Phenotypes associated with this allele

• Allele Symbol: Wnt3a^vt
• Allele Name: vestigial tail
• Allele ID: MGI:1857088
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt3a^vt/Wnt3a^vt	B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J	MGI:3604386
hm2	Wnt3a^vt/Wnt3a^vt	involves: A * A/Gr * C57BR	MGI:3604383
hm3	Wnt3a^vt/Wnt3a^vt	involves: C3H/HeJ * C57BL/6J * C57BR	MGI:3604384
hm4	Wnt3a^vt/Wnt3a^vt	involves: C57BR	MGI:2676425
ht5	Wnt3a^tm1Amc/Wnt3a^vt	involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR	MGI:3604385
cx6	Lrp6^Gt(Ex187)Byg/Lrp6^+ Wnt3a^vt/Wnt3a^+	involves: 129P2/OlaHsd * C57BL/6 * C57BR	MGI:3604382
cx7	Lrp6^Gt(Ex187)Byg/Lrp6^+ Wnt3a^vt/Wnt3a^vt	involves: 129P2/OlaHsd * C57BL/6 * C57BR	MGI:3604380

Genotype
MGI:3604386

hm1

• Allelic Composition: Wnt3a^vt/Wnt3a^vt
• Genetic Background: B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

thoracic vertebral transformation ( J:69781 )

• transformation of thoracic vertebra 9 (T9) to T10

• transformation of T13 to lumbar vertebra 1 (L1)

cervical vertebral transformation ( J:69781 )

• homeotic transformation of cervical vertebra 2 (C2) to C1 is seen in some homzygotes

lumbar vertebral transformation ( J:69781 )

• transformation of L6 to sacral vertebra 1 (S1)

sacral vertebral transformation ( J:69781 )

• transformation of S4 to S3

Genotype
MGI:3604383

hm2

• Allelic Composition: Wnt3a^vt/Wnt3a^vt
• Genetic Background: involves: A * A/Gr * C57BR

limbs/digits/tail

abnormal tail morphology ( J:14984 )

• at E9.5, the unsegmented mesoderm of the tail tip often appears more loosely knit

abnormal tail bud morphology ( J:14984 )

• more neural tissue is seen in the tail beginning at E11

decreased ventral ectodermal ridge size ( J:14984 )

• a reduction is seen in the ventral ectodermal ridge of the tail

vestigial tail ( J:14984 )

• decreased tail size can be distinguished at E11

embryo

abnormal neural tube morphology ( J:14984 )

• at E10 the ventral aspect of the neural tube separates from the rest by a capillary cleft and at E11 in some embryos multiple structures resembling neural tubes are seen surrounding a central blood vessel

abnormal tail bud morphology ( J:14984 )

• more neural tissue is seen in the tail beginning at E11

decreased ventral ectodermal ridge size ( J:14984 )

• a reduction is seen in the ventral ectodermal ridge of the tail

nervous system

abnormal neural tube morphology ( J:14984 )

• at E10 the ventral aspect of the neural tube separates from the rest by a capillary cleft and at E11 in some embryos multiple structures resembling neural tubes are seen surrounding a central blood vessel

digestive/alimentary system

abnormal tailgut morphology ( J:14984 )

• the tail gut (a diverticulum of the cloaca) does not extend as deeply into the tail in homozygotes

Genotype
MGI:3604384

hm3

• Allelic Composition: Wnt3a^vt/Wnt3a^vt
• Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BR

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:31335 )

• the most caudal vertebrae have abnormal centers of ossification

decreased caudal vertebrae number ( J:31335 )

• the number of vertebrae with caudal morphology is reduced to 2 - 15 compared to 18 - 25 in heterozygous mice

vestigial tail ( J:31335 )

embryo

abnormal somite development ( J:31335 )

• by E11.5, differences in somite number are seen in the caudal region

skeleton

abnormal caudal vertebrae morphology ( J:31335 )

• the most caudal vertebrae have abnormal centers of ossification

decreased caudal vertebrae number ( J:31335 )

• the number of vertebrae with caudal morphology is reduced to 2 - 15 compared to 18 - 25 in heterozygous mice

abnormal bone ossification ( J:31335 )

• the most caudal vertebrae have abnormal centers of ossification

Genotype
MGI:2676425

hm4

• Allelic Composition: Wnt3a^vt/Wnt3a^vt
• Genetic Background: involves: C57BR

limbs/digits/tail

decreased caudal vertebrae number ( J:13062 )

• the tail terminates in a rudiment of irregular fused vertebrae

vestigial tail ( J:13062 )

• the rudiment of the tail is usually less than 1 cm although it may vary from about normal length to essentially absent

skeleton

decreased caudal vertebrae number ( J:13062 )

• the tail terminates in a rudiment of irregular fused vertebrae

reproductive system

reduced female fertility ( J:13062 )

♀ • some female homozygotes are sterile

Genotype
MGI:3604385

ht5

• Allelic Composition: Wnt3a^tm1Amc/Wnt3a^vt
• Genetic Background: involves: 129S1/Sv * C3H/HeJ * C57BL/6J * C57BR

mortality/aging

premature death ( J:31335 )

• only about 50% of compound heterozygotes live longer than 4 weeks compared to 90% of Wnt3a^vt heterozygotes

limbs/digits/tail

absent tail ( J:31335 )

skeleton

abnormal thoracic vertebrae morphology ( J:31335 )

• deformities seen as far anterior as the 7th thoracic vertebra

decreased thoracic vertebrae number ( J:31335 )

• the most severely affected mutants have a reduction in the number of thoracic vertebrae

decreased lumbar vertebrae number ( J:31335 )

• none of the compound heterozygotes have all of the lumbar vertebrae

absent sacral vertebrae ( J:31335 )

• no normal sacral vertebrae are seen

embryo

decreased embryo size ( J:31335 )

• the most severely affected mutants are smaller than wild-type littermates

spina bifida ( J:31335 )

• the most severely affected mutants display spina bifida of the posterior neural tube

abnormal somite development ( J:31335 )

• somites do not extend as far caudally as in wild-type embryos and malformed somites are seen rostral to the last somite

nervous system

spina bifida ( J:31335 )

• the most severely affected mutants display spina bifida of the posterior neural tube

behavior/neurological

hindlimb paralysis ( J:31335 )

• the most severely affected mutants display hindlimb paralysis

growth/size/body

decreased embryo size ( J:31335 )

• the most severely affected mutants are smaller than wild-type littermates

renal/urinary system

abnormal urination ( J:31335 )

• in several cases severely affected mutants displayed accumulation of urine in the kidneys and ureters

digestive/alimentary system

abnormal intestine morphology ( J:31335 )

• in several cases severely affected mutants displayed hyperextended intestines

Genotype
MGI:3604382

cx6

• Allelic Composition: Lrp6^Gt(Ex187)Byg/Lrp6⁺; Wnt3a^vt/Wnt3a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

limbs/digits/tail

kinked tail ( J:64989 )

• variable penetrance of tail kinks is seen and the penetrance is increased compared to either single heterozygote

Genotype
MGI:3604380

cx7

• Allelic Composition: Lrp6^Gt(Ex187)Byg/Lrp6⁺; Wnt3a^vt/Wnt3a^vt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BR

limbs/digits/tail

vestigial tail ( J:64989 )

• at E11.5 and E13.5 truncation of the tail is more severe than in Wnt3a^vt single homozygotes