• at 14 days of gestation, the centrally located nuclei of the lens fibers are seen to be abnormally small and dark with indistinct nucleoli (J:5104)

• nuclear degeneration is followed by swelling and vacuolization of the lens fibers (J:5104)

• the main lens fiber mass degenerates (J:5114)

• the epithelial cells form multiple layers of atypical cells (J:5114)

• by electron microscopy, changes can be seen in the nuclear envelope of the primary lens fibers in 12-day embryos (J:30791)

• lens opacities are visible when the eyes first open at 14 days