hm1

Mip^Cat-Lop/Mip^Cat-Lop
involves: STOCK Rb(6.15)1Ald

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

vision/eye

abnormal lens fiber morphology ( J:6702 )

• no regular arrangement of layers of lens fibers

cataracts ( J:6702 )

• opaque lenses

small lens ( J:6702 )

microphthalmia ( J:6702 )

• very small eyes

ht2

Mip^Cat-Lop/Mip⁺
involves: STOCK Rb(6.15)1Ald

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

vision/eye

total cataracts ( J:6702 )

• total lens opacity; in rare few the opacity is less than total

• opacity is present at the time the eyes first open (P12)

microphthalmia ( J:6702 )

• slightly reduced eye size; less severe than displayed by homozygous mutant mice

Mouse Models of Human Disease	OMIM ID	Ref(s)
Major Intrinsic Protein of Lens Fiber; MIP	154050	J:31574
Cataract, Autosomal Dominant	604219	J:31574