About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Amhtm1Bhr
targeted mutation 1, Richard R Behringer
MGI:1857126
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Amhtm1Bhr/Amhtm1Bhr either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:2450393
hm2
Amhtm1Bhr/Amhtm1Bhr involves: 129S7/SvEvBrd * C57BL/6 MGI:2653866
ht3
Amhtm1Bhr/Amh+ involves: 129S7/SvEvBrd * C57BL/6 MGI:2450405
cx4
Amhtm1Bhr/Amhtm1Bhr
ArTfm/Y
either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:2450394
cx5
Amhtm1Bhr/Amh+
Amhr2tm1Bhr/Amhr2tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6 MGI:3042189
cx6
Amhtm1Bhr/Amhtm1Bhr
Amhr2tm1Bhr/Amhr2tm1Bhr
Not Specified MGI:3042185


Genotype
MGI:2450393
hm1
Allelic
Composition
Amhtm1Bhr/Amhtm1Bhr
Genetic
Background
either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhtm1Bhr mutation (2 available); any Amh mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• focal hyperplasia in 27% of males 10 weeks or older
• in spite of the hyperplasia, the cells were functionally normal
• one neoplasm containing multiple foci of leydig cell hyperplasia was detected

reproductive system
N
• XX females were fertile and displayed normal uteri containing morphologically normal oviducts
• focal hyperplasia in 27% of males 10 weeks or older
• in spite of the hyperplasia, the cells were functionally normal
• one neoplasm containing multiple foci of leydig cell hyperplasia was detected
• XY male mice developed hypoplastic female structures derived from the Mullerian duct, namely a uterus, uncoiled oviducts, and a vagina
• uterine horns paralleled the vas deferens and joined to form cervix that opened into a vagina
• the physical association of the uterine horns with the vas deferens caused the horns to be pulled caudally
• XY males displayed normal sized testes that were fully descended and spermatogenesis was unimpaired
• proper differentiation of the Wolffian duct system
• 13% of males were able to impregnate wild-type females
• infertility putatively due to a blockage of sperm movement resulting in a diversion from the normal pathway




Genotype
MGI:2653866
hm2
Allelic
Composition
Amhtm1Bhr/Amhtm1Bhr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhtm1Bhr mutation (2 available); any Amh mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

endocrine/exocrine glands
• increased numbers of preantral and small antral follicles at 25 days and 4 months
• reduced number of primordial follicles observed at 4 months, with further decrease at 13
• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age

homeostasis/metabolism
• observed in females 4 months of age

reproductive system
• increased numbers of preantral and small antral follicles at 25 days and 4 months
• reduced number of primordial follicles observed at 4 months, with further decrease at 13
• while the ovaries were morphologically normal at 25 days and 13 months, the weight was 1.8 fold higher than wild-type at 4 months of age




Genotype
MGI:2450405
ht3
Allelic
Composition
Amhtm1Bhr/Amh+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhtm1Bhr mutation (2 available); any Amh mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

endocrine/exocrine glands
• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice

reproductive system
• the ovarian weight was greater than that of wild-type mice and less than that of homozygous mutant mice




Genotype
MGI:2450394
cx4
Allelic
Composition
Amhtm1Bhr/Amhtm1Bhr
ArTfm/Y
Genetic
Background
either: (involves: 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhtm1Bhr mutation (2 available); any Amh mutation (19 available)
ArTfm mutation (1 available); any Ar mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• absence of vas deferens
• XY male mice developed undescended dysfunctional testes, uteri, coiled oviducts, and a vagina with an opening

endocrine/exocrine glands




Genotype
MGI:3042189
cx5
Allelic
Composition
Amhtm1Bhr/Amh+
Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm1Bhr mutation (0 available); any Amhr2 mutation (23 available)
Amhtm1Bhr mutation (2 available); any Amh mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

neoplasm
• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age

reproductive system
• unilateral stromal tumors observed in the testes of some mice at 6 to 7 months of age




Genotype
MGI:3042185
cx6
Allelic
Composition
Amhtm1Bhr/Amhtm1Bhr
Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm1Bhr mutation (0 available); any Amhr2 mutation (23 available)
Amhtm1Bhr mutation (2 available); any Amh mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice developed normally and were fertile
• males developed Mullerian duct derivatives
• male mice had testes of normal size that were properly descended into the scrotal sac
• normal differentiation of male-specific Wolffian duct-derived tissue
• spermatogenesis was unimpaired, however males were infertile due to the presence of female reproductive organs that blocked sperm transfer





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory