Mouse Genome Informatics
involves: A/J
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• at 14 days of gestation, the centrally located nuclei of the lens fibers are seen to be abnormally small and dark with indistinct nucleoli (J:5104)
• nuclear degeneration is followed by swelling and vacuolization of the lens fibers (J:5104)
• the main lens fiber mass degenerates (J:5114)
• the epithelial cells form multiple layers of atypical cells (J:5114)
• by electron microscopy, changes can be seen in the nuclear envelope of the primary lens fibers in 12-day embryos (J:30791)
• lens opacities are visible when the eyes first open at 14 days

Mouse Models of Human Disease
Cataract 15, Multiple Types; CTRCT15 615274 J:31574