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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Wnt3avt
vestigial tail
MGI:1857088
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Wnt3avt/Wnt3avt B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J MGI:3604386
hm2
Wnt3avt/Wnt3avt involves: A * A/Gr * C57BR MGI:3604383
hm3
Wnt3avt/Wnt3avt involves: C3H/HeJ * C57BL/6J * C57BR MGI:3604384
hm4
Wnt3avt/Wnt3avt involves: C57BR MGI:2676425
ht5
Wnt3atm1Amc/Wnt3avt involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR MGI:3604385
cx6
Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3avt
involves: 129P2/OlaHsd * C57BL/6 * C57BR MGI:3604380
cx7
Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3a+
involves: 129P2/OlaHsd * C57BL/6 * C57BR MGI:3604382


Genotype
MGI:3604386
hm1
Allelic
Composition
Wnt3avt/Wnt3avt
Genetic
Background
B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• transformation of thoracic vertebra 9 (T9) to T10
• transformation of T13 to lumbar vertebra 1 (L1)
• homeotic transformation of cervical vertebra 2 (C2) to C1 is seen in some homzygotes
• transformation of L6 to sacral vertebra 1 (S1)
• transformation of S4 to S3




Genotype
MGI:3604383
hm2
Allelic
Composition
Wnt3avt/Wnt3avt
Genetic
Background
involves: A * A/Gr * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at E9.5, the unsegmented mesoderm of the tail tip often appears more loosely knit
• more neural tissue is seen in the tail beginning at E11
• a reduction is seen in the ventral ectodermal ridge of the tail
• decreased tail size can be distinguished at E11

embryo
• at E10 the ventral aspect of the neural tube separates from the rest by a capillary cleft and at E11 in some embryos multiple structures resembling neural tubes are seen surrounding a central blood vessel
• more neural tissue is seen in the tail beginning at E11
• a reduction is seen in the ventral ectodermal ridge of the tail

nervous system
• at E10 the ventral aspect of the neural tube separates from the rest by a capillary cleft and at E11 in some embryos multiple structures resembling neural tubes are seen surrounding a central blood vessel

digestive/alimentary system
• the tail gut (a diverticulum of the cloaca) does not extend as deeply into the tail in homozygotes




Genotype
MGI:3604384
hm3
Allelic
Composition
Wnt3avt/Wnt3avt
Genetic
Background
involves: C3H/HeJ * C57BL/6J * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• the most caudal vertebrae have abnormal centers of ossification
• the number of vertebrae with caudal morphology is reduced to 2 - 15 compared to 18 - 25 in heterozygous mice

embryo
• by E11.5, differences in somite number are seen in the caudal region

skeleton
• the most caudal vertebrae have abnormal centers of ossification
• the number of vertebrae with caudal morphology is reduced to 2 - 15 compared to 18 - 25 in heterozygous mice
• the most caudal vertebrae have abnormal centers of ossification




Genotype
MGI:2676425
hm4
Allelic
Composition
Wnt3avt/Wnt3avt
Genetic
Background
involves: C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• the tail terminates in a rudiment of irregular fused vertebrae
• the rudiment of the tail is usually less than 1 cm although it may vary from about normal length to essentially absent

skeleton
• the tail terminates in a rudiment of irregular fused vertebrae

reproductive system
• some female homozygotes are sterile




Genotype
MGI:3604385
ht5
Allelic
Composition
Wnt3atm1Amc/Wnt3avt
Genetic
Background
involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (23 available)
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only about 50% of compound heterozygotes live longer than 4 weeks compared to 90% of Wnt3avt heterozygotes

limbs/digits/tail

skeleton
• deformities seen as far anterior as the 7th thoracic vertebra
• the most severely affected mutants have a reduction in the number of thoracic vertebrae
• none of the compound heterozygotes have all of the lumbar vertebrae
• no normal sacral vertebrae are seen

embryo
• the most severely affected mutants are smaller than wild-type littermates
• the most severely affected mutants display spina bifida of the posterior neural tube
• somites do not extend as far caudally as in wild-type embryos and malformed somites are seen rostral to the last somite

nervous system
• the most severely affected mutants display spina bifida of the posterior neural tube

behavior/neurological
• the most severely affected mutants display hindlimb paralysis

growth/size/body
• the most severely affected mutants are smaller than wild-type littermates

renal/urinary system
• in several cases severely affected mutants displayed accumulation of urine in the kidneys and ureters

digestive/alimentary system
• in several cases severely affected mutants displayed hyperextended intestines




Genotype
MGI:3604380
cx6
Allelic
Composition
Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3avt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (6 available)
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• at E11.5 and E13.5 truncation of the tail is more severe than in Wnt3avt single homozygotes




Genotype
MGI:3604382
cx7
Allelic
Composition
Lrp6Gt(Ex187)Byg/Lrp6+
Wnt3avt/Wnt3a+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (6 available)
Wnt3avt mutation (2 available); any Wnt3a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• variable penetrance of tail kinks is seen and the penetrance is increased compared to either single heterozygote





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory