5565480
hm10
Atmtm1Awb/Atmtm1Awb involves: 129S6/SvEvTac MGI:3761095
hm11
Atmtm1Awb/Atmtm1Awb involves: 129S6/SvEvTac * C57BL/6 MGI:3615662
cx12
Atmtm1Awb/Atmtm1Awb
Pim1tm1Mjn/Pim1+
involves: 129 * 129S6/SvEvTac * C57BL/6J MGI:5491072
cx13
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
involves: 129 * C57BL * FVB/N * SJL MGI:3710183
cx14
Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3850721
cx15
Atmtm1Awb/Atmtm1Awb
Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:5819196
cx16
Atmtm1Awb/Atmtm1Awb
Nbntm1Jpt/Nbntm1Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:3615888
cx17
Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3615663
cx18
Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 MGI:3615669
cx19
Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129S6/SvEvTac * 129/Sv MGI:3771170
cx20
Atmtm1Awb/Atm+
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:5614077
cx21
Atmtm1Awb/Atmtm1Awb
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6 MGI:5614078
cx22
Atmtm1Awb/Atmtm1Awb
BC029214em1Spj/BC029214em1Spj
involves: A/J * C57BL/6NTac MGI:5829795


Genotype
MGI:5565477
hm1
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
129S6/SvEvTac-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 113 days
• one mouse out of 40 survives to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:5565476
hm2
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
A.129S6-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• 4 out of 40 mice develop hepatocellular carcinomas as compared to 0 in wild type controls
• tumors were only found in male mice

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
• heterozygote x heterozygote matings produced fewer homozygotes than the expected Mendelian ratio
• Background Sensitivity: the number of homozygous pups produced from heterozygotes on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1
• median survival time is 385 days
• 4 mice out of 40 survive to 18 months of age

neoplasm
• Background Sensitivity: mice are resistant to thymic lymphomas as compared to mice on the BALB/c, 129S6/SvEvTac, C57BL/6, B6AF1, 129S6B6F1, 129S6AF1 backgrounds
• 3 out of 40 mice develop thymic lymphomas by 18 months of age
• 4 out of 40 mice develop hepatocellular carcinomas as compared to 0 in wild type controls
• tumors were only found in male mice




Genotype
MGI:5829788
hm3
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
A.129S6-Atmtm1Awb/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following exposure to 5 Gy of whole-body gamma radiation, 2 of 2 mice (>12 weeks of age) die within 5 days post-treatment

homeostasis/metabolism
• following exposure to 5 Gy of whole-body gamma radiation, 2 of 2 mice (>12 weeks of age) die within 5 days post-treatment




Genotype
MGI:5565475
hm4
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
B6.129S6-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
• heterozygote x heterozygote matings produced fewer homozygotes than the expected Mendelian ratio
• Background Sensitivity: the number of homozygous pups produced from heterozygotes on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio
• median survival time is 353 days
• 8 mice out of 40 survive to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• Background Sensitivity: mice are less susceptible to thymic lymphomas than on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 backgrounds
• 21 out of 40 mice die of thymic lymphomas




Genotype
MGI:5565474
hm5
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
CByJ.129S6-Atmtm1Awb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 74 days, no mice survive beyond 109 days
• Background Sensitivity: survival time is shortest on this background as compared to the A/J, C57BL/6, 129S6B6F1, B6AF1 and 129S6AF1 backgrounds

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:2175703
hm6
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: 129S6/SvEvTac-Atmtm1Awb or (involves: 129S6/SvEvTac * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Oxidated stress in the brain of Atmtm1Awb/Atmtm1Awb mice indicated by increased levels of heme oxygenase

mortality/aging
• mutant mice die from radiation induced toxicity to the gastrointestinal tract at doses that do not kill control mice
• many mice die from thymic lymphoma; none survived greater than 4.5 months of age without a thymic lymphoma

growth/size/body
• homozygotes appear smaller at birth
• female and male homozygotes weigh less that control littermates from P8 to 3 months of age

immune system
N
• no abnormalities in B lymphocytes, granulocytes or myeloid cells observed
• increased number of immature double positive cells
• reduced number of mature single-positive Cd4+ and Cd8+ T lymphocytes
• 59% reduction in Cd3/Cd4 double positive T lymphocytes
• 67% reduction in Cd3/Cd8 double positive T lymphocytes
• reduction in Cd5, Cd4, and Cd8 positive T lymphocytes
• using Cd69 as a marker of activation, the number of Cd3/Cd69 or Cd8/Cd69 positive cells is reduced, but still present

reproductive system
• absence of primordial and mature ovarian follicles
• no proliferation or degeneration in as part of the estrous cycle
• complete absence of mature gametes
• absence of mature sperm
• reduced number of cells
• degeneration of cells evident
• some barren of all cells except Sertoli cells
• females never enter estrous
• females never exhibit copulation plugs
• normal mating behavior evident by the presence of copulation plugs in control females; however, pregnancy never results

neoplasm
• thymic lymphomas are highly metastatic and consist of immature T cells

cellular
• complete absence of mature gametes
• absence of mature sperm
• significant increase in the number of lysosomes in cerebellar Purkinje cells and in pyramidal cells of the hippocampus in the absence of any neuronal degeneration at 4-12 weeks of age, before the onset of T cell lymphoma
• mutant fibroblasts show increased radioresistant DNA synthesis (RDS) after 5 to 15 Gy of gamma-irradiation compared to controls, indicating that cell cycle checkpoints are abnormal
• mutant fibroblasts grew more slowly in culture than control cells
• tissues from mutants are under oxidative stress and suffer oxidative damage, especially in the brain
• oxidative damage to proteins and lipids as indicated by elevated nitrotyrosine levels in the brain (but not the liver) and elevated F2-isoprostanes in the testes (indicative of lipid damage)
• activity of the isozyme, heme oxygenase, is increased 600% in the cerebellum (but not in the cortex)

behavior/neurological
• mutant mice were not able to stay on a rota-rod as long as controls
• impaired performance was not due to decreased strength since mice were able to suspend from a wire lid as long as controls
• mutant mice reared less often than controls
• reduced horizontal activity was shown by reduced movement around an open field
• in addition, the maximum difference in stride lengths was greater in mutant mice, suggestive of ataxia

nervous system
N
• no defects in brain architecture
• no evidence of neurodegeneration
• heme oxygenase 1 is increase in Purkinje cells, indicating oxidative damage particularly in these cells

hematopoietic system
• increased number of immature double positive cells
• reduced number of mature single-positive Cd4+ and Cd8+ T lymphocytes
• 59% reduction in Cd3/Cd4 double positive T lymphocytes
• 67% reduction in Cd3/Cd8 double positive T lymphocytes
• reduction in Cd5, Cd4, and Cd8 positive T lymphocytes
• using Cd69 as a marker of activation, the number of Cd3/Cd69 or Cd8/Cd69 positive cells is reduced, but still present

endocrine/exocrine glands
• absence of primordial and mature ovarian follicles
• reduced number of cells
• degeneration of cells evident
• some barren of all cells except Sertoli cells
• thymic lymphomas are highly metastatic and consist of immature T cells

homeostasis/metabolism
• mutant mice die from radiation induced toxicity to the gastrointestinal tract at doses that do not kill control mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ataxia telangiectasia DOID:12704 OMIM:208900
J:34193 , J:57115




Genotype
MGI:5565479
hm7
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 139 days
• 4 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:5565478
hm8
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds

growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 200 days
• 5 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time (least to most) on the following strain backgrounds is ranked as BALB/c < 129S6/SvEvTac < 129S6AF1 < 129S6B6F1 < C57BL/6 < A/J < B6AF1

neoplasm
• almost all mice die of thymic lymphomas
• Background Sensitivity: mice have a higher thymic lymphoma incidence than do homozygous Atmtm1Awb mice on the C57BL/6, B6AF1 and A/J backgrounds




Genotype
MGI:5565480
hm9
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• pups of the same sex measured weekly from 5-12 weeks of age weigh less than wild type controls at all time points

mortality/aging
N
• Background Sensitivity: the number of homozygous pups produced from heterozygote matings on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 and B6AF1 backgrounds reaches the expected Mendelian ratio; fewer homozygous pups are produced on the C57BL/6 and A/J backgrounds
• median survival time is 451 days
• 6 mice out of 39 survive to 18 months of age
• Background Sensitivity: survival time is longest on this background as compared to A/J, BALB/c, 129S6/SvEvTac, C57BL/6, 129S6B6F1 and 129S6AF1 backgrounds

neoplasm
• Background Sensitivity: mice are less susceptible to thymic lymphomas than on the BALB/c, 129S6/SvEvTac, 129S6B6F1, 129S6AF1 backgrounds
• 5 out of 20 males and 13 out of 20 mice die of thymic lymphomas




Genotype
MGI:3761095
hm10
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

mortality/aging
• median survival is 16 weeks

immune system
N
• thymic apoptosis following exposure to radiation is normal
• B cells have about a 5-fold reduction in class switch recombination to IgG1
• there is small increase in switch junctions showing three or more nucleotide insertions

cellular
N
• mouse embryonic fibroblast cells arrest and undergo apoptosis following exposure to ionizing radiation
• lymphoma cells show Chromosome 14 translocations at the TCR alpha/delta locus
• DNA losses in distal Chromosome 12 near the Igh locus
• mouse embryonic fibroblasts exposed to radiation fail to arrest at the G1/S transition unlike similarly treated wild-type cells
• 10%-20% of B cells harbored IgH-specific breaks, 0.5%-3.5% carried IgH translocations, and 20%-30% had non-IgH associated instability
• incubation with DNA-PKcs kinase inhibitors dramatically increases genomic instability and almost doubles the frequency of myc/IgH translocations

growth/size/body

hematopoietic system
• B cells have about a 5-fold reduction in class switch recombination to IgG1
• there is small increase in switch junctions showing three or more nucleotide insertions

neoplasm

homeostasis/metabolism




Genotype
MGI:3615662
hm11
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• majority die with thymic lymphomas

mortality/aging
• majority die with thymic lymphomas by 5 months of age, 2.9% live up to 10 months, and none live beyond 15 months

neoplasm
• majority die with thymic lymphomas

cellular
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage




Genotype
MGI:5491072
cx12
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Pim1tm1Mjn/Pim1+
Genetic
Background
involves: 129 * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Pim1tm1Mjn mutation (0 available); any Pim1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• no defect in homology directed repair is detected in MEFs or ear fibroblasts




Genotype
MGI:3710183
cx13
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Ppm1dtm1Lad/Ppm1dtm1Lad
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129 * C57BL * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Ppm1dtm1Lad mutation (1 available); any Ppm1d mutation (12 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the median lifespan of 69 days

neoplasm
• based on median survival time, mice carrying double Atmtm1Awb allele were no more resistant to tumor formation induced by myc than mice with homozygous wild-type Ppm1d+ allele




Genotype
MGI:3850721
cx14
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Rad52tm1Aps/Rad52tm1Aps
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Rad52tm1Aps mutation (1 available); any Rad52 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice develop thymic tumors

mortality/aging
• median survival is 33 weeks compared to 16 weeks for Atmtm1Awb homozygotes

neoplasm
• mice develop thymic tumors
• unlike in Atmtm1Awb homozygotes, mice rarely develop T cell lymphomas

immune system

growth/size/body

hematopoietic system

homeostasis/metabolism




Genotype
MGI:5819196
cx15
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Cep63Gt(EUCE0251h11)Hmgu mutation (0 available); any Cep63 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• significant reduction in cortical thickness, as determined in motor and visual cortex sections at P60, similar to that in single Cep63Gt(EUCE0251h11)Hmgu homozygotes




Genotype
MGI:3615888
cx16
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Nbntm1Jpt/Nbntm1Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Nbntm1Jpt mutation (1 available); any Nbn mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no embryos detected at E10, stage of death not determined




Genotype
MGI:3615663
cx17
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Rad50tm2Jpt mutation (1 available); any Rad50 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although die of malignancy, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 42% living longer than 5 months, 20.5% surviving to 10 months and 18% surviving to 15 months

neoplasm
• although mutants develop lymphomas, the latency of lymphomagenesis is increased compared to homozygous Atmtm1Awb mice

cellular
N
• growth of MEFs and sensitivity to irradiation is comparable to wild-type indicating rescue of the slower growth of MEFs and increased sensitivity to gamma-irradiation that is seen in homozygous Atmtm1Awb mice
• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage
• exhibit some chromosomal instability, however it is slightly reduced relative to homozygous Atm mice

hematopoietic system
• 4 of 42 develop anemia




Genotype
MGI:3615669
cx18
Allelic
Composition
Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Rad50tm2Jpt mutation (1 available); any Rad50 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although most succumb to anemia, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 85% living longer than 5 months of age

neoplasm
• 16 of 67 develop lymphoma

hematopoietic system
• most succumb to anemia
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

immune system
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice




Genotype
MGI:3771170
cx19
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic
Background
involves: 129S6/SvEvTac * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cells undergo fail to exhibit increased levels of apoptosis following exposure to ionizing radiation




Genotype
MGI:5614077
cx20
Allelic
Composition
Atmtm1Awb/Atm+
Rad50tm4.1Jpt/Rad50+
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• cellularity is increased compared to mutant mice wild-type for Atm
• 2-fold larger than in mutant mice wild-type for Atm

hematopoietic system
N
• unlike mutant mice wild-type for Atm, the LSK population is similar to wild-type controls

nervous system
N
• unlike mutant mice wild-type for Atm, no mice with hydrocephaly are seen

endocrine/exocrine glands
• cellularity is increased compared to mutant mice wild-type for Atm
• 2-fold larger than in mutant mice wild-type for Atm




Genotype
MGI:5614078
cx21
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
Rad50tm4.1Jpt/Rad50+
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• marked increase in the latency of thymic lymphomas compared to mutant mice wild-type for Rad50




Genotype
MGI:5829795
cx22
Allelic
Composition
Atmtm1Awb/Atmtm1Awb
BC029214em1Spj/BC029214em1Spj
Genetic
Background
involves: A/J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (89 available)
BC029214em1Spj mutation (0 available); any BC029214 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• double homozygotes are born at the expected Mendelian frequencies and closely resemble single Atmtm1Awb homozygotes

immune system
• splenic B cells show no further defect in class switch recombination relative to that in single Atmtm1Awb homozygotes
• mice show a similar reduction of B cell number in spleen relative to single Atmtm1Awb homozygotes
• mice show a similar reduction of T cell number in spleen relative to single Atmtm1Awb homozygotes
• at 6-8 weeks of age, mice show a similar reduction of total cell numbers in spleen relative to single Atmtm1Awb homozygotes

hematopoietic system
• splenic B cells show no further defect in class switch recombination relative to that in single Atmtm1Awb homozygotes
• mice show a similar reduction of B cell number in spleen relative to single Atmtm1Awb homozygotes
• mice show a similar reduction of T cell number in spleen relative to single Atmtm1Awb homozygotes
• at 6-8 weeks of age, mice show a similar reduction of total cell numbers in spleen relative to single Atmtm1Awb homozygotes





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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory